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Cardio-tonic effect of the aqueous extract of whole plant of Crataegus aronia syn:
azarolus (L) on isolated Rabbit's heart
Shatoor, AS
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume: 6, Issue: 26, Pages: 1901-1909, DOI: 10.5897/AJPP12.135, Published: JUL
2012
Publisher ACADEMIC JOURNALS, P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND,
LAGOS 73023, NIGERIA
ISSN: 1996-0816
Abstract
The aim of this work is to study the effect of aqueous extract of whole plant of Crataegus
aronia on the force of contraction and heart rate of isolated rabbit's heart. Six Isolated
rabbit's hearts were perfused through aorta in a Langendorff mode. Heart rate and
contractility were determined for 5 min in the presence of 8 concentrations of C. aronia
aqueous extract (1, 2, 5, 10, 20, 40, 100 and 200 mg/ml) or adrenaline (0.05 mM) as
control drug. The changes after each treatment were compared with their baseline
values. Data were collected with the help of PowerLab data acquisition and analyzed by
Labchart Pro 7 software. At all time intervals recorded, there were no significant changes
in the force of contraction nor the heart rate (HR) after infusion of low concentrations of
the extract (1, 2, 5 and 10 mg/ml). The maximum increase in force of contraction occurred
at a dose of 40 mg/ml, while the maximum decrease in HR occurred at a dose of 20 mg/ml
(P < 0.01). The highest doses of the extract (100 and 200 mg/ml) caused hardening of the
heart, stopping of the perfusion fluid from entering and stopped the beating of the heart.
Therefore, the aqueous extract of whole plant of C. aronia syn: azarolus (L) showed a
positive inotropic and negative chronotropic effects on isolated rabbit's heart.
Keywords
Author Keywords:Crataegus aronia; cardiovascular; rabbits
KeyWords Plus:OXYGEN CONSUMPTION; MEDICINAL-PLANTS; CONTROLLED
TRIAL; RATE REDUCTION; FAILURE; HAWTHORN; THERAPY; MORTALITY;
MILRINONE; SAPONINS
Author Information
Reprint Address: Shatoor, AS E-mail Addresses:[email protected]
King Khalid Univ, Coll Med, Cardiol Sect, Dept Internal Med, Abha 24121, Saudi Arabia.
Addresses:
[ 1 ] King Khalid Univ, Coll Med, Cardiol Sect, Dept Internal Med, Abha 24121, Saudi
Arabia
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