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Metabolic Risk Factors of Sporadic Alzheimer#cod#x00027;s Disease:
Implications in the Pathology, Pathogenesis and Treatment
Sasanka Chakrabarti 1 ;Vineet Kumar Khemka 1 ;Anindita Banerjee 1, 2 ;Gargi Chatterjee 1 ;Anirban Ganguly 1 ;Atanu Biswas 3 ;
1 Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India. ; 2 Department of
Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia, India. ; 3 Department of Neuromedicine, Bangur Institute of
Neurosciences (BIN), Kolkata, India. ;
Figure 1. Risk factors of Alzheimer#cod#x00027;s disease. Gene -environment interactions may be the underlying mechanism of sporadic AD. Environmental risk factors
include those present in external environment or extra-genetic internal milieu of the body. The risk factors may affect the functions of AD-related genes or their regulatory
regions by methylation, oxidation or other mechanisms. Gene polymorphisms, on the other hand, may aggravate the effects of the risk factors on AD pathogenesis. Drugs,
diet and life-style may prevent the interaction of risk factors with AD pathogenic mechanisms.
Aging and Disease,null,6(4),282-299. Doi:10.14336/AD.2014.002
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