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ECE187 Introduction to Biomedical Imaging and Sensing (4 units) Imaging and sensing fundamentals: imaging theory, image processing, pattern recognition, digital radiography, computed tomography, magnetic resonance imaging, ultrasound imaging, optical microscopy, super resolution imaging, fluorescence imaging, and Raman scattering sensing. Grading Policy: 30% 40% 40% Problem sets Midterm Final approximately 3 sets in class, close book in class, close book Suggested References: 1. J. T. Bushbert, J. A. Seilbert, E. M. Leidholdt Jr, and J. M. Boone, The essential physics of medical imaging (Lippincott Williams & Wilkins, 2011). 2. N. B. Smith and A. Webb, Introduction to medical imaging: physics, engineering and clinical applications (Cambridge, 2011). 3. J. Mertz, Introduction to optical microscopy (Roberts and Company Publishers, 2010). Course Outline: - Introduction – biomedical imaging and sensing at a glance - General image characteristics, data acquisition and image reconstruction Spatial resolution, signal-to-noise ratio, contrast, image filtering, data acquisition, artifacts, Fourier transform, sonograms. - X-ray planar radiography and computed tomography Introduction of X-ray, instrumentation for planar radiography, X-ray contrast agents, computed Tomography (CT), image reconstruction in CT. - Magnetic resonance imaging (MRI) Introduction, effects of strong magnetic field on protons in the body, basis of MR signal detection, MRI imaging and image reconstruction, MRI contrast agents. - Ultrasound imaging Acoustic wave fundamentals, instrumentation, ultrasound transducers, clinical diagnostic, image characteristics, Doppler ultrasound for blood flow measurements. - Optical imaging and sensing Optical microscopy, fluorescence imaging, confocal microscopy, super resolution imaging, Raman scattering and surface enhance Raman scattering for biochemical sensing.