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Test Development and Advisory Committee Acceptable Abbreviations and Terminology Page 2 – Anatomic Pathology Page 3 – Blood Banking Page 4 – Chemical Pathology Page 5-6 – Cytopathology Page 7 – Dermatopathology Page 8 – Forensic Pathology Page 8 – Hematology Page 9 – Management and Informatics Page 10 – Medical Microbiology Page 11 – Molecular Genetic Pathology Page 12 – Neuropathology Page 13 – Pediatric Pathology Pages 14 – 19 – Main list of abbreviations Pages 20 – 25 – compilation of TDAC abbreviations 8/3/2016 Updated 1/2017 The Anatomic Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology ACTH AFP AIDS AJCC ANA ANCA ASCO/CAP Beta-HCG CBC CK CMV DCIS DNA EBV EGFR EM EMA EVG 5FU GIST GMS HHV8 HIV HPV HSIL IHC INR IUD IV LSIL NK NOS NUT PAS PEComa PIN PLAP PSA TTF-1 TUR WBC WT1 adrenocorticotrophic hormone alpha fetoprotein acquired immunodeficiency syndrome American Joint Commission on Cancer antinuclear antibody anti-neutrophil cytoplasmic autoantibody American Society of Clinical Oncology/College of American Pathologists beta-human chorionic gonadotropin complete blood count cytokeratin cytomegalovirus ductal carcinoma in situ deoxyribonucleic acid Epstein Barr virus epidermal growth factor receptor electron microscopy epithelial membrane antigen elastic van Gieson fluorouracil gastrointestinal stromal tumor Gomori methenamine silver human herpes virus 8 human immunodeficiency virus human papillomavirus high grade squamous intraepithelial lesion immunohistochemistry international normalized ratio intrauterine device intravenous low grade squamous intraepithelial lesion natural killer not otherwise specified nuclear in testis periodic acid Schiff perivascular epithelioid cell prostatic intraepithelial neoplasia placental alkaline phosphatase prostate specific antigen thyroid transcription factor transurethral resection white blood cell count Wilms tumor associated antigen Down the road, Wegener granulomatosis should be changed to granulomatosis with polyangiitis. There is no dash in “S100 protein”. PNET now Ewing sarcoma – 1/2016 Granulocytic sarcoma now myeloid sarcoma – 1/2016 Updated 2/2017 The Blood Banking/Transfusion Medicine Test Development and Advisory Committee Acceptable Abbreviations and Terminology ADAMTS13 a disintegrin & metalloprotease with a thrombospondin type 1 motif, member 13 AHF antihemophilia factor AHG antihuman globulin aPTT activated partial thromboplastin time BMT bone marrow transplant CAP College of American Pathologists CBC complete blood count CD cluster designation CLIA Clinical Laboratory Improvements Amendments CMV cytomegalovirus CONSORT consolidated standards of reporting trials CT computerized tomography CXR chest x-ray DAT direct antiglobulin test DDAVP 1-desamino-8-D-arginine vasopressin (desmopressin) DVT deep vein thrombosis EIA enzyme immunoassay EKG echocardiogram EPO erythropoietin FDA Food & Drug Administration FFP fresh frozen plasma G-CSF granulocyte colony stimulating factor GI gastrointestinal GVHD graft vs. host disease H1 & H2 histamine 1 & 2 HBV hepatitis B virus HCV hepatitis C virus HDFN hemolytic disease of the fetus and newborn HIV human immunodeficiency virus HLA human leukocyte antigen HPA human platelet antigen HPC hematopoietic progenitor cell HTLV human T-lymphotropic virus ICU intensive care unit IgG immunoglobulin G INR international normalized ratio ITP immune thrombocytopenic purpura IVIG intravenous immune globulin LDH lactate dehydrogenase LISS low ionic strength solution MRI magnetic resonance imaging NAT nucleic acid amplification test PEG polyethylene glycol PLT platelet PO per oral PT prothrombin time RBC red blood cell RhIG Rh immune globulin RPM revolutions per minute TACO transfusion associated circulatory overload TRALI transfusion related acute lung injury TTP thrombotic thrombocytopenic purpura VWF von Willebrand factor WBC white blood cell/count Change Coombs to AHG Change Aprotinin to DDAVP Updated 2/2017 The Chemical Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology ACTH ADH AFP ALT ANA AST BNP CBC CDC CEA CK-MB CLIA CLSI CMS CPT CSF DRG EDTA FDA HbX etc. hCG HCT HDL HGB HIPAA HLA HPLC ICD-10 IDL IgA etc. IL-1 etc. INR K2 EDTA LC-MS/MS LD LDL MALDI-TOF MCV NT-ProBNP OSHA PAMG-1 POC PSA PTH RBC rpm SS-A/Ro SS-B/La TSH VIPoma VLDL adrenocorticotropic hormone antidiuretic hormone alpha fetoprotein alanine aminotransferase antinuclear antibody aspartate aminotransferase B-type natriuretic peptide complete blood count Centers for Disease Control carcinoembryonic antigen creatine kinase-muscle or brain type Clinical Laboratory Improvements Amendments Clinical Laboratory Standards Institute Center for Medicare and Medicaid Services Current Procedural Terminology cerebrospinal fluid diagnosis related group ethylenediaminetetraacetic acid Food & Drug Administration hemoglobin A1c, C, D, E, S, etc. human chorionic gonatotrophin hematocrit high density lipoprotein cholesterol hemoglobin Health Insurance Portability and Accountability Act human leukocyte antigen high performance liquid chromatography international classification of diseases version 10 intermediate density lipoprotein cholesterol immunoglobulin A, D, E, G, M interleukin 1 international normalized ratio K2 ethylenediaminetetraacetic acid liquid chromatography tandem mass spectrometry lactate dehydrogenase low density lipoprotein cholesterol matrix-assisted laser desorption-time-of-flight mass spectrometry mean corpuscular volume N-terminal pro-B-type natriuretic peptide Occupational Safety and Health Administration placental alpha microglobulin-1 point of care prostate specific antigen parathyroid hormone red blood cell count revolutions per minute Anti-SSA autoantibodies Anti-SSB autoantibodies thyroid stimulating hormone vasoactive intestinal polypeptide very low density lipoprotein cholesterol Change “autoanalyzer” to “chemistry analyzer” Enzyme units are always U/L and hormones and proteins of unknown molecular weight are IU/L. Updated 12/2016 The Cytopathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology AFB acid-fast bacilli AGC atypical glandular cells AIS adenocarcinoma in situ ALTS ASCUS/LSIL triage study ASCCP American Society for Colposcopy and Cervical Pathology ASC-H atypical squamous cells, cannot rule out high grade squamous intraepithelial lesion ASC-US atypical squamous cell of undetermined significance ATHENA addressing the need for advanced HPV diagnostics AUS/FLUS atypia of undetermined significance/follicular lesion of undetermined significance BAL bronchoalveolar lavage BCG therapy changes Bacillus Calmette-Guérin therapy changes BSO bilateral salpingo-oophorectomy CDC Centers for Disease Control and Prevention CEA carcinoembryonic antigen CK cytokeratin CLIA Clinical Laboratory Improvement Amendments CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMS Center for Medicare and Medicaid Services CMV cytomegalovirus COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computerized tomography EMA epithelial membrane antigen ER estrogen receptor ERCP endoscopic retrograde choledochopancreatic duodenography EBUS guided endobronchial ultrasound guided EUS guided endoscopic ultrasound guided FDA Food and Drug Administration FISH fluorescent in-situ hybridization FNA fine needle aspiration GIST gastrointestinal stromal tumor GMS Grocott methenamine silver hpf high power field HPV human papilloma virus HSIL high grade squamous intraepithelial lesion IHC immunohistochemistry INR international normalized ratio IPMN intraductal papillary mucinous neoplasm LCA leukocyte common antigen LDH lactate dehydrogenase LEEP loop electrocautery excision procedure LSIL low grade squamous intraepithelial lesion LMP last menstrual period MEN multiple endocrine neoplasia N/C ratio nuclear cytoplasmic ratio NILM negative for intraepithelial lesion or malignancy NK natural killer OSHA Occupational Safety and Health Administration panCK pancytokeratin panNET pancreatic neuroendocrine tumor PAS periodic acid Schiff PLAP placental alkaline phosphatase PNET primitive neuroectodermal tumor PR progesterone receptor PSA prostate specific antigen Continued on next page PSMA PTH RCC SMA TAH TB TJC prostate specific membrane antigen parathormone renal cell carcinoma (where appropriate) smooth muscle actin total abdominal hysterectomy tuberculosis The Joint Commission Pap test – should be - liquid-based cervical cytology (don’t summarily change old questions) Anal Pap – should be - liquid-based anal cytology For Pap/GYN/anal screening questions, the stem should read “The most likely/best interpretation (not dx) is”. Diagnostic cytology questions should ask “The most likely diagnosis is:”. All GYN questions that have “recommended follow-up” should include “most recent ASCCP guidelines”. 2007 NCI Thyroid Conference = National Cancer Institute Thyroid FNA State of the Science Conf. This is now changed to “The Bethesda System for Reporting Thyroid Cytopathology”. MFH – now – pleomorphic undifferentiated sarcoma Metastatic goblet cell carcinoid tumor – now- metastatic mixed adenoneuroendocrine carcinoma When appropriate, answer order should be: unsatisfactory, benign, atypical, suspicious, and malignant – not alphabetical. Virtual slides should be FNAs, not scrapes. Avoid SurePath for virtual microscopy. Updated 9/2015 The Dermatopathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology CAP CD1 CLIA CPT DNA EBV EMA ERG FDA GFAP IgA IgD IgE IgG IgM LEOPARD MiTF MUM-1 MYC PAS stain TNF- College of American Pathologists cluster designation Clinical Laboratory Improvements Amendments current procedural terminology deoxyribonucleic acid Epstein-Barr virus epithelial membrane antigen Electroretinography or Ergosterol Food & Drug Administration Glial Fibrillary Acidic Protein immunoglobulin A immunoglobulin D immunoglobulin E immunoglobulin G immunoglobulin M Lentigines, EKG abnormality, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retarded growth, Deafness (congenital syndrome) Microphthalmia Transcription Factor Multiple Myeloma Oncogene 1 myelocytomatosis periodic acid Schiff tumor necrosis factor alpha “follicular lymphoma” not “follicle cell lymphoma” according to WHO Updated 11/2016 The Forensic Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology 25I-NBOMe ACLS AIDS AV AVM CMV CPR CT D-MORT ED EEG EKG EPA HACEK Hib HIPAA HPV IVDA MDMA MRI MVC NAME NYCLAD OTC PTSD THC TORCH derivative of the phenethylamine hallucinogen 2C-I (N-bomb, Smiles, 25I, 25C, 25B) advanced cardiovascular life support acquired immune deficiency syndrome atrioventricular arteriovenous malformation cytomegalovirus cardiopulmonary resuscitation computed tomography Disaster Mortuary Operational Response Teams emergency department electroencephalogram electrocardiogram environmental protection agency Haemophilus aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella Haemophilus influenzae, serotype b Health Insurance Portability and Accountability Act human papilloma virus intravenous drug abuser methylenedioxymethamphetamine (Ecstacy) magnetic resonance imaging motor vehicle collision National Association of Medical Examiners nylon clad bullet over the counter post-traumatic stress disorder Tetrahydrocannabinol (T)oxoplasmosis, (O)ther agents, (R)ubella, (C)ytomegalovirus, and (H)erpes simplex “TASER” should be changed to electronic control device. The Hematopathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology - Updated 3/2016 ADP adenosine diphosphate ALK anaplastic lymphoma kinase ALL acute lymphoblastic leukemia AML acute myeloid leukemia aPTT activated partial thromboplastin time ATP adenosine triphosphate CAP College of American Pathologists CBC complete blood count CLIA Clinical Laboratory Improvements Amendments CLL chronic lymphocytic leukemia CML chronic myelogenous leukemia CMV cytomegalovirus DNMT3A DNA methyltransferase 3 alpha DVT deep vein thrombosis EBER EBV-encoded RNA EBV Epstein-Barr virus EDTA ethylenediaminetetraacetic acid ELISA elisa assay EMA epithelial membrane antigen FISH fluorescence in-situ hybridization G-6-PD glucose-6-phosphate dehydrogenase GMS Gomori methenamine silver Hb or Hgb hemoglobin HHV8 human herpesvirus 8 HPLC high-performance liquid chromatography IHC immunohistochemistry INR international normalized ratio MALT lymphoma mucosa-associated lymphoid tissue lymphoma MCH mean corpuscular hemoglobin MCHC mean corpuscular hemoglobin concentration MCV mean corpuscular volume MDS myelodysplastic syndrome MDS/MPN myelodysplastic/myeloproliferative neoplasms MGUS monoclonal gammopathy of undetermined significance MLL (KMT2A) mixed lineage leukemia MPN myeloproliferative neoplasms MPO myeloperoxidase NPM1 nucleophosmin gene PAS periodic acid Schiff PCR polymerase chain reaction PMF primary myelofibrosis PNH paroxysmal nocturnal hemoglobinuria Ph’ chromosome Philadelphia chromosome Plt platelet PT/INR prothrombin time/international normalized ratio PTLD post-transplant lymphoproliferative disorders QC quality control RAEB refractory anemia with excess blasts RARS refractory anemia with ring sideroblasts RBC red blood cell RDW red cell distribution width RNA ribonucleic acid SLL small lymphocytic lymphoma SNP single nucleotide polymorphism TCR T cell receptor TdT terminal deoxynucleotidyl transferase TIA1 T cell intracellular antigen 1 TIBC total iron binding capacity WBC white blood cell Updated 4/2016 The Management and Informatics Test Development and Advisory Committee Acceptable Abbreviations and Terminology ACGME ACO aPTT CAP CBC CDC CLIA CMS CPOE CPT CSF CV DICOM EMR ER FDA FTE H&E HIPAA HIS HL7 HMO HTML HTTP ICD IHC IRB IT JPEG LIS LOINC OSHA PDF PHI PR QC RFP RBC ROC SD SNOMED SWOT TAT TIFF VPN WBC Accreditation Council for Graduate Medical Education accountable care organization activated partial thromboplastin time College of American Pathologists complete blood count Centers for Disease Control Clinical Laboratory Improvements Amendments Centers for Medicare/Medicaid computerized provider order entry Current Procedural Terminology cerebrospinal fluid coefficient of variation Digital Imaging and Communications in Medicine electronic medical record – do not use EHR and change old questions individually, as warranted estrogen receptor Food and Drug Administration full-time equivalent hematoxylin and eosin Health Insurance Portability and Accountability Act hospital information system Health Level 7 health maintenance organization hypertext markup language hypertext transfer protocol International Classification of Diseases immunohistochemistry institutional review board information technology joint photographic experts group laboratory information system Logical Observation Identifiers Names and Codes Occupational Safety and Health Administration portable document format protected health information progesterone receptor quality control request for proposal red blood cells receiver operator curve standard deviation Systemized Nomenclature of Medicine strengths, weaknesses, opportunities, threats turn around time Tagged Image File Format virtual private network white blood cells Per the 2014 TDAC, TJC will no longer be used as an abbreviation for The Joint Commission. It will be referred to as Joint Commission, with no abbreviation. Updated 3/2016 The Medical Microbiology Test Development and Advisory Committee Acceptable Abbreviations and Terminology ADH arginine dihydrolase (SS only) AML acute myeloid leukemia ARDS acute respiratory distress syndrome BAL bronchoalveolar lavage BCYE buffered charcoal yeast extract CAMP Christie-Atkins-Munch-Petersen test CLSI Clinical Lab Standards Institute CMV cytomegalovirus CNA colistin nalidixic acid CNS central nervous system COPD chronic obstructive pulmonary disease CSF cerebrospinal fluid CT computed tomography DNA deoxyribonucleic acid EBV Epstein-Barr virus EIA enzyme immunoassay G6PD glucose-6-phosphate dehydrogenase deficiency GMS Gomori (or Grocott) methenamine silver H&E hematoxylin & eosin HBV hepatitis B virus HHV human herpes virus HIV human immunodeficiency virus HSV herpes simplex virus LDC lysine decarboxylase test (SS only) MALDI-TOFmatrix-assisted laser desorption-time-of-flight mass spectrometry MIC minimal inhibitory concentration MRI magnetic resonance imaging NAAT nucleic acid amplification test ODC ornithine decarboxylase (SS only) PAS periodic acid Schiff PCR polymerase chain reaction PYR pyrrolidonyl amidase reactivity RNA ribonucleic acid RPR rapid plasma reagin RSV respiratory syncytial virus SBA sheep blood agar (SS only) VZV varicella zoster virus When referring to the Gram stain, it should be capitalized. When referring to the gram reactivity of an organism, gram-negative or positive, it is not capitalized. Updated 11/2016 The Molecular Genetic Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology aCGH AFP BAC CAP CBC CLIA CMV CpG CPT CSF CT DNA EBV FISH HbF HbS HBV HCV HIV HPV HSV LOH MCV MEN MRI NGS PCR RNA rRNA SNP STR array comparative genomic hybridization alpha fetoprotein baculovirus array College of American Pathologists complete blood count Clinical Laboratory Improvement Amendment cytomegalovirus CpG (?) islands current procedural terminology cerebrospinal fluid computed tomography deoxyribonucleic acid Epstein-Barr virus fluorescent in-situ hybridization hemoglobin F hemoglobin S hepatitis B virus hepatitis C virus human immunodeficiency virus human papillomavirus herpes simplex virus loss of heterozygosity mean corpuscular volume multiple endocrine neoplasia magnetic resonance imaging next generation sequencing polymerase chain reaction ribonucleic acid ribosomal ribonucleic acid single nucleotide polymorphism short tandem repeat Fusion genes will be noted with a slash not a dash. ABL is now ABL1. Next generation sequencing (not high-throughput or massively parallel). Chromosomal microarray, not chromosome microarray Updated 3/2016 The Neuropathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology ALS ATRX CADASIL CD CNS COPD CSF DNA EEG EGFR EM EMA FDG-PET GFAP GI H&E HSV LFB MDMA MR MRI PLAP PPD test PTAH SPECT WHO amyotrophic lateral sclerosis alpha thalassemia/mental retardation syndrome X-linked cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy cluster designation central nervous system chronic obstructive pulmonary disease cerebrospinal fluid deoxyribonucleic acid electroencephalogram epidermal growth factor receptor electron microscopy epithelial membrane antigen fluoro-deoxyglucose positron emission tomography glial fibrillary acidic protein gastrointestinal hematoxylin & eosin herpes simplex virus luxol fast blue methylenedioxymethamphetamine (Ecstasy) magnetic resonance magnetic resonance imaging placental alkaline phosphatase purified protein derivative phosphotungstic acid hematoxylin single photon emission tomography World Health Organization Immunoreactive “to” not “for”. EM only for nerve and muscle and selected diseases in which EM is required. Updated 8/2016 The Pediatric Pathology Test Development and Advisory Committee Acceptable Abbreviations and Terminology ALT alanine aminotransferase AST aspartate aminotransferase CBC complete blood count CHARGE syndrome coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness. CSF cerebrospinal fluid DNA deoxyribonucleic acid ESR erythrocyte sedimentation rate FISH fluorescent in-situ hybridization G6PD glucose-6-phosphate dehydrogenase deficiency GM-CSF granulocyte-macrophage colony-stimulating factor HUS hemolytic uremic syndrome IgA immunoglobulin A IgD immunoglobulin D IgE immunoglobulin E IgG immunoglobulin G IgM immunoglobulin M IPEX immunodysregulation polyendocrinopathy enteropathy x-linked syndrome MEN IIb multiple endocrine neoplasia type 2 mRNA messenger ribonucleic acid NF neurofibromatosis PAS periodic acid Schiff PEComa perivascular epithelioid cell tumor VACTERL vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities VMA vanillylmandelic acid WAGR Wilms tumour, aniridia, genitourinary anomalies, and retardation WBC white blood cell If a syndrome is named after a patient, there is an apostrophe – Lou Gehrig’s disease. If it is named after the doctor, there is no apostrophe. ABBREVIATIONS Official statement of policy from ABP regarding the use of abbreviations (as of 18 June 1987): "Avoid abbreviations in the development of questions except for the very few that have been in existence for many years and are well known by students, residents, and staff at all levels of the healthcare industry." ABC ACOG ACD sol ADCC ADP AgNOR AGUS (AGCUS) AHF AHG AHRQ AIS AIDS AIHA ALK ALS ALT ANF ANSI APIC ASCP ASCUS ASO AST ASTM atm ATP ATPase aconite, belladonna, chloroform or antigen-binding capacity American College of Obstetricians and Gynecologists citric acid, trisodium citrate, dextrose solution antibody dependent cell-mediated cytotoxicity adenosine diphosphate silver nucleolar organizer region (use abbreviated form) atypical glandular cells of undetermined significance antihemophilic factor antihemophilic globulin or antihuman globulin Agency for Healthcare Research and Quality adenocarcinoma in situ acquired immunodeficiency syndrome autoimmune hemolytic anemia ok as is antilymphocytic serum or amyotrophic lateral sclerosis alanine aminotransferase antinuclear factor American National Standards Institute Association for Professionals in Infection Control and Epidemiology American Society for Clinical Pathology atypical squamous cells of undetermined significance antistreptolysin-O aspartate aminotransferase American Society for Testing and Materials atmosphere (OK not capped) adenosine triphosphate adenosine triphosphatase B cell BCG bcr BEI BFU-E BGG BNP BSA bone-marrow-derived cell (antibody-forming cell precursor) bacille Calmette-Guérin (BCG vaccine) breakpoint cluster region butanol-extractable iodine burst-forming unit, erythrocyte bovine gamma globulin B-type natriuretic peptide bovine serum albumin or bismuth-sulfite agar CAP CADASIL C:Ag CAP CALLA or cALLA CBH CCP CCR CD CDR CEA CFU-C CFU-E CFU-GM CFU-S CGD CH CH College of American Pathologists cerebral autosomal dominant arteriopathy with subacute ischemic leukoencephalopathy coagulant antigen College of American Pathologists common ALL antigens (HEM uses CALLA) cutaneous basophil hypersensitivity ciliocytophthoria creatinine clearance cluster designation central dose rate carcinoembryonic antigen colony-forming unit, culture colony-forming unit, erythrocyte colony-forming unit, granulocyte-macrophage colony-forming unit, spleen chronic granulomatous disease Christchurch chromosome constant heavy (as in chain) CIF chemotactic factor inactivator cIg cytoplasmic immunoglobulin CIN inulin clearance or carcinoma in situ Cl chemical symbol for chloride Con A concanavalin A; a plant mitogen COP colloidal osmotic pressure CPD citrate phosphate dextrose CPDA-1 citrate-phosphate-dextrose-adenine (anticoagulant) CREST phenomenon calcinosis, Reynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia CSF colony-stimulating factor or cerebrospinal fluid CTL cytotoxic or cytolytic T lymphocytes CV coefficient of variation Cyclic Amp cyclic adenosine 3 ,5 -monophosphate Cyclic Gmp cyclic guanosine 3 ,5 -monophosphate DCIS DAT DDAVP DEHP W O.D. DHEA or DHEA-S DH DiDi DL DM DNA DNase DNCB DNP DPG DPT dsDNA DTT ductal carcinoma in situ direct antiglobulin test or testing 1-desamino-8-D-arginine (vasopressin) di(2-ethylhexyl)phthalate (a plasticizer) delta optical density dehydroepiandrosterone sulfate delayed hypersensitivity diamnionic/dichorionic Donath-Landsteiner antibody double minute; DMs is the plural deoxyribonucleic acid deoxyribonuclease dinitrochlorobenzene dinitrophenol 2, 3-diphosphoglycerate combination injection for immunization against diphtheria, pertussis, and tetanus double-stranded DNA dithiothreitol (a reagent) EAC EACA EAT EBNA ECF-A EDTA EGFR EIA ELAT ELISA EMA EMB ERCP ESR sheep cells coated with antibody and complement or Ehrlich ascites carcinoma epsilon aminocaproic acid experimental allergic thyroiditis Epstein-Barr nuclear antigen eosinophil chemotactic factor of anaphylaxis ethylenediaminetetraacetic acid epidermal growth factor receptor enzyme immunoassay enzyme-linked antiglobulin test enzyme-linked immunosorbent assay epithelial membrane antigen or endomysial antibody (celiac disease) eosin-methylene blue agar endoscopic retrograde cholangiopancreatography erythrocyte sedimentation rate fFN FISH FITC FLP F-T4 FTA-ABS FMH fetal fibronectin fluorescence in situ hybridization fluorescein isothiocyanate fragment length polymorphism free thyroxine fluorescent treponemal antibody-absorption fetomaternal hemorrhage G-CSF GA (GT GFAP GGT GISA granulocyte colony-stimulating factor copolymer of L-glutamic acid and L-tyrosine glial fibrillary acidic protein (cells) gamma glutamyl transferase glycopeptide-insensitive Staphylococcus aureus GIST GL GM-CSF Gy gastrointestinal stromal tumor (leiomyoblastoma) copolymer of L-glutamic acid and L-alanine granulocyte-macrophage colony-stimulating factor gray (SI unit, refers to gray matter--1 Gy = 100 rads) hCG HDL HDL-C HES HETE HF HiB HiCN HIV-1 HL-A HLA HMSN hp HP/HPF HPL HPLC H-PLL HPV HTLA HTLV-III HVA human chorionic gonadotropin high density lipoprotein high density lipoprotein-?? hydroxyethyl starch hydroxyeicosatetraenoic high frequency Hemophilus influenza, type B hemoglobin or cyanmethemoglobin human immunodeficiency virus, type 1 histocompatible lymphocytes-antigens homologous leukocytic antibodies hereditary motor and sensory neuropathy horsepower high power/high power field human placental lactogen high performance liquid chromatography hapten-poly-L-lysine conjugate human papillomavirus high titer, low acidity (antibody) human T-cell lymphotropic virus, type III homovanillic acid Ia IBC ID50 IEEE Ig IG Ig cell IL-1 IL-2 IL-3 IMDM Ir IrE IV I.V. Ir gene-controlled antigen iron binding capacity (transferrin iron binding capacity) median infective dose Institute of Electrical and Electronic Engineers immunoglobulins; five classes: IgA, IgG, IgM, IgD, IgE immune globulin immunoglobulin beta cell interleukin-1 interleukin-2 interleukin-3 Iscove modified Dulbecco medium immune response (gene) immune response (gene) to ragweed Roman numeral four intravenous, interventricular, intervertebral, intravascular, intraventricular, invasive J JCAHO Joule equivalent, i.e., J/kg = Joule of energy per kilogram of absorber Joint Commission on Accreditation of Healthcare Organizations k K kev Ki-1 KLH kPa LAAM LATS LCA LCH LCIS LCM LD LD50 LDH LDL kilo chemical symbol for potassium kilo electron volt a tumor marker (numeric 1) keyhole-limpet hemocyanin kilopascal Leva alpha acetyl methodology long-acting thyroid stimulator leukocyte common antigen Langerhans cell histiocytosis lobular carcinoma in situ lymphocytic choriomeningitis or left costal margin lactate dehydrogenase median lethal dose lactate dehydrogenase low density lipoprotein LEEP Leu7+ cells LFB LFT LN2 LOH LP/LPF lm lx loop electrocautery excision procedure natural killer cells luxol fast blue stain liver function test a tumor marker loss of heterozygosity low power/low power field lumen, luminous flux lux, illuminance MAG MALT MART MBP 2-ME MCAD M-CFS MDS MELAS MEM MEN MGG MGUS MH-IH MHC MICE MIF MKI MLC MLR mmHg mN MOSP MPNST MPO MRSA MW myelin-associated glycoprotein mucosa-associated lymphoid tissue melanoma antigen recognized by T-cells (don’t spell out; all caps) myelin basic protein 2-mercaptoethanol medium-chain coenzyme A dehydrogenase macrophage colony-stimulating factor myelodysplastic syndrome mitochondrial myopathy with encephalopathy or myoclonic epilepsy, lactic acidosis, stroke-like episodes minimal essential medium multiple endocrine neoplasia (syndrome); types I, II, IIb, or III May-Grünwald Giemsa monoclonal gammopathy of undetermined significance Mueller-Hinton IsoVitaleX* hemin agar mean hemoglobin concentration or major histocompatibility complex monocytic incidental cardiac excresence merthiolate-iodine-formaldehyde mytosis karyorrhexis index mixed lymphocyte culture mixed lymphocyte reaction millimeters of Mercury millinewton (unit of measurement) myelin oligodendrocyte-specific protein malignant peripheral nerve sheath tumor myeloperoxidase methicillin-resistant Staphylococcus aureus molecular weight Na NAD NANA NANBH NAT NCCLS NIAID Nm NOR NSE chemical symbol for sodium nicotinamide-adenine dinucleotide N-acetylneuraminic acid non A, non B hepatitis neonatal alloimmune thrombocytopenia (also NAIT) or nucleic acid test(ing) National Committee for Clinical Laboratory Standards National Institute of Allergy and Infectious Diseases newton meter (unit of measurement) nucleolus organizer regions neuron-specific enolase OAF OD O-F OT OTC osteoclast activity factor optical density oxidative-fermentative (medium) old tuberculin ornithine transcarbamylase PAIgG Pap PAP PCNA PCR PGD platelet-associated IgG Papanicolaou the peroxidase, antiperoxidase procedure proliferating cell nuclear antigen polymerase chain reaction (reverse transcriptase PCR) phosphogluconate dehydrogenase PHA passive hemagglutination or phytohemagglutinin (assay) pI an isoelectric point Pi protease inhibitor PIC/NF stain picroindigocarmine/nuclear fast red stain PIN prostatic intraepithelial neoplasia PIP proximal interphalangeal (joint) PiSZ a phenotype associated with antiproteinase or antitrypsin PiZZ a genotype associated with antiproteinase or antitrypsin PLAP placental alkaline phosphatase PLP proteolipid protein PLS passive leukocyte-sensitizing activity PNA peptide nucleic acid PNET primitive neuroectodermal tumor POCT point-of-care testing POEMS syndrome polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes PPD purified protein derivative PPF plasma protein fraction PRA panel-reactive antibodies (blood banking terminology) PTAH phosphotungstic acid hematoxylin PTH parathyroid hormone PVP polyvinylpyrrolidone PVP-I povidone-iodine R:Ag Ragg RAST RFLP RIBA RNase ROC related antigen rheumatoid agglutinators radioallergosorbent test restriction fragment length polymorphism recombinant immunoblot assay ribonuclease receiver operator characteristic or curve SARS severe acute respiratory syndrome SC sickle cell(s) S-C disease sickle cell/hemoglobin C disease sIg surface immunoglobulin SIL squamous intraepithelial lesion SI units Système International d’Unités SLL small lymphocytic lymphoma SMA smooth muscle antibody SmIgG surface membrane immunoglobulin G SNagg serum normal agglutinators SNP single nucleotide polymorphism spp. species SOX synrome sialadenitis, osteoarthritis, and xerostomia SRS-A slow-reacting substance of anaphylaxis SSA or SS-A serum-specific antibody, example: anti-RO (SS-A) antibody SSB or SS-B serum-specific autoantigen, example: La (SS-B) autoantigen SSPE subacute sclerosing panencephalitis Ss-Slp genetic locus within the H2 complex of mice-controlling concentration and allotype variation of a serum alpha-globulin Tac TBG T cell TCR TD TDLU TDM TGF TH TI (Not sure, but may stand for transactivated complex per DAN) thyroxine binding globulin thymus-derived lymphocyte (helper cell) T-cell receptor T-cell delayed hypersensitivity or thymus-dependent terminal duct lobular unit therapeutic drug monitoring or thymus-derived mediator transforming growth factor or (less-used) tumor growth factor T-cell helper thymus-independent antigen TK Tla TNF-alpha/beta TPI TPO TRALI TRH TS TSH TSI TSTA TT tTG TTF TTV T-T4 T-cell killer thymus leukemia mediator tumor necrosis factor-alpha/beta Treponema pallidum immobilization thrombopoietin transfusion-related acute lung injury thyrotropin releasing hormone T-cell suppressor thyroid stimulating hormone triple sugar iron (agar) tumor-specific transplantation-like antigens thrombin time tissue transglutaminase thyroid transcription factor TT virus (initials of first patient), also used for transfusion-transmitted virus total thyroxine v V VCA VLDL VMA VNTR XLD volt coefficient of variation or visual acuity viral capsid antigen very low density lipoprotein vanillylmandelic acid variable number tandem repeat xylose-lysine-deoxycholate agar ZZAP sulfhydryl-proteolytic enzyme (a reagent) Compilation of all TDAC abbreviations – 11/17/2016 25I-NBOMe aCGH ACGME ACLS ACO ACTH ADAMTS13 ADH ADP AFB AFP AGC AHF AHG AIDS AIS AJCC ALK ALL ALS ALT AML ANA ANCA aPTT ARDS ASCCP ASCO ASC-H ASC-US AST ATP ATRX AUS/FLUS AV AVM derivative of the phenethylamine hallucinogen 2C-I (N-bomb, Smiles, 25I, 25C, 25B) array comparative genomic hybridization Accreditation Council for Graduate Medical Education advanced cardiovascular life support accountable care organization adrenocorticotrophic hormone a disintegrin & metalloprotease with a thrombospondin type 1 motif, member 13 arginine dihydrolase (SS only) adenosine diphosphate acid-fast bacilli alpha fetoprotein atypical glandular cells antihemophilia factor antihuman globulin acquired immunodeficiency syndrome adenocarcinoma in situ American Joint Commission on Cancer anaplastic lymphoma kinase acute lymphoblastic leukemia amyotrophic lateral sclerosis alanine aminotransferase acute myeloid leukemia antinuclear antibody anti-neutrophil cytoplasmic autoantibody activated partial thromboplastin time acute respiratory distress syndrome American Society for Colposcopy and Cervical Pathology American Society of Clinical Oncology atypical squamous cells, cannot rule out high grade squamous intraepithelial lesion atypical squamous cell of undetermined significance aspartate aminotransferase adenosine triphosphate alpha thalassemia/mental retardation syndrome X-linked atypia of undetermined significance/follicular lesion of undetermined significance atrial ventricular arteriovenous malformation BAC baculovirus array BAL bronchoalveolar lavage BCG therapy changes Bacillus Calmette-Guérin therapy changes BCYE buffered charcoal yeast extract Beta-HCG beta-human chorionic gonadotropin BMT bone marrow transplant BNP B-type natriuretic peptide BSO bilateral salpingo-oophorectomy CADASIL cerebral autosomal dominant arteriopathy with subcortical infarcts & leukoencephalopathy CAMP Christie-Atkins-Munch-Petersen test CAP College of American Pathologists CBC complete blood count CD cluster designation CD1 cluster designation CDC Centers for Disease Control CEA carcinoembryonic antigen CGH comparative genomic hybridization CHARGE syndrome coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness. CK cytokeratin CK-MB creatine kinase-muscle or brain type CLIA Clinical Laboratory Improvements Amendments CLL CLSI CML CMS CMV CNA CNS COPD CpG CPOE CPR CPT CSF CT CV CXR chronic lymphocytic leukemia Clinical Laboratory Standards Institute chronic myelogenous leukemia Center for Medicare and Medicaid Services cytomegalovirus colistin nalidixic acid central nervous system chronic obstructive pulmonary disease CpG (?) islands computerized provider order entry cardiovascular resuscitation Current Procedural Terminology cerebrospinal fluid computed tomography coefficient of variation chest x-ray DAT DCIS DDAVP DICOM DNA DNMT3A DRG DVT direct antiglobulin test ductal carcinoma in situ 1-desamino-8-D-arginine vasopressin (desmopressin) Digital Imaging and Communications in Medicine deoxyribonucleic acid DNA methyltransferase 3 alpha diagnosis related group deep vein thrombosis EBER EBUS guided EBV EDTA EEG EGFR EIA EKG ELISA EM EMA EMG EMR EPA EPO ER ERCP ERG ESR EUS guided EVG EBV-encoded RNA endobronchial ultrasound guided Epstein-Barr virus ethylenediaminetetraacetic acid electroencephalogram epidermal growth factor receptor enzyme immunoassay echocardiogram elisa assay electron microscopy epithelial membrane antigen electromyograph electronic medical record – do not use EHR and change old questions individually, as warranted environmental protection agency erythropoietin estrogen receptor endoscopic retrograde choledochopancreatic duodenography Electroretinography or Ergosterol erythrocyte sedimentation rate endoscopic ultrasound guided elastic van Gieson 5FU FDA FDG-PET FISH FFP FNA FTE fluorouracil Food & Drug Administration fluoro-deoxyglucose positron emission tomography fluorescent in-situ hybridization fresh frozen plasma fine needle aspiration full-time equivalent G6PD G-CSF GFAP GI GIST GMS glucose-6-phosphate dehydrogenase deficiency granulocyte colony stimulating factor glial fibrillary acidic protein gastrointestinal gastrointestinal stromal tumor Gomori (or Grocott) methenamine silver GVHD graft vs. host disease H1 & H2 histamine 1 & 2 Hb or HgbX etc. hemoglobin A1c, C, D, E, F, S, etc. HBV hepatitis B virus hCG human chorionic gonatotrophin HCT hematocrit HCV hepatitis C virus HDFN hemolytic disease of the fetus and newborn HDL high density lipoprotein cholesterol H&E hematoxylin & eosin HGB hemoglobin HHV human herpes virus HHV8 human herpes virus 8 HIPAA Health Insurance Portability and Accountability Act HIS hospital information system HIV human immunodeficiency virus HLA human leukocyte antigen HL7 Health Level 7 HMO health maintenance organization HPA human platelet antigen HPC hematopoietic progenitor cell hpf high power field HPLC high performance liquid chromatography HPV human papillomavirus HSIL high grade squamous intraepithelial lesion HSV herpes simplex virus HTLV human T-lymphotropic virus HTML hypertext markup language HTTP hypertext transfer protocol HUS hemolytic uremic syndrome ICD ICD-10 ICU IDL IgA etc. IHC IL-1 etc. INR IPEX IPMN IRB IT ITP IUD IV IVIG International Classification of Diseases international classification of diseases version 10 intensive care unit intermediate density lipoprotein cholesterol immunoglobulin A, D, E, G, M immunohistochemistry interleukin 1 international normalized ratio immunodysregulation polyendocrinopathy enteropathy x-linked syndrome intraductal papillary mucinous neoplasm institutional review board information technology immune thrombocytopenic purpura intrauterine device intravenous intravenous immune globulin JPEG joint photographic experts group K2 EDTA K2 ethylenediaminetetraacetic acid LD LDC LDH LDL LEEP LEOPARD lactate dehydrogenase lysine decarboxylase test (SS only) lactate dehydrogenase low density lipoprotein cholesterol loop electrocautery excision procedure Lentigines, EKG abnormality, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retarded growth, Deafness (congenital syndrome) luxol fast blue laboratory information system LFB LIS LMP LOH LOINC LSIL last menstrual period loss of heterozygosity Logical Observation Identifiers Names and Codes low grade squamous intraepithelial lesion MALDI-TOF matrix-assisted laser desorption-time-of-flight mass spectrometry MALT lymphoma mucosa-associated lymphoid tissue lymphoma MCH mean corpuscular hemoglobin MCHC mean corpuscular hemoglobin concentration MCV mean corpuscular volume MDMA methylenedioxymethamphetamine (Ecstacy) MDS myelodysplastic syndrome MDS/MPN myelodysplastic/myeloproliferative neoplasms MEN multiple endocrine neoplasia MEN IIb multiple endocrine neoplasia type 2 MGUS monoclonal gammopathy of undetermined significance MIC minimal inhibitory concentration MiTF Microphthalmia Transcription Factor MLL (KMT2A) mixed lineage leukemia MPN myeloproliferative neoplasms MPO myeloperoxidase MRI magnetic resonance imaging mRNA messenger ribonucleic acid MUM-1 Multiple Myeloma Oncogene 1 MYC myelocytomatosis NAAT NAME NAT N/C ratio NF NGS NILM NK NOS NPM1 NT-ProBNP NUT nucleic acid amplification test National Association of Medical Examiners nucleic acid amplification test nuclear cytoplasmic ratio neurofibromatosis next generation sequencing negative for intraepithelial lesion or malignancy natural killer not otherwise specified nucleophosmin gene N-terminal pro-B-type natriuretic peptide nuclear in testis ODC OSHA OTC ornithine decarboxylase (SS only) Occupational Safety and Health Administration over the counter PAMG-1 placental alpha microglobulin-1 panCK pancytokeratin PAS periodic acid Schiff PCR polymerase chain reaction PDF portable document format PEComa perivascular epithelioid cell Ph’ chromosome Philadelphia chromosome PHI protected health information PIN prostatic intraepithelial neoplasia PLAP placental alkaline phosphatase PLT platelet PMF primary myelofibrosis PNET primitive neuroectodermal tumor PNH paroxysmal nocturnal hemoglobinuria PO per oral POC point of care PPD test purified protein derivative PR progesterone receptor PSA prostate specific antigen PSMA PT PTAH PTH PTH PT/INR PTLD PYR prostate specific membrane antigen prothrombin time phosphotungstic acid hematoxylin parathyroid hormone parathormone prothrombin time/international normalized ratio post-transplant lymphoproliferative disorders pyrrolidonyl amidase reactivity QC quality control RAEB RARS RBC RDW RFP RhIG RNA ROC RPM RPR rRNA RSV refractory anemia with excess blasts refractory anemia with ring sideroblasts red blood cell red cell distribution width request for proposal Rh immune globulin ribonucleic acid receiver operator curve revolutions per minute rapid plasma reagin ribosomal ribonucleic acid respiratory syncytial virus SBA SD SLL SMA SNOMED SNP SPECT SS-A/Ro SS-B/La STR SWOT sheep blood agar (SS only) standard deviation small lymphocytic lymphoma smooth muscle actin Systemized Nomenclature of Medicine single nucleotide polymorphism single photon emission tomography Anti-SSA autoantibodies Anti-SSB autoantibodies short tandem repeat strengths, weaknesses, opportunities, threats TACO TAH TAT TB TCR TdT TIA1 TIBC TIFF TNF- TORCH TRALI TSH TTF-1 TTP TUR transfusion associated circulatory overload total abdominal hysterectomy turn around time tuberculosis T cell receptor terminal deoxynucleotidyl transferase T cell intracellular antigen 1 total iron binding capacity Tagged Image File Format tumor necrosis factor alpha (T)oxoplasmosis, (O)ther agents, (R)ubella, (C)ytomegalovirus, and (H)erpes simplex transfusion related acute lung injury thyroid stimulating hormone thyroid transcription factor thrombotic thrombocytopenic purpura transurethral resection VACTERL VLDL VMA VPN VWF VZV vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities very low density lipoprotein cholesterol vanillylmandelic acid virtual private network von Willebrand factor varicella zoster virus WAGR Wilms tumour, aniridia, genitourinary anomalies, and retardation WBC WHO WT1 white blood cell/count World Health Organization Wilms tumor associated antigen TDAC NOTES AP Down the road, Wegener granulomatosis should be changed to granulomatosis with polyangiitis. There is no dash in “S100 protein”. PNET now Ewing sarcoma – 1/2016 Granulocytic sarcoma now myeloid sarcoma – 1/2016 Chem Change “autoanalyzer” to “chemistry analyzer” Enzyme units are always U/L and hormones and proteins of unknown molecular weight are IU/L. Cyto Pap test – should be - liquid-based cervical cytology (don’t summarily change old questions) Anal Pap – should be - liquid-based anal cytology For Pap or GYN questions, the stem should now read “The most likely interpretation is”. All GYN questions that have “recommended follow-up” should include “most recent ASCCP guidelines”. 2007 NCI Thyroid Conference = National Cancer Institute Thyroid FNA State of the Science Conf. This is now changed to “The Bethesda System for Reporting Thyroid Cytopathology”. MFH – now – pleomorphic undifferentiated sarcoma Metastatic goblet cell carcinoid tumor – now- metastatic mixed adenoneuroendocrine carcinoma DP “follicular lymphoma” not “follicle cell lymphoma” according to WHO FP “TASER” should be changed to electronic control device. M&I Per the 2014 TDAC, TJC will no longer be used as an abbreviation for The Joint Commission. It will be referred to as Joint Commission, with no abbreviation. MMB When referring to the Gram stain, it should be capitalized. When referring to the gram reactivity of an organism, gram-negative or positive, it is not capitalized. MGP Fusion genes will be noted with a slash not a dash. ABL is now ABL1. Next generation sequencing (not high-throughput or massively parallel). Chromosomal microarray, not chromosome microarray NP Immunoreactive “to” not “for”. EM only for nerve and muscle and selected diseases in which EM is required. Pedi If a syndrome is named after a patient, there is an apostrophe – Lou Gehrig’s disease. If it is named after the doctor, there is no apostrophe.
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