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The cardiac function curve (bottom) is related to the left ventricular pressure-volume relations (top). Top. Stroke volume (double-headed arrow) is the
difference between end-systolic volume (ESV) and end-diastolic volume (EDV). EDV at end-diastolic pressure (EDP = 10 mm Hg) is illustrated on the
diastolic pressure-volume relation; ESV is determined by the end-systolic pressure (ESP) and the end-systolic pressure-volume relation (ESPVR or
Emax). Therefore, for any EDP, cardiac output can be calculated if heart rate is known. Bottom. An increase in EDP increases EDV and cardiac output. At
an EDP of 510 mm Hg, an increase in contractility would result in an increased stroke volume because the ESPVR shifts to the left; therefore, cardiac
output increases at the same EDP and the cardiac function curve shifts up.
Source: Chapter 22. Ventricular Dysfunction in Critical Illness, Principles of Critical Care, 3e
Citation: Hall JB, Schmidt GA, Wood LH. Principles of Critical Care, 3e; 2005 Available at: http://mhmedical.com/ Accessed: May 08, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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