Download Michal A. Olszewski, D.V. M., Ph.D. Associate Professor of Internal

Michal A. Olszewski, D.V. M., Ph.D.
Associate Professor of Internal Medicine
VAMC Research Service
Box 2399
Phone: 845-5238
Fax: 845-3241
Email: [email protected]
Education and Training
Education
10/1982-04/1988
DVM, Warsaw University of Life Sciences, College of Veterinary Medicine, Warsaw,
Poland
07/1993-12/1997
PhD, Dissertation Title: Inflammatory Mediators, Activated Neutrophils, and
Bronchospasmin Equine Small Airways: Implications for Inflammation in the Development
of Recurrent Airway Obstruction., Department of Large Animal Clinical Sciences, College
of Veterinary Medicine, Michigan State University, East Lansing, MI
PostDoctoral Training
09/1988-01/1989
Clinical Training, Clinical Internship, Department of Internal Medicine, College of Veterinary
Medicine, Warsaw University of Life Sciences, Warsaw, Poland
09/1989-09/1992
Clinical Training, clinical and Research Training, Department of Internal Medicine, College
of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
12/1991-07/1992
Clinical Training, Research and Clinical Training in Equine Internal Medicine: First Medical
- Equine, Small Animal and Avian Clinic, Veterinary University, Vienna, Austria
09/1992-07/1993
Postdoctoral Fellow, Large Animal Clinical Sciences, Department of Large Animal Clinical
Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI
01/1998-03/1998
Research Fellow, Large Animal Clinical Sciences, Department of Large Animal Clinical
Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI
03/1998-08/1999
Postdoctoral Research Fellow, "Multidisciplinary Research Training in Lung Diseases",
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,
University of Michigan, Ann Arbor, MI
08/1999-10/2002
Postdoctoral Research Fellow, Investigator Training in Pulmonary Immunology. VA Career
Development/Research Enhancement Award Program, VA Medical Center, Ann Arbor, MI
Additional Education
01/1989-09/1989
Military Veterinary Medical Center, Warsaw, Poland
Academic, Administrative, Clinical and Military Appointments
Academic Appointments
12/2003-09/2007
Research Investigator in Internal Medicine - Pulmonary/Critical Care, University of
Michigan - Ann Arbor
10/2007-12/2010
Research Assistant Professor in Internal Medicine - Pulmonary/Critical Care, University of
Michigan - Ann Arbor, Ann Arbor, Michigan
01/2011-09/2015
Assistant Professor of Internal Medicine, Research Biologist, Ann Arbor Veterans Affairs
Healthcare System, University of Michigan - Ann Arbor, Ann Arbor, Michigan
09/2015-present
Associate Professor of Internal Medicine, University of Michigan Medical School, Ann
Arbor, Michigan
Grants
Current Grants
Modulation of Immune Defenses in Pathobiology of Chronic Infections VA Medical Merit Grant
Michal Olszewski, PI
01/2015-12/2018. $1,260,400 ($313,625)
Michal A Olszewski
Jan 05, 2016
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BX0002120-01: Recruited Lung Dendritic Cells and the Orchestration of Local Immune Responses VA BLRD (Merit
Review Grant)
Co-I with Effort (Principal Investigator: John Osterholzer)
01/2014-12/2017. $603,000 ($180,000)
5 T32 AI007413-25: Research Training in Experimental Immunology NIH-DHHS-US- 13-PAF00677
Co-I with Effort (Principal Investigator: Kunkel, Steve L;Moore, Bethany B)
08/2013-07/2018. $1,439,180 ($287,836)
IPA Jintao Xu VA-US- 15-PAF06354
Xu, Jintao, PI
07/2015-06/2016. $48,091 ($48,091)
Fellowship award: TNA-alpha modulates plasicity in classically-activated dendritic cells during cryptococcal infection
The American Association of Im- 15-PAF07899
Olszewski, Michal A, PI
09/2015-08/2016. $22,920 ($22,920)
IPA Carol Wilke VA-US- 16-PAF01008
Wilke, Carol A, PI
09/2015-08/2016. $35,000 ($2,917)
Past Grants
0001: Deactivation of Pulmonary Innate Immune Defenses VA BLRD
MA Olszewski, PI
10/2002-09/2005. $386,100 ($138,700)
Pulmonary Defenses to Opportunistic Infections in Compromised Host VA Medical Merit Grant
Co-I with Effort (Principal Investigator: Galen Toews)
04/2004-03/2009. $1,042,200 ($233,200)
Modulation of Pulmonary Host Defenses in Pathogenesis of Chronic Infections VA Medical Merit Grant
Olszewski MA, PI
10/2006-09/2009. $721,000 ($257,000)
Modulation of Pulmonary Defenses in PathobiologyOf Chronic Infections VA Medical Merit Grant
OLSZEWSKI, MICHAL, PI
04/2010-10/2014. $1,193,000 ($317,500)
IPA Yafeng Qiu VA-US- 13-PAF07353
Qiu, Yafeng, PI
10/2013-10/2014. $11,947 ($11,947)
USAID International Scholar Support, Bench Fees
MA Olszewski, PI
10/2014-03/2015. $12,000 ($12,000)
IPA Carol Wilke VA-US- 15-PAF05290
Wilke, Carol A, PI
01/2015-06/2015. $15,229 ($15,229)
Honors and Awards
International
1986
Veterinary Student Exchange/Travel Award from Veterinary School, Hanover, Germany,
1986
1991-1992
Austrian Minister of Education Fellowship, 1991-1992
1992-1993
Kosciuszko Foundation Fellowship, 1992-1993
1995
Graduate Student International Travel Award from MSU 1995
Michal A Olszewski
Jan 05, 2016
2 of 11
National
1995-1997
National Research Service Award from USPHS (Pharmacological Training Grant)
1995-1997
Institutional
1981-1987
President of Warsaw Agricultural University Awards, 1981, 1984, 1985, 1986, 1987
1993-1996
College of Veterinary Medicine Post-DVM Fellowships, 1993-1996
1996-1997
Graduate Student Proposal Research Grant ($4000), Large Animal Clinical Science, MSU
1996-1997
1998-1999
NIH Multidisciplinary Training Program in Lung Diseases 1998-1999
2006-2014
Annual Department of Veterans Affairs Performance Awards 2006- 2013
2012-present
Graduate Student Affairs Committee, Graduate Immunology Program - University of
Michigan
2012
Faculty Recognition Award for Outstanding Mentorship, University of Michigan, UROP,
2012
Memberships in Professional Societies
1993-present
Member, American Thoracic Society
1999-present
Member, American Society for Microbiology
2008-present
Member, Medical Mycological Society of the Americas
2012-present
Member, American Association of Immunologists
Editorial Positions, Boards, and Peer-Review Service
Study Sections
International
2007-2011
Welcome Trust Intermediate Level Research Development Fellowship Grant Proposal (Ad
Hoc)
2010-2011
Grant proposal review, "Elise Richter Programme" -Austrian Science Fund (Ad Hoc)
2010
EU Sponsored Research Grant Proposals for the Foundation for Polish Science
(immunology grants) (Ad Hoc)
2011
Fellowship FEC Grant Proposal, Medical Research Council, UK (Ad Hoc)
2012
Welcome Trust Sir Henry Dale Fellowship Grant Proposal (Ad Hoc)
National
2010-2012
American Heart Association, Microbiology Study Section (Ad Hoc)
2013-2014
VA ORD Infectious Disease B Scientific Peer Review Study Seciton (Ad Hoc)
Regional
2012
Michigan Institute for Clinical Health Research, Pilot Grant Program (Ad Hoc)
Institutional
2014
Reviewed applications for T32 Immunology Postdoctoral Fellowship applications (Ad Hoc)
Editorial Boards
2011-present
Editorial Board Member, International Journal of Clinical and Experimental Immunology
2013-present
Editorial Board Member, Infection and Immunity
2014-present
Academic Editor, PLOS ONE
Michal A Olszewski
Jan 05, 2016
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Journal Reviewer
1997
American Journal of Respiratory Cell and Molecular Biology, Mbio, Infection and Immunity,
Journal of Immunology, PLOS One, PLOS Pathogens, Journal of Clinical and
Experimental Immunology, Respiratory Care, Journal of Surgical Research, Medical
Mycology, Canadian Journal of Microbiology, Journal of Antimicrobial Chemotherapy,
Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology
European Journal of Immunology (Ad Hoc)
Teaching
Graduate Student
01/2013-present
Postdoctoral Fellow
02/2004-02/2005
Alison Eastman, BS, University of Michigan
Danica Petrovic-Djergovic, M.D., Ph.D., University of Michigan
06/2007-11/2007
Jami Milam, Ph.D., University of Michigan
01/2011-12/2013
Jafeng Qiu, DVM, Ph.D., University of Michigan
06/2011-08/2014
Michael Davis, Ph.D., University of Michigan
10/2011-06/2013
Ben Murdock, Ph.D., University of Michigan
09/2014-present
Lori Neal, Ph.D., University of Michigan
Teaching Activity
Regional
01/1998-01/2012
Invited Teaching Presentations at graduate courses at Michigan State University.
Pulmonary Immunology (Investigating the Lungs LCS 901, PTH 901) years 1994, 1996,
1998, 2000 and 2002, 2004, 2006, 2010, 2012
01/2011-10/2014
Michigan State University: Ph.D. student Guidance Committee (Eilidh Wilson, DVM, Ph.D.)
Institutional
01/1987-01/1991
Teaching Instructor at the College of Veterinary Medicine, Warsaw Agricultural University,
200-300 hrs/year to 3rd, 4th and 5th-year Veterinary Medical Students Courses: Clinical
Diagnostic, Internal Medicine, Clinical Pathology Labs and Clinical Clerkships.
01/1993-01/1996
Teaching Assistant at graduate courses at Michigan State University. Pulmonary
Immunology (Investigating the Lungs LCS 901, PTH 901) years 1994, 1996
01/1999-01/2002
Supervision of Ph.D. and MS students working in Huffnagle/Toews Laboratory
01/2002-present
Mentoring/Supervision of UROP Students at The University of Michigan and the Advance
Lab Class Students (MICRO 399, CMB 399, CMB 499, INTMED 399)
01/2010-01/2012
University of Michigan: Eukaryote Microbiology (MB 460). Invited lectures on fungal
microbiology. (Fall)
01/2011-01/2013
University of Michigan: Experimental immunology (IMM 850). Course Co-director
Committee and Administrative Services
Committee Services
International
2009-2012
Program Committee for the ATS 2010, 2011 and 2012 International Conference Assembly
for Mycobacterial and Pulmonary Infections (MTPI), Member
Regional
2003-present
Committee for Animal Studies IACUC at the VAMC Ann Arbor, Chair, Voting Member
2011-present
Steering Committee for the 2012, 2013, and 2014 Midwest Neglected Infectious Diseases
Meeting, Steering Committee Member
Michal A Olszewski
Jan 05, 2016
4 of 11
Institutional
1995-1997
Postgraduate Training Committee, Dept of Large Animal Clinical Sciences, Michigan State
University, College of Veterinary Medicine., Graduate student representative
2007-2009
T32 Training Grant, Unit of Laboratory Animal Medicine, University of Michigan Medical
School, Steering Committee Member
2011-present
Interdisciplinary Training Program in Pulmonary Diseases -, Trainer.
2012-present
Graduate Student Affairs Committee ( GSAC) Graduate Program in Immunology,
University of Michigan Graduate School, committee member
Administrative Services
Volunteer
2000-2009
President, Treasurer, Polish American Congress, Ann Arbor, Michigan, Polish American
Congress Ann Arbor Chapter, President from 2006-9, Treasurer 2000-2006
2006-2011
Assistant Scout Master, Troop 27, Boy Scouts of America, Ann Arbor Michigan, Ann Arbor,
Michigan, Served as Assistant Scout Master, for Troop 27 , in Ann Arbor, MI
2010-present
Board Member, Polish Cultural Fund Ann Arbor, Ann Arbor, MI, Non-profit organization
focused on organizing, co-sponsoring and promoting Polish cultural events in Ann Arbor.
The events include, Ann Arbor Polish Film Festival (annual event), concerts and meetings
with Polish artists, and exhibitions.
Visiting Professorships and Extramural Invited Presentations
Visiting Professorships
10/2009
Modulation of Pulmonary Host Responses in Cryptococcal Infections, Department of
Molecular Genetics and Microbiology, Duke University, October 2009, Durham, NC
03/2013
Evasion of Immune Defenses by Fungal Pathogen, Grand Valley State University,
Department of Microbiology, March 2013, Allendale, MI
04/2013
Survival, Evasion Resistance and Escape: Role of Cryptococcal Virulence Factors in
Modulating Host Resposnes, University of Minnesota, Department of Microbiology and
Immunology, April 2013, Minneapolis, MN
12/2013
"Microphage versus C.neoformons: A Story of Two Monsters", School of Medicine and
Biomedical Sciences, State University of New York, Department of Microbiology and
Immunology, December 2013, Buffalo, New York
04/2015-present
"Cryptococcal Interactions with Macrophages", Xinjiang Medical University First Affiliated
Hospital, April 2015, Ürümqi, China
04/2015-present
"Animal Models in Translational Research: Human and Mouse when Together and when
Apart?", Fudan University Affiliated Huandong Hospital, April 2015, Shanghai, China
04/2015-present
"Interaction of Cryptococcal Virulence Factors with the Mechanisms of Host Defenses",
Shanghai Institute of Medical Mycology, Changzheng Hospital,, April 2015, Shanghai,
China
Extramural Invited Presentations
1.
Effectiveness of bronchodilators in therapy of recurrent airway obstruction in the horse, 21st Conference
on Diseases of Respiratory Tract in Horses Polish Association of Veterinary Science: Section of
Physiology and Pathology of Horses', June 1995, Czerniejewo, Poland
2.
Mediators of Anaphylaxis but Not Activated Neutrophils May Be Responsible for Cholinergically Mediated
Bronchospasm in Heaves, International Symposium on Allergic Diseases of the Horse, Havemayer
Foundation Workshop,, January 2002, Hortobagy-Mata, Hungary
3.
Cryptococcal Urease, a Virulence Factor that Facilitates CNS Dissemination by Enhancing C. neoformans
Persistence in the Lungs and its Microvascular Sequestration during Fungemia., 7th International
Conference on Cryptococcus and Cryptococcosis, September 2008, Nagasaki, Japan
4.
Role of C. neoformans Virulence Factors in Pathogenesis of Cryptococcosis, NIAID, NIH, April 2011,
Bethesda, MD
5.
Pulmonary Macrophage Activation during Cryptococcal Infections, 8th International Conference on
Cryptococcus and Cryptococcosis, May 2011, Charleston, SC.
Michal A Olszewski
Jan 05, 2016
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Cryptococcus and Cryptococcosis, May 2011, Charleston, SC.
6.
Th1, Th2 and beyond; the role of Th-bias in pathogenesis of cryptococcal infections, Midwest Neglected
Disease Meeting, University of Notre Dame, August 2011, South Bend , IN
7.
Interactions with Macrophages: The bug, the cell, or inflammatory microenvironment?
, 9th International Conference on Cryptococcus and Cryptococcosis, May 2014, Amsterdam, Netherlands
8.
Cryptococcus neoformans-induced macrophage lysosomal damage crucially contributes to fungal
virulence, Gordon Research Conference "Immunology of Fungal Infections", January 2015, Galveston, TX
9.
Invited lecture April 20, 2015: "Cryptococcal Interactions with Macrophages", Shanghai Agricultural
Academy of Science Institute, April 2015, Shanghai, China.
10.
"Study of Respiratory and Digestive Track Infectious Diseases", Xinjiang Province Annual ID Physician
Conference, April 2015, Changji, China
11.
"Interaction of Cryptococcal Virulence Factors with the Mechanisms of Host Defenses", Xinjiang Medical
University, First Affiliated Hospital, Ürümqi, China
Seminars
1.
Pathogenesis of C. neoformans Infections - Interface between the Host and the Microbe, Dept of Internal
Medicine Section of Infectious Diseases University Illinois in Chicago, July 2005, Chicago, Illinois
2.
The Dynamics of the Host-Microbe Relationship in the Pathogenesis of Cryptococcal Infections, Dept of
Microbiology, The Ohio State University, February 2006, Columbus, OH
3.
Role of Cryptococcal Urease in Pulmonary Virulence and CNS Dissemination of C. neoformans, NIAID,
NIH, April 2009, Bethesda, MD
Bibliography
Peer-Reviewed Journals and Publications
1.
Olszewski MA, Laber G: Production of free oxygen radicals by phagocytes lavaged from respiratory tract
as well as from peripheral blood of horses with Chronic Obstructive Pulmonary Disease (COPD) in
comparison to healthy animals. Wien Tierärzt Monatsschr 80: 332-337, 1993.
2.
Kluciński W, Winnicka A, Olszewski M, Sikora J, Sitarska E, Niemiałtowski M, Muzylak M, Bylinka G,
Wyszyński M: Phagocytic activity of polymorphonuclear leukocytes lavaged from the lungs of horses with
clinically diagnosed chronic pulmonary disease. Zentralbl Veterinarmed A 41(7): 558-567, 1994.
PM8831271
3.
Zhang XY, Olszewski MA, Robinson NE: Beta 2-adrenoceptor activation augments acetylcholine release
from tracheal parasympathetic nerves. Am. J. Physiol. 268(6 12-6): L950-L956, 1995. PM7611436
4.
Olszewski MA, Robinson NE, Yu MF, Derksen FJ: Effects of hydrogen peroxide on isolated trachealis
muscle of horses. Am. J. Vet. Res. 56(11): 1479-1485, 1995. PM8585660
5.
Robinson NE, Derksen FJ, Olszewski MA, Buechner-Maxwell VA: The pathogenesis of chronic obstructive
pulmonary disease of horses. Br. Vet. J. 152(3): 283-306, 1996. PM8762605
6.
Derksen FJ, Olszewski M, Robinson NE, Berney C, Lloyd JW, Hakala J, Matson C, Ruth D: Use of a
hand-held, metered-dose aerosol delivery device to administer pirbuterol acetate to horses with 'heaves'.
Equine Vet. J. 28(4): 306-310, 1996. PM8818596
7.
Olszewski MA, Robinson NE, Derksen FJ: In vitro responses of equine small airways and lung
parenchyma. Respir Physiol 109(2): 167-176, 1997. PM9299648
8.
Zhu FX, Zhang XY, Olszewski MA, Robinson NE: Mechanism of capsaicin-induced relaxation in equine
tracheal smooth muscle. Am. J. Physiol. 273(5 17-5): L997-L1001, 1997. PM9374726
9.
Zhang XY, Zhu FX, Olszewski MA, Robinson NE: Effects of enantiomers of beta 2-agonists on ACh
release and smooth muscle contraction in the trachea. Am. J. Physiol. 274(1 18-1): L32-L38, 1998.
PM9458798
10.
Olszewski MA, Robinson NE, Zhu FX, Zhang XY, Tithof PK: Mediators of anaphylaxis but not activated
neutrophils augment cholinergic responses of equine small airways. Am. J. Physiol. 276(3 20-3):
L522-L529, 1999. PM10070118
11.
Robinson NE, Derksen FJ, Olszewski M, Berney C, Boehler D, Matson C, Hakala J: Determinants of the
maximal change in pleural pressure during tidal breathing in COPD-affected horses. Vet. J. 157(2):
160-165, 1999. PM10204411
12.
Derksen FJ, Olszewski MA, Robinson NE, Berney C, Hakala JE, Matson CJ, Ruth DT: Aerosolized
Michal A Olszewski
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12.
Derksen FJ, Olszewski MA, Robinson NE, Berney C, Hakala JE, Matson CJ, Ruth DT: Aerosolized
albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction. Am. J. Vet. Res.
60(6): 689-693, 1999. PM10376893
13.
Olszewski MA, Zhang XY, Robinson NE: Pre- and postjunctional effects of inflammatory mediators in
horse airways. Am. J. Physiol. 277(2 21-2): L327-L333, 1999. PM10444527
14.
Huffnagle GB, Traynor TR, McDonald RA, Olszewski MA, Lindell DM, Herring AC, Toews GB: Leukocyte
recruitment during pulmonary Cryptococcus neoformans infection. Immunopharmacology 48(3): 231-236,
2000. PM10960662
15.
Robinson NE, Olszewski MA, Boehler D, Berney C, Hakala J, Matson C, Derksen FJ: Relationship
between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a
bronchodilator trial. Equine Vet. J. 32(5): 393-400, 2000. PM11037260
16.
Olszewski MA, Huffnagle GB, McDonald RA, Lindell DM, Moore BB, Cook DN, Toews GB: The role of
macrophage inflammatory protein-1 alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus
neoformans infection. J. Immunol. 165(11): 6429-6436, 2000. PM11086082
17.
Olszewski MA, Huffnagle GB, Traynor TR, McDonald RA, Cook DN, Toews GB: Regulatory effects of
macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus
neoformans depend on expression of early inflammatory cytokines. Infect. Immun. 69(10): 6256-6263,
2001. PM11553568
18.
Myc A, Kukowska-Latallo JF, Bielinska AU, Cao P, Myc PP, Janczak K, Sturm TR, Grabinski MS, Landers
JJ, Young KS, Chang J, Hamouda T, Olszewski MA, Baker JR: Development of immune response that
protects mice from viral pneumonitis after a single intranasal immunization with influenza A virus and
nanoemulsion. Vaccine 21(25-26): 3801-3814, 2003. PM12922114
19.
Olszewski MA, Noverr MC, Chen GH, Toews GB, Cox GM, Perfect JR, Huffnagle GB: Urease expression
by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous
system invasion. Am. J. Pathol. 164(5): 1761-1771, 2004. PM15111322
20.
Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden M: Leptin corrects host defense
defects after acute starvation in murine pneumococcal pneumonia. Am. J. Respir. Crit. Care Med. 173(2):
212-218, 2006. PM16210671
21.
Chen GH, Olszewski MA, McDonald RA, Wells JC, Paine R, Huffnagle GB, Toews GB: Role of
granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus
neoformans infection during murine allergic bronchopulmonary mycosis. Am. J. Pathol. 170(3):
1028-1040, 2007. PM17322386
22.
Olszewski MA, Falkowski NR, Surana R, Sonstein J, Hartman A, Moore BB, Huffnagle GB, Toews GB:
Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs. Am. J.
Respir. Crit. Care Med. 176(9): 921-929, 2007. PM17702970
23.
Chen GH, McNamara DA, Hernandez Y, Huffnagle GB, Toews GB, Olszewski MA: Inheritance of immune
polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse
model. Infect. Immun. 76(6): 2379-2391, 2008. PM18391002/PMC2423067
24.
Wozniak KL, Ravi S, Macias S, Young ML, Olszewski MA, Steele C, Wormley FL: Insights into the
mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of
pulmonary cryptococcosis. PLoS ONE 4(9): e6854, 2009. PM19727388/PMC2731172
25.
Osterholzer JJ, Surana R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL, Huffnagle GB, Toews
GB, Olszewski MA: Cryptococcal urease promotes the accumulation of immature dendritic cells and a
non-protective T2 immune response within the lung. Am. J. Pathol. 174(3): 932-943, 2009.
PM19218345/PMC2665753
26.
Osterholzer JJ, Milam JE, Chen GH, Toews GB, Huffnagle GB, Olszewski MA: Role of dendritic cells and
alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus
neoformans. Infect. Immun. 77(9): 3749-3755, 2009. PM19564388/PMC2737986
27.
Jain AV, Zhang Y, Fields WB, McNamara DA, Choe MY, Chen GH, Erb-Downward J, Osterholzer JJ,
Toews GB, Huffnagle GB, Olszewski MA: Th2 but not Th1 immune bias results in altered lung functions in
a murine model of pulmonary Cryptococcus neoformans infection. Infect. Immun. 77(12): 5389-5399,
2009. PM19752036/PMC2786439
28.
Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski
MA: Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic
dissemination of highly virulent Cryptococcus neoformans H99. Am. J. Pathol. 175(6): 2489-2500, 2009.
PM19893050/PMC2789623
29.
Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB: Accumulation of CD11b+
Michal A Olszewski
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29.
Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB: Accumulation of CD11b+
lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and
differentiation of Ly-6Chigh monocytes. J. Immunol. 183(12): 8044-8053, 2009. PM19933856/PMC-
30.
Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB,
Huffnagle GB, Olszewski MA: CD11c+ cells are required to prevent progression from local acute lung
injury to multiple organ failure and death. Am. J. Pathol. 176(1): 218-226, 2010.
PM19948830/PMC2797884
31.
Hardison SE, Ravi S, Wozniak KL, Young ML, Olszewski MA, Wormley FL: Pulmonary infection with an
interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation
and protection. Am. J. Pathol. 176(2): 774-785, 2010. PM20056835/PMC2808084
32.
Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA: TLR9 signaling is
required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs.
Am. J. Pathol. 177(2): 754-765, 2010. PM20581055
33.
Olszewski MA, Zhang Y, Huffnagle GB: Mechanisms of cryptococcal virulence and persistence. Future
Microbiol 5(8): 1269-1288, 2010. PM20722603
34.
Chen GH, Osterholzer JJ, Choe MY, McDonald RA, Olszewski MA, Huffnagle GB, Toews GB: Dual roles
of CD40 on microbial containment and the development of immunopathology in response to persistent
fungal infection in the lung. Am. J. Pathol. 177(5): 2459-2471, 2010. PM20864680/PMC2966803
35.
Osterholzer JJ, Chen GH, Olszewski MA, Zhang YM, Curtis JL, Huffnagle GB, Toews GB: Chemokine
receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung
infection. Am. J. Pathol. 178(1): 198-211, 2011. PM21224057
36.
Arora S, Olszewski MA, Tsang TM, McDonald RA, Toews GB, Huffnagle GB: Effect of cytokine interplay
on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans. Infect.
Immun. 79(5): 1915-1926, 2011. PM21383052
37.
Qiu Y, Zeltzer S, Zhang Y, Wang F, Chen GH, Dayrit J, Murdock BJ, Bhan U, Toews GB, Osterholzer JJ,
Standiford TJ, Olszewski MA: Early induction of CCL7 downstream of TLR9 signaling promotes the
development of robust immunity to cryptococcal infection. J. Immunol. 188(8): 3940-3948, 2012.
PM22422883
38.
He X, Lyons DM, Toffaletti DL, Wang F, Qiu Y, Davis MJ, Meister DL, Dayrit JK, Lee A, Osterholzer JJ,
Perfect JR, Olszewski MA: Virulence factors identified by Cryptococcus neoformans mutant screen
differentially modulate lung immune responses and brain dissemination. Am. J. Pathol. 181(4): 1356-1366,
2012. PM22846723
39.
Qiu Y, Davis MJ, Dayrit JK, Hadd Z, Meister DL, Osterholzer JJ, Williamson PR, Olszewski MA: Immune
modulation mediated by Cryptococcal laccase promotes pulmonary growth and brain dissemination of
virulent Cryptococcus neoformans in mice. PLoS ONE 7(10): e47853, 2012. PM23110112
40.
Wozniak KL, Hardison S, Olszewski M, Wormley FL: Induction of protective immunity against
cryptococcosis. Mycopathologia 173(5-6): 387-394, 2012. PM22143898
41.
Osterholzer JJ, Christensen PJ, Lama V, Horowitz JC, Hattori N, Subbotina N, Cunningham A, Lin Y,
Murdock BJ, Morey RE, Olszewski MA, Lawrence DA, Simon RH, Sisson TH: PAI-1 promotes the
accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial
cell injury. J. Pathol. 228(2): 170-180, 2012. PM22262246
42.
Qiu J, Olszewski MA, Williamson PR: Cryptococcus neoformans growth and protection from innate
immunity are dependent on expression of a virulence-associated DEAD-Box protein, Vad1. Infect. Immun.
81(3): 777-788, 2013. PM23264050
43.
Davis MJ, Tsang TM, Qiu Y, Dayrit JK, Freij JB, Huffnagle GB, Olszewski MA: Macrophage M1/M2
polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans
infection MBio 4(3): 2013. PM23781069
44.
Szymczak WA, Davis MJ, Lundy SK, Dufaud C, Olszewski M, Pirofski LA: X-linked immunodeficient mice
exhibit enhanced susceptibility to Cryptococcus neoformans infection MBio 4(4): 2013. PM23820392
45.
Osterholzer JJ, Olszewski MA, Murdock BJ, Chen GH, Erb-Downward JR, Subbotina N, Browning K, Lin
Y, Morey RE, Dayrit JK, Horowitz JC, Simon RH, Sisson TH: Implicating exudate macrophages and Ly-6C
high
monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury J. Immunol.
190(7): 3447-3457, 2013. PM23467934
46.
Qiu Y, Dayrit JK, Davis MJ, Carolan JF, Osterholzer JJ, Curtis JL, Olszewski MA: Scavenger receptor a
modulates the immune response to pulmonary Cryptococcus neoformans infection J. Immunol. 191(1):
238-248, 2013. PM23733871
47.
Murdock BJ, Huffnagle GB, Olszewski MA, Osterholzer JJ: IL-17 enhances host defense against
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47.
Murdock BJ, Huffnagle GB, Olszewski MA, Osterholzer JJ: Interleukin-17A enhances host defense against
cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma
interferon production Infect. Immun. 82(3): 937-948, 2014. PM24324191
48.
Wozniak KL, Olszewski MA, Wormley FL: Molecules at the interface of cryptococcus and the host that
determine disease susceptibility. Fungal Genetics and Biology 14: 00198-4, 2014. 25445308
49.
Stolberg VR, Martin B, Mancuso P, Olszewski MA, Curtis JL, and Chensue S.W: Role of C-C Chemokine
Receptor 4 in Natural killer Cell Activation during Acute Cigarette Smoke Exposure. Am J Pathol 184(2):
454-63, 2014. PM24333113
Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Wormley FL: STAT1 signaling is essential for
protection against Cryptococcus neoformans infection in mice J. Immunol. 193(8): 4060-4071, 2014.
PM25200956
50.
51.
52.
Murdock BJ, Teitz-Tennenbaum S, Chen GH, Dils AJ, Malachowski AN, Curtis JL, Olszewski MA,
Osterholzer JJ: Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes
fungal clearance in mice with cryptococcal lung infection J. Immunol. 193(8): 4107-4116, 2014.
PM25225664
Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Wormey FL: STAT1 Signaling within
macrophages is required for antifungal activity against Cryptococcus neoformans. Infect Immun 83:
4513-27, 2015. 26351277
53.
Davis MJ, Eastman AJ, Qiu Y, Gregorka B, Curtis JL, Osterholzer JJ, Swanson J, Olszewski, MA:
Macrophage lysosome damage is a crucial component of virulence for fungal pathogen. J . Immunol 2015;
194: 2219-31
PM25637026
54.
Eastman AJ, He X, Qiu, Y, Davis MJ, Vedula P, LyonsDM, ParkY-D; Hardison SE; Malachowski A;
Wormley FL; Williamson PR, Olszewski MA: Cryptococcal heat shock protein 70 homologue Ssa1
contributes to pulmonary expansion of C. neoformans during the afferent phase of the immune response
by promoting macrophage M2 polarization. J. Immunol 194(12): 5999-6010, 2015. 25972480
55.
Eastman AJ, Osterholzer JJ, Olszewski, MA: Role of dendritic cell-pathogen interactions in the immune
response to pulmonary cryptococcal infection. Future Microbiology 10: 1837-57, 2015. 26597428
56.
Chen GH, Teitz-Tennenbaum S, Neal LM, Murdock BJ, Malachowski AN, Dils AJ, Olszewski MA,
Osterholzer JJ.: Local GM-CSF dependent differentiation and activation of pulmonary dendritic cells and
macrophages protects against progressive cryptococcal lung infection in mice. J. Immunol. (In Press)
Book Chapters
1.
Wozniak KL, Olszewski MA, Wormley FL.: Host Immune Responses Against Pulmonary Fungal
Pathogens. Pulmonary Infection, Edited by Amer Amal InTech, Chapters published March 14, 2012 under
CC BY 3.0 license, 2012. March, 2012
Other Media
Review article
1.
Olszewski MA, Zhang Y, Zeltzer S: Th1, Th2 and beyond; what we know about the adaptive immunity for
fungal infections, J Invasive Fungal Infect, 2010.
Abstracts
1.
Zhang Y, Wang F, Hardison SE, Love CK, Chen G, Osterholzer JJ, Wormley FL, Toews GB, Adler A,
Williamson PR, Huffnagle GB, Olszewski, MA.: Cryptococcal virulence factor Ssa1 interferes with the
innate host responses by inducing the alternative activation of macrophages during the afferent phase of
the immune response in the infected lungs., ASM Gen. Meeting, San Diego, CA, 2010.
2.
Osterholzer JJ, Chen G, Olszewski MA, Curtis JL, Huffnagle GB, and Toews GB.: Dendritic cells derived
from recruited Ly6C-high monocytes promote T1 immune responses within the lungs of mice infected with
a fungal pathogen., ATS International Conference, New Orleans 5/10, New Orleans, 2010.
3.
Osterholzer JJ, Chen G, Olszewski MA, Curtis JL, Huffnagle GB, and Toews GB.: Classically-activated
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3.
Osterholzer JJ, Chen G, Olszewski MA, Curtis JL, Huffnagle GB, and Toews GB.: Classically-activated
CD11c+ CD11b+ exudate macrophages are derived from recruited Ly6C-high CD11b+ monocytes in the
lungs of mice with fungal pneumonia., ATS International Conference,, New Orleans, 2010.
4.
Chen GH, Osterholzer JJ, Olszewski MA, McDonald RA, Huffnagle GB, and Toews GB.: Interplay of
CD40-Dependent and Independent Mechanisms in the Pathogenesis of Murine Allergic
Bronchopulmonary Mycosis., ATS International Conference, New Orleans, 2010.
5.
Qiu Y, Lyons DM, Zhang Y, He X, Zeltzer S, Dayrit J, Curtis JL, Williamson PR, Olszewski, MA: The Role
of Macrophage Scavenger Receptor A during Pulmonary Infections with C. neoformans., 8th International
Conference on Cryptococcus and Cryptococcosis, 5/2011,, Charleston, SC, 2011.
6.
He X, Dayrit J, Qiu Y, Zhang Y, Wang F, Hardison SE, Wormley FL, Yoon-Dong P, Adler A, Williamson
PR, Huffnagle GB, Olszewski, MA.: Cryptococcal virulence factor Ssa1 induces alternative activation of
macrophages but not classical activation of macrophages in vivo and in vitro, 8th International Conference
on Cryptococcus and Cryptococcosis, Charleston, SC, 2011.
7.
Zeltzer S, Zhang Y, Chen G, Osterholzer JJ, Lyons DM, Meister DL, Lu Y, Wang F, Toews GB, Bhan U,
Standiford TJ, Olszewski, MA.: Decrease in CCR2 ligand Induction Contributes to Altered Immune
Response to C. neoformans in TLR9-/- mice through Changes in Early Leukocyte Accumulation, 8 th
International Conference on Cryptococcus and Cryptococcosis, Charleston, SC, 2011.
8.
Meister DL, Zhang Y, Zeltzer S, Lyons DM, Coomes S, Lu Y, Huffnagle GB, Moore BB, Toews GB,
Olszewski, MA: Immune Reconstitution in C. neoformans Infected Mice Results in Persitent Inflammation
and Imbalance between Pro-Inflammatory and Regulatory Cytokines in the Lungs., 8th International
Conference on Cryptococcus and Cryptococcosis, Charleston, SC, 2011.
9.
Lyons DM, Toffaletti DL, Zhang Y, Wang F, Lee A, Dayrit J, Perfect JR, Olszewski, MA.: Mutants Selected
for a Decreased Survival in Human Cerebrospinal Fluid Exhibit Differential Potentials for Pulmonary
Virulence and CNS Dissemination in Murine Host., 8th International Conference on Cryptococcus and
Cryptococcosis, Charleston, SC, 2011.
10.
Zhang Y, Zeltzer S, Chen G, Osterholzer JJ, Lyons DM, Meister DL, Lu Y, Wang F, Toews GB, Bhan U,
Standiford TJ, Olszewski, MA.: TLR9 Facilitates Protective Immunity To C. neoformans By Supporting
Early Production Of MCP3/5 And The Accumulation Of Ly6c+ Monocytes And DC In The Lungs, ATS
International Conference, Denver, 2011.
11.
Zhang Y, Meister DL, Zeltzer S, Lyons DM, Coomes S, Lu Y, Huffnagle GB, Moore BB, Toews GB,
Olszewski, MA.: Transient Depletion Of T-Cells Followed By C. neoformans Infection Induces Pathological
Response That Mimics Immune Reconstitution Disease, ATS International Conference, Denver, 2011.
12.
Qiu J, Williamson PR, Olszewski, MA.: Strain of Cryptococcus neoformans in a Mouse Model,
International Conference on Cryptococcus and Cryptococcosis, Charleston, SC, 2011.
13.
Davis MJ, Tsang T, Dayrit JK, Qiu Y, Osterholzer JJ, Olszewski, MA: Changes in cytokine environment
dynamically alter M1 / M2 macrophage polarization in opportunistic fungal infection, ATS International
Conference, 2012.
14.
Murdock BJ, Chen G, Morey RE, Huffnagle GB, Toews GB, Olszewski MA, Osterholzer JJ: Critical Role of
GM-CSF in the Local Differentiation of CD11b+ Dendritic Cells and Exudate Macrophages from
Ly-6C(High) Monocytes in Mice with Persistent Cryptococcal Lung Infection, ATS International
Conference, 2012.
15.
Qiu Y, Dayrit JK, Davis MJ, Lyons DM, Meister DL, Hadd Z, Osterholzer JJ, Olszewski, MA.: Fungal
Pathogen Exploits Scavenger Receptor A To Promote A Non-Protective Immune Response In The
Infected Lungs, ATS International Conference, 2012.
16.
Murdock BJ, Chen G, Carver MP, Huffnagle GB, Toews GB, Olszewski MA, Osterholzer JJ: Identification
of Early (Dendritic Cell) and Late (CD4+ T Cell) Sources of IL-10 Production in Mice with Persistent
Cryptococcal Lung Infection, ATS International Conference, 2012.
17.
Osterholzer JJ, Christensen PJ, Lama VN, Horowitz JC, Subotina N, Murdock BJ, Morey RE, Olszewski
MA, Simon RH, Sisson TH: PAI-1 Promotes the Accumulation of Exudate Macrophages and Worsens
Pulmonary Fibrosis Following Type II Alveolar Epithelial Cell Injury, ATS International Conference, 2012.
18.
Osterholzer JJ, Chen G, Lin Y, Subotina N, Murdock BJ, Morey RE, Olszewski MA, Sisson TH: PAI-1
Promotes the Accumulation of Exudate Macrophages and Worsens Pulmonary Fibrosis Following Type II
Alveolar Epithelial Cell Injury, ATS International Conference, 2012.
19.
Davis MJ, Qui Y, Olszewski MA.: Lysosome damage facilitates intracellular parasitism by Cryptococcus
neoformans. (Awarded best poster in postdoc category by GRC), 2013 Gordon research conference
"Immunology of fungal infections", Galveston, TX, 2013.
20.
Davis MJ, Tsang T, Qui Y, Dayrit JK, Freij, JB, Huffnagle GB, Olszewski MA. : Macrophage Plasticity in
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20.
Davis MJ, Tsang T, Qui Y, Dayrit JK, Freij, JB, Huffnagle GB, Olszewski MA. : Macrophage Plasticity in
Cryptococccal Infection, 2013 Gordon research conference "Immunology of fungal infections", Galveston,
TX, 2013.
21.
Qui Y, Davis MJ, Dayrit JK , Lyons DM, and Olszewski MA: Scavenger receptor A modulates the immune
response to pulmonary Cryptococcus neoformans infection, 2013 Gordon research conference
"Immunology of fungal infections", Galveston, TX, 2013.
22.
Olszewski MA, Davis MJ, Qiu Y, Chapman R, Malachowski AN, Vedula P, Swanson JA.: Inhibition of
Cryptococcus neoformans-mediated phagolysosome damage by induced lysosomal renitence constrains
fungal growth, AAI Honolulu, HA, Honolulu, HA, 2013.
23.
Qiu Y, Malachowski A, Vedula P, Falkowski NR, Erb-DownwardJR, FreemanCM, MancusoP,
ChensueSW, Huffnagle GB, Curtis JL, Olszewski MA.: Altered Pulmonary Innate esponses to Bacterial
Products in Tobacco Smoke-Exposed Mice are linked to Reprograming of Epithelial Host Defense Gene
Induction, ATS International Conference, Philadelphia PA, 2013.
24.
Osterholzer JJ, Murdock BJ, Chen G, Huffnagle GB, Olszewski MA: Relationships between Interleukin-10,
Immunomodulatory Dendritic Cells, T Regulatory Cells, and Persistent Fungal Lung Infection in Mice, ATS
International Conference, Philadelphia PA, 2013.
25.
Murdock BJ, Davis MJ, Huffnagle GB, Olszewski MA, Osterholzer JJ: Role of IL-17 in Mice Which Develop
Persistent Cryptococcal Lung Infection, ATS International Conference, Philadelphia PA, 2013.
26.
Osterholzer JJ, Murdock BJ, Chen G, Huffnagle GB, Olszewski MA: Transient Blockade of IL-10 Signaling
Enhances Fungal Clearance and Th1/Th17 Effector Responses in Mice with Early and Established
Cryptococcal Lung Infection, ATS International Conference, Philadelphia PA, 2013.
27.
Davis MJ, Qiu YF, Swanson JA, Olszewski MA: Inhibition of C. neoformans-mediated Phago-lysosome
Damage by Induced Lysosomal Renitence Constrains Fungal Growth, Denver, CO., 2013.
28.
Qui Y, Sandy AR, Hadd Z, Davis MJ, Chapman R, Carolan J, Maillard I and Olszewski MA: The role of
Notch signaling in immune response to cryptococcal infection in a mouse model, Denver, CO, Denver,
CO., 2013.
29.
Olszewski MA, Osterholzer JJ, Davis MJ, Qiu YF, Tsand T, Huffnagle GB: Interactions with macrophages:
the bug, the cell, or inflammatory microenvironment., 9th ICCC, Amsterdam, Netherlands, Mycoses, 57,
2014.
30.
Leopold Wager CM, Hole CR, Wozniak K, Olszewski MA, Wormley FL Jr: STAT1-induced macrophage
activation is essential for protection against Cryptococcus neoformans in mice, 9th ICCC, Amsterdam,
Netherlands, Mycoses, 57, 2014.
31.
Hadd ZD, Qui Y, Sandy AR, Malachowski AN, Cho WS, Davis MJ, Eastman AJ, Maillard I, Olszewski MA:
T-cell restricted notch signaling promotes immune protection against C. neoformans in the infected mice.,
9th ICCC, Amsterdam, Netherlands, Mycoses, 57, 2014.
32.
Eastman AJ, Carolan J, Potchen N, Davis MJ, Qiu Y, Malachowski AN, Krycxzek I, Cavassani K, Kunkel
S, Osterholzer J, Olszewski MA: TNF-alpha-induced stability of DC1 programming is requred for
maintenance of protective Th1/Th17 immune response against Cryptococcus neoformans., 9th ICCC,
Amsterdam, Netherlands, Mycoses, 57, 2014.
33.
Osterholzer JJ, Murdock bJ, Chen G, Huffnagle GB, Olszewski MA: Transient blockade of IL-10 signaling
enhances fungal clearance and Th1/Th17 effector responses in mice with early and established
cryptococcal lung infection, ATS International Conference, San Diego, CA, Mycoses, 57, 2014.
34.
Davis MJ, Neal LM, Eastman AJ, Olszewski MA: Cryptococcus.neoformans-induced lysosmal damage
promotesfungal intracellular parasitism, Gordon Research Conference, Galveston, TX, Fungal
Immunology, 2015.
35.
Neal L, Qiu Y, Chung J, Cho WS, Maillard I, Olszewski MA: T-cell restricted Notch signaling contributes
topulmonary cytokine responses and control of fungal dissemination during Cryptococcus neoformans
infection., Gordon Research Conference, Galveston, TX, Fungal Immunology, 2015.
36.
Eastman AJ, Potchen N, Carolan J, Malachowski AN, Kryczek I, Cavassani K, Kunkel S., Osterholzer J,
OlszewskiMA: TNFα-induced epigenetic modifications support a DC1 program in dendritic cells during
protective immunity tocryptococcal infection., Gordon Research Conference, Galveston, TX, Fungal
Immunology, 2015.
37.
Afifi MYM, Eastman AJ, Qiu Y, Carolan J, Malachowski A, Stolberg V, Curtis JL, Olszewski MA:
TNF-alphapromotes optimal accumulation CD11b+ and CD103+ DC in pulmonary nodes and optimal
DC/T-cell interactions tosupport protective immune response in pulmonary cryptococcal infection, Gordon
ResearchConference, Fungal Immunology, 2015.
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