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SARS and the Realization That Diseases Know No Border Division of Emerging Infectious Disease Center for Disease Control, Taiwan 1 SARS was the first disease that attacked the whole world since the globalization. 2 What is SARS? This disease was known as atypical pneumonia before WHO formally named it as severe acute respiratory syndrome (SARS) in March, 2003. But SARS are more severe than atypical pneumonia caused by known bacteria or viruses. 3 Where does SARS come from1? The origins of SARS virus are uncertain, but it is believed to come from China. From November 2002, an atypical pneumonia (SARS) outbreak occurred in Quangdong Province. Evidence showed that the outbreak in Hong Kong started from an infected professor, traveling from Quangdong to Hong Kong. 4 Where does SARS come from2? In February 2003, this man arrived in Hong Kong and transmitted the disease to staffs and other guests in the hotel he stayed. A nosocomial transmission occurred in the hospital that the man stayed. Then the disease was transmitted globally by infected index patients in Hong Kong. 5 SARS outbreak in the world 6 Distribution of Global Probable SARS Cases Probable Case No. China 5327 Hong Kong 1755 Taiwan 346 Canada 251 Singapore 238 Viet Nam 63 Legend Number of probable case 1-5 6 - 14 15 - 29 30 - 251 252 - 5327 26 Sep. 2003 Number of Global Probable SARS Cases Total : 8,098 probable cases Death: 774 cases Major hot spots: China: 5,327 cases (349 death) HK: 1,755 cases (299 death) Taiwan : 346 cases (37 death) Canada: 251 cases (43 death) Singapore: 238 cases (33 death) 26 Sep. 2003 WHO 8 Areas with Local Transmission of SARS, WHO Date of areas with local transmission Country Area Started Lifted Toronto 16 Mar 14 May 60 Guandong 16 Mar 13 Jun 90 Beijing 11 Apr 24 Jun 75 Hong Kong 16 Mar 21 Jun 98 Taiwan 21 May 5 Jul 46 Singapore 16 Mar 30 May 76 16 Mar 28 Apr 44 Canada China Viet Nam Hanoi Duration(Day) 9 SARS outbreak in Taiwan 10 Diagram of SARS Transmission In the East Asia 11 Probable SARS Cases in Taiwan Probable SARS Cases n = 664* Virus PCR or Ab (+) n = 346 (52.1%) survival n = 273 Both negative n = 317 (47.8%) deceased (n = 73) CFR = 21.1% directly due to SARS n = 37 CFR = 10.7% * one case without specimen CFR: Case Fatality Rate SARS related n = 36 CFR = 10.4% survival n = 210 Deceased (n = 107) CFR = 33.8% 12 30 (4) (1) 25 病例數 (Case Number) (2) (1) 和平醫院事件 (5) (2) 仁濟醫院事件 (3) (3) 台大醫院事件 20 (4) 高雄長庚事件 (5) 關渡醫院事件 15 (6) 陽明醫院事件 10 (6) 5 0 2/25 3/4 3/11 3/18 3/25 4/1 4/8 4/15 4/22 4/29 5/6 5/13 5/20 5/27 6/3 6/10 台灣地區SARS可能病例流行曲線 (資料公布時間: 6月25日 9:00) Epidemiological curve of SARS probable cases in Taiwan 6/17 6/24 發病日 onset SARS Transmission in Health Care Facilities, Taiwan March 14-Apr.22 China HK NTUH 4/9 Hoping Hospital 151 5/2 NTUH 52 MK 17 Apr. 21 May 15 May 31 Closed JG End Nursing Jen Chi 4/30 32 K. H. ChangGung Junghsin Memorial 2 Hospital Apr. 23 44 K.H. Med Univ. PengHu. 7 14 Lessons We Learned in the SARS Outbreak Delayed alert & reporting Hospital infection Ineffective command channel Logistic exhaust Quarantine cost too high Social panic: poor media communication Travel and economy cost: NT$150 billions (3.75 billions Euro) 15 SARS Control in Taiwan in the Post-SARS Period 16 Challenges for SARS Control in the Winter, 2003-2004 Influenza and SARS might occur at the same season in the winter of 2003-2004. It is difficult to differentiate initial clinical symptoms and signs between influenza and SARS. Highly infectious influenza will occupy medical resources for SARS treatment. 17 SARS Control Programs in Taiwan Fever Patients Surveillance Influenza Immunization Isolation of Fever Patients Reporting and Alert System Collection of International Outbreak Information Border and Home Quarantine Hospital Infection Control National Medical Care System of Communicable Diseases 18 Conclusion Better knowledge and experiences in SARS prevention, diagnosis and treatment More stringent disease control strategies Improved international collaboration SARS will come again, but will not become a significant threat 19 Thank You for Your Attention 20