Download Young Investigator Proposal

Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
Program Purpose
ACRIN is pleased to announce an opportunity for junior faculty (assistant professors and
instructors within the first seven years post-fellowship or post-training) to carry out an ancillary
research project using the ACRIN imaging archive and associated case data. Available images
and data were collected during the conduct of ACRIN clinical trials and subject to ACRIN’s
quality assurance processes. The initiative is intended to introduce junior faculty to ACRIN and
to engage them in an ACRIN research endeavor that can be completed within a relatively short
timeframe and will result in a publication.
This program is made available through the ACRIN Fund for Imaging Innovation.
Award Specifics
Individual award: $10,000 plus analysis support from the ACRIN Biostatistics Center
Number of awards: 5
Application deadline: September 15, 2011
Program Description
 Image and Data Resource
Award recipients will have access to the data ACRIN has compiled from its conduct of 21
multicenter clinical trials over the past 12 years. While oncologic imaging is ACRIN’s primary
research focus, clinical trials related to arthritis, Alzheimer’s disease, and cardiovascular disease
have also been conducted. A list follows of ACRIN trials for which the primary aim has been
published, accrual completed, or approximately 20 cases are available. The complete list of
ACRIN protocols can be viewed at www.acrin.org/protocolsummarytable.aspx.
Data from ACRIN’s 13 actively accruing trials may be available in some circumstances;
specifically, if the planned research does not conflict with a protocol’s specific aims and the
release of data is approved by the ACRIN Data and Safety Monitoring Committee.
 Types of Research
Trial data (images, clinical, and outcome data) form a rich resource for further investigation.
Potential secondary research opportunities include:
o Developing new image analysis approaches for diagnosis, characterization of disease, or
prediction of outcome;
o Studying the prevalence of findings in a specified cohort;
o Analyzing trial data against alternate endpoints;
o Surveying image quality or radiation dose.
Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
 Review Criteria
Applications will be scored on criteria to include:
1. Overall scientific merit
2. Potential for affect on clinical care
3. Prospects for using data to support some aspect of a future ACRIN trial
4. Feasibility to carry out with existing archived data and images
5. Feasibility to complete within approximately one year from the date of award notice
Application Process
The application should not exceed 2 pages (using typical NIH format requirements for fonts and
margins). It should include a brief background, specific aims, and a brief description of methods.
Description of methods should include the specific ACRIN data to be used in the study.
Data collected for ACRIN trials can be found on the in the data forms available for each protocol
on the ACRIN Web site (an example can be found at www.acrin.org/Default.aspx?tabid=257 .
Available preliminary data may be included in the background section; however, preliminary
data are not required. Literature references should be included and do not count in the 2 page
limit. Applications should also include a letter of support from the applicant’s department chair.
Applications must be received no later than September 15, 2011.
The application should be submitted with a cover letter that includes the research project’s name
and the applicant’s name and contact information to:
Mitchell D. Schnall, MD, PhD
ACRIN Network Chair
1818 Market Street
Suite 1600
Philadelphia, PA 19103
Attn: Young Investigator Initiative
Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
Summary of ACRIN protocols with primary results published or manuscript in process or open
with ~ 20 cases accrued.
ABDOMINAL PROTOCOLS
Study #
(orange =
collaborator)
Study Name and PI
Modality
Status
6656
Colon Cancer:
Diagnostic Accuracy of CT
Colonography
C. Daniel Johnson, MD
Computed
Tomography
Results
Published
6659
Prostate Cancer:
Staging with MRI and MRS
Jeffrey C. Weinreb, MD
MRI
Results
Published
6664
Colorectal Cancer:
Screening with CT Colonography
C. Daniel Johnson, MD
Computed
Tomography
Results
Published
6665
Malignant GI Stromal Tumors:
Treatment Monitoring with PET
Burton Eisenberg, MD
RTOG Study Chair
Annick Van den Abbeele, MD
ACRIN Principal Investigator
Positron Emission
Tomography
Primary Aim
Paper
Submitted
Liver Cancer:
Treatment with RF Ablation
Gerald Dodd, III, MD
Radiofrequency
Ablation
In Analysis
RTOG
6673
Accrual
(orange =
goal)
117
117
134
134
2617
2600
63
63
51
40
18
24
6687
DoD
18F-Fluoride PET as a Biomarker
for Prostate Cancer and Bone
Metastases
Evan Y. Yu, MD
Note: ARRA funding supports this
trial.
Positron Emission
Tomography
Open
Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
BREAST PROTOCOLS
Comparison of Full-Field Digital
Mammography with Digital Breast
Tomosynthesis in Screening CallBack Rate
Emily F. Conant, MD
261
550
Mammography
Open
6652
Breast Cancer:
Screening with Digital
Mammography
Etta Pisano, MD
Mammography
Results
Published
6657
Breast Cancer:
Treatment Monitoring with
Dynamic MRI
Nola M. Hylton, PhD
ACRIN Principal Investigator
Laura J. Esserman, MD, MBA
CALGB Study Chair
MRI
In Analysis
356
377
6666
Breast Cancer:
Screening with Ultrasound
Wendie A. Berg, MD, PhD
Ultrasound
In Analysis
2809
2809
6667
Breast Cancer:
Screening of Contralateral Breast
with MRI
Constance Lehman, MD, PhD
6683
Computer Aided Detection and
Digital Mammography
Etta D. Pisano, MD
4006
Note: Funded by the PA
Department of Health and carried
out by ACRIN PA Network
institutions
CALGB
6688
VCU
Phase II Study of FLT PET in
Invasive Breast Cancer
Paul R. Jolles, MD, VCU Study
Chair
ACRIN Co-Investigators
David Mankoff, MD, PhD
Lale Kostakoglu, MD, MPH
Note: ARRA funding supports this
trial.
Results
Published
Computed
Tomography
Positron Emission
Tomography
In Analysis
Open
49529
49520
1007
1007
N/A
43
54
Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
CARDIOVASCULAR PROTOCOLS
4005
CT Coronary Angiogram vs
Traditional Care for Low-Risk ED
Pts with Potential Acute Coronary
Syndromes
Harold Litt, MD, PhD
Computed
Tomography
Open
1140
1365
Note: Funded by the PA
Department of Health and carried
out by ACRIN PA Network
institutions
GYNECOLOGICAL PROTOCOLS
6651
GOG
6671
GOG
6682
Cervical Cancer:
Staging with CT and MRI
Hedvig Hricak, MD, PhD
Magnetic Resonance
Imaging
Results
Published
208
208
Cervical and Endometrial Cancers:
Staging with PET/CT
Mostafa Atri, MD
ACRIN Principal Investigator
Michael Gold, MD
GOG Principal Investigator
Positron Emission
Tomography
Open
141
380
Cervical Cancer:
64Cu-ATSM PET/CT Assessment
of Tumor Hypoxia
Farrokh Dehdashti, MD
Positron Emission
Tomography
Open
19
100
HEAD/NECK/NEURO PROTOCOLS
6658
Supraglottic Cancer:
Volume Measurement Reliability
with CT
Suresh Mukherji, MD
Computed
Tomography
Results
Published
6662
Malignant Glioma:
Volume Measurement Reliability
with MRI
Birgit B. Ertl-Wagner, MD
Magnetic Resonance
Imaging
Results
Published
Recurrent Glioblastoma:
Substudy Tumor Staging with MR
Perfusion Imaging and MR
Spectroscopy
A. Gregory Sorensen, MD
ACRIN Principal Investigator
Mark Gilbert, MD
RTOG Study Chair
Magnetic Resonance
Imaging
In Analysis
NABTT
6677
RTOG
24
24
48
48
121
Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
6685
Staging of Head and Neck Cancer:
Assessment of FDG-PET/CT and
the Impact on N0 Neck Surgical
Treatment
Val J. Lowe, MD,
Brendan C. Stack, Jr., MD, FACS
Positron Emission
Tomography
Open
6686
Newly Diagnosed Glioblastoma:
Substudy of Tumor Assessment
with Advanced MRI
A. Gregory Sorensen, MD
ACRIN Principal Investigator
Mark Gilbert, MD
RTOG Study Chair
Magnetic Resonance
Imaging
Accrual
Complete
RTOG
33
292
60
264
NEUROSCIENCE PROTOCOLS
Evaluation of a Novel PET
Radiopharmaceutical to Identify
Patients with Alzheimer’s Disease
Steven E. Arnold, MD
4003
Note: Funded by the PA
Department of Health and carried
out by ACRIN PA Network
institutions
Evaluation of a Novel PET
Radiopharmaceutical to Identify
Patients with Alzheimer’s Disease
James Mountz, MD, PhD
4004
Note: Funded by the PA
Department of Health and carried
out by ACRIN PA Network
institutions
Positron Emission
Tomography
In Analysis
32
30
Positron Emission
Tomography
In Analysis
24
30
Magnetic Resonance
Imaging
In Analysis
53
54
Magnetic Resonance
Imaging
In Analysis
192
184
OTHER PROTOCOLS
Knee Articular Cartilage Damage
in Osteoarthritis: MRI Image
Markers
Timothy J. Mosher, MD
4001
6660
Note: Funded by the PA
Department of Health and carried
out by ACRIN PA Network
institutions
Pediatric Malignancy:
Staging with Whole-Body MRI
Marilyn Siegel, MD
Summary
of ACRIN
Clinical
Trials:
Results
Publishe
d, In
6661
Analysis,
and Open
with ~ 20
Cases
6680
Accrued
SWOG
as of
June 8,
2011
6654
NCI LSS
6668
RTOG
6678
Young Investigator Initiative
for the
Conduct of ACRIN Ancillary Research
Radiofrequency Ablation of Bone
Metastases Using CT Guidance
Damian E. Dupuy, MD
Radiofrequency
Ablation
Results
Published
66
75
ACRIN SPECT Component of the
SWOG S0518 Carcinoid Treatment
Trial
Lale Kostakoglu, MD
ACRIN Investigator
SPECT
Open
92
NA
THORACIC PROTOCOLS
National Lung Screening Trial
Denise Aberle, MD
Computed
Tomography
In Analysis
18894
25000
Lung Cancer: FDG-PET
Assessment for Stage III NonSmall Cell Lung Cancer
Mitchell Machtay, MD
Positron Emission
Tomography
In Follow-up
251
250
Lung Cancer:
Evaluation of Treatment Response
with PET
Wolfgang Weber, MD
Positron Emission
Tomography
Open
91
228