Download Document

SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
BIOGRAPHICAL






Name
Date of Birth
Place of Birth
Citizenship
Marital Status
Home address
Mohamed Labib Salem
December 28, 1962
Zifta, Gharbia, Egypt
Egyptian
Married with 3 kids
1551 Sam Rittenburg Blvd, Apartment 116, Charleston,
SC 29407, USA
Phones:
+1-843-766-0898 (Home)
+1-843-817-3426 (Cell)
FAX
+1-843-792-2556

Permanent Position
Professor of Immunology
Zoology Department
Faculty of Science
Tanta University
Egypt

Current Position
Assistant Research Professor
Cancer Immunology
Director, Vaccine Projects, Surgical Oncology
Department of Surgery
Medical University of South Carolina,
Charleston, SC 29425,
Phone: +1- 843-792-7576 (Office)
Phone: +1- 843-792-8504 (lab.)
Fax: +1-843-792-2556
e-mails: [email protected];
[email protected]
EDUCATION
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
1
SALEM, MOHAMED LABIB, PhD






Curriculum Vitae
High School Diploma
10/1977- 6/1980
Kish Military High School, Zifta, Egypt
B.S., Biology (Major); General Zoology (Minor)
10/1980-5/1984
Faculty of Science, Tanta University, Egypt
Post-graduate Diploma, Comparative Anatomy
9/1985-12/1986
Faculty of Science, Tanta University, Egypt
M.S., Biology (Major); Comparative Anatomy (Minor)
9/1986-9/1989
Faculty of Science, Tanta University, Egypt
Ph.D., ImmunoEndocrinology
9/1991-12/1995
The research project was accomplished in the Department of Immunology, Kyushu
University, Japan (27 months),Oct. 1992 to Dec. 31, 1995). The research project
was funded by a pre-doctoral fellowship from the Cultural Affairs and Missions
Sector, Ministry of Higher Education, Egypt. PhD Graduation was from Tanta
University, Egypt.
PhD courses in Pathological Sciences
04/1999-3/2001
Completed 2 years out of 3 years required for Ph.D. in Pathological Sciences,
Department of Immunology, Medical Institute of Bioregulation, Kyushu University,
Japan
ACADEMIC POSITIONS
 Demonstrator, General Zoology
10/1984-9/1989
Zoology Department, Tanta University, Egypt
 Assistant Lecturer, General Zoology
10/1989-9/1992
Zoology Department, Tanta University, Egypt
 Visiting Researcher, Immunology
10/1992-12/1994
Department of Immunology, Kyushu University, Japan
 Assistant Lecturer, Zoology
1/1995-1/1996
Faculty of Science, Tanta University, Egypt
 Assistant Professor, Immunology
2/1997-8/2001
Faculty of Science, Tanta University, Egypt
 Research Associate, Cancer Immunology
10/1997-3/2001
Department of Immunology Kyushu University, Japan
 Associate Professor, Immunology
9/2001-11/2005
Department of Zoology, Faculty of Science, Tanta University, Egypt
 Post Doctoral Fellow, Immunology
6/2001-6/2002
Department of Surgery, Medical University of South Carolina, USA
 Professor of Immunology
12/2006-present
Department of Zoology, Faculty of Science, Tanta University, Egypt
 Assistant Research Professor, Cancer Immunology
7/2002-present
Department of Surgery, Medical University of South Carolina, USA
 Director, Vaccine Laboratories
2005-present
Section of Surgical Oncology, Hollings Cancer Center,
Medical University of South Carolina. Charleston, SC, USA
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
2
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
MEMBERSHIP IN PROFESSIONAL SOCIETES
 American Association of Cancer Research (AACR)
 American Association of Immunologist (AAI)
 International Society of Biological Therapy (SBT)
 International Society of Cytokine (ISC)
 International Immunopharmacology
 European Society of Cancer Immunology
 Committee of Hollings Cancer Center
 Association of Egyptian-American Scholars
 The American Association of Yemeni Scientists and Professionals
 The Association of African Biomedical Scientists
 Egyptian Society of Immunology
 German-Egyptian Society of Zoology
 Arab Union Society of Biology
 Tumor Host Interaction Program, Medical University of South,
South Carolina, Charleston, SC
 Tumor Vaccine and Cell Therapy Working Group
 International Society of Poets
COMMITTEE
 Advisory committee for Flow Cytometry Facility, Hollings Cancer Center, Medical
University of South Carolina. Charleston, SC, USA.

PhD committee for Iris Moralez (PhD student).

Cancer Immunology and Immunotherapy committee for the annual retreat.
TEACHING EXPERIENCE: LECTURE

Tumor Immunology
2005-now
Postgraduate Students, Medical University of South Carolina, USA

Immunology
1996-1997
Undergraduate Students at Faculty of Science, Tanta University, Egypt

Tumor Immunology
1996-1997
Postgraduate Students at Faculty of Science, Tanta University, Egypt

Molecular Biology
1996-1997
Undergraduate Students at Faculty of Science, Tanta University, Egypt
LABORATORY TEACHING EXPERIENCE
 Practical Animal Physiology (1984~1992)
Undergraduate students, Faculty of Science, Faculty of Pharmacy, and Faculty of
Dentistry and Faculty of Education, Tanta University, Egypt
 Vertebrate Anatomy (1984~1992)
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
3
SALEM, MOHAMED LABIB, PhD





Curriculum Vitae
Undergraduate students, Faculties of Sciences and Faculty of Education, Tanta
University, Egypt
Histology (1984~1992)
Undergraduate students, Faculty of Science, Faculty of Pharmacy, and Faculty of
Dentistry and Faculty of Education, Tanta University, Egypt
Histochemistry (1989~1992)
Undergraduate students, Faculty of Sciences, Tanta University, Egypt
Comparative Anatomy (1984~1992)
Undergraduate students, Faculty of Sciences, Tanta University Egypt
Embryology (1984~1992)
Undergraduate students, Faculty of Sciences, Tanta University, Egypt
Immunology (1995~1996)
Postgraduate students, Faculty of Sciences, Tanta University, Egypt
ACADEMIC SUPERVISION
A- At the Medical University of South Carolina
 Wessam Hassan Elnemr (PhD student, Al-Azhar University)
 James Kuhlen (MD student, 2-month rotation)
 Elizabeth C. Little (PhD student); (2-month rotation)
 Dr. Ahmed Khafagy (3-month fellowship, Suez Canal University)
 Osama Naga, (Research Specialist I)
 Haley Brimmer (Middle School Student, Shadowing Day)
 Amir A. AL-Khami (PhD student)
 Ginny Williams (PhD student); (2-month rotation)
 Elizabeth C. Little (PhD student); (2-month rotation)
 Maria-Anna Alicia (PhD/MD Fellow); (2-month rotation)
 Marcela C. Diaz-Montero (Instructor)
 Sabry El Naggar (PhD student)
 Andre Kadima (Post-doctoral fellow)
 Yuehua Zhou (Research specialist)
 Carolina Velez ((Research specialist)
2007~
2007
2007~
2007
2007~
2007
2006~
2006
2006
2006
2005~
2004~2006
2001~2007
2001-2003
2003-2004

Eben Pariser (Undergraduate College student), (3-month rotation) 2002

Alyson Browning, (Ph.D. student); (3-month rotation)
2002

Jarrett E. Walsh (MD student); (3-month rotation)
2003

Rufei Lu (high school student); (3-month rotation)
2003
B- At Tanta University, Egypt
 Nahla A. AL Said, B.Sc., M.Sc., (Ph.D. work)
1997-2000
“Interference of anti-inflammatory drugs with Schistosomiasis infection”
 Iman M. Yoness, B.Sc., (M.Sc. work)
1997-2001
“Interference of anti-inflammatory drugs with azoxymethane-induced
colon cancer”
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
4
SALEM, MOHAMED LABIB, PhD


Curriculum Vitae
Heba M. Al Ashry, B,Sc., (M.Sc. work)
“Interference of inflammatory and anti-inflammatory drugs with
Trichnella spiralis infection”
Asmaa L. Mohamed, B.Sc., (M.Sc. work)
“Interference of histamine and its antagonists with mammary
adenocarcinoma”
1996-2003
1999-now
LANGUAGE SKILLS
 Arabic: Native
 English: Fluent, reading, writing and speaking
 Japanese: Good speaking, fair writing and reading.
EDITORIAL REVIEW
Grant Reviews
 Broad Medical Research Program, USA
 Swiss National Science Foundation, (Berne, Switzerland)
Journal and Grant Reviews
 Journal of Cellular and Molecular Medicine
 J. Neuroimmunology
 Immunology Letter
 Methods and Findings in Experimental and Clinical Pharmacology
 Medical Science Monitor
 International Immunopharmacology
 Vaccine
 Human Immunology
 Cancer Immunology and Immunotherapy
 Planta Medica
 Journal of Food Composition and Analysis
 Turkish Journal of Veterinary and Animal Sciences
EDITORIAL BORAD
 American Journal of Immunology (Science Publication), Regional Editor
 TheScientificWorld’s Editorial Network (Immunology and Inflammation)
RESEARCH INTERESTS
My preclinical research is focuses on improving cancer-based vaccination through
different approaches, including: 1) optimizing in vivo-based dendritic cell vaccination; 2)
utilizing cytokines to improve peptide-based vaccination; 3) utilizing novel compounds with
cytokine-like effects (Toll-like receptor ligands) to augment peptide-based vaccination; and
4) combination of chemotherapy with adoptive therapy and peptide-based vaccination. I
use different preclinical models, including colon cancer, lymphoma, and melanoma cancer
models, as well as different type of transgenic and knockout mice.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
5
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
My clinical research focuses on characterization of the immunoregulatory cells that
associate with advanced stage of cancers. I focus my studies on the immature myeloidderived suppressive cells (MDSC) and CD4+CD25+FoxP3+ T regulatory (Treg). A great
interest is to develop efficacious strategies that can interfere with regulatory function of
these cells or approaches that induce the differentiation of these cells into
immunopotentiating population.
HONORS/AWARDS
 Incentive (Encouraging) National Award in Biology; Academy of Scientific Research
and Technology-Egypt, July 16 2004.
 Phase VII Award, Hollings cancer Center, Department of Defense, 11/01/200410/31/226
 Selective Poem award: “Title: We All Shall Die”, International Society of Poets, 2006
 Selective Poem award: “Painless Pain”, International Society of Poets, 2006.
 Selective Poem award: “I Feel Like None”, International Society of Poets, 2007.
 Research Excellence Award from Marine Polymer Technologies, Inc.
 Awarded a Junior Research Scholarship by the Ministry of Higher Education,
Egypt, for the period October 1992 through December 1994 while pursuing
graduate degree studies.
INVITED LECTURES
 Immunomodulatory and immunotherapeutic potentials of Nigella sativa, the
black seed. The 1st International Conference on Prophetic Medicine, Abha
Private Hospital, Abha, Saudi Arabia, King Saudi Arabia, February, 2008.
 Lymphodepletion: A bad for good immunotherapy. Internal Speaker, Cancer
Immunology and Immunotherapy Lecture Series, Hollings Cancer Center,
Medical University of South Carolina, Charleston, USA. February 2008.
 Development of Molecular Cancer Therapies: From Bench to Bedside of
Cancer Vaccines. A graduate student course at Department of Microbiology
and Immunology, Medical University of South Carolina.
 Optimizing Cancer Immunotherapy By Creating Beneficial Host
Microenvironments, Department of Surgery, Medical University of South
Carolina, USA; June 11, 2007.
 Novel Adjuvant Approaches for Optimization of Peptide-based Cancer
Vaccines. Faculty of Medicine and Health Sciences, United Arab Emirates
University, United Arab Emirates, Al-Ain, 30 May, 2004
 Optimization of T cell responses to vaccination: Applications for cancer
immunotherapy. Presented to the Permanent Committee for Professorship
Promotion, Ministry of Higher Education, Ain Shams University, Egypt,
November 15, 2006.
 Influence of Female Sex Hormones on Immune Responses. Center for
Biomedical Physics, Temple University School of Medicine, Philadelphia,
Pennsylvania, USA. 24 November, 2000.
RESEARCH SUPPORT
Pending grants
Source: Tanta University, Egypt
Role:
Principle Investigator
Title:
Establishing “Animal research vivarium” at Tanta University.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
6
SALEM, MOHAMED LABIB, PhD
Goal:
Curriculum Vitae
Establishing a state-of-art VIVARIUM as a core animal facility at Tanta University
will pave the road to its full accreditation by the AAALAC Int.
Source: National Cancer Institute (R01)
Period: Submitted in June 2007 Cycle, Pending
Role:
Principle Investigator
Title:
Maximizing memory T cell responses by matured post chemotherapy dendritic
cells.
Goal:
The major goal of this project is to manipulate dendritic cells expanded after
treatment of the recipient host with cyclophosphamide before adoptive T cell
therapy to enhance the overall anti-tumor immunity.
Ongoing Research Grants
Source: National Cancer Institute (R01)
Period: 07/04/01–06/30/2009
Title:
Altering post vaccination T cell contraction
Goal: The major goal of this project is to define the cytokines (IL-2, IL-12, IL-7, type
IFNs) and danger signal) that modulate programmed T cell contraction the in
vivo response to peptide-based cancer vaccine.
Role:
Co-Principle Investigator; Principle Investigator, Dr. David J Cole
Completed Research Grants
Source: Phase VII Award, Department of Defense
Period: 11/01/2004-10/31/226
Role:
Principle Investigator
Title:
Preclinical assessment of the novel peptide-based cancer vaccine F2
gel/CEA/IL-12
Goal:
The major goal of this project is to develop novel cancer therapeutics vaccine to
colon carcinoma utilizing a novel IL-12 delivery system designated F2 gel
matrix.
Source: Hollings Cancer Center, Medical University of South Carolina
Period: 01/01/2005-12/13/2007
Role:
Principle Investigator
Title:
Immature myeloid immunosuppressor cells in breast cancer patients:
Implications for anti-tumor vaccination.
Goal: The major goal of this grant is to explore how expansion of certain immune cells
called immature myeloid cells suppresses the immune response in breast
cancer patients.
Source:
Period:
Role:
Title:
Goal:
Marine Polymer Technologies Inc., Danvers, Massachusetts, USA
06/01/2004-12/31/2006
Principle Investigator
Evaluation of F2 gel/IL-12-based vaccination on hepatic fibrosis and protection
after Schistosoma mansoni infection.
The major goal of this project is to develop F2 gel/IL-12 as a novel strategy for
schistosoma vaccine.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
7
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
Source: Chain Reaction for a Cure a Breast Cancer
Period: 01/01/05–21/31/2009
Title:
Circulating myeloid suppressor cells in breast cancer patients: Implications for
future vaccine development
Goal:
The primary goal of this project is to characterize the phenotype of immature
myeloid cells in peripheral blood of early breast cancer patients. The secondary
goal is to induce differentiation of these immunosuppressive cells into
immunopotentiating cells.
Role:
Principle Investigator
Source: National Cancer Institute (R01)
Period: 07/01/01–06/30/2004
Title:
In Vivo Effector T Cell Response to Peptide Vaccination
Goal:
The major goal of this project was to define the in vivo response of antigenspecific
T cells to a novel peptide-based cancer vaccine and cytokines.
Role:
Co-Principle Investigator
Source: Marine Polymer Technology, Boston, USA
Period: 07/01/01–06/30/2004
Title: Characterization of p-GlcNAc (F2 gel matrix) as an immune adjuvant and a
delivery system for cytokines
Goal: The main goal of this project was to define the optimal conditions for the delivery
of cytokines by F2 gel matrix
Role: Co-Principle Investigator; Principle Investigator, Dr. William Gillanders, M.D.
Source: Tanta University, Egypt
Period: 01/01/97–12/31/2003
Title:
New Technology for control of the intermediate host of schistosomiasis in Egypt,
Laboratory and semi field application.
Goal:
The main goal of this grant is to develop new technology to enhance the
efficacy, lower toxicity of the chemical that are used in field to kill the snail that
serve as the intermediate host harboring the infective stage of Schistosoma
mansoni, a worm that case a global liver disease.
Role:
Co-Principle Investigator; Principle Investigator, Dr. Mohamed Mona, PhD
Source: Section of Missions, Ministry of Higher Education, Egypt
Period: 10/13/1992- 12/311994
Title:
Interrelationship between estrogen and immune responses
Goal:
The major goal of this fellowship was to explore the role of endogenous
cytokines in the interrelationship between female sex steroids and inflammatory
immune responses
Role:
Fellow (Pre-doctoral fellowship)
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
8
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
WORKSHOPS
1- Head and Neck Multidisciplinary research Workshop. Hollings Cancer Center,
Medical University of South Carolina, Charleston, SC, USA, April 19 th, 2007.
2- Hematological Malignancies Symposium. February 13, 2007. Riviera Theatre &
Conference Centre, Charleston, SC, USA.
3- Tenure Mentoring Workshop, Cosponsored by Office of the provost and the Faculty
Senate, Medical University of South Carolina, SC, USA. Friday, May 12, 2006.
4- Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group
(TVACT). Washington, DC, Convention Center USA, April, 2006.
5- Cancer Chemoprevention: Bridging Statewide Partnerships: The Science
Driving The Latest Cancer Chemoprevention Strategies. The Citadel Holliday
Alumni Center, March 16-17, 2006.
6- Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group
(TVACT). Washington, DC, Convention Center USA, April, 2005.
7- Translational Therapeutics Spring Symposium, Hollings Cancer Center, Citadel
Alumni House, Charleston, SC, USA, March. 11, 2005.
8- Hematological Malignancies Symposia. Medical University of South Carolina,
Charleston, SC, USA, Feb. 24, 2005.
9- The Translational Therapeutics Spring Seminar, Citadel Holliday Alumni Center,
Charleston, SC, USA, March 11, 2005.
10- Immunotherapy of Cancer X: Tumor Vaccine and Cell Therapy Working Group
(TVACT). Orlando, Florida, USA, March 26, 2004.
11- Gene Regulation in Cancer. Hollings Cancer Center, Medical University of South
Carolina, March 12, 2004.
12- Grantsmanship workshop. Organized by National Institute of Health with Dr. Ronald
Geller, Health Research Associates. Medical University of South Carolina, Charleston,
SC. Part 1, March 11, 2003; Part 2: April 29, 2003; and Part 3: May 20, 2003.
13- Modulation of Angiogenesis and Apoptosis in Cancer Therapy. Hollings Cancer
Center, Medical University of South Carolina, Charleston, SC, USA, March 14, 2003.
14- Tumor Immunology Primer, organized by Society for Biological Therapy. Hilton
La Jolla Torrey Pines, San Diego, CA, USA, November 7, 2002.
15- OSHA Requirements: Hazard Community/Hazardous waste disposal, Blood
borne pathogen standard, Tuberculosis, Fire safety and Ergonomics. On line
workshop at Local network, Medical University of South Carolina, Charleston, SC,
USA, Dec. 13th, 2001.
16- Human Subject Assurance Online Training Modules. Intranet work, Medical
University of South Carolina, Charkeston, SC, USA. August 19, 2002.
17- Developing Skills in Molecular Pathology. Faculty of Medicine, Zagazig University,
Egypt, April 2-3, 1997.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
9
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
18- Mollecular Pathology, Flow Cytometry, Immage Cytometry, In Situ
hyperidization, PCR and ELISA Techniques. Pathology Dept., Faculty of Medicine,
Zagazig Univ, Egypt, May 6-7, 1997.
19- Environmental Variability of Natural Wildlife. Faculty of Science, Tanta Univ.,
Under Cure of Ministry of Environmental affairs, Egypt, May 10, 1997.
20- English Course for Graduate studies. Faculty of Education, Tanta University,
Egypt, Nov. ~ Dec., 1994.
21- Molluscicidal Evaluation from the Plant Origin in the Control of Schistosoma
mansoni Snails. Theodor Bilharz Institute, Cairo, Egypt, May 27, 1996.
22- Educational Program for Teaching. Graduate studies, Faculty of Education, Tanta
Univ., Egypt, June 1995.
23- Cultivation and Molluscicidal Application of Ambrosia Martima Plant. Building of
Gharbia Governorate, December 23, 1995.
24- The Winter Advanced Course for Immunology & Infectious Diseases
(WACIID)'1994. Tokyo, Japan, Feb. 13-16, 1994.
25- HLA and Tumors. Tumori Instituti Pascali, Napoli, Italy, Dec. 2-6, 1996.
26- Immunosuppressive Drugs & the Immune System. Tumori Instituti Pascali, Napoli,
Italy, 2-11 Nov., 1994.
27- International English Language Testing System (IELTS) course, Center number
EG002, Writing Examiner Number EG002/02/89, Speaking Examiner Number
EG002/02/89, August 24, 1992. British Council, Alexandria, Egypt.
CONFERENCES: ORAL PRESENTATION
1- Mohamed L. Salem, Ismail M. AL-Sharkawy, and Abdelfattah A Sadakah. Faculty
Research Development Project (FRDP) to support life sciences in Egypt. Annual
American-Egyptian Association Scholars (AEAS) conference, Dec. 25-27, 2006,
National research Center, Cairo, Egypt.
2- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders, David J.
Cole. Cyclophosphamide Preconditioning Enhances The Antigen-specific CD8 T Cell
Responses to Peptide Vaccination: Evidence of Enhanced Innate Immunity and Induction
of A Beneficial Cytokine Milieu. Tumor vaccine & Cell Therapy (TVACT) Working
Group: Immunotherapy of Cancer XI, April 15, 2005, Garden Grove, California, USA.
3- Mohamed L. Salem, Andre Kadima, David J. Cole, and William E. Gillanders. Mediation
of the adjuvant effect of the toll-like receptor 3 (TLR3) agonist by induction of a rapid
beneficial inflammatory cytokine milieu. 7th International Conference of Anticancer
Research. 25-30 October 2004, Corfu, Greece.
4- Walid A. Osta, Yian Chen, Joshua Glenn, Kaidi Mikhitarian, Mohamed L. Salem, David
J. Cole, Michael Mitas, and William E. Gillanders. Defining the Mechanisms underlying
Inhibition of breast cancer carcinogenesis by EpCAM gene silencing. 7th International
Conference of Anticancer Research. 25-30 October 2004, Corfu, Greece.
5- Mohamed L Salem, Yuehua Zhou, Andre N Kadima, Christophe L Nguyen, Mark P
Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders.
Sustained release of interleukin-12 from a novel delivery system using a poly-N-acetyly
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
10
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
glucoseamine-based polymer matrix enhances peptide-based cancer vaccine. Tumor
Vaccine & Cell Therapy (TVACT) Working Group: Immunotherapy of Cancer X.
Orlando, Florida, USA, March 26, 2004.
6- Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders. Double-
stranded RNA (dsRNA) danger motif is potent adjuvant for accentuating peptide-based
vaccine by bridging innate and adaptive immunity. 3rd Annual Research Retreat, Wild
Dunes, Charleston, SC, USA, December 23rd, 2003.
7- Mohamed L Salem, Yuehua Zhou, Andre N Kadima, Christophe L Nguyen, Mark P
Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders.
Sustained release of interleukin-12 from a novel delivery system using a poly-N-acetyly
glucoseamine-based polymer matrix enhances peptide-based cancer vaccine. Recent
concepts in cancer management. Helnal Paletine Hotel, Montaza Palace,
Alexanderia, Egypt, 22-24 Oct, 2003.
8- Mohamed L Salem, Andre Kadima, Mark P Rubinstein, Marina Demcheva, John N
Vournakis, David J Cole, William E Gillanders. Mechanisms of enhanced antigen-specific
T cell response following vaccination with a novel peptide-based cancer vaccine and
systemic interleukin-2 (IL-2). J. Immunother., 25(6):S35, 2002. 17th annual Scientific
Meeting of the Society for Biological Therapy, November 7-10, La Jolla, California,
USA.
9- Mark P Rubinstein, Andre Kadima, Mohamed L Salem, Christophe L Nguyen, William E
Gillanders, David J Cole. Systemic administration of IL-15 augments the antigen-specific
primary CD8+ T cell response following vaccination. J. Immunotherapy, 25(6):S18, 2002.
17th annual Scientific Meeting of the Society for Biological Therapy, November 710, La Jolla, California, USA.
10- Mohamed L. Salem, Kenji Kishihara, Matsuzaki G. and Nomoto K. Subcutaneous
treatment with linoleic acid suppresses the growth of EL4 thymoma in mice through
augmentation of Cytolysis of CD8 and production of IFN-. The Autumn Conference of
Immunology, 19-21 Nov., 2000, Abstract no. 48, Page: 25Chicago, USA.
11- Mohamed L. Salem, Wael Attia Y., Wageh Awara A., Al Mehallawy A. Immunotoxicity of
cadmium chloride in mice: Time course study. "HLA and Tumours", Italy, Naples, Dec.
2-6, 1996.
12- Mohamed L. Salem. Increase of the bacteriostatic function against early infection of
mice with Listeria monocytogenes after treatment with beta-estradiol. J. Egypt German
Society of Zoology, Vol.23(A), Comp. Physiol, 347-378, Feb. 1997.
13- Mohamed L. Salem, Wael Attia Y., Wageh Awara A., Al Mehallawy A. Immunotoxicity of
cadmium chloride in mice. J. Union Arab Biology, Vol. 6 (A) Zoology, 531-554, Nov.
1996.
14- Mohamed L. Salem
estradiol on Macrophage Functions. Proc. Jap. Soc. Immunol., Kyoto, Japan Nov.
1994.
CONFERENCES: POSTER PRESENTATION & ABSTRACTS
1- Mohamed L. Salem, Sabry EL-Naggar, Andre Kadima, Marcela Diaz, Amir A. AL-Khami,
Wiiliam E. Gillanders, Marina Demcheva, John N Vournakis, and David Cole. Poly-N___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
11
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
acetyl glucosamine gel (F2 gel) matrix is a novel non-viral delivery system that augments
the efficacy of CD8+ T cells responses to vaccination with naked DNA plasmid encoding
HIV-1 p37. Cancer Drug Discovery and Development: Bridging Academic and
Industry Partenrships; Spring Symposium. Kiawah Island, SC, USA; Marc 23-24,
2007.
2- Mohamed L. Salem, Amir A. Al-Khami, Hany. Al-Wahsh, Wael Attia, Yousry Al-Bolkiny,
Hala Hussain, Sabry A. EL-Naggar, Marina Demcheva, John Vournakis, and David J.
Cole , and Ismail M. Al-Sharkawy: Paracrine delivery of low non-toxic levels of IL-12 from
poly-N-acetyl glucosamine gel (F2 gel) matrix lowered the liver and lung fibrosis induced
by Schistosoma mansoni eggs. 13th International Congress of Immunology, Rio De
Janeiro, Brazil-August 21-25, 2007
3- Mohamed L. Salem, C. Marcela Diaz-Montero, Yian Chen, Sabry A. EL-Naggar, Andre
N. Kadima, William E. Gillanders and David J. Cole: The TLR3 agonist poly (I:C) acted
directly on mouse CD8 T cells and augmented their antigen-specific responses upon
adoptive transfer into naïve recipient mice. 96th Annual Meeting of American
Association of Immunologists (AAI), May 18-22, 2007, Miami Beach Convention
Center, Miami, Florida, USA.
4- Amir A. Al-Khami, Alberto Monetro, Marcela Diaz, David J. Cole, and Mohamed L.
Salem: Circulating Levels of CD4+ CD25+ T cells Correlate with Clinical Cancer Stage
and Inversely Correlate with CD8+ T cells. 96th Annual Meeting of American
Association of Immunologists (AAI), May 18-22, 2007, Miami Beach Convention
Center, Miami, Florida, USA
5- Alberto Monetro, Amir A. Al-Khami, Marcela Diaz, David J. Cole, and Mohamed L.
Salem: Circulating Immature Myeloid Cells (ImC) Levels Correlate with Clinical Cancer
Stage and Cyclophosphamide (CTX) Treatment. 96th Annual Meeting of American
Association of Immunologists (AAI), May 18-22, 2007, Miami Beach Convention
Center, Miami, Florida, USA.
6- Mohamed L. Salem, Sabry EL-Naggar, Andre Kadima, Marcela Diaz, Narender Nath,
Amir A. AL-Khami, and David Cole. Cyclophosphamide treatment leads to striking
expansion of functional dendritic cells in vivo: Implications for cancer immunotherapy.
98th Annual Meeting for American Association of Cancer Research (AACR). April
14-18, 2007. Los Angeles, CA.
7- Kristi Vissage, Alberto Montero, Mohamed L. Salem, David Cole, and Marcela DíazMontero. Increased Levels of Circulating Immature Myeloid Cells (ImC) Correlates with
Advanced Cancer Stage and Doxorubicin/Cyclophosphamide Treatment. 6th Annual
Research Retreat. Citadel, Charleston, SC, USA. November 17th, 2006.
8- Mohamed L. Salem, Sabry EL-Naggar, Andre Kadima, Marcela Diaz, and David
J.Cole. Cyclophosphamide treatment leads to striking expansion of functional dendritic
cells in vivo: Implications for therapeutic tumor-specific adoptive immunotherapy. 6th
Annual Research Retreat. Citadel, Charleston, SC, USA. November 17th, 2006.
9- Mohamed L. Salem, Sabry A. EL-Naggar, Andre Kadima, Marcela Diaz-Montero,
William E. Gillanders, and David J. Cole. Vaccination using Toll-like receptor ligand
(TLRL)-primed dendritic cells and TLR3L poly I:C administration leads to an
augmentation of antigen-specific memory CD8+ T cell responses. 97th Annual Meeting
for American Association of Cancer Research (AACR). April 1-5, 2006.
Washington, DC.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
12
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
10- Marcela Diaz-Montero, Andre Kadima, Sabry A. EL-Naggar, Narender Nath, David J.
Cole, and Mohamed L. Salem. Sustained generation and survival of antigen-specific
CD62Lhigh CD8+ T-cells though in vitro conditioning with interleukin-12: implications for
anti-tumor adoptive immunotherapy. 97th Annual Meeting for American Association
of Cancer Research (AACR). April 1-5, 2006. Washington, DC.
11- Mohamed L. Salem, Sabry A. EL-Naggar, Andre Kadima, Marcela Diaz-Montero,
William E. Gillanders, and David J. Cole. Vaccination using Toll-like receptor ligand
(TLRL)-primed dendritic cells and TLR3L poly I:C administration leads to an
augmentation of antigen-specific memory CD8+ T cell responses. 5th Annual
Research Retreat, Citadel, Charleston, SC, USA. November 18th, 2005.
12- Mohamed L. Salem, Sabry A. EL-Naggar, Andre Kadima, Marcela Diaz-Montero,
William E. Gillanders, and David J. Cole. Cyclophosphamide preconditioning enhances
the antigen-specific CD8+ T cell responses to peptide vaccination: evidence of
enhanced innate immunity and induction of a beneficial cytokine milieu. 5th Annual
Research Retreat, Citadel, Charleston, SC, USA. November 18th, 2005.
13- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders,
David J. Cole. Temporal induction of a beneficial inflammatory cytokine milieu relative
to peptide vaccination is crucial for the optimal adjuvanticity of the TLR3 agonist
polyinosinic-polycytidylic acid (Poly I:C). 96th Annual Meeting for American
Association of Cancer Research (AACR). Anaheim, California, USA, April 16-21,
2005.
14- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders,
David J. Cole. Cyclophosphamide Preconditioning Enhances The Antigen-specific CD8
T Cell Responses to Peptide Vaccination: Evidence of Enhanced Innate Immunity and
Induction of A Beneficial Cytokine Milieu. The American Association of
Immunologists (AAI), April 2-6, 2005. San Diego, CA, USA.
15- Narender Nath, Shalinendra Giri, Ratna. Prasad, Mohamed L. Salem, Avtar K. Singh,
and Inderjit Singh. 5-aminoimidazole-4-carboxymide ribonucleoside: a novel
Immunomodulator in experimental autoimmune encephalomyelitis. The American
Association of Immunologists (AAI), April 2-6, 2005. San Diego, CA, USA.
16- Mark P Rubinstein, Andre N Kadima, Mohamed L Salem, Christophe L Nguyen,
William E Gillanders, David J Cole. Retrovirally-modified T cells persist after adoptive
transfer but exhibit discordant gene expression associated with a lack of therapeutic
ability. The American Association of Immunologists (AAI), April 2-6, 2005. San
Diego, CA, USA.
17- Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, David J. Cole, and William E.
Gillanders. Novel non-viral delivery system enhances the efficacy of DNA vaccines
targeting cytotoxic T lymphocytes. 4th Annual Research Retreat, November 11th,
2004, Charleston, SC, USA.
18- Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders. Doublestranded RNA (dsRNA) danger motif is potent adjuvant for accentuating peptide-based
vaccine by bridging innate and adaptive immunity. Immunotherapy of Cancer X:
Tumor Vaccine and Cell Therapy Working Group (TVACT). Orlando, Florida, USA,
March 26, 2004.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
13
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
19- Mohamed L Salem, Andre N Kadima, David J Cole, William E Gillanders. Doublestranded RNA (dsRNA) danger motif is potent adjuvant to accentuate peptide-based
cancer vaccine by bridging innate and adaptive immunity. 95th Annual Meeting for
American Association of Cancer Research, March 27-31, 2004, Orange County
Convention Center, Orlando, FL, USA.
20- Waild Osta, Mike Mitas, Yian Chen, Mohamed L. Salem, Kaidi Mikhitarian and Carlton
Barnett. 3rd Annual Research Retreat, Wild Dunes, Charleston, SC, USA,
December 23rd, 2003, PP. 67.
21- Mohamed L Salem, Yuehua Zhou, Andre N Kadima, David J Cole, William E
Gillanders. Double-stranded RNA (dsRNA) Danger Motif Bridges Innate and Adaptive
Immunity and Is Potent Adjuvant for Accentuating Peptide-Based Cancer Vaccine. 3rd
Annual Research Retreat, December 23rd, 2003, Wild Dunes, Charleston, SC, USA.
22- Mohamed L Salem, Andre N Kadima, Yuehua Zhou, Christophe L Nguyen, Mark P
Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillanders.
Mechanisms of enhanced antigen-specific T cell response to a novel peptide-based
cancer vaccine: paracrine release of interleukin-12 results in enhancement of antigen
presentation and appears to be interferon-gamma dependent. 94th Annual Meeting for
American Association of Cancer Research, July10-14, 2003, Washington
Convention Center, Washington, DC, USA.
23- Mohamed L Salem, Andre N Kadima, Yuehua Zhou, David J Cole, William E
Gillanders. Exploring the interplay between innate and adaptive immunity: polyinosine:
cytosine (Poly I:C) enhances the antigen-specific T cell response to a peptide-based
cancer vaccine. Basic Aspects of tumor immunotherapy (C5) Feb 17-23, 2003,
Keystone, Colorado, Denver, USA.
24- Grab J. Dennis, R. Bucala and Mohamed L. Salem: A Role for Peripheral Blood
Fibrocytes in African trypanosomiasis and Lyme disease. South African Veterinary
Association. 74(3):87-101, 2003.
25- Mohamed L Salem, Andre Kadima, Mark P Rubinstein, Marina Demcheva, John N
Vournakis, David J Cole, William E Gillanders: Paracrine release of IL-12 from a
modular peptide-based cancer vaccine enhances the antigen-specific CD8 T cell
response. 2nd Annual Research Retreat, August 23rd, 2002, Wild Dunes,
Charleston, SC, USA Page:48.
26- Mohamed L Salem, Andre Kadima, Mark P Rubinstein, Marina Demcheva, John N
Vournakis, David J Cole, William E Gillanders: Paracrine release of IL-12 from a
modular peptide-based cancer vaccine enhances the antigen-specific CD8 T cell
response. 93rd Annual Meeting for American Association of Cancer Research,
April 6-10, 2002, San Francisco, CA, USA, Abstract#3002, page:606.
27- Mark P Rubinstein, Andre N Kadima, Mohamed L Salem, Christophe L Nguyen,
William E Gillanders, David J Cole: Persistence and function of adoptively transferred
retrovirally-transduced T cells in vivo. 93rd Annual Meeting for American Association
of Cancer Research, April 6-10, 2002, San Francisco, CA, USA. Abstract#2193,
page:441.
28- Mark P Rubinstein, Andre N Kadima, Ch ristophe L Nguyen, Mohamed L Salem,
William E Gillanders, David J Cole: Systemic administration of IL-15 augments primary
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
14
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
T cell response to vaccination. 16th Annual Meeting for Society for Biological
Therapy of Cancer, Bethesda, Maryland, USA 9 - 11 November 2001.
29- Mohamed L. Salem, Kenji Kishihara, Matsuzaki G. and Nomoto K. Subcutaneous
treatment with linoleic acid suppresses the growth of EL4 thymoma in mice through
augmentation of Cytolysis of CD8 and production of IFN-. The Autumn Conference of
Immunology, 19-21 Nov., 2000, Abstract no. 48, Page: 25Chicago, USA.
30- Mohamed L. Salem, Matsuzaki G. and Nomoto K. Influence of -estradiol on Listeria
monocytogenes infection. Japanese Soc. for Microbiol., March 28-31, 1994 Tokyo,
Japan.
31- Mohamed L. Salem, Matsuzaki G. and Nomoto K. -estradiol-induce d inhibition of
macrophages function during Listeria monocytogenes infection. The Winter Advanced
Course for Immunology and Infectious Diseases (WACIID)'1994". Tokyo, Japan,
Feb., 13-16, 1994.
BIBLIOGRPAHY
Review articles:
1. Mohamed L. Salem: Bridging scientific enterprise in developed and less developed
countries: Ideas for improving Sciences in developing countries. The BioMed
Scientist, Vol. 3, June 2007: 3-4.
2. Faris Q. AL-Enzi and Mohamed L. Salem. Career preference among university’s
faculty: Literature review. Education Resources Information Center (ERIC), 2007.
3. Mohamed L. Salem, Mark P Rubinstein, and David J Cole. Tumours:
Immunotherapy. Encyclopedia life Sciences. April 16, 2007 John Wiley & Sons, Ltd.
4. Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders,
David J. Cole. Novel non-viral delivery approaches for IL-12 protein and gene
systems: curbing toxicity and enhancing adjuvant activity. J. Interferon & Cytokine
Research, 2006, 26(9): 593-608.
5. Mohamed L. Salem, Immunomodulatory and immunotherapeutic properties of
Nigella sativa L. seeds. Int. Immunopharmacology. Vol 5/13-14:1749-1770
6. Mohamed L. Salem. Estrogen, A Double-edged Sword: Modulation of TH1- and TH2mediated Inflammations by Differential Regulation of TH1/TH2 Cytokine Production.
Current Drug Targets-Inflammation & Allergy, 3: 95-102, 2004.
7. Grab J. Dennis, Mohamed L. Salem, J.Dumler, R. Bucala and N-H Lanners A role for
the peripheral blood fibrocytes in leishmaniasis? Trends Parasitol., 20:12, 2003.
8. Grab J. Dennis, Mohamed L. Salem, J. Chesney, R. Bucala and N-H Lanners: A
Role for Peripheral Blood Fibrocytes in Lyme disease? Med Hypotheses. 59:1-10,
2002.
9. Mark P Rubinstein, Mohamed L. Salem. The influence of primary antigen encounter
on the generation of T-cell memory. Trends Immunol. (News and Comment), 23, 3:
123-124, 2002.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
15
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
Original Peer Reviewed Articles
10. Alberto J Montero, Mohamed L. Salem, Elizabeth Garrett-Mayer, David Cole, Marcela
Diaz Increased Levels of Circulating Myeloid-Derived Suppressor Cells in Solid Tumor
Patients Correlate With Advanced Clinical Cancer Stage, Increased Tumor Burden,
and Cyclophosphamide Containing Chemotherapy. 2007, Submitted, Journal of
Clinical Oncology.
11. Mohamed L. Salem, Marcela Diaz, Amir A. AL-Khami, Sabry EL-Naggar, and David
Cole. Immature dendritic cells expand after cyclophosphamide treatment and
augment anti-tumor T cell adoptive immunotherapy upon their activation in vivo. 2007,
Submitted, Journal of Experimental Medicine.
12. C. Marcela Díaz-Montero, Sabry El Naggar, Randa El Naggar, Amir Al Khami, Alberto
J Montero., David J Cole., and Mohamed L Salem. Priming of naive cells in the
presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results
in superior anti-tumor activity. Cancer Immunology & Immunotherapy, 2007 Aug 28;
[Epub ahead of print].
13. Mark P Rubinstein, Mohamed L. Salem, Andre N Kadima, Christophe L Nguyen,
William E Gillanders, David J Cole Retrovirally-modified T cells persist after adoptive
transfer but exhibit discordant gene expression associated with a lack of therapeutic
ability. Cancer Gene Therapy, 2007 In Press.
14. Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, and William E. Gillanders,
David J. Cole. Cyclophosphamide Preconditioning Enhances the Antigen-specific
CD8 T Cell Responses to Peptide Vaccination: Evidence of Enhanced Innate
Immunity and Induction of a Beneficial Cytokine Milieu. J Immunother. 2007
Jan;30(1):40-53.
15. Mohamed L. Salem, Provision of cytokines and cytokine-inducing adjuvants along
with peptide-based vaccination accentuated intrahepatic retention of antigen-activated
CD8+ T cells: opposing roles for natural killer and Kupffer cells. Egyptian Journal of
Experimental Biology (Zoology). 2006, 2: 33 – 47.
16. Mohamed L. Salem, Andre Kadima, Sabry EL-Naggar, William E. Gillanders, and
David J. Cole. The adjuvant effects of the toll-like receptor 3 ligand polyinosiniccytidylic acid (poly I:C) on antigen-specific CD8 T cell responses are partially
dependent on NK cells and macrophages with the induction of a beneficial cytokine
milieu. Vaccine. 2006 12(24):5119-5132.
17. Mohamed L. Salem, Mohsen Zommara and K. Imaizumi. Dietary supplementation of
tiger nut (Cyperus esculentus L) attenuates inflammatory cell responses in
apolipoprotein E knockout mouse. American Journal of Immunology 1 (1): 60-67,
2005.
18. Narender Nath, Shalinendra Giri, Ratna. Prasad, Mohamed L. Salem, Avtar K. Singh,
and Inderjit Singh. 5-aminoimidazole-4-carboxymide ribonucleoside: a novel
Immunomodulator with therapeutic efficacy in experimental autoimmune
encephalomyelitis (EAE). J Immunol. 2005 Jul 1;175(1):566-74.
19. Mohamed L. Salem, Andre N Kadima, David J Cole, William E Gillanders. Defining
the Antigen-Specific T-Cell Response to Vaccination and Poly(I:C)/TLR3 Signaling:
Evidence of Enhanced Primary and Memory CD8 T-Cell Responses and Antitumor
Immunity. J Immunother. 2005 May-Jun;28(3):220-8.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
16
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
20. Mohamed L. Salem, Systemic treatment with n-6 polyunsaturated fatty acids
attenuates EL4 thymoma growth and metastasis through enhancing specific and nonspecific anti-tumor cytolytic activities and production of TH1 cytokines. Int.
Immunopharmacology. 2005, Vol 5/6 pp 947-960.
21. Osta WA, Chen Y, Mikhitarian K, Mitas M, Mohamed L. Salem, Hannun YA, Cole DJ,
Gillanders WE. EpCAM is overexpressed in breast cancer and is a potential target for
breast cancer gene therapy. Cancer Res. 2004 Aug 15;64(16):5818-24.
22. Mohamed L. Salem, Andre N Kadima, Yuehua Zhou, Christophe L Nguyen, Mark P
Rubinstein, Marina Demcheva, John N Vournakis, David J Cole, William E Gillander
Paracrine release of interleukin-12 stimulates interferon-gamma production and
dramatically enhances antigen-specific T-cell response after vaccination with a novel
peptide-based cancer vaccine. J Immunol. 2004 May 1;172(9):5159-67.
23. Christophe L Nguyen, Mohamed L. Salem, Mark P Rubinstein, Marina Demcheva,
John N Vournakis, David J Cole, William E Gillanders. Mechanisms of enhanced
antigen-specific T cell response following vaccination with a novel peptide-based
cancer vaccine and systemic interleukin-2 (IL-2). Vaccine 21:2318-2328, 2003
24. Mark P Rubinstein, Andre N Kadima, Mohamed L. Salem, Christophe L Nguyen,
William E Gillanders, David J Cole. Transfer of TCR genes into mature T cells is
accompanied by the maintenance of parental T cell avidity. J Immunol. 170:1209-17,
2003
25. Mark P Rubinstein, Andre N Kadima, Mohamed L. Salem, Christophe L Nguyen,
William E Gillanders, David J Cole. Systemic administration of IL-15 augments the
antigen-specific primary CD8+ T cell response following vaccination with peptidepulsed dendritic cells. J Immunol. 169:4928-35, 2002.
26. Mohamed L. Salem, K. Kishihara and K. Nomoto. N-3 Polyunsaturated fatty acids
accentuate B16 melanoma growth and metastasis through suppression of tumoricidal
function of T cells and macrophages. Anticancer Research 20:3195-3204, 2000.
27. Mohamed L. Salem and Hossain M. Shorab. In vivo acute depletion of CD8+ T cells
upregulates the anti-viral activity of NK cells against murine cytomegalovirus. Int. J.
Immunopharmacology. 22:707-718, 2000.
28. Mohamed L. Salem and Hossain M. Shorab. Protective effect of the black seed oil
from Nigella sativa against murine cytomegalovirus infection. Int. J.
Immunopharmacology. 22:729-740, 2000.
29. Mohamed L. Salem, Matsuzaki G., Kishihara K., Madkour G. and Nomoto K. estradiol suppresses the T cell-mediated delayed-type hypersensitivity through
suppression of antigen presenting cell function and Th1 induction. International
Archives of Allergy and Immunology 121:161-169, 2000.
30. Mohamed L. Salem, Hossain SM, and Nomoto K. Mediation of the
immunomodulatory effects of beta-estradiol on inflammatory responses by inhibition
of recruitment and activation of the inflammatory cells, and their gene expression of
TNF-alpha and IFN-gamma. International Archives of Allergy and Immunology
121:235-245, 2000.
31. Mohamed L. Salem and W. El Shouny. Exopolysaccharides produced by
Pseudomonas syringae pathovars suppress tumor cell proliferation and augment
thymocyte proliferation in vitro. Az. J. Pharm Sci 25: 175-188, 2000.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
17
SALEM, MOHAMED LABIB, PhD
Curriculum Vitae
32. Mohamed L. Salem and Randa Ez Al Deen Al Nagar. Immunomodulatory and
antitumor effects of simultaneous treatment of mice with n-3 and n-6 polyunsatrated
fatty acids. J. Union Arab Biol, Vol. 14A:489-505, 2000.
33. Mohamed L. Salem and Wael Y Attia. Synergestic effect of beta-estradiol and
progesterone on the distribution of the immune cells in the lymphoid tissues. J. Union
Arab Biol, Vol 14A:293-307, 2000.
34. Mohamed L. Salem, Matsuzaki G., Gamal Madkour, and Nomoto K. -estradiolinduced suppression of macrophages functions in the course of Listeria
monocytogenes infection is mediated by suppression of IL-12 and TNF-alpha
expression. Int. J. Immunopharm 21;487-497, 1999.
35. Mohamed L. Salem. Increase of the bacteriostatic function against early infection of
mice with Listeria monocytogenes after treatment with beta-estradiol. J. Egypt
German Society of Zoology, Vol.23(A), Comp. Physiol, 347-378, Feb. 1997.
36. Wael Attia Y., Randa El-Naggar E., Mohamed L. Salem, and El-Bolkiny S. Influence
of prolactin and prolactin antagonist, bromocriptine, on the regulation of the immune
response. J. Egypt German Society of Zoology, Vol.23(A), Comp. Physiol., 325-346,
Feb. 1997.
37. El-Bolkiny E., Mohamed L. Salem, Wael Attia Y., and AL-Sharkawy I. Toxicological
study of Ammi majus as a plant mollusccicide on the hemolysis and hemolysis-related
parameters. J. Egypt German Society of Zoology, Vol.23 (A), Comp. Physiol. 3793401, Feb. 1997.
38. Mohamed L. Salem, Wael Attia Y., Wageh Awara A., Al Mehallawy A. Immunotoxicity
of cadmium chloride in mice. J. Union Arab Biology, Vol. 6 (A) Zoology, 531-554, Nov.
1996.
39. Fouad A. Abou-Zaid; Siham B. Salem and Mohamed L. Salem. Oesteology of
Psammomys obesus I. The cranial region. Delta J. Sci. 13 (4): 2087-3002, 1989.
40. Fouad A. Abou-Zaid; Siham B. Salem and Mohamed L. Salem. Oesteology of
Psammomys obesus. II. The post-cranial region. Delta J. Sci. 13 (4): 3003-3024,
1989.
41. Fouad A. Abou-Zaid; Siham B. Salem and Mohamed L. Salem. Histological studies
on the digestive system of the fat sand rat Psammomys obesus. Delta J. Sci. 12 (2):
1141-1166, 1988.
THESIS
o MS: Anatomical studies on the rodent of the genus Psammomys found in Egypt deserts.
Tanta University, Faculty of Science, Egypt, September 1989.
o PhD: Influence of contraceptive hormones on the interrelationship between endocrine
and immune systems. Tanta University, Faculty of Science, Egypt and Kyushu
University-Fukuoka, Japan, December 1995.
___________________________________________________________________________________________
SALEM, MOHAMED LABIB, PhD
October 2007
18