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Table S2. List of all the KEGG pathways with the number of annotated ECs. KEGG pathways Biosynthesis of antibiotics Purine metabolism Starch and sucrose metabolism Pyrimidine metabolism Thiamine metabolism Pentose and glucuronate interconversions Glycolysis / Gluconeogenesis Phenylalanine metabolism Pentose phosphate pathway Phenylpropanoid biosynthesis Methane metabolism Cysteine and methionine metabolism Pyruvate metabolism Oxidative phosphorylation Amino sugar and nucleotide sugar metabolism Glyoxylate and dicarboxylate metabolism Carbon fixation in photosynthetic organisms Glutathione metabolism Arginine and proline metabolism Aminoacyl-tRNA biosynthesis Carbon fixation pathways in prokaryotes Glycerophospholipid metabolism Alanine, aspartate and glutamate metabolism Frutose and mannose metabolism Galactose metabolism Glycerolipid metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Citrate cycle (TCA cycle) Porphyrin and chlorophyll metabolism Riboflavin metabolism Glycine, serine and threonine metabolism Sulfur metabolism Terpenoid backbone biosynthesis Tyrosine metabolism Aminobenzoate degradation Phosphatidylinositol signaling system On carbon pool by folate Lysine degradation Fatty acid biosynthesis Nitrogen metabolism Valine, leucine and isoleucine degradation N-Glycan biosynthesis Pantothenate and CoA biosynthesis Various types of N-glycan biosynthesis N unigenes N enzynes 722 364 565 110 316 99 211 76 159 20 114 23 201 66 150 41 173 51 127 24 171 52 158 93 127 54 133 22 132 72 122 43 143 56 99 46 109 65 102 69 104 46 112 55 95 46 120 53 106 36 81 35 76 51 82 39 96 61 67 27 83 55 67 37 52 45 58 42 52 10 53 30 48 36 35 12 33 18 50 26 37 25 32 17 34 27 31 17 Other glycan degradation Inositol phosphate metabolism T cell receptor signaling pathway Alpha-Linolenic acid metabolism Streptomycin biosynthesis Tryptophan metabolism Isoquinoline alkaloid biosynthesis Selenocompound metabolism Propanoate metabolism Histidine metabolism Nicotinate and nicotinamide metabolism Butanoate metabolism Linoleic acid metabolism Drug metabolism - other enzymes Drug metabolism - cytochrome P450 Valine, leucine and isoleucine biosynthesis Cyanoamino acid metabolism Lysine biosynthesis Tropane, piperidine and pyridine alkaloid biosynthesis Aflatoxin biosynthesis Tetracycline biosynthesis Biosynthesis of unsaturated fatty acids Polyketide sugar and unit biosynthesis Novobiocin biosynthesis Ascorbate and aldarate metabolism mTOR signaling pathway Arachidonic acid metabolism Metabolism of xenobiotics by cythocrome P450 Ubiquinone and other terpenoid-quinone biosynthesis Biotin metabolism beta-Alanine metabolism Sphingolipid metabolism Ether lipid metabolism Monobactam biosynthesis Styrene degradation Folate biosynthesis Taurine and hypotaurine metabolism Butirosin and neomycin biosynthesis Glycosphingolipid biosynthesis - ganglio series Glycosphingolipid biosynthesis - globo series C5-Branched dibasic acid metabolism Fatty acid degradation Vitamin B6 metabolism Steroid biosynthesis Fatty acid elongation Flavonoid biosynthesis 47 39 45 40 39 43 37 48 30 39 45 32 26 40 28 26 29 32 29 12 12 26 18 20 32 28 14 20 22 15 29 37 21 21 10 17 10 11 25 11 13 13 13 14 11 14 21 33 6 18 20 15 24 27 19 26 23 21 8 28 12 19 14 18 20 4 4 12 8 16 19 4 8 8 13 12 20 16 12 12 9 19 8 5 7 9 7 9 10 14 9 9 Lipopolysaccharide byosynthesis Glycosaminoglycan biosynthesis - heparan sulfate / heparin Glycosaminoglycan biosynthesis - chondroitin sulfate / derma… Glycosaminoglycan degradation Steroid degradation Toluene degradation Geraniol degradation Primary bile acid biosynthesis Other types of O-glycan biosynthesis Carotenoid biosynthesis Diterpenoid biosynthesis Indole alkaloid biosynthesis Synthesis and degradation of ketone bodies Peptidoglycan biosynthesis Biosynthesis of ansamycins Coprolactam degradation Caffeine metabolism Lipoic acid metabolism Photosynthesis Sesquiterpenoid and triterpenoid biosynthesis Zeatin biosynthesis Glucosinolate biosynthesis Betalain biosynthesis D-Glutamine and D-glutamate metabolism Penicillin and cephalosporin biosynthesis Glycosphingolipid biosynthesis - lacto and neolacto series Cutin, suberine and wax biosynthesis beta-Lactam resistance Biosynthesis of siderophore group nonribosomal peptides Atrazine degradation Steroid hormone biosynthesis Biosynthesis of vancomycin group antibiotics Retinol metabolism Anthocyanin biosynthesis Chlorocyclohexane and chlorobenzene degradation Phosphonate and phosphinate metabolism D-Alanine metabolism Chloroalkane and chloroalkene degradation Carbapenem biosynthesis Fluorobenzoate degradation Benzoate degradation Flavone and flavonol biosynthesis 6 14 14 25 5 9 9 8 10 14 7 5 9 3 11 10 2 5 7 3 6 3 1 2 2 4 4 2 2 4 4 5 0 1 3 2 1 2 3 1 1 1 6 8 8 7 4 5 5 4 4 10 7 5 6 2 4 6 2 3 5 3 5 3 1 2 2 4 4 2 2 4 3 2 0 1 3 2 1 2 4 1 1 1