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CURRICULUM VITAE PEDRO F. ESCOBAR, M.D. CLEVELAND CLINIC 9500 Euclid Ave. Cleveland, OH 44195 PERSONAL DATA: Place and Date of Birth: Caguas, P.R., USA September 7, 1971 Home Address: 1390 Slate Court Cleveland Heights, OH 44118 Work Address: Cleveland Clinic Desk A81, 9500 Euclid Ave. Cleveland, OH 44195 Tel 216-445-8486 Fax 216-444-8551 Email [email protected] Marital Status: Married Wanda I. Lopez Children: Pedro A. Escobar Lopez Anamarie Escobar Lopez EDUCATION AND TRAINING: Undergraduate Education: 1989-1994 B.S. Biochemistry Florida Institute of Technology Melbourne, Florida Medical Education: 1994-1998 M.D. University of Puerto Rico San Juan, P.R., USA Internship: 1998-1999 University of Puerto Rico Department of Obstetrics and Gynecology San Juan, P.R., USA Residency: 1999-2002 Northwestern University Department of Obstetrics and Gynecology Chicago, IL EDUCATION AND TRAINING - continued Fellowship: 2002-2003 Research Cleveland Clinic Department of Cancer Biology Cleveland, OH Fellowship: 2003-2004 Breast Surgery Cleveland Clinic Department of General Surgery Cleveland, OH Fellowship: 2004-2006 Gynecologic Oncology Cleveland Clinic Department of Obstetrics and Gynecology Cleveland, OH APPOINTMENT AND POSITIONS 2002-2003 Research Fellow Cleveland Clinic Department of Obstetrics and Gynecology/Cancer Biology 2003-2004 Clinical Fellow Cleveland Clinic Department of Surgery 2004-2006 Clinical Fellow Cleveland Clinic Department of Obstetrics and Gynecology 2006-2008 Assistant Staff Gynecologic OncologyBreast Surgeon Florida Gynecologic Oncology Lee Cancer Center, Lee Memorial Hospital 2008-Present Staff Cleveland Clinic OB/GYN and Women’s Institute Section of Gynecologic Oncology 2009 - Present Director, Robotic and Minimally Invasive Surgery/Section of Gynecologic Oncology OB/GYN and Women’s Institute 2009 – Present Assistant Professor Department of Ob-Gyn Ponce School of Medicine APPOINTMENT AND POSITIONS – continued 2009 – Present Physician Advisor International Leadership Board Cleveland Clinic 2009 – Present Advisory Board Member Center for International Medical Education Cleveland Clinic 2009 – Present Assistant Professor of Surgery Cleveland Clinic Lerner College of Medicine of Case Western University 2009 – Present Joint Appointment Genomic Medicine Institute Lerner Research Institute 2010 – Present Director of Minimally Invasive and Robotic Surgery OB/GYN and Women’s Health Institute BOARD CERTIFICATION December 2005 American Board of Obstetrics and Gynecology April 2008 Subspecialty Board Certification Gynecologic Oncology Fellow – The American Board of Obstetrics and Gynecology Fellow – American College of Surgeons LICENSURE State of Ohio (#35-08-1008-E) State of Illinois (#036-103602) State of Florida (ME 95829) Commonwealth of Puerto Rico, USA (016410) MEDICAL SOCIETY MEMBERSHIP Society of Surgical Oncology American Society of Clinical Oncology MEDICAL SOCIETY MEMBERSHIP - continued American College of Surgeons Society of Gynecologic Oncology American Society of Breast Disease American College of Obstetrics and Gynecology Royal Society of Medicine (Fellow) Advancing Minimally Invasive Gynecology Worldwide The International Society for Gynecologic Endoscopy International College of Surgeons – (Fellow) International Gynecologic Cancer Society American Congress of Obstetrics and Gynecology Society of Laparoendoscopic Surgeons HONORS Alpha Omega Alpha – 1997 Cum Laude – Florida Institute of Technology – 1994 New Investigator Award Finalist – American Institute of Ultrasound in Medicine – 2001 Resident’s Award – Excellence in Operative Endoscopy, Northwestern University – 2002 American Association for Cancer Research – Minority Scholar in Cancer Research Award - 2003 American Association for Cancer Research – Advances in Breast Cancer Research Travel Award – 2003 ASCO / AACR / NCI Clinical Cancer Research Workshop – 2003 Best Poster Award – 25th Annual Miami Breast Cancer Conference – 2008 Best Paper Award - Mimimally Invasive Gynecolgic Oncology - AAGL – 2010 INTERNATIONAL RESEARCH Preventive Oncology International Optical Imaging / Biopsy – Cervical Cancer Screening Breast Cancer Surgery / Awareness Project Site Director – Dominican Republic – 2004 Lifeline Biotechnologies – Visiting surgical instructor in breast surgery Beijing Third University Hospital, China – 2005 GRANTS – PRINCIPAL INVESTIGATOR Genomic Stability and DNA Polymerase beta in ovarian and breast cancer. Research Programs Council, The Cleveland Clinic, RPC#07223, $25,000. April 22, 2003-April 21, 2004 CLINICAL RESEARCH Principle Investigator: ARC 08993 Advanced Laparoscopic and Minimally Invasive Surgery Workshops in Gynecology (eSirius 0090) Principle Investigator: BIBF 1199.15 Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of BIBF 1120 in combination with standard treatment of Carboplatin and paclitaxel compared to placebo plus Carboplatin and paclitaxel in patients with advanced ovarian cancer Principle Investigator: PT-301 A non-interventional prospective study of the correlation of the Precision Therapeutics, Inc. Chemoresponsive assay with progression-free survival in patients with recurrent epithelial ovarian, peritoneal, or fallopian tube cancer Co-Investigator: Gynecologic Oncology Group – 187 Phase II study of Paclitaxel for Ovarian Stromal Tumors as second-line therapy Co-Investigator: IRB # 4614 Ganapathi – The use of microarray technology for identifying relevant genes in chemotherapy resistant ovarian cancer (internal) Co-Investigator: Gynecologic Oncology Group – 209 Phase 3 randomized study of Doxorubicin, Paclitaxel, Cisplatin, and G-CSF v. Carboplatin and Paclitaxel in patients with Stage III, IV, or recurrent endometrial cancer Co-Investigator: Gynecologic Oncology Group – 205 A Phase II trial of radiation therapy and weekly Cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva Co-Investigator: Gynecologic Oncology Group – 9917 A dose-escalating phase I study with an expanded cohort to assess the feasibility of intraperitoneal Carboplatin (NSC #214270) and intravenous Paclitaxel (NSC #673089) in patients with previously untreated epithelial ovarian, primary, peritoneal, or fallopian tube carcinoma CLINICAL RESEARCH – continued Co-Investigator: Gynecologic Oncology Group – 9916 A phase I trial of intravenous Paclitaxel Carboplatin and Intraperitoneal Paclitaxel or intravenous Docetaxel, Intraperitoneal Carboplatin and Intraperitoneal Paclitaxel in patients with optimal Stage III epithelial ovarian carcinoma or primary peritoneal carcinoma Co-Investigator: Gynecologic Oncology Group – 212 A randomized phase III trial of maintenance chemotherapy comparing 12, monthly cycles of single agent Paclitaxel or Xyotax versus no treatment until documented relapse in women with advanced ovarian or primary peritoneal cancer achieve a complete clinical response to primary platinum/taxane chemotherapy Co-Investigator: Gynecologic Oncology Group – 210 A molecular staging study of endometrial carcinoma Co-Investigator: Gynecologic Oncology Group – 9918 Phase I trial of tailored radiation therapy with concomitant Cetuximab and Cisplatin in the treatment of patients with cervical cancer Co-Investigator: Gynecologic Oncology Group – 218 A phase III trial of Carboplatin and Paclitaxel plus placebo versus Carboplatin and Paclitaxel plus concurrent Bevacizumab followed by placebo, versus Carboplatin and Paclitaxel plus concurrent and extended Bevacizumab in women with newly diagnosed, previously untreated, Stage III or IV, epithelial ovarian or primary peritoneal cancer Co-Investigator: Gynecologic Oncology Group – 222 Prospective evaluation of pelvic exenteration in patient with recurrent cervical cancer Co-Investigator: Gynecologic Oncology Group – 219 A phase III randomized trial of weekly Cisplatin and radiation versus Cisplatin and Tirapazamine and radiation in Stage IB2, IIA, IIB, IIIB and IVA cervical cancer limited to the pelvis CLINICAL RESEARCH – continued Co-Investigator: AVF4119s A phase II trial of a vascular endothelial growth factor (VEGF) monoclonal antibody, Avastin, in combination with cytotoxic chemotherapy Carboplatin and Paclitaxel for recurrent/advanced endometrial cancer Co-Investigator Fran1807-CC307 Fran-Detection of early stage ovarian cancer: a clinical protocol to evaluate plasmalogens to detect the presence of early stage ovarian cancer in women scheduled for surgery with a pelvic mass or a suspected ovarian malignancy Co-Investigator: Gene2807-CC356 A phase II, multicenter, randomized, blinded, placebo-controlled trial of Carboplatin and Gemcitabine plus Bevacizumab in patients with Platinum-sensitive recurrent ovary, primary peritoneal, or fallopian tube carcinoma Co-Investigator: MEPL 1808-CC521 Multi-center, randomized, double-blind, phase III efficacy study comparing Phenoxodiol in combination with Carboplatin versus Carboplatin with placebo in patients with Platinum resistant or refractory late-stage epithelial ovarian, fallopian or primary peritoneal cancer following at least second line Platinum therapy INVITED LECTURES Cleveland Clinic Grand Rounds Department of Obstetrics and Gynecology 2003 Mastology Society of Dominican Republic “Recent Advances in Breast Cancer Surgery” 2004 Lee Memorial Hospital Fort Myers, Florida Cancer Center 2004 Caribe Gynecology 1st Annual Meeting Ponce, Puerto Rico “Minimally Invasive Surgery in Gynecology” 2004 INVITED LECTURES - continued Royal Society of Medicine Section of Oncology London, U.K. Breast Cancer “Sylvia-Lawler Prize Lecture” 2005 Florida Society of Gynecologic Oncologist “Breast Endoscopy” Annual Meeting 2005 Caribe Gynecology 2nd Annual Meeting Ponce, Puerto Rico “Breast Disease” 2005 Lee Memorial Hospital Fort Myers, Florida Cancer Center 2005 Third-Beijing University Hospital China Grand Rounds “Breast Endoscopy” 2005 The Cleveland Clinic Updates in Gynecologic Endoscopy, Instructor 2003-2006 Society of Gynecologic Oncology Breast Course Annual Meeting 2007 University of South Dakota School of Medicine Grand Rounds “Breast Endoscopy” 2007 Caribe Gynecology 4th Annual Meeting Ponce, Puerto Rico “Robotic Surgery in Gynecology” 2007 INVITED LECTURES - continued Florida Obstetrics and Gynecology Society Annual Meeting Naples, Florida “Breast Lab” 2007 American College of Surgeons – Puerto Rico Chapter 58th Annual Meeting San Juan, PR, USA “Robotic and Minimally Invasive Surgery in Gynecologic Oncology February 2008 Caribe Gynecology 5th Annual Meeting Ponce, Puerto Rico “Breast Cancer: Risk and New Alternatives”; “Cervical Cancer Updates: New Modalities and Alternatives for Management” August 2008 Hillcrest Hospital Women’s Health and Education Breast, Cervical and Ovarian Carcinoma October 22, 2008 Hospital Episcopal San Lucas Surgical Rounds and Teaching Ob/Gyn Department Ponce, Puerto Rico October 10, 2008 Hospital Episcopal San Lucas Surgical Rounds and Teaching Ob/Gyn Department Ponce, Puerto Rico December 19-20, 2008 Cleveland Society of Ob-Gyn Cleveland, Ohio “An Update on the Management of Molar Pregnancy and Gestational Trophoblastic Disease” January 21, 2009 Precision Therapeutics, Inc. San Juan, Puerto Rico “New Trends in Managing Cancer” February 12, 2009 INVITED LECTURES - continued Grand Rounds Hillcrest Hospital “Update on Robotic and Minimally Invasive Surgery for Gynecology” March 19, 2009 Advances in Gynecologic Surgery Cleveland Clinic “Single-Port Laparoscopy and NOTES May 14, 2009 Single-Port Laparoscopy, NOTES, and Endoluminal Surgery Cleveland Clinic “Robotic Single-Port Lymphadenectomy” May 29, 2009 Healthwise Connection Program Mayfield Community Center “Advantages of Robotic Surgery in Gynecology” June 10, 2009 BIT Life Sciences’ 2nd World Cancer Congress Beijing, China “Tissue-culture Based Chemosensitivity Assays in the Management of Patients with Ovarian Cancer” June 24, 2009 Hospital Episcopal San Lucas Surgical Rounds and Teaching Ob/Gyn Department Ponce, Puerto Rico June 30, 2009 Caribe Gynecology 6th Annual Meeting Ponce, Puerto Rico “Breast Cancer: Risk and New Alternatives”; “Cervical Cancer Updates: New Modalities and Alternatives for Management” August 6, 2009 International Gynecology Invitational Symposium Cleveland Clinic “Single Port Laparoscopy”; “The Difficult Abdominal Hysterectomy” August 24-26, 2009 INVITED LECTURES - continued Loyola University School of Medicine Chicago, Illinois “Single Port Laparoscopy (LESS) in Gynecologic Oncology September 30, 2009 American College of Obstetricians and Gynecologists Minneapolis Minneapolis, MN “Single Incision Laparoscopic Surgery (SILS) “Breast Disease: What’s Important and Why?” November 14, 2009 American Association of Gynecologic Laparoscopists Symposium Orlando, Florida “Laparoendoscopic Single Site Surgery (LESS) in Gynecologic Oncology November 15-19, 2009 Integrative and Translational Genomic Medicine Seminar Series Cleveland Clinic “Single-Port Laparoscopy for Prophylactic Surgery” November 20, 2009 Minimally Invasive Gynecology and Ambulatory Gynecology Cleveland Clinic Florida Fort Lauderdale, Florida “BSO & Hysterectomy: An oncologist’s perspective, conservative management of gynecologic malignancies.” January 22-25, 2010 60th Annual Meeting – American College of Surgeons Puerto Rico Chapter San Juan, Puerto Rico “Single Port Laparoscopy in Gynecologic Cancer Surgery” February 25-27, 2010 Pan American Robotic Oncology Symposium Houston, Texas “Robotic-Assisted Single Site Surgery in Gynecologic Oncology” February 27, 2010 Cleveland Clinic Center for Surgical Innovation Cleveland, Ohio Single Port Laparoscopy in Gynecology Conference Director “Single Port Applications in Gynecologic Oncology” “Single Port Robotic Surgery and Future Trends” March 4-5, 2010 INVITED LECTURES - continued SGO 2010 Annual Meeting on Women’s Cancer San Francisco, California Montz Symposium: Future of Minimally Invasive Surgery in Gynecologic Oncology March 2010 Cleveland Clinic Grand Rounds “Single Port Laparoscopy” March 24, 2010 St. Vincent Health Center Erie, PA Grand Rounds “Robotic Surgery in Gynecology” April 30, 2010 Advances in Gynecologic Surgery Single-Port Laparoscopy, NOTES, and Endoluminal Surgery Cleveland Clinic May 14-15, 2010 National Congress Ob-Gyn Cali, Columbia Laparoendoscopic Single Site Surgery May 18-21, 2010 International Society for Gynecologic Endoscopy Sydney, Australia Single Port Laparoscopy May 26-29, 2010 Advances in Minimally Invasive Surgery Gynecologic Robotic Surgery The Hilton Beachwood July 20, 2010 10ma Convención Científica Facultad Médica HIMA San Pablo Caguas Ponce, PR Single Port Laparoscopy and Robotic Surgery September 17-18, 2010 INVITED LECTURES - continued Spotlight on Cleveland Clinic “Advances in Minimally Invasive Surgery in Gynecologic Oncology from Research to Clinical Practice” October 5, 2010 AAGL Global Congress of Minimally Invasive Gynecology Las Vegas, Nevada “Robotic Single-Site Surgery: New Horizons with VESPA Technology” “Getting Started with Single-Port Laparoscopy – Basic Procedures” “Potential Applications in Gynecologic Oncology” “Single Port Surgery: Present and Future” November 8, 2010 2nd International Gynecology Invitational Symposium on Minimally Invasive Surgery Cleveland Clinic Conference Director “Single Port Robotics, Research and Clinical Practice” December 1-3, 2010 7th Annual Minimal Access Gynecology Ft. Lauderdale, Florida “Single-Port Laparoscopy from Research to Clinical Practice” “Managing the Complex Adnexal Mass” January 21-24, 2011 Trends and Technologies in Gynecologic Surgery and Oncology Gate Institute, Holy Cross Hospital Cambridge, Maryland “Single Port Access Surgery in Gynecology” “Laparoscopic Evaluation of Pelvic Mass” April 2-3, 2011 MINIMALLY INVASIVE SURGICAL LABS/COURSES Ohio State University-Covidien Columbus, Ohio August 22, 2009 University of Cincinnati-Covidien September 11, 2009 Pavia Hospital-Olympus San Juan, Puerto Rico October 9, 2009 MINIMALLY INVASIVE SURGICAL LABS/COURSES – continued Universidad Autónoma de Centroamérica-Costa Rica-Olympus October 19, 2009 Greater Baltimore Medical Center and Johns Hopkins Baltimore, Maryland Multispecialty Single Port Laparoscopic Surgery Symposium April 23, 2010 Cleveland Clinic-Covidien Cleveland, Ohio Single Incision Laparoscopic Surgery Course: Hysterectomy and other Gynecologic Applications July 17, 2010 Intuitive Surgical San Francisco, CA September 9-10, 2010 AAGL Global Congress of Minimally Invasive Gynecology Las Vegas, Nevada Innovations in Robotics and Laparoscopy in Oncology November 8, 2010 Single Port Laparoscopy November 9, 2010 Sirio Libanes Hospital Sao Paulo, Brazil LESS Training February 17-19, 2011 Hospital HIMA-San Pablo Caguas, PR Surgical preceptor for Minimally Invasive Surgery February 24-26, 2011 SGO 2011 Annual Meeting Orlando, Florida Advanced Robotic Surgery for the Gynecologic Oncologist March 4, 2011 Cleveland Clinic-Covidien Cleveland, Ohio Surgical Advancements in Gyn Surgery: Minimally Invasive Hysterectomy Options March 12, 2011 EDITORIAL BOARDS Editorial Board (2006-present): International Seminars in Surgical Oncology Editorial Panel (2006-present): Breast Cancer Reviews Editorial Board (2008-present): Diagnostic and Therapeutic Endoscopy Editorial Board (2010-present): “The Open Breast Cancer Journal” NATIONAL COMMITTEES Society of Gynecologic Oncology Candidate Representative – Breast committee American Society of Breast Disease ASBD Breast Education Committee The Susan G. Komen Breast Cancer Foundation Scientist Reviewer for National Grant Cycle 2006-2007 Scientist Reviewer for National Grant Cycle 2007-2008 Department of Defense, United States Grant Reviewer 2009 Journal of Minimally Invasive Gynecology Ad- hoc Reviewer 2010 International Journal of Gynecology and Obstetrics Ad- hoc Reviewer 2010 AAGL, Oncology Special Interest Group (SIG) Board Member 2010 PEER REVIEWED ABSTRACTS Escobar PF, Cohen L, Fishman D. Three-dimensional power Doppler ultrasound: Does it improve the detection of ovarian cancer? The Society of Gynecologic Oncologist; 32nd Annual Meeting, March 2000 Escobar PF, Lurain JF. Multiagent chemotherapy for high-risk gestational trophoblastic disease. Oral presentation at the XI World Congress on Gestational Trophoblastic Disease. Santa Fe, New Mexico, USA., October 27-31, 2001. PEER REVIEWED ABSTRACTS – continued Escobar PF, Cohen, L, Fishman D. Three-dimensional ultrasound and ovarian cancer. Oral presentation at the American Institute of Ultrasound in Medicine. 45th Annual Convention, March 2001. Fishman DA, Cohen L, Bozorgi K, Singh D, O’Donnell A, Donnely MA, O’Rourke J, Escobar PF, Lurain J. Ultrasound for detection of early stage epithelial ovarian carcinoma. 33rd Annual Meeting, Society of Gynecologic Oncologist, March 2001. Bhattacharyya N, Escobar PF, Banerjee S. A DNA repair gene-potential marker for ovarian cancer. The 8th World Congress on Advances in Oncology / 5th International Symposium on Molecular Medicine, October 2003, Crete, Greece. Escobar PF, Wang L, Bhattacharyya N, Banerjee S. Truncated Forms of DNA Polymerase in Serous Borderline Ovarian Tumors. Poster Presentation. American Association for Cancer Research. Annual Meeting – Washington, D.C., 2003. Escobar PF, Markman M, Rose P, Zanotti K, Webster K, Belinson JL. Phase 2 Trial of Carboplatin, Paclitaxel and Irinotecan in Ovarian, Fallopian Tube and Primary Peritoneal Cancers. Oral poster presentation. American Society of Clinical Oncology-Annual Meeting, Chicago, IL 2003. Escobar PF, Bhattacharyya N, Grundfest S, Crowe J, Banerjee S. Expression of Ubiquitously Expressed Transcript, a Novel Gene in Infiltrating Ductal Breast Carcinoma. Poster Presentation. AACR-Advances in Breast Cancer Research, Special Meeting, Huntington Beach, CA, 2003 Escobar PF, Belinson JL, White A, Shakhova NM, Feldchtein FI, Kareta MV, Gladkova ND. Diagnostic Efficacy of Optical Coherence Tomography in The Management of PreInvasive and Invasive Cancer of The Uterine Cervix and The Vulva. Presentation: Eurogin 2003 4/12-16, Paris France. Escobar PF, Belinson JL. Diagnostic Efficacy of Optical Coherence Tomography in the Management of Pre-Invasive and Invasive Cancer of the Uterine Cervix and the Vulva. November/December 2003, Volume 9, Issue 6. The Cancer Journal, The Radium Society. Escobar PF, Patrick RJ, Crowe JP. Second primary gynecologic neoplasms in patients with breast carcinoma. Poster Presentation, Society of Gynecologic Oncologist, 35th annual meeting, San Diego, CA 2004. Escobar PF, Elder JA, Patrick RJ, Lee KB, Ribicki LA, Crowe JP. Can hormone therapy use predict the clinical presentation of breast carcinoma. Poster Presentation, Society of Gynecologic Oncologist, 35th annual meeting, San Diego, CA 2004. PEER REVIEWED ABSTRACTS – continued Escobar PF, Bhattacharyya N, Zanotti K, Belinson JL, Banerjee S. Alterations of a DNA repair pathway gene in early stage ovarian cancer. Poster Presentation, Society of Gynecologic Oncologist, 35th annual meeting, San Diego, CA 2004. Feldchtein F, Gladkova N, Shakhova N, Zuccaro G, Shen B, Kareta M, Belinson J, Escobar PF. Clinical applications of optical coherence tomography: Cleveland Clinic Studies. Great Lakes Photonics Symposium June 7-11 2004. Escobar PF, Patrick RJ, Rybicki LA, Crowe JP. Prognostic Significance of Residual Breast Disease and Axillary Lymph Node Involvement After Primary Induction Chemotherapy for Locally Advanced Breast Cancer. American Society of Breast Surgeons, 5th Annual Meeting, Las Vegas, NV 2004. Saubhik Sengupta, Michael Berk, Rhonda Oates, Escobar PF, Jerome Belinson, Yan Xu. LPA receptors in ovarian cancer cells as potential therapeutic targets for blocking metastatic spread. AACR-Annual meeting, 2004. PF Escobar, R Patrick, Rybicki L, Grundfest-Broniatowski, KIM JA, Crowe JP. Clinical predictors of residual breast disease after primary induction chemotherapy. Journal of Clinical Oncology Suppl Vol22,No14S, 49s (Abstract No. 688),July 15,2004. Escobar PF, Patrick RJ, Rybicki LA, Crowe JP. Prognostic Significance of Residual Breast Disease and Axillary Lymph Node Involvement After Primary Induction Chemotherapy for Locally Advanced Breast Cancer. Cleveland Clinic Research Day 2004. Escobar PF, Patrick RJ, Rybicki LA, Crowe JP. Primary gynecologic neoplasms and clinical outcomes in patients diagnosed with breast carcinoma. American Society of Breast Disease, Las Vegas, NV, April 14-16,2005 L. A. Rojas-Espaillat, A. M. Otanes, W. R. Romero, Escobar PF, J. L. Belinson, L. B. Rojas. Clinical presentation and management of gestational trophoblastic disease: The experience in developing countries. The 2007 Annual Meeting on Women's Cancer. P. Roland, M. Stegman, M. Curcio, R. Boothby, E. Grendys, Escobar PF, J. Orr. The use of chemotherapy and hospice services in patients with ovarian cancer at the end of life. The 2007 Annual Meeting on Women's Cancer. Luis Rojas-Espaillat, Escobar PF, Chad Michener, Yaomin Xu, John Barnard, Jerome Belinson, Peter Rose, Charles Biscotti, Ronald Bukowski, Ram Ganapathi. Molecular profiling of purified ovarian carcinoma cells from ascites demonstrates a novel resource for biomarker and prognostic studies. The 2006 Annual Meeting on Women’s Cancer. PEER REVIEWED ABSTRACTS – continued Luis Rojas-Espaillat, Andrew Green, Escobar PF, Vernon Cannon, Mehdi Kebria, Jerome L. Belinson, Peter Rose, Chad Michener. Transmural intestinal involvement with ovarian, peritoneal or tubal cancer and the potential implications for therapies with bevacizumab. The 2006 Annual Meeting on Women’s Cancer. Escobar PF, Patrick RJ, Rybicki LA, Crowe JP. The 2003 staging system for breast cancer: results of stage migration on survival and future comparisons among stage groups. Society of Surgical Oncology San Diego, CA, March 23-26, 2006. Escobar PF, C. Merril, T.M. Menocal, S. Salenius, P.Y.Roland, E. Grendys, J.W.Orr . Disparities in Genetic Testing: A Descriptive Study of Cancer Genetic Services in a Community Hospital Comprehensive Cancer Program. European Society of Gynecologic Oncology, Berlin, Germany – Annual Meeting 2007 Escobar PF, C.A. Mantz, R. Ross, and S. Selinus. Accelerated Partial Breast Irradiation Using the Mammosite Device: Outcomes for patients treated for pure ductal carcinoma in situ. European Society of Gynecologic Oncology, Berlin, Germany – Annual Meeting 2007 Mantz C, Brown A, Kokal W, Escobar PF, Kowalsky J, Skowronski C. Favorable Acute Toxicity Utilizing the SAVI Partial Breast Brachytherapy Device: Initial Results of a Phase II Trial. 25th Annual Miami Breast Cancer Conference-2008. Partial Breast Brachytherapy Utilizing the Single-entry, Multicatheter SAVI Device in Patients with less than 7mm Skin-to-Cavity Distance: Favorable Acute Skin Toxicity Outcomes from a Phase II Trial. C. Cross, A. Brown, P. Escobar, W. Kokal, C. Mantz. Astro 2008. Rasool N, Drake R, Michener C, Escobar P, Rose P, Simpkins F. Phase II pilot Study of Bevacizumab in combination with Carboplatin and Paclitaxel for treatment of patients with recurrent/advanced-stage Endometrial Cancer: Interim analysis of safety and tolerability. Gynecol Oncol 116, March 2010, S2-S169. Podzielinski I, Quick A, DeSimone C, Chino J, Escobar P, Cohn D, Lopez M, AlvarezSecord A, Havrilesky L, Seamon L. Primary radiation therapy for medically inoperable patients with clinical stage I and II endometrial cancer. Gynecol Oncol 116, March 2010, S2-S169. Liotta M, Drake R, Yang B, Escobar P, Chiesa-Vottero A, Rose P. Vulvar intraepithelial neoplasia 3 simplex type is a distinct entity associated with invasive carcinoma of the vulva. Gynecol Oncol 116, March 2010, S2-S169. PEER REVIEWED ABSTRACTS – continued Escobar P, Nickles Fader A, Rojas-Espaillat L. Laparoendoscopic single-site riskreducing salpingo-oophorectomy: surgical outcomes and learning curve analysis. Gynecol Oncol 116, March 2010, S2-S169. Escobar PF, Nickles Fader A, Rojas-Espaillat L. A multi-institutional experience with laparoendoscopic single-site surgery in gynecologic oncology. Female Pelvic Medicine & Reconstructive Surgery, Vol 16, 2 suppl, March/April 2010. Escobar PF, Starks D, Nickles Fader A, Rojas-Espaillat L. Multi-institutional experience with single-port laparoscopic hysterectomy with staging for endometrial cancer. Society of Laparoendoscopic Surgeons, New York, NY, September 2010. Bedaiwy M, Escobar PF. Laparoendoscopic single-site (LESS) gonadal sparing surgery. American Society of Reproductive Medicine, Denver, Colorado, October 2010. Nickles Fader A, Seamon LG, Escobar PF, Frasure HE, Havrilesky LA, Zanotti KM, Alvarez SA, Rheaume S, Bogges J, Sfakanios G, Cantrell LA, Billow M, Cohn D, Fowler J, Gehrig PA. Surgical Staging for Type II Endometrial Cancer: Laparotomy or Minimally Invasive Surgery? Journal of Minimally Invasive Gynecology 17 (2010) S1S24. AAGL Annual Meeting Las Vegas, Nevada Nov 8-12, 2010. Bedaiwy MA, Starks D, Falcone T, Hurd W, Escobar PF. Laparo-endoscopic single site (LESS) surgery in patients with benign adnexal disease: A comparative study. Journal of Minimally Invasive Gynecology 17 (2010) S90-S108. AAGL Annual Meeting Las Vegas, Nevada, Nov 8-12, 2010. Starks D, Hood C, Fader AN, Frasure H, Escobar PF. Bilateral salpingo-oophorectomy by laparoscopic single site surgery (LESS) versus conventional laparoscopy: A comparison of short term outcomes and immediate costs. Journal of Minimally Invasive Gynecology 17 (2010) S90-S108. AAGL Annual Meeting Las Vegas, Nevada, Nov 812, 2010. Uppal S., Frumovitz M, Escobar PF, Ramirez PT. Laparo-endoscopic single site surgery in gynecology – a review of the literature and available technology. Journal of Minimally Invasive Gynecology 17 (2010) S178-188. AAGL Annual Meeting Las Vegas, Nevada, Nov 8-12, 2010. Liotta M, Escobar PF. Single-port para-aortic lymph node dissection. Gynecol Oncol 120 (2011) S2-S133. doi:10.1016/j.ygyno.2010.12.024. SGO Annual Meeting, Orlando, Florida, March 2011. PEER REVIEWED ABSTRACTS – continued Escobar PF, Frumovitz M, Soliman P, Frasure H, Starks D, Nickles Fader A, Ramirez P. Comparison of single-port laparoscopy versus standard laparoscopy versus robotic surgery in patients with endometrial cancer: A multi-institutional study. Gynecol Oncol 120 (2011) S2-S133. doi: 10.1016/j.ygyno.2010.12.039. SGO Annual Meeting, Orlando, Florida, March 2011. Bedaiwy MA, Escobar PF. Laparoendoscopic single-site surgery (LESS) in gynecology. SGS Annual Meeting, San Antonio, Texas, April 2011. Oral and Video Presentation. BOOK CHAPTERS Escobar PF, Chiesa-Votero A, Michener CM. Cervical Dysplasia, Sokol & Sokol Gynecology 2007. Rose PG, Escobar PF, Biscotti C, Flemming P. Uterine Sarcomas and Unusual Endometrial Carcinomas. Textbook of Uncommon Cancers Third Edition 2006. Orr JW, Escobar PF, Roland PY. Cervical Cancer. General Surgery: Principles and International Practice: Springer (January 2009) Nickles Fader A, Escobar P, Seamon L, Fowler J. Laparoscopic and Robotic Advances in Gynecologic Malignancies. Basic Advanced and Robotic Laparoscopy: Elsevier Inc., Philadelphia 2010. Paraiso MFR, Escobar PF. Laparoscopic and robotic-assisted total and supracervical hysterectomy. Walters MD, Barber MD(eds): Hysterectomy for Benign Disease (with CD). Elsevier Inc., Philadelphia, 2010. PEER-REVIEWED PUBLICATIONS Cohen LS, Escobar PF, Scharm C, Glimco B, Fishman DA. Three-dimensional power Doppler ultrasound improves the diagnostic accuracy for ovarian cancer prediction. Gynecol Oncol.2001 Jul;82(1):40-8. Escobar PF, Markman M, Zanotti K, Webster K, Belinson J. Phase 2 trial of pegylated liposomal doxorubicin in advanced endometrial cancer. J Cancer Res Clin Oncol. 2003 Nov;129(11):651-4. Escobar PF, Lurain JR, Singh DK, Bozorgi K, Fishman DA. Treatment of high-risk gestational trophoblastic neoplasia with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine chemotherapy. Gynecol Oncol 2003 91; 552-557. PEER-REVIEWED PUBLICATIONS - continued Escobar PF, Markman M, Rose P, Zanotti K, Webster K, Belinson JL. Phase 2 Trial of Carboplatin, Paclitaxel and Irinotecan In Ovarian, Fallopian Tube and Primary Peritoneal Cancers. Gynecol Oncol. 2004 (92) 192-196. Sandruck J, Escobar PF, Lurain JR, Fishman DA. Uterine leiomyosarcoma metastatic to the sphenoid sinus: a case report and review of the literature. Gynecol Oncol. 2004 (92) 701-704. Escobar PF, Belinson JL, White A, Shakhova NM, Feldchtein FI, Kareta MV, Gladkova ND. Diagnostic Efficacy of Optical Coherence Tomography in The Management of PreInvasive and Invasive Cancer of The Uterine Cervix and The Vulva. Int J Gynecol Cancer 2004, 14, 470-474. Sokol AI, Paraiso MFR, Cogan SL, Bedaiwy MA, Escobar PF, Barber MD. Prevention of vesicovaginal fistulas after laparoscopic hysterectomy with electrosurgical cystotomy in female mongrel dogs. Am J Obst Gynecol March 2004 • Volume 190 • Number 3. Wang L, Bhattacharyya N, Chelsea DM, Escobar PF, Banerjee S. A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype. Cancer Res. 2004 Nov 1;64(21):7673-7. Escobar PF, Baynes D, Crowe JP. Ductoscopy-assisted microdochectomy. Int J Fertil Womens Med. 2004 Sep-Oct;49(5):222-4. Escobar PF, VonGruenigen V. First case of a centropelvic recurrence after radical trachelectomy: literature review and implications for the preoperative selection of patients. Commentary. Women's Oncology Review 4 (3), pp. 209-210 Kefah Mokbel, Escobar PF and Tadaharu Matsunaga. Mammary ductoscopy: current status and future prospects. Eur J Surg Oncol. 2005 Feb;31(1):3-8. Escobar PF, Rojas-Espalliat L, Belinson JL. Optical diagnosis of cervical dysplasia. A promising strategy in low-resource settings. Int. J Gynecology and Obstetrics 2005 Apr;89(1):63-4. Green A, Escobar PF. Michener CM, VonGruenigen V. The Martius Flap Neovagina Revisited. Int. J Gynecol Cancer 2005, 15,964-966. Escobar PF, Michener CM, Rose PG. Second-look Operation Improves Survival in Suboptimal Debulked Stage III Ovarian Cancer. (Letter) Int J Gynecol Cancer. 2005 Nov-Dec;15(6):1258; author reply 1259. Green AE, Escobar PF, Stellato T, Hallowell P, von Gruenigen VE. Bariatric Surgery in the field of gynecologic oncology. Int J Gynecol Cancer. 2005 Nov-Dec;15(6):1254-7. PEER-REVIEWED PUBLICATIONS - continued Escobar PF, Rose P. Taxotere in Ovarian Cancer. Expert Opin Pharmacother. 2005 Dec;6(15):2719-26. Escobar PF, Patrick RJ, Sebek B, Procop G, Rice J, Crowe JP. Schistosomiasis presenting with microcalcifications on mammography. Breast J. 2005 NovDec;11(6):489-90. Noriega-Rangel J, Escobar PF. Anatomical and Surgical Considerations for Minimally Invasive Surgery of Adnexal Mass Lesions. MedUNAB Vol 8 No.8 Agosto 2005. Sarakbi WA, Escobar PF, Mokbel K.The potential role of breast ductoscopy in breast cancer screening. Int J Fertil Womens Med. 2005 Sep-Oct;50(5 Pt 1):208-11. Escobar PF, Keith L, Reeves J. Long-term follow-up of isolated pathologic and physiologic abnormalities preceding breast cancer. Int J Fertil Womens Med Nov-Dec; 50 -2005 Escobar PF, Crowe JP, Matsunaga T, Mokbel K. Clinical Applications of Mammary Ductoscopy. American Journal of Surgery.191 (2006) 211–215. Al Sarakbi W, Worku D, Escobar PF, Mokbel K. Breast papillomas: current management with a focus on a new diagnostic and therapeutic modality. Int Semin Surg Oncol. 2006 Jan 17;3(1):1 Escobar PF, Patrick R, Rybicki L, Al-Husaini N, Michener CM, Crowe JP. Primary Gynecologic Neoplasms and Clinical Outcomes in Patients Diagnosed with Breast Carcinoma. Int J Gynecol Cancer 2006, 16 (Suppl. 1), 118–122 Escobar PF, Patrick RJ, Rybicki LA,Grundfest-Broniatowski SF, Kim JA, Crowe JP. Prognostic Significance of Residual Breast Disease and Axillary Lymph Node Involvement in Patients with Locally Advanced Breast Cancer. Annals of Surgical Oncology 2006 Jun;13(6):783-7. Epub 2006 Apr 12. Crowe JP, Patrick RJ, Rybicki LA, Escobar PF, Weng DE, Budd GT, Tubbs RR, Procop GW, Hicks DG. A Data Model to Predict HER2 Status in Breast Cancer Based on the Clinical and Pathologic Profiles of A Large Patient Population at a Single Institution. The Breast 2006 May 19. Escobar PF, Patrick RJ, Sebek B, Procop G, Rice J, Crowe JP. Multiple Myeloma of the Breast. Breast J. 2006 Jul-Aug;12(4):387-8. PEER-REVIEWED PUBLICATIONS - continued Escobar PF, L. Rojas-Espaillat, S. Tisci, C. Enerson, J. Brainard, J. Smith, N. J.Tresser, F.I. Feldchtein, L.B. Rojas, J.L.Belinson. Optical Coherence Tomography as a Diagnostic Aid to Visual Inspection and Colposcopy for Pre-Invasive and Invasive Cancer of the Uterine Cervix. Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1815-22. Kim KS, Sengupta S, Berk M, Kwak YG, Escobar PF, Belinson J, Mok S, Xu Y. Hypoxia Enhances Lysophosphatidic Acid Responsiveness in Ovarian Cancer Cells and Lysophosphatidic Acid Induces Ovarian Tumor Metastasis In vivo.Cancer Res. 2006 Aug 15;66(16):7983-90. Kim KS, Sengupta S, Berk M, Kwak YG, Escobar P, Belinson J, Mok S, Xu Y. Lysophosphatidic acid down regulates tissue inhibitor of metalloproteinase’s, which are negatively involved in lysophosphatidic acid-induced cell invasion. Oncogene. 2006 Nov 27 Escobar PF, Breast duct micro-endoscopy. (Letter) Breast. 2006 Dec;15(6):704. Epub 2006 Aug 9. Crowe JP, Patrick RJ, Rybicki LA, Budd GT, Escobar PF, Tubbs RR, Hicks DG. HER2 status in bilateral breast cancer. Int J Fertil Womens Med. 2006 Sep-Oct;51(5):219-23. McBee WC, Escobar PF, Falcone T. Which ovarian masses need intervention? Cleve Clin J Med. 2007 Feb;74(2):149-57. Escobar PF, Patrick RJ, Rybicki LA, Weng DE, Crowe JP.The 2003 revised TNM Staging system for breast cancer:Results of Stage re-classification on survival and future comparisons among stage groups. Ann Surg Oncol. 2007 Jan;14(1):143-7. Epub 2006 Oct 22. McBee WC, Emery SP, Escobar PF. Heterotopic pregnancy presenting at 18 weeks gestational age. J. Repro. Med 2007 Aug; 52(8). Escobar PF. Case study. Metastasis to the breast from extramammary sites. Breast Cancer Reviews, Issue No 16, Summer 2007, ISSN 1747-8138. Escobar PF, Howard JL, Kelly J ,Roland PY, Grendys E, Dosoretz D , Orr JW. Uretero-Arterial Fistulas after Radical Pelvic Surgery: Pathogenesis, Diagnosis and Therapeutic Modalities. Int J Gynecol Cancer 2007 Vol 6. Escobar PF,Orr JW, Roland PY, Grendys EC. Ovarian cancer at young age: the contribution of mismatch-repair defects in a population-based series of epithelial ovarian cancer before age 40 (Letter). Int J Gynecol Cancer 2007 Vol 6. PEER-REVIEWED PUBLICATIONS - continued Orr JW, Naumann W, Escobar PF, "Attitude is a little thing that makes a big difference" Winston Churchill. Gynecol Oncol. 2008 Apr;109(1):147-51; author reply 151-3. Sengupta S, Michener CM, Escobar PF, Belinson J, Ganapathi R.Ovarian Cancer Immuno-reactive Antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion. Gynecol Oncol. 2008 Mar 5. Orr J Jr, Kelley J 3rd, Dizon D, Escobar P, Fleming E, Gemignani M, Hetzel D, Hoskins W, Kieback D, Kilgore L, LaPolla J, Lewin S, Lucci J, Markman M, Pothuri B, Powell CB, Tejada-Berges T. Society of gynecologic oncologists position paper: breast cancer care. Gynecol Oncol. 2008 Jul;110(1):7-12. Escobar PF, ORR JW. HPV Vaccine. The Female Patient 2008, Vol. 33, No.11:18-22 Escobar PF, Nickles Fader A, Paraiso MP, Kaouk JH, Falcone T. Robotic Assisted Laparo-Endoscopic Single Site Surgery in Gynecology: Initial Report and Technique. J Minim Invasive Gynecol. 2009 Sept-Oct; 16(5): 589-91. Nickles Fader A, Escobar PF. Laparoendoscopic Single-Site Surgery (LESS) in Gynecologic Oncology: Technique and Initial Report. Gynecol Oncol. 2009 Aug; 114(2): 157-61. Escobar PF. Office Hysteroscopy in HNPCC Patients. Int J Gynecol Cancer. 2009 Aug; 19(6):1152. Liotta M, Rose PG, Escobar PF. Pulmonary hypertension in two patients treated with bevacizumab for recurrent ovarian cancer. Gynecol Oncol. 2009 Nov; 115(2):308-9 Escobar PF, Nickles Fader A. Promising minimal surgical approach for gynecologic disease. Doi:10.1016/j.ygyno. 2009.07.018. Nickles Fader A, Ueda SM, Escobar PF. New Minimally Invasive Treatment Options in Gynecologic Oncology. US Obstet and Gyn (In Press). Escobar PF, Bedaiwy M, Nickles Fader A, Falcone T. Laparo-Endoscopic Single Site (LESS) Surgery in Patients with Benign Adnexal Disease. Fertil Steril. 2010 Apr; 93(6):2074.e7-2074.e10. Epub 2010 Jan 25. Escobar PF, Nickles Fader A, Rojas-Espaillat L. A Multi-Institutional Experience with Laparoendoscopic Single-Site Surgery in Gynecologic Oncology. Oral poster presentation. SGS 36th Annual Scientific Meeting, Tucson, Arizona, April 12, 2010. Escobar PF. Laparoendoscopic single-site (LESS) lymphadenectomy in Gynecologic Oncology: Technique and Instrumentation (Accepted Int J Gynecol Cancer 2010). PEER-REVIEWED PUBLICATIONS - continued Escobar PF, Starks DC, Nickles Fader A, Barber M, Rojas-Espaillat L. Single-Port Risk Reducing Salpingo-Oophorectomy with and without Hysterectomy: Surgical Outcomes and Learning Curve Analysis. Gynecol Oncol. 2010 Oct;119(1):43-7. Escobar PF, Nickles Fader A, Rasool N, Rojas-Espaillat L. Single-Port Laparoscopic Pelvic and Para-Aortic Lymphadenectomy: Development of a Technique and Instrumentation. Int J Gynecol Cancer 2010 Oct;20(7): 1268-73. Nickles Fader A, Cohen S, Escobar PF, Gunderson C. Laparoendoscopic Single-Site Surgery (LESS) in Gynecology. Curr Opin Obstet and Gyn 2010 Aug;22(4): 331-8. Escobar PF, Starks D, Nickles Fader A, Catenacci M, Falcone T. Single Port and Natural Orifice Surgery in Gynecology. Fertil Steril 2010 Dec;94(7): 2497-502. Escobar PF, Kaouk JH, Geisler D, Kroh M, Nickles Fader A, Falcone T. Single-Port Laparoscopy, NOTES, and Endoluminal Surgery. Diagnostic and Therapeutic Endoscopy, Vol 2010, Article ID 710130, 2 pages, 2010. doi:10.1155/2010/710130 Fader AN, Rojas-Espaillat L, Okechukwu I, Grumbine F, Escobar P. Laparoendoscopic Single-Site Surgery (LESS) in Gynecology: A multi-institutional evaluation. Am J Obstet Gynecol. 2010 Nov;203(5):501.e1-6. Escobar PF, Haber GP, Kaouk J, Kroh M, Chalikonda S, Falcone T. Single-Port Surgery: Laboratory Experience with the da Vinci “VESPA” Platform”. (Accepted JSLS 2010) Bedaiwy MA, Escobar PF. Laparoendoscopic Single Site (LESS) Gonadal Sparing Surgery. Fertil Steril Vol 94, No 4, Supplement, September 2010. Haber GP, White M, Autorino R, Escobar P, Kroh M, Chalikonda S, Khanna R, Forest S, Yang B, Altunrende F, Stein R, Kaouk J. Novel Robotic da Vinci Instruments for Laparoendoscopic Single-Site Surgery. Urology 2010 Dec;76(6): 1279-82. Escobar PF, Kebria M, Falcone T. Evaluation of a novel single-port robotic platform in the cadaver model for the performance of various procedures in gynecologic oncology. Gynecol Oncol. 2011 Mar;120(3):380-4. doi: 10.1016/j.ygyno.2010.11.005 Nickles Fader A, Levinson K, Gunderson C, Winder A, Escobar PF. Laparoendoscopic Single-Site Surgery in Gynecology: A New Frontier in Minimally Invasive Surgery. J Minim Access Surg. 2011 Jan;7(1):71-7. PEER-REVIEWED PUBLICATIONS - continued Bedaiwy MA, Escobar PE, Pinkerton J, Hurd W. Laparoendoscopic single-site salpingectomy in isthmic and ampullary ectopic pregnancy: preliminary report and technique. J Minim Invasive Gynecol, 2011 Mar-Apr; 18(2):230-3. doi: 10.1016/j.jmig.2010.12.004 Liotta M, Escobar PF. Hormone replacement after breast cancer: is it safe? Clin Obstet Gynecol 2011 Mar;54(1):173-9. Frumovitz M, Escobar P, Ramirez PT. Minimally invasive surgical approaches for patients with endometrial cancer. Clin Obstet Gynecol. 2011 Jun;54(2):226-34. REFERENCES Jerome L. Belinson, M.D. The Cleveland Clinic Fellowship Director Gynecologic Oncology Joseph P. Crowe, M.D. The Cleveland Clinic Director Breast Center, Chief Breast Surgeon Peter Rose, M.D. The Cleveland Clinic Chief, Section of Gynecologic Oncology John R. Lurain, M.D. Northwestern University Fellowship Director, Gynecologic Oncology 4/11