Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Young Investigator Initiative for the Conduct of ACRIN Ancillary Research Program Purpose ACRIN is pleased to announce an opportunity for junior faculty (assistant professors and instructors within the first seven years post-fellowship or post-training) to carry out an ancillary research project using the ACRIN imaging archive and associated case data. Available images and data were collected during the conduct of ACRIN clinical trials and subject to ACRIN’s quality assurance processes. The initiative is intended to introduce junior faculty to ACRIN and to engage them in an ACRIN research endeavor that can be completed within a relatively short timeframe and will result in a publication. This program is made available through the ACRIN Fund for Imaging Innovation. Award Specifics Individual award: $10,000 plus analysis support from the ACRIN Biostatistics Center Number of awards: 5 Application deadline: September 15, 2011 Program Description Image and Data Resource Award recipients will have access to the data ACRIN has compiled from its conduct of 21 multicenter clinical trials over the past 12 years. While oncologic imaging is ACRIN’s primary research focus, clinical trials related to arthritis, Alzheimer’s disease, and cardiovascular disease have also been conducted. A list follows of ACRIN trials for which the primary aim has been published, accrual completed, or approximately 20 cases are available. The complete list of ACRIN protocols can be viewed at www.acrin.org/protocolsummarytable.aspx. Data from ACRIN’s 13 actively accruing trials may be available in some circumstances; specifically, if the planned research does not conflict with a protocol’s specific aims and the release of data is approved by the ACRIN Data and Safety Monitoring Committee. Types of Research Trial data (images, clinical, and outcome data) form a rich resource for further investigation. Potential secondary research opportunities include: o Developing new image analysis approaches for diagnosis, characterization of disease, or prediction of outcome; o Studying the prevalence of findings in a specified cohort; o Analyzing trial data against alternate endpoints; o Surveying image quality or radiation dose. Young Investigator Initiative for the Conduct of ACRIN Ancillary Research Review Criteria Applications will be scored on criteria to include: 1. Overall scientific merit 2. Potential for affect on clinical care 3. Prospects for using data to support some aspect of a future ACRIN trial 4. Feasibility to carry out with existing archived data and images 5. Feasibility to complete within approximately one year from the date of award notice Application Process The application should not exceed 2 pages (using typical NIH format requirements for fonts and margins). It should include a brief background, specific aims, and a brief description of methods. Description of methods should include the specific ACRIN data to be used in the study. Data collected for ACRIN trials can be found on the in the data forms available for each protocol on the ACRIN Web site (an example can be found at www.acrin.org/Default.aspx?tabid=257 . Available preliminary data may be included in the background section; however, preliminary data are not required. Literature references should be included and do not count in the 2 page limit. Applications should also include a letter of support from the applicant’s department chair. Applications must be received no later than September 15, 2011. The application should be submitted with a cover letter that includes the research project’s name and the applicant’s name and contact information to: Mitchell D. Schnall, MD, PhD ACRIN Network Chair 1818 Market Street Suite 1600 Philadelphia, PA 19103 Attn: Young Investigator Initiative Young Investigator Initiative for the Conduct of ACRIN Ancillary Research Summary of ACRIN protocols with primary results published or manuscript in process or open with ~ 20 cases accrued. ABDOMINAL PROTOCOLS Study # (orange = collaborator) Study Name and PI Modality Status 6656 Colon Cancer: Diagnostic Accuracy of CT Colonography C. Daniel Johnson, MD Computed Tomography Results Published 6659 Prostate Cancer: Staging with MRI and MRS Jeffrey C. Weinreb, MD MRI Results Published 6664 Colorectal Cancer: Screening with CT Colonography C. Daniel Johnson, MD Computed Tomography Results Published 6665 Malignant GI Stromal Tumors: Treatment Monitoring with PET Burton Eisenberg, MD RTOG Study Chair Annick Van den Abbeele, MD ACRIN Principal Investigator Positron Emission Tomography Primary Aim Paper Submitted Liver Cancer: Treatment with RF Ablation Gerald Dodd, III, MD Radiofrequency Ablation In Analysis RTOG 6673 Accrual (orange = goal) 117 117 134 134 2617 2600 63 63 51 40 18 24 6687 DoD 18F-Fluoride PET as a Biomarker for Prostate Cancer and Bone Metastases Evan Y. Yu, MD Note: ARRA funding supports this trial. Positron Emission Tomography Open Young Investigator Initiative for the Conduct of ACRIN Ancillary Research BREAST PROTOCOLS Comparison of Full-Field Digital Mammography with Digital Breast Tomosynthesis in Screening CallBack Rate Emily F. Conant, MD 261 550 Mammography Open 6652 Breast Cancer: Screening with Digital Mammography Etta Pisano, MD Mammography Results Published 6657 Breast Cancer: Treatment Monitoring with Dynamic MRI Nola M. Hylton, PhD ACRIN Principal Investigator Laura J. Esserman, MD, MBA CALGB Study Chair MRI In Analysis 356 377 6666 Breast Cancer: Screening with Ultrasound Wendie A. Berg, MD, PhD Ultrasound In Analysis 2809 2809 6667 Breast Cancer: Screening of Contralateral Breast with MRI Constance Lehman, MD, PhD 6683 Computer Aided Detection and Digital Mammography Etta D. Pisano, MD 4006 Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions CALGB 6688 VCU Phase II Study of FLT PET in Invasive Breast Cancer Paul R. Jolles, MD, VCU Study Chair ACRIN Co-Investigators David Mankoff, MD, PhD Lale Kostakoglu, MD, MPH Note: ARRA funding supports this trial. Results Published Computed Tomography Positron Emission Tomography In Analysis Open 49529 49520 1007 1007 N/A 43 54 Young Investigator Initiative for the Conduct of ACRIN Ancillary Research CARDIOVASCULAR PROTOCOLS 4005 CT Coronary Angiogram vs Traditional Care for Low-Risk ED Pts with Potential Acute Coronary Syndromes Harold Litt, MD, PhD Computed Tomography Open 1140 1365 Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions GYNECOLOGICAL PROTOCOLS 6651 GOG 6671 GOG 6682 Cervical Cancer: Staging with CT and MRI Hedvig Hricak, MD, PhD Magnetic Resonance Imaging Results Published 208 208 Cervical and Endometrial Cancers: Staging with PET/CT Mostafa Atri, MD ACRIN Principal Investigator Michael Gold, MD GOG Principal Investigator Positron Emission Tomography Open 141 380 Cervical Cancer: 64Cu-ATSM PET/CT Assessment of Tumor Hypoxia Farrokh Dehdashti, MD Positron Emission Tomography Open 19 100 HEAD/NECK/NEURO PROTOCOLS 6658 Supraglottic Cancer: Volume Measurement Reliability with CT Suresh Mukherji, MD Computed Tomography Results Published 6662 Malignant Glioma: Volume Measurement Reliability with MRI Birgit B. Ertl-Wagner, MD Magnetic Resonance Imaging Results Published Recurrent Glioblastoma: Substudy Tumor Staging with MR Perfusion Imaging and MR Spectroscopy A. Gregory Sorensen, MD ACRIN Principal Investigator Mark Gilbert, MD RTOG Study Chair Magnetic Resonance Imaging In Analysis NABTT 6677 RTOG 24 24 48 48 121 Young Investigator Initiative for the Conduct of ACRIN Ancillary Research 6685 Staging of Head and Neck Cancer: Assessment of FDG-PET/CT and the Impact on N0 Neck Surgical Treatment Val J. Lowe, MD, Brendan C. Stack, Jr., MD, FACS Positron Emission Tomography Open 6686 Newly Diagnosed Glioblastoma: Substudy of Tumor Assessment with Advanced MRI A. Gregory Sorensen, MD ACRIN Principal Investigator Mark Gilbert, MD RTOG Study Chair Magnetic Resonance Imaging Accrual Complete RTOG 33 292 60 264 NEUROSCIENCE PROTOCOLS Evaluation of a Novel PET Radiopharmaceutical to Identify Patients with Alzheimer’s Disease Steven E. Arnold, MD 4003 Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions Evaluation of a Novel PET Radiopharmaceutical to Identify Patients with Alzheimer’s Disease James Mountz, MD, PhD 4004 Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions Positron Emission Tomography In Analysis 32 30 Positron Emission Tomography In Analysis 24 30 Magnetic Resonance Imaging In Analysis 53 54 Magnetic Resonance Imaging In Analysis 192 184 OTHER PROTOCOLS Knee Articular Cartilage Damage in Osteoarthritis: MRI Image Markers Timothy J. Mosher, MD 4001 6660 Note: Funded by the PA Department of Health and carried out by ACRIN PA Network institutions Pediatric Malignancy: Staging with Whole-Body MRI Marilyn Siegel, MD Summary of ACRIN Clinical Trials: Results Publishe d, In 6661 Analysis, and Open with ~ 20 Cases 6680 Accrued SWOG as of June 8, 2011 6654 NCI LSS 6668 RTOG 6678 Young Investigator Initiative for the Conduct of ACRIN Ancillary Research Radiofrequency Ablation of Bone Metastases Using CT Guidance Damian E. Dupuy, MD Radiofrequency Ablation Results Published 66 75 ACRIN SPECT Component of the SWOG S0518 Carcinoid Treatment Trial Lale Kostakoglu, MD ACRIN Investigator SPECT Open 92 NA THORACIC PROTOCOLS National Lung Screening Trial Denise Aberle, MD Computed Tomography In Analysis 18894 25000 Lung Cancer: FDG-PET Assessment for Stage III NonSmall Cell Lung Cancer Mitchell Machtay, MD Positron Emission Tomography In Follow-up 251 250 Lung Cancer: Evaluation of Treatment Response with PET Wolfgang Weber, MD Positron Emission Tomography Open 91 228