Download SELECTED PUBLICATIONS: Nanette H

SELECTED PUBLICATIONS: Nanette H. Bishopric, M.D., F.A.C.C.
Bishopric N (2005). Evolution of the heart from bacteria to man. Ann New York Acad
Sci., in press.
Webster KA, Graham RM, Bishopric NH (2005). BNip3 and signal-specific programmed
death in the heart. J Mol Cell Cardiol. 38:35-45.
Turner MS, Haywood GA, Andreka P, You L, Martin PE, Evans WH, Webster KA,
Bishopric NH (2004). Reversible connexin 43 dephosphorylation during hypoxia and
reoxygenation is linked to cellular ATP levels. Circ Res. 95:726-33.
Graham RM, Frazier DP, Thompson JW, Haliko S, Li H, Wasserlauf BJ, Spiga MG,
Bishopric NH, Webster KA (2004). A unique pathway of cardiac myocyte death caused
by hypoxia-acidosis. J Exp Biol. 207(Pt 18):3189-200.
Andreka P, Tran T, Webster KA, Bishopric NH (2004). Nitric oxide and promotion of
cardiac myocyte apoptosis. Mol Cell Biochem. 263:35-53.
Miller TE, Estrella E, Myerburg RJ, Garcia de Viera J, Moreno N, Rusconi P, Ahearn
ME, Baumbach L, Kurlansky P, Wolff G, Bishopric NH (2004). Recurrent third-trimester
fetal loss and maternal mosaicism for long-QT syndrome. Circulation 109:3029-34.
Andreka P, Aiyar N, Olson LC, Wei JQ, Turner MS, Webster KA, Ohlstein EH,
Bishopric NH (2002). Bucindolol displays intrinsic sympathomimetic activity in human
myocardium. Circulation 105:2429-34.
Dougherty CJ, Kubasiak LA, Prentice H, Andreka P, Bishopric NH, Webster KA (2002).
Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after
oxidative stress. Biochem J. 362(Pt 3):561-71.
Bishopric NH, Andreka P and Webster KA. Apoptosis and risk with the use of calcium
antagonists. In: Calcium Channel Antagonists in Clinical Medicine, 3rd edition, ed. M.
Epstein. Hanley and Belfus, Philadelphia, 2002.
Bishopric NH, Andreka P, Slepak T, Webster KA (2001). Molecular mechanisms of
apoptosis in the cardiac myocyte. Curr Opin Pharmacol.1:141-50.
Andreka P, Zang J, Dougherty C, Slepak TI, Webster KA, Bishopric NH (2001).
Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis. Circ
Res. 88:305-12.
Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH
(2001). Control of cardiac-specific transcription by p300 through myocyte enhancer
factor-2D. J Biol Chem. 276:7575-85.
Webster KA, Prentice H, Bishopric NH. Redox regulation of zinc finger transcription
factors. In: Antioxidants and Redox Signaling, 3: 535-548, 2001.
Webster KA, Discher DJ, Hernandez O, Yamashita K and Bishopric NH. A glycolytic
pathway to apoptosis of hypoxic cardiac myocytes: molecular pathways of increased acid
production. In: Oxygen Sensing: Molecules to Man, S. Lahiri and N. Prabhakar, eds.
Kluwer. Academic Press, London UK, 2000.
Webster KA and Bishopric NH. Molecular aspects and gene therapy prospects for
diastolic failure. In: Cardiology Clinics, SJ Kovacs, ed., W.B. Saunders and Co. Volume
18(3): 621-635, 2000.
Webster KA, Discher DJ, Kaiser S, Hernandez O, Sato B, Bishopric NH. Hypoxiaactivated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is
independent of p53 (1999). J Clin Invest. 104:239-52.
Ing DJ, Zang J, Dzau VJ, Webster KA, Bishopric NH (1999). Modulation of cytokineinduced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. Circ Res.84:21-33.
Wu CF, Bishopric NH, Pratt RE (1997). Atrial natriuretic peptide induces apoptosis in
neonatal rat cardiac myocytes. J Biol Chem. 272:14860-6.
Eschenhagen T, Fink C, Remmers U, Scholz H, Wattchow J, Weil J, Zimmermann W,
Dohmen HH, Schafer H, Bishopric N, Wakatsuki T, Elson EL (1997). Three-dimensional
reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle
model system. FASEB J. 11:683-94.
Bishopric NH, Zeng GQ, Sato B, Webster KA (1997). Adenovirus E1A inhibits cardiac
myocyte-specific gene expression through its amino terminus. J Biol Chem. 272:2058494.
Haywood GA, Tsao PS, von der Leyen HE, Mann MJ, Keeling PJ, Trindade PT, Lewis
NP, Byrne CD, Rickenbacker PR, Bishopric NH, Cooke JP, McKenna WJ and Fowler
MB (1996). Expression of inducible nitric oxide synthase in human heart failure.
Circulation 93: 1087-1094.
Wu XS, Bishopric NH, Discher DJ, Murphy BJ and Webster KA (1996). Physical and
functional sensitivity of zinc finger transcription factors to redox change. Mol Cell Biol
16(3): 1035-1046.
Bodi I, Bishopric NH, Discher DJ, Wu X, Webster KA (1995). Cell-specificity and
signaling pathway of endothelin-1 gene regulation by hypoxia. Cardiovasc Res. 30:97584.
Webster KA, Discher DJ, and Bishopric NH (1994). Regulation of Fos and Jun
immediate-early genes by redox or metabolic stress in cardiac myocytes. Circ Res 74:
679-686.
Webster KA, Discher DJ, and Bishopric NH (1993). Induction and nuclear accumulation
of Fos and Jun proto-oncogenes in hypoxic cardiac myocytes. J Biol Chem 268: 1685216859.
Bishopric NH, Jayasena V and Webster KA (1992): Positive regulation of the skeletal aactin gene by Fos and Jun. J. Biol. Chem 267: 25535-25540.
Bishopric NH, Sato B and Webster KA (1992): ß-adrenergic regulation of a myocardial
actin gene via a cyclic AMP-independent pathway. J Biol Chem 267: 20932-20936.
Webster KA and Bishopric NH (1992): Molecular regulation of cardiac myocyte
adaptations to chronic hypoxia. J Mol Cell Cardiol 24: 741-752.
Sartorelli V, Hong, N.A., Bishopric NH, and Kedes LH (1992): Myocardial activation of
the human cardiac a-actin promoter by helix-loop-helix proteins. Proc Natl Acad Sci 89:
4047-4051.
Bishopric NH and Kedes LH (1991). Adrenergic regulation of the skeletal a-actin gene
promoter during myocardial cell hypertrophy. Proc Natl Acad Sci 88: 2132-2136.
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Abstracts
TE Miller, TV Pham, MJ Smets, L You, A Bassett, P Kurlansky, LL Baumbach-Reardon,
RJ Myerburg, NH Bishopric (2004). Novel mutations (S338F and F339S) in cardiac
KvLQT1 S6 Domain hinder KvLQT1-KCNE1 co-assembly. Circulation 110(17): III-16
#67. (AHA 11/2004).
Li HF, Bishopric NH, Webster KA (2004). C-Jun N-terminal Kinase (JNK) promotes
apoptosis at reperfusion under energy-limiting conditions by phosphorylating IRS-1 and
blocking insulin signaling to Akt/PKB. Circulation 110(17):III-58 #268. (AHA 11/2004).
L Baumbach, T Miller, H Travers, L You, ME Ahearn, W Lanier, E Estrella, S Elliott, R
Myerburg, N Bishopric (2004). Complexities of molecular diagnosis for ventricular
arrhythmias. American Society of Human Genetics 54th Annual Meeting Abstracts
(Toronto, Canada), October 26-30, 2004, p. 390, #2141.
Wei JQ, Slepak T, Pessanha M, Faysal J, Andreka P, Webster KA and Bishopric NH
(2003). Transcription coactivator p300 is a critical regulator of cardiac hypertrophy.
Miami Nature Biotechnology Short Reports, 14:51.
Miller T, Estrella E, You LJ, Lanier W, Young ML, Baumbach L, Myerburg RJ,
Bishopric NH (2003). Compound heterozygous mutation of both alpha and beta subunits
of IKs is associated with Romano-Ward Syndrome. Circulation 108:IV-182.
Miller T, Estrella E, You LJ, Lanier W, Young ML, Baumbach L, Myerburg RJ,
Bishopric NH (2003). Compound heterozygous mutation of both alpha and beta subunits
of IKs is associated with Romano-Ward Syndrome. American J for Human Genetics
(Suppl) 73(5): 552, #2251 (ASHG 11/03).
Tran TH, Andreka P, Dougherty C, Webster KA and Bishopric NH (2003). C-Jun Nterminal kinase protects cardiomyocytes against stress-induced apoptosis by direct
interaction with APAF-1. Miami Nature Biotechology Short Reports 14:64.
Wei JQ, Pessanha M, Faysal J, Webster KA, Bishopric NH (2002). Adenovirus target
protein p300 mediates cardiomyopathy and heart failure. Circulation 106:II-231-232.
Turner MS, Haywood GA, Dougherty C, Andreka P, Evans WH, Webster KA, Bishopric
NH (2002). Regulation of connexin 43 phosphorylation by ATP during
hypoxia/reoxygenation and metabolic inhibition in cardiac myocytes. Circulation 106:II313.
Baumbach L, Miller T, Estrella E, Ahearn ME, Kurlansky P, Myerburg R, Bishopric NH
(2002). A cardiac ion channel (KVLQT1) mutation predisposes to drug-induced
arrhythmia: direct evidence of genetic susceptibility to an acquired disorder. Platform
presentation, Amercian Society of Medical Genetics Annual Meeting, San Diego, CA.
Dougherty CJ, Kubasiak LA, Discher DJ, Prentice H, Bishopric NH, Webster KA (2001).
Coupled electron flow through mitochondrial complex II initiates a survival pathway
through c-Jun N-Terminal kinase in reoxygenated cardiac myocytes. Circulation 104:
Supp 17:445.
Andreka P, Dougherty CJ, Slepak TI, Webster KA, Bishopric NH (2001). The
apoptosome is a target of Jun kinase in nitric oxide-induced cardiac myocyte apoptosis.
Circulation 104: Supp 17:681.
Gullestad L, Haywood G, Aass H, Ross H, Yee G, Geiran O, Kjekshus J, Simonsen S,
Fowler M, and Bishopric N. (1996) Expression of angiotensin II receptor subtypes in
heart transplant recipients. (Presented at European Society of Cardiology, Birmingham,
U.K.)
Wu XS, Discher DJ, Bishopric NH, Webster KA (1996). Developmental regulation of
redox-sensitive Sp1 isoforms in the heart. Circulation 94: I-483.
Wu CF, Pratt RE, Bishopric NH (1996). Cyclic AMP and cyclic GMP exert opposing
effects on cardiac myocyte apoptosis. Circulation 94: I-282.
Zeng GQ, Webster KA, Sato B, Bishopric NH (1996). E1A induces both p53-dependent
and -independent apoptosis in cardiac myocytes. Circulation 94: I-158, 1996.