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Life| Nutrition www.fitpro.com What causes hangovers? Yo u booze, the physiological effects of a hangover Although many factors can contribute to hangover symptoms, the two main factors are dehydration and the toxic effects of alcohol on the body’s systems. Alcohol is a diuretic which means that it speeds the loss of water from the body causing the body to dehydrate. This then leads to many of the common hangover symptoms you can experience including thirst, weakness, dizziness, and headaches and so on. In the liver alcohol is broken down to acetaldehyde by an enzyme called alcohol dehydrogenase. Acetaldehyde is then further broken down into a harmless substance called acetate and eventually leaves your body as carbon dioxide and water. The average person takes about 60 minutes to break down 10g alcohol into acetaldehyde. Acetaldehyde is then rapidly converted to acetate. If you drink a large glass of wine (250ml) for example, your body takes about three hours to break down the alcohol. How quickly you break down alcohol will depend on a number of factors such as body size, gender and if you have food in your digestive system or not. If you drink more than your body can process you will have higher amounts of both alcohol and acetaldehyde circulating the body. Acetaldehyde is between 10-30 times more toxic than alcohol itself. At high doses in the body it causes nausea, vomiting, sweating and other symptoms akin to the hangover. Although there is no acetaldehyde in your system when you have a zero blood alcohol level, some of the after-effects of the toxin may persist the morning after.2 Effect of a hangover on physical performance It happens to many of us at some time or another. You drink too much, pay for it the next day and then think you can make up for a drinking binge with a workout. Sadly, the reality is that you can’t, says Linia Patel, as even a little alcohol can hamper progress and performance. 60 | Oct Nov 2012 | Make no mistake, once the high is over, it does not mean that the effects from the alcohol are over. The effects linger long after the blood concentration has fallen to zero. Therefore even the day after a night of boozing the chemical effects of alcohol on the body are still very prevalent.7 Exercise is a complex activity utilising many of the body’s organs including the central nervous system, the cardiovascular system and the muscular system. Each of these elements is negatively affected by alcohol. Alcohol is a depressant, not a stimulant. It slows down the activity in the central nervous system, which means the brain. Concentration, co-ordination, reaction time and balance are all negatively affected by alcohol consumption.8 A study done on a group of rugby players looked at the impact of alcohol on aerobic performance the morning after. The study found that even the ‘smallest dose’ of alcohol (i.e., a single unit) had a negative effect on aerobic performance. Other studies confirm these findings suggesting that aerobic performance capacity can be affected by as much as 11-25% due to a hangover.7,8 There is also strong evidence that shows that other performance areas that are compromised include strength, power, speed, muscular endurance and cardiovascular endurance as well as recovery.8 Alcohol and muscle development Research shows that alcohol cancels out physiological gains that you may have received from your workout. A study done on rats reported that long-term alcohol use diminishes protein synthesis and causes muscle wasting. Findings also suggested that even short-term alcohol use can impede muscle growth.9 There’s also a suggestion that when exercising with alcohol in the body, the body will produce far greater amounts of lactate which causes muscle pain and cramps It is thought that alcohol affects muscle development both directly and indirectly. Alcohol’s direct impact is at cellular level where it has been shown to decrease protein synthesis and increase the process of muscle atrophy. Indirectly, alcohol affects sleep patterns and hormonal production. In order to build bigger, stronger muscles or to simply increase muscle tone your body needs the right hormones and balance of calories as well as time to repair. Alcohol reduces sleep quality; which in turn hinders the production of important hormones (like human growth hormone). Research also shows that alcohol can negatively affect the muscle building hormone testosterone. A recent study showed that low levels of testosterone, induced by alcohol intake, limited conditioning progress in individuals. The research compared levels of protein synthesis in participants consuming beer or non-alcohol beer for three weeks while following the same diet composition. Scientists found that the beer group had significantly lower testosterone levels and also lower protein synthesis activity compared to the non-alcohol beer. Low testosterone levels can compromise muscle building, since the hormone plays a vital role in initiating this.8,9 Alcohol and muscles at work Alcohol dehydrates your body. Your liver needs water to dissolve and expel the toxins produced from alcohol breakdown. When your body’s reserves run out, the liver borrows water from other organs including muscles and the brain. Muscle is composed of 75% water.9 When your muscle cells are dehydrated, they can’t work as efficiently. Disrupting the water balance in your muscle cells affects your ability to produce adenosine triphosphate (ATP) within the muscle. ATP is your muscles’ source of energy. It provides the fuel necessary for your muscles to contract. Loss of ATP will result in a muscle weakness as well as a loss of endurance. Muscle weakness may then be further exacerbated by low blood sugar levels that you may experience when you are hung over.10 Your liver is slow at metabolising ethanol: on average, it takes about one hour for every unit of alcohol. The undivided attention that your liver has to give to alcohol means that it is not able to produce the glucose that exercising muscles need. Abnormally low levels of blood sugar (hypoglycaemia) may be of particular concern if you are doing a longer moderate to intense exercise session. While some may argue that exercising without glucose is a plus as it burns fat, without glucose it will not be possible to exercise at anywhere near your maximum capacity. There’s also a suggestion that when exercising with alcohol in the body, the body will produce far greater amounts of lactate. This causes muscle pain and cramps. 8,10 When it comes to physical performance, it’s not hard to see that alcohol detracts rather than enhances overall physical performance. You booze – you lose. Fitness orientated individuals particularly need to be aware of the physiological effects of booze – and how if we choose to drink you can minimise the impact of the hangover.fp To see the references mentioned visit www.fitpro.com/references | Oct Nov 2012 | 61