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Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie Herr PD Dr. rer. nat. Bernd Jung Department of Diagnostic, Interventional and Pediatric Radiology University Hospital of Bern Inselspital Bern 3010 Bern [email protected] University Degrees 2000 MSc Physics (Dipl.-Phys.), University of Karlsruhe, Germany 2005 PhD (Dr. rer. rat.), University of Freiburg, Germany 2013 PD, Venia Legendi for Medical Physics, University of Freiburg Professional Experience 06/2005 – 12/2006 Postdoctoral Research Fellow Dept. of Radiology, Medical Physics University Medical Center, Freiburg, Germany 01/2007 – 02/2008 Application Manager Bayer Schering Pharma, Business Unit Diagnostic Imaging, Berlin, Germany 04/2008 – 12/2010 Postdoctoral Research Fellow & Assistant Director of Cardiovascular MRI Group Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Germany 04/2008 -12/2013 Consultant for MR imaging Bayer Schering Pharma, Berlin, Germany 01/2011 – 12/2013 Group leader of Cardiovascular MRI Research Group Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Germany 05/2012 – 06/2012 Research sabbatical Dept. of Radiology, Northwestern University, Chicago, USA 01/2014 – present Team leader MR Physics University Institute of Diagnostic, Interventional and Pediatric Radiology, Bern 12.02.2015 1 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie Honours and Awards 2003 - 2006 Student Stipend, International Society for Magnetic Resonance in Medicine (ISMRM) 2004 Travel Grant, German Scientific Society 2004 Travel Grant, GlaxoSmithKline Foundation 2005 2nd Winner Gorter Award, Deutsche Sektion der ISMRM 2005 Travel Grant, German Research Foundation (DFG) 2006 Young Investigator Award Finalist, Winner of the W.S. Moore Award, ISMRM 2010 Travel Grant, Deutscher Akademischer Austauschdienst (DAAD) 2011 Travel Grant, GlaxoSmithKline Foundation Review Activity Peer-reviewed Journals: Applied Magnetic Resonance (APMR) Biomedical Engineering Clinical Physiology and Functional Imaging (CPF) European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) International Society for Magnetic Resonance in Medicine (ISMRM) Journal of Cardiovascular Magnetic Resonance (JCMR) Journal of Computer Assisted Tomography (JCAT) Journal of Magnetic Resonance in Medicine (JMRI) Magnetic Resonance in Medicine (MRM) Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA) Medical Physics Funding Institutions: Deutsche Forschungsgemeinschaft (DFG) Medical Research Council (MRC), UK Netherlands Organisation for Scientific Research (NWO) Schweizer Nationalfonds (SNF) Wellcome Trust, UK 12.02.2015 2 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie Funding ID Research Grant: DFG (FO 507/3-1, 2 years): Analyse der myokardialen Synchronizität des linken und rechten Herzens mit MR Phasenkontrastbildgebung (Co-Investigator). Research Grant: DFG (JU 2687/4-1, 3 years): Entwicklung von parallelen Bildgebungs-Methoden für multi-dimensionale und multi-parametrische MRT (PI). Research Grant: EUROSTARS Programme (01QE1004D, 3 years): PANG PreAmplifier the Next Generation: MR-compatible and wireless (PI). Academic Research Collaboration with University of Taipeh, Taiwan. DAAD (2 years): Fluss-sensitive 4D MRT im rechtsseitigen kardiovaskulären System (PI). Research Grant: DFG (JU 2687/9-1, 2 years): MRT basierte Charakterisierung der Flussphänomene bei Herzersatzsystemen (PI). DFG (JU 2687/10-1, 2 years): Entwicklung experimenteller Methoden zur Messung dreidimensionaler Temperaturfelder in technischen Strömungen mithilfe von MRT (Principal Investigator). Publications Journal Papers C. Binter, R. Ramb, B. Jung, S. Kozerke. A g-factor metric for k-t SENSE and k-t PCA based parallel imaging. Magn Reson Med, in press. N. Hübner, A. Merkle, B. Jung, D. Elverfeldt, L. Harsan. Analysis of left ventricular function of the mouse heart during experimentally induced hyperthyroidism and recovery. NMR in Biomed 2015; 28:116-23. W. Buchenberg, W. Mader, G. Hoppe, R. Lorenz, M. Menza, M. Büchert, J. Timmer, B. Jung. An in vitro study to simulate the intracardiac magnetohydrodynamic effect. Magn Reson Med 2014; Epub. Z. Stankovic, J. Fink, J. Collins, E. Semaan, M. Russe, J. Carr, M. Markl, M. Langer, B. Jung. K-t GRAPPA Accelerated 4D Flow MRI of Liver Hemodynamics: Influence of different acceleration factors on qualitative and quantitative assessment of blood flow. MAGMA 2014; Epub. R. Ramb, C. Binter, G. Schultz, J. Assländer, F. Breuer, M. Zaitsev, S. Kozerke, B. Jung. A g-factor metric for k-t-GRAPPA and PEAK-GRAPPA based parallel imaging. Magn Reson Med 2014; Epub. 12.02.2015 3 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie W. Buchenberg, T. Dadakova, J. Groebner, M. Bock, B. Jung. Comparison of two fiber-optical temperature measurement systems in magnetic fields up to 9.4T. Magn Reson Med 2014; Epub. D. Freudenhammer, E. Baum, B. Peterson, B. Böhm, B. Jung, S. Grundmann. Volumetric intake flow measurements of an IC engine using Magnetic Resonance Velocimetry. Experiments in Fluids 2014; 55. T. Wehrum, M. Kams, C. Strecker, F. Guenther, A. Geibel, J. Drexl, A. Hennemuth, M. Schumacher, B. Jung, A. Harloff. Prevalence of potential retrograde embolization pathways in the proximal descending aorta in stroke patients and controls. Cerebrovasc Dis 2014; Epub. I. Codreanu, M. Robson, O. Rider, T. Pegg, C. Dasanu, B. Jung, K. Clarke, C. Holloway. Details of left ventricular radial wall motion supporting the ventricular theory of the third heart sound obtained by cardiac MR. Br J Radiol 2014; 87. Z. Stankovic, B. Jung, J. Collins, M. Russe, W. Euringer, Z. Csatari, L. Stehlin, P. Strohm, M. Langer, M. Markl. Reproducibility of 4D Flow MRI of Arterial and Portal Venous Liver Hemodynamics: Influence of field strengths and spatio-temporal resolution. Magn Reson Med 2013; Epub. J. Weber, P. Veith, B. Jung, G. Ihorst, O. Moske-Eick, S. Meckel, H. Urbach, C. Taschner. MR Angiography at 3 Tesla to assess proximal Internal Carotid Artery Stenoses: Contrast-enhanced or 3D Time-of-Flight MR angiography? Clin Neuroradiol 2014; Epub. S. Schnell, M. Markl, P. Entezari, R. Mahadewia, E. Semaan, Z. Stankovic, B. Jung. k-t GRAPPA Accelerated 4D Flow MRI in the Aorta: Effect on Scan Time, Image Quality and Quantification of Flow and Wall Shear Stress. Magn Reson Med 2013; Epub. D. Föll, M. Menza, A. Usman, T. Wengenmeyer, A. Stroh, C. Bode, J. Carr, M. Markl, B. Jung. Cold Ischemic Time and Time after Transplantation Alter Segmental Myocardial Velocities after Heart Transplantation. Eur J Cardiothorac Surg 2014;45:502-8. R. Lorenz, J. Bock, J. Snyder, J. Korvink, B. Jung, M. Markl. Influence of Eddy Current, Maxwell and Gradient Field Corrections on 3D Flow Visualization of 3D CINE PC-MRI Data. Magn Reson Med 2013; Epub. 12.02.2015 4 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie K. Odening, B. Jung, C. Lang, D. Ziupa, M. Menza, G. Franke, S. Perez Feliz, M. Brunner, G. Koren, M. Zehender, C. Bode, M. Sermesant, D. Föll. Spatial Correlation of Action Potential Duration, Contraction Duration, and Diastolic Dysfunction in Transgenic LQT2 Rabbits. Heart Rhythm 2013;10:1533-41. J. Geiger, D. Hirtler, J. Buerk, B. Stiller, R. Arnold, B. Jung, M. Langer, M. Markl. Postoperative Pulmonary and Aortic 3D Hemodynamics in Patients after Repair for Transposition of the Great Arteries (D-TGA). Eur Radiol 2014;24:200-8. K. Egger, A. Harloff, B. Jung, S. Meckel. Pitfall of Fluid-Attenuated Inversion Recovery (FLAIR) MR Imaging in Acute Stroke – does Magnetic Field Strength Influence the Tissue Clock? Clin Neuroradiol 2013; Epub. F. Wassermann, D. Hecker, B. Jung, M. Markl, A. Seifert, S. Grundmann. Phase-Locked 3D3C-MRV Measurements in a Bi-stable Fluidic Oscillator. Exp Fluids 2013;54:1487. I. Codreanu, T. Pegg, J. Selvanayagam, M. Robson, O. Rider, C. Dasanu, B. Jung, D. Taggart, S. Golding, K. Clarke, C. Holloway. Normal values of regional and global myocardial wall motion in young and elderly individuals using Navigator Gated Tissue Phase Mapping. Age 2014;36:231-41. I. Codreanu, M. Robson, O. Rider, T. Pegg, C. Dasanu, B. Jung, K. Clarke, C. Holloway. Effects of ventricular insertion sites on rotational motion of left ventricular segments studied by cardiac MR. Br J Radiol 2013;86:20130326. C .Benk, A. Mauch, F. Beyersdorf, R. Klemm, M. Russe, P. Blanke, J. Korvink, M. Markl, B. Jung. First 4D MRI Flow Analysis in an in-Vitro System Modelling Continuous Left Ventricular Support: Effect of Cannula Position in the Thoracic Aorta. Eur J Cardiothorac Surg 2013;44:551-8. B. Jung, M. Weigel. Spin Echo Magnetic Resonance Imaging. J Magn Reson Imaging 2013;37:805-17. B. Jung, K. Odening, E. Dall’Armellina, D. Föll, M. Menza, J. Schneider. A Comprehensive Quantitative Comparison of Regional Myocardial Motion in Mice, Rabbits and Humans using Phase Contrast MRI. J Cardiovasc Magn Reson 2012;14:87. D. Hirtler, J. Geiger, B. Jung, M. Siepe, M. Markl, R. Arnold. 4-Dimensional Magnetic Resonance Flow Analysis in the Course of Interrupted Aortic Arch Reveals Complex Morphology and Quantifies Amount of Collateral Blood Flow. Pediatric Radiology 2013;43:1037-1040. 12.02.2015 5 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie S. Bauer, M. Markl, D. Föll, M. Russe, Z. Stankovic, B. Jung. K-t-GRAPPA accelerated Phase Contrast MRI: Improved assessment of blood flow and 3-directional myocardial motion during breath-hold. J Magn Reson Imaging 2013;38:1054-62. Z. Stankovic, Z. Csatari, P. Deibert,W. Euringer, B. Jung, W. Kreisel, J. Geiger, M. Russe, M. Langer, M. Markl. A feasibility study to evaluate splanchnic arterial and venous hemodynamics by flow-sensitive 4D MRI compared with Doppler ultrasound in patients with cirrhosis and controls. Eur J Gastroenterol Hepatol 2013; 25:669-75. J. Mangual, D. Föll, B. Jung, G. Pedrizzetti, A. Kheradvar. Aging does not Affect Radial Viscoelastic Behavior of the Left Ventricle. Cardiology 2013;125:38-49. D. Föll, S. Taeger, C. Bode, B. Jung, M. Markl. Age- and Gender- Related Flow Characteristics in the Left Heart. Eur Heart J Cardiovasc Imaging 2013;14:366-73. M. Markl, R. Rustogi, M. Galizia, A. Goyal, J. Collins, A. Usman, B. Jung, D. Foell, J. Carr. Myocardial T2-Mapping and Velocity Mapping: Changes in Regional Left Ventricular Structure and Function after Heart Transplantation. Magn Reson Med 2013;70:517-26. Grundmann, F. Wassermann, R. Lorenz, B. Jung, C. Tropea. Experimental Investigation of Helical Structures in Swirling Flows. International Journal of Heat and Fluid Flow 2012;37:51–63. D. Föll, B. Jung, E. Germann, F. Staehle, C. Bode, M. Markl. Hypertensive Heart Disease: MR Tissue Phase Mapping Reveals Altered Left Ventricular Rotation and Regional Myocardial Long-Axis Velocities. Eur Radiol 2013;23:339-47. D. Föll, B. Jung, E. Germann, F. Staehle, C. Bode, J. Hennig, M. Markl. Segmental myocardial velocities in dilated cardiomyopathy with and without left bundle branch block. J Magn Reson Imaging 2013;37:119-26. M. Markl, J. Geiger, B. Jung, D. Hirtler, R. Arnold. Non-invasive evaluation of 3d hemodynamics in a complex case of single ventricle physiology. J Magn Reson Imaging 2012;35:933–937. E. Dall’Armellina, B. Jung, C. Lygate, S. Neubauer, M. Markl, J. Schneider. Improved Method for Quantification of Regional Cardiac Function in Mice using Phase Contrast MRI. Magn Reson Med 2012;67:541-51. 12.02.2015 6 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie S. Meier, A. Hennemuth, J. Drexl, J. Bock, B. Jung, T. Preusser. A fast and noise-robust method for computation of intravascular pressure difference maps from 4D PC-MRI data. Med Image Anal 2012. A. Barker, F. Staehle, J. Bock, B. Jung, M. Markl. Analysis of Complex Cardiovascular Flow with Three-Component AccelerationEncoded MRI. Magn Reson Med 2012;67:50-61. J. Ruhhammer, D. Ruh, K. Foerster, C. Heilmann, F. Beyersdorf, A. Barker, B. Jung, A. Seifert, F. Goldschmidtboeing, P. Woias. Arterial strain measurement by implantable capacitive sensor without vessel constriction. Conf Proc IEEE Eng Med Biol Soc. 2012:535-8. D. Föll, B. Jung, E. Germann, J. Hennig, C. Bode, M. Markl. Magnetic resonance tissue phase mapping: Analysis of age-related and pathologically altered left ventricular radial and long-axis dyssynchrony. J Magn Reson Imaging 2011;34:518-25. B. Jung, A. Stalder, S. Bauer, M. Markl. On the undersampling strategies to accelerate time-resolved 3D imaging using k-t-GRAPPA. Magn Reson Med 2011;66:966–975. S. Bauer, M. Markl, M. Honal, B. Jung. Dependence of the image quality on reconstruction and acquisition parameters for GRAPPA based parallel imaging. Magn Reson Med 2011;66:402-9. I. Codreanu, M. Robson, O. Rider, T. Pegg, B. Jung, C. Dasanu, K. Clarke, C. Holloway. Chasing the reflected wave back into the heart: a new hypothesis while the jury is still out. Vasc Health Risk Manag 2011;7:365-73. I. Codreanu, T. Pegg, J. Selvanayagam, M. Robson, O. Rider, C. Dasanu, B. Jung, D. Taggart, K. Clarke, C. Holloway. Details of Left Ventricular Remodelling and the Mechanism of Paradoxical Ventricular Septal Motion after Coronary Artery By-pass Graft Surgery. J Invasive Cardiol 2011;23:276-82. J. Geiger, M. Markl, B. Jung, J. Grohmann, B. Stiller, M. Langer, R. Arnold. 4D-MR flow analysis in patients after repair for Tetralogy of Fallot. Eur Radiol 2011; 21:1651-7. F. Staehle, B. Jung, S. Bauer, J. Leupold, J. Bock, R. Lorenz, D. Föll, M. Markl. Acceleration Phase Mapping of Myocardial Function. Magn Reson Med 2011;65:1335-45. 12.02.2015 7 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie I. Codreanu, M. Robson, S. Golding, B. Jung, K. Clarke, C. Holloway. Longitudinally and circumferentially directed movements of the left ventricle studied by cardiovascular magnetic resonance phase contrast velocity mapping. J Cardiovasc Magn Reson 2010;12:48. J. Mangual, B. Jung, J. Ritter, A. Kheradvar. Modeling Radial Viscoelastic Behavior of the Left Ventricle in a Cardiac Cycle. Ann Biomed Eng 2010;38:3102-11. H.H. Peng, S. Bauer, H. Chung, J. Hennig, B. Jung, M. Markl. Optimized Parallel Imaging for Dynamic PC-MRI with Multi-Directional Velocity Encoding. Magn Reson Med 2010;64:472-80. D. Föll, B. Jung, F. Staehle, E. Schilli, C. Bode, J. Hennig, M. Markl. Magnetic Resonance Tissue Phase Mapping of Myocardial Motion - New Insights in Age and Gender. Circulation - Cardiovascular Imaging 2010;3:54-65. C. Jahnke, D. Föll, G. Heinrichs, B. Jung, T. Bley, M. Handke, C. Bode, A. Geibel. Three-Dimensional Echocardiography for Quantitative Analysis of Left-Ventricular Aneurysm. Echocardiography 2010;27:64-68. J. Geiger, T. Baumann, R. Arnold, M. Uhl, B. Jung, M. Markl. Rare case of supraaortic artery anomaly in a patient with congenital cardiac defect. J Cardiovasc Med 2009;10:654-56. T. Schenkel, M. Malve, M. Reik, M. Markl, B. Jung, H. Oertel. MRI-Based CFD Analysis of Flow in a Human Left Ventricle: Methodology and Application to a Healthy Heart. Ann Biomed Eng 2009;37:503-15. D. Föll, B. Jung, E. Schilli, F. Staehle, A. Geibel, J. Hennig, C. Bode, M. Markl. Visualization of Multidirectional Regional Left Ventricular Dynamics by High Temporal Resolution Tissue Phase Mapping. J Magn Reson Imaging 2009;29:1043-52. B. Jung, P. Ullmann, M. Honal, J. Hennig, M. Markl. Parallel MRI with Extended and Averaged GRAPPA Kernels (PEAK-GRAPPA): SNR Optimized Fast Dynamic Imaging with High Acceleration Factors. J Magn Reson Imaging 2008; 28:1226-32. B. Jung, P. Ullmann, M. Honal, J. Hennig, M. Markl. K-t-Space Accelerated Phase Contrast MRI. Magn Reson Med 2008; 60:1169-77. 12.02.2015 8 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie B. Jung, M. Honal, J. Hennig, M. Markl. K-t-Space Accelerated Myocardial Perfusion. J Magn Reson Imaging 2008; 28:1080-5. M. Markl, A. Harloff, T. Bley, M. Zaitsev, B. Jung, E. Weigang, M. Langer, J. Hennig, A. Frydrychowicz. Time Resolved 3D MR Velocity Mapping at 3T: Improved Navigator Gated Assessment of Vascular Anatomy and Blood Flow. J Magn Reson Imaging 2007;25:824-31. A. Frydrychowicz, J. Winterer, M. Zaitsev, B. Jung, J. Hennig, M. Langer, M. Markl. Visualization of Iliac und Proximal Femoral Artery Hemodynamics Using Time-Resolved 3D Phase Contrast MRI at 3T. J Magn Reson Imaging 2007;25:1085-92. A. Frydrychowicz, A. Harloff, B. Jung, M. Zaitsev, E. Weigang, T. Bley, M. Langer, J. Hennig, M. Markl. Time-Resolved 3D MR Flow Analysis at 3T: Visualization of Normal and Pathological Aortic Vascular Hemodynamics. J Comput Assist Tomogr 2007;31:9-15. B. Jung, D. Föll, P. Böttler, S. Petersen, J. Hennig, M. Markl. Detailed Analysis of Myocardial Motion in Volunteers and Patients using High Temporal Resolution MR Tissue Phase Mapping. J Magn Reson Imaging 2006; 24:1033-39. B. Jung, M. Zaitsev, J. Hennig, M. Markl. Navigator Gated High Temporal Resolution Tissue Phase Mapping of Myocardial Motion. Magn Reson Med 2006; 55:937-942. S. Petersen, L. Hudsmith, M. Robson, H. Doll, J. Francis, F Wiesmann, B. Jung, J. Hennig, H. Watkins, S. Neubauer. Sex-specific characteristics of cardiac function, geometry and mass in young adult elite athletes. J Magn Reson Imaging 2006; 24:297-303. B. Jung, M. Markl, D. Föll, J. Hennig. Investigating Myocardial Motion by MRI using Tissue Phase Mapping. Eur J Cardiothorac Surg 2006; 29:150-157. B. Jung, B. Kreher, M. Markl, J. Hennig. Visualization of Tissue Velocity Data from Cardiac Wall Motion Measurements with Myocardial Fiber Tracking: Principles and Implications for Cardiac Fiber Structures. Eur J Cardiothorac Surg 2006; 29:158-164. 12.02.2015 9 Universitätsinstitut für Diagnostische, Interventionelle und Pädiatrische Radiologie G. Buckberg, A. Mahajan, B. Jung, M. Markl, J. Hennig, M. Ballester-Rodes. MRI myocardial motion and fiber tracking: a confirmation of knowledge from different imaging modalities. Eur J Cardiothorac Surg 2006; 29:165-177. S. Petersen, B. Jung, F. Wiesmann, J. Selvanayagam, J. Francis, J. Hennig, S. Neubauer, M. Robson. Myocardial tissue phase mapping with cine phase-contrast mr imaging: regional wall motion analysis in healthy volunteers. Radiology 2006; 238:816-826. B. Jung, B. Schneider, M. Markl, B. Saurbier, A. Geibel, J. Hennig. Measurement of Left Ventricular Velocities: Phase Contrast MRI Velocity Mapping Versus Tissue-Doppler-Ultrasound in Healthy Volunteers. J Cardiovasc Magn Reson 2004; 6:777-783. B. Jung, J. Hennig, K. Scheffler. Single-Breathhold 3D-TrueFISP Cardiac Cine Imaging. Magn Reson Med 2002; 48:921-925. Book Chapters D. Föll, T. Faber, M. Markl, C. Bode, B. Jung. Cardiac Mapping (4th Edition): Magnetic Resonance Phase Mapping for Myocardial Structural Abnormalities relevant to Arrhythmias. Wiley-Blackwell 2012; Chapter 76:828-835. B. Jung, M. Markl. Magnetic Resonance Angiography: Principles and Applications. Phase Contrast MRI and Flow Quantification. Springer 2012; Chapter 3:51-64. B. Jung, D. Föll. MRI techniques for measuring heart motion and deformation: Phase Contrast Imaging. Taylor & Francis, in press. Patents B. Jung, P. Ullmann; Method for Accelerating data acquisition in dynamic magnetic resonance measurements (MRT) using parallel imaging. U.S. patent US-2008-0242972-A1, issued October 10, 2008 Conference Proceedings Not listed, approximately 130 12.02.2015 10