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Download Biomimetic 3D modelling for cancer research
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BIOMIMETIC 3D MODELLING FOR CANCER RESEARCH 1Y. Ma, 2A. Ruys, 3P. Boughton, 4M. Zhang, 5A. Hong 1University of Sydney, Sydney, 2006, Australia; 2 University of Sydney, Sydney, 2006, Australia; 3 University of Sydney, Sydney, 2006, Australia; 4 University of Sydney, Sydney, 2006, Australia; 5 Royal Prince Alfred Hospital, Sydney, 2050, Australia e: [email protected] Tissue engineering plays an important role in cancer research. In this study a biomimetic model is created and modified to suit the need of drug delivery and radiation oncology in vitro. This biomimetic model, a synthetically based 3D scaffold is modified from its composition and porosity for cancer application. For composition optimization, naturally derived as well as synthetic coatings are added and compared, with assistance of melanoma cell culture, to explore and verify an optimal composition structure for cancer cell growth. Two commonly used and previously proved materials – collagen and bioactive glass, are included in the study while results indicate that a better cell growth is generated by an advanced bioactive glass coating. In porosity study, functionally graded model, is created to identify a specific porosity for certain cell line.
