Download Mind-Body Medicine in Women*s Cancers and Health

Mind-Body Medicine in
Women’s Cancers and
Health
presented by Sat Dharam Kaur ND
What is Mind-Body Medicine?
 uses awareness, relaxation, concentration, and
intentional redirection of thoughts and emotions (words,
images, feelings) to influence physical health
 the natural healing capacity within us is our most
powerful ally in becoming and staying well
 thoughts, feelings, beliefs and attitudes affect the
physical body positively or negatively
 exercise, posture, yoga, breathing practices – affect our
mental-emotional state. There is a reciprocal
relationship between body and mind.
The Language of Mind-Body Medicine
“The brain and peripheral nervous system, the endocrine and
immune systems, and indeed, all the organs of our body
and all the emotional responses we have, share a common
chemical language and are constantly communicating with
one another.” Dr. James Gordon, Mind-Body specialist, Harvard
psychiatrist, founder/director of the Center for Mind-Body Medicine
Our thoughts, consisting of words, images, body sensations
and emotional feelings, are translated into the common
chemical language of the:
1) nervous
system – neurotransmitters
2) endocrine
system – hormones
3) immune system
– cytokines
Together, these thoughts, chemicals and systems
inform our health.
Mind-Body Therapies
 Biofeedback
 Cognitive Behav Therapy
 Relaxation Techniques
 Expressive Arts
(Dance, Art, Music)
 Emotional Freedom
Technique
 Visualization
 NMT/BodyTalk
 Mindfulness
 Breathing Exercises
 Meditation
 Yoga/Pilates
 Prayer, Sacred Ritual
 Tai Chi
 Hypnosis
 Qigong
 Reiki, Therapeutic Touch
 Support Groups
Mechanisms by Which Mind-Body
Medicine Affects Cancer
 nervous, endocrine and immune system are intimately
linked = psychoneuroimmunoendocrine system
 the cells of each of the 3 systems can express receptors for
the mediators (cytokines, hormones and neurotransmitters)
of the other 2 systems
 immune, nervous and endocrine products coexist in
lymphoid, endocrine and neural tissue
 endocrine and neural mediators can affect the immune
system because the immune organs are irrigated and
innervated by them.
 immune mediators can affect endocrine and neural function.
Some leukocytes pass blood-brain barrier.
Mechanisms by Which Mind-Body
Medicine Affects Cancer
 immune mediators, such as cytokines, affect the brain
 CNS shows an immune response via glial cells, ependymal
cells or neurons
 immune cells can produce neurotransmitters and hormones
 nervous and endocrine cells can produce cytokines
 thus stress and anxiety make us more vulnerable to
infection, cancer and autoimmune disease
 wholeness, self-empowerment, joy and hope help us
overcome immune related diseases and be healthier
 health results when the nervous, immune and endocrine
systems and their mediators are in balance
What are Cytokines?
 soluble messengers that immune cells produce to
either attack an invading organism or talk to other
immune cells
 form part of the immune response that can either assist
development of cancer or inhibit it
 are involved in chronic inflammatory pathways
associated with cancer development
 cytokines may try to promote tissue repair, but
inadvertently promote tumour growth and invasiveness
Cytokines and Cancer
 tumours contain immune cells and both pro and antiinflammatory cytokines
 pro-inflammatory cytokines are associated with fatigue,
depression, cognitive impairment, anorexia and
cachexia, pain, toxicity of treatment and resistance to
treatment
 physical activity modifies cytokine levels and decreases
fatigue in cancer patients
8, 887-899 (Nov 2008)
Nature Reviews Cancer
Cytokines and Cancer
Tumour Microenvironment
Pro-tumorigenic Cytokines (Th2)
Anti-tumorigenic Cytokines (Th1)
TNF-α,TGF-β, IL-4, IL-5, IL-6, IL-8, IL-10,
IL-13
IL-2, IFN-Y, IL-12, IL-18
promoted by stress, depression,
anxiety, social isolation, high cortisol,
obesity, infection, high-intensity
exercise, trauma
promoted by sleep, yoga, tai chi,
mindfulness, meditation, relaxation,
moderate exercise, support groups,
positive reframing, weight loss
Cytokines and Th1/Th2 Immunity
 Cytokines play an important role in both directing tumour
progression or improving anti-tumour immunity
 they regulate key immune pathways through the balance
between cell-mediated (Th1) and humoral (Th2)
responsiveness.
 deregulation between Th1 and Th2 immune response is
associated with cancer progression
 loss of Th1-type responses are evident in tumour bearing
animals and cancer patients
Bioscience 13, 6255-6268, May 1, 2008
Frontiers in
Tai Chi Intervention Affects Cytokines
 A controlled study was performed in 32 lung cancer survivors who
practiced Tai Chi during a 16-week period. The percentages of
interferon γ-producing CD3 T lymphocyte cells (T1) and interleukin
4-producing CD3 T lymphocyte cells (T2) and CD3 T lymphocyte
subsets (T helper cell type 1 [TH1], TH2; cytotoxic T cell type 1
[Tc1], Tc2) were determined as well as levels of hormones βendorphin, general catecholamines, and cortisol.
 Whereas the T1/T2 and Tc1/Tc2 ratios in the control group
decreased in the natural course of postsurgical non-small cell
lung cancer recovery (both P < .01), no changes were observed in
the Tai Chi group. The differences in changes in the T1/T2 and
Tc1/Tc2 ratios (both P < .01) and in T2 and Tc2 levels (P < .01)
between the 2 groups were significant. The cortisol level increased
in the control group (P < .05) but not in Tai Chi group.
Tai Chi Intervention Affects Cytokines cont’d
 A 16-week Tai Chi exercise significantly diminished the
magnitude of the decreased T1/T2 ratio in the natural
course of recovery in a population of postsurgical nonsmall cell lung cancer survivors.
 Tai Chi may have a role in ameliorating the imbalance
between humoral and cellular immunity, potentiating
human immunity against tumors. Cancer Nurs. 2013
Jul-Aug;36(4):E27-34
Yogic Meditation Decreases
Pro-Inflammatory Cytokines
 one study found that brief daily yogic meditation may reverse the pattern
of increased NFκB-related transcription of pro-inflammatory cytokines in
leukocytes
 yoga therapy has the potential to reduce cancer stem cell survival, selfrenewal and tumor growth by modifying the tumor micro-environment
through various mechanisms such as;
1) reducing hypoxia and cancer stem cell activity by enhanced
oxygenation
2) promoting NK cell activity directly (or indirectly through down
regulating NFκB expression), thereby enhancing NK cell mediated
cancer stem cell lysis
3) by minimizing abnormal expressions or activities of various
hormones, cytokines, chemokines and tumor signaling pathways. J
Stem Cells 2012;7(4):261-7
Yoga Practice Increases Vitality
and Decreases Inflammation
 Breast cancer treatment with chemotherapy and radiation often results in
fatigue, decreased vitality and increased inflammation
 Inflammation can be measured by assessing the pro-inflammatory
cytokines IL-6, TNF-α, and IL-1β.
 Chronic inflammation is associated with cancer growth and recurrence.
 A controlled study of 200 breast cancer survivors who practiced hatha yoga
for 90 minutes twice weekly for 12 weeks, found that yoga practice
improved vitality, decreased fatigue and decreased IL-6, TNF-α, and IL-1β
in comparison to a control group.
 The more frequently women practiced, the greater the increase in vitality
and decrease in fatigue.
 Regular yoga practice has substantial health benefits due to its ability to
decrease fatigue, increase vitality and decrease inflammation.
Oncol. 2014 Apr 1;32(10):1040-9.
J Clin
Mindfulness Meditation Decreases
Pro-Inflammatory Cytokines
 Early stage breast cancer patients, who did not receive
chemotherapy, self-selected into an 8-week MBSR
program or into an assessment only, control group.
 At the first assessment (i.e., before MBSR start),
reductions in peripheral blood mononuclear cell NK cell
activity (NKCA) and IFN-gamma production with
increases in pro-inflammatory IL-4, IL-6, and IL-10
production and plasma cortisol levels were observed
for both the MBSR and Non-MBSR groups of
breast cancer patients.
Obesity, Exercise and
Cytokines
 obesity is characterized by chronic mild inflammation with
increased CRP and fibrinogen Int J Obes Relat Metab Disord 2001
Oct;25(10):1407-15
 adipose tissue functions as a secretory organ for
inflammatory markers, including TNF-α, IL-6, IL-8, and
VEGF Biochem Soc Trans 2005 Nov;33(Pt 5):1078-81
 increased production and release of TNF-α, IL-6, and IL-8
by adipose tissue are associated with degree of obesity
 diet and/or exercise induced weight loss is associated with a
reduction in these inflammatory factors Am J Clin Nutr 2004
Apr;79(4):544-51.
Obesity, Exercise and
Cytokines
 exercise interventions of moderate intensity led to significant
reductions in circulating levels of IL-6, TNF-α, and IL-8 in
healthy individuals Prev Med 2005 Apr;40(4):432-7
 the biological response to exercise was found to be
dependent on the intensity and duration of the activity
Sports
Med 2001 Feb;31(2):115-44.
 an acute session of high intensity exercise induced
significant increases in interleukin (IL)-6, IL-8, IL-10, tumor
necrosis factor-α, and monocyte chemotactic protein-1
compared with rest. J Inflamm Res 2014 Jan 9;7:9-17
Yoga Helps Manage Breast Cancer
Related Lymphedema
 Secondary arm lymphedema affects at least 20% of women after treatment
for breast cancer, requiring lifelong professional treatment and selfmanagement.
 Participants were randomised to receive either an 8-
week yoga intervention (n = 15), consisting of a weekly 90-minute teacherled class and a 40-minute daily session delivered by DVD, or to a usual
care wait-listed control group (n = 13).
 Primary outcome measures were: arm volume of lymphedema measured
by circumference and extra-cellular fluid measured by bioimpedance
spectroscopy.
 Secondary outcome measures were: tissue induration measured by
tonometry; levels of sensations, pain, fatigue, and their limiting effects all
measured by a visual analogue scale (VAS) and quality of life based on the
Lymphedema Quality of Life Tool (LYMQOL). Measurements were
conducted at baseline, week 8 (post-intervention) and week 12 (four weeks
after cessation of the intervention).
Yoga Helps Manage Breast Cancer
Related Lymphedema
 At week 8, the intervention group had a greater decrease in
tissue induration of the affected upper arm compared to the
control group, as well as a greater reduction in the symptom
sub-scale for QOL. There was no difference in arm volume of
lymphedema or extra-cellular fluid between groups at week 8;
however, at week 12, arm volume increased more for the
intervention group than the control group (p = 0.032).
 Yoga may reduce lymphedema when practiced regularly. BMC
Compl Altern Med 2014 Jul 1;14:214
Yoga Improved Wound Healing After
Breast Cancer Surgery
 distress in breast cancer patients can delay recovery from
surgery
 one study of breast cancer patients compared a postsurgery 4 week yoga program (33 women) vs supportive
therapy and exercise rehabilitation (36 women)
 the yoga group had a decreased duration of hospital stay,
decreased days of drain retention and suture removal
compared to controls
 the yoga group had a decrease in TNF-alpha levels
following surgery Int J Yoga 2008 Jan;1(1):33-41
Relaxation and Visualization
Improves Wound Healing
 60 patients were randomised to receive standard care or standard care
plus a 45-min psychological intervention that included relaxation and
guided imagery with take-home relaxation CDs for listening to for 3 days
before and 7 days after surgery.
 In both groups tubes were inserted during surgery and removed at 7
days after surgery and analysed for hydroxyproline as a measure of
collagen deposition and wound healing.
 Intervention group patients showed a reduction in perceived stress
compared with the control group, controlling for age.
 Patients in the intervention group had higher hydroxyproline deposition in
the wound than did control group patients.
 A brief relaxation intervention prior to surgery can reduce stress and
improve the wound healing response in surgical patients. The
intervention may have particular clinical application for those at risk of
poor healing following surgery. Brain Behav Immun. 2012 Feb;26(2):212-7
Mindfulness Meditation Decreases
Pro-Inflammatory Cytokines cont’d
 Over time women in the MBSR group re-established their NKCA
and cytokine production levels.
 In contrast, breast cancer patients in the Non-MBSR group
exhibited continued reductions in NKCA and IFN-gamma
production with increased IL-4, IL-6, and IL-10 production.
 Moreover, women enrolled in the MBSR program had reduced
cortisol levels, improved QOL, and increased coping effectiveness
compared to the Non-MBSR group. In summary, MBSR is a
program that is feasible for women recently diagnosed with early
stage breast cancer and the results provide preliminary evidence
for beneficial effects of MBSR; on immune function, QOL, and
coping. Brain Behav Immun 2008 Aug;22(6):969-81.
Psychoneuroimmunoendocrine Markers
Improve After 8 Week MBSR Program
 One study investigated the ongoing effects of participation in a
mindfulness-based stress reduction (MBSR) program on quality
of life (QL), symptoms of stress, mood and endocrine, immune
and autonomic parameters in early stage breast and
prostate cancer patients.
 Forty-nine patients with breast cancer and 10 with
prostate cancer enrolled in an eight-week MBSR program that
incorporated relaxation, meditation, gentle yoga and daily home
practice. Demographic and health behaviors, QL, mood, stress
symptoms, salivary cortisol levels, immune cell counts,
intracellular cytokine production, blood pressure (BP) and heart
rate (HR) were assessed pre- and post-intervention, and at 6and 12-month follow-up.
Psychoneuroimmunoendocrine Markers
Improve After 8 Week MBSR Program
 Patients were assessed pre- and post-intervention and at 6and 12-month follow-up, respectively.
 Significant improvements in overall symptoms of stress were
maintained over the follow-up period.
 Cortisol levels decreased systematically over the course of the
follow-up.
 Immune patterns over the year supported a continued reduction
in Th1 (pro-inflammatory) cytokines. Systolic blood pressure
(SBP) decreased from pre- to post-intervention and heart rate
reduced. Brain Behav Immun 2007 Nov;21(8):1038-49.
Stress, Cortisol and Cancer
 DNA damage is increased by exposure to stress and
stress hormones (cortisol, catecholamines)
 Stress-related psychosocial factors are associated with
higher incidence, poorer survival and increased
mortality in cancer patients
Clin Pract Oncol
2008 Aug:5(8):466-75
Cortisol and Cancer
 Women’s stress increases with a cancer diagnosis, as well as
anxiety about treatment, prognosis, and disruptions in daily
living.
 Cancer-related stress has a negative impact on health, possibly
via neuroendocrine pathways and their effects on the immune
system
 Cortisol, a steroid hormone secreted by the adrenal cortex, is
used to assess hypothalamic-pituitary-adrenal axis function and
is a reliable measure of physiological stress. J Clin Pathol
2012;65:934-9
 Cortisol affects multiple physiological processes, including
metabolic and immune responses (e.g., suppresses T
lymphocyte functions and natural killer cell cytotoxicity).
Cortisol and Cancer
 Women living with breast cancer have higher cortisol
levels compared to healthy women, and higher cortisol
levels are associated with greater disease severity in
women with breast cancer.
 Neuroendocrine regulation of cortisol and other adrenal
hormones may contribute to cancer progression and
health outcomes through multiple mechanisms.
 Women with breast cancer may show decreases in
cortisol levels if they are taught stress management
techniques.
Exercise, Depression and Cortisol
 85 women treated for breast cancer were randomly allocated to a
6-month exercise and hypocaloric healthy eating program plus
usual care, or usual care alone (control group).
 Women in the intervention group received three supervised
exercise sessions per week and individualized dietary advice,
supplemented by weekly nutrition seminars.
 Compared with the control group, the intervention group exhibited
a reduction in depressive symptoms
 The intervention group had an increase in morning
salivary cortisol at the 6-month follow-up indicating a change in
HPA axis regulation. Breast Cancer Res. 2014 Apr 14;16(2):R39
Exercise, Depression and
Cortisol cont’d
Cognitive Behavioural Therapy,
Cortisol and Breast Cancer
 One study examined the effects of a cognitive-behavioral stress
management group intervention on serum cortisol levels in
women being treated for stage I or II breast cancer.
 Women were taught to examine the positive benefits breast
cancer had made on their lives, and to reframe their experiences
in this light.
 The participants who showed increased benefit-finding
had reduced serum cortisol levels, whereas control subjects did
not.
 These findings suggest that positive interpretations of the breast
cancer experience can influence physiological parameters such
as cortisol among women with early stage breast cancer.
Psychosom Med. 2000 May-Jun;62(3):304-8.
Cortisol, Cytokines and Cancer
 fatigued breast cancer survivors show a blunted cortisol response
to an experimental psychological stressor.
 relative to non-fatigued control survivors, fatigued breast cancer
survivors showed increases in production of pro-inflammatory IL1beta and IL-6 following the stressor
 fatigued participants showed significantly less salivary cortisol
increase after the stressor
 blunted cortisol responses were associated with significantly
increased production of IL-6 in response to stress.
 enhanced inflammatory processes in fatigued breast cancer
survivors may stem in part from decreased glucocorticoid response
to stress. Brain Behav Immun 2007 Mar;21(3):251-8.
Mood, Neurotransmitters and
Cancer
 reduced emotional expression has been consistently related to
susceptibility or fast progression of breast cancer, often occurring after
rejection and separation-related events.
 the neuropeptide oxytocin is low in response to rejection or separation.
 oxytocin may protect against the development of breast cancer and
slow its progression.
 healthy female subjects were treated with placebo or 35mg of cortisol
orally in a double-blind study. Seventy minutes later, blood was
sampled for determination of oxytocin and cortisol levels.
 after cortisol treatment, oxytocin levels increased proportional to
Emotion Expression-out score. These preliminary findings provide a
potential mechanism for associations in the literature between
emotional expressive behavior and breast cancer Biol Psychol 2007
May;75(2):119-23.
Personality Traits and Cancer
 118 women, 58 diagnosed with breast cancer and 60
healthy women, of similar ages and personal
circumstances were assessed in psychological aspects
and stressful life events.
 the results revealed more stressful vital events in the
last two years in the group of women with breast
cancer and significant differences in the degree of
current distress
 women with breast cancer obtained higher scores in
current anger, resignation, and neuroticism.
Psychol 2008 Nov;11(2):522-30
Span J
How to Facilitate Emotional
Expression in Patients?
 ask open-ended questions about their life and
relationships such as:
 “What is your relationship like with your parents?”
 “What is your relationship like with your work?”
 “What is your relationship like with your spouse?”
 “What is your relationship like with your children?”
 “What causes you anxiety?”
 “What are your current stressors?”
How to Facilitate Emotional
Expression in Patients?
 “What is the multidimensional family background?”
 “How do you relate to your friends?”
 “How do you relate to yourself?”
 “Do you judge yourself harshly for something?”
 “Are you angry about something?”
 “Is there an unresolved conflict blocking you in any
way?”
 “Do you feel trapped?”
 “Are you grieving about something? Is there a loss?”
How to Facilitate Emotional
Expression in Patients?
 “How do you take care of yourself?”
 “Is there something you would like to be different in
your life?”
 “How is life occurring to you right now? Check in with
yourself at this very moment. Not with what your mind
says. Not how it should be. Not how it isn’t. But how is
it occurring? What is true for you right now?”
 health is about wholeness - our emotional, physical
and spiritual lives come together with integrity
Ways to Increase Oxytocin
 higher oxytocin levels increase the strength of human
bonding, increase our trust in others, decrease our anxiety in
social situations, decrease aggressive behaviour and help us
to feel calm and content in our intimate relationships.
 a deficit of oxytocin may make us more susceptible to social
isolation and depression, and we’ll have trouble nourishing
ourselves and others
Ways to Increase Oxytocin
 we can offset social isolation and increase oxytocin levels
through: 1) hugging; 2) holding hands; 3) watching an
emotionally compelling movie; 4) looking into each others
eyes; 5) singing or chanting with other people; 6) dancing
with a partner; 7) doing something thrilling with others (such
as bungee jumping); 8) exercising with a friend or group; 9)
taking a friend out to dinner; 10) telling someone you love
them; receiving a massage; 11) having sex with someone
you care about; 12) stroking a pet; 13) being together in fun
social ways
Psychiatr Pol. 2012 Nov-Dec;46(6):1043-52.
Horm Behav. 2012 Mar;61(3): 429-35
Mind-Body Factors that Disrupt the
Psychoneuroimmuoendocrine System
 social isolation increases morbidity and mortality
 maternal deprivation or loss early in life
 long term care-giving to an ill partner
 disruption of the circadian rhythm (night shifts)
 age-related dysregulation
 obesity
 chronic stress, with blunted or elevated cortisol and
catecholamines
 oxidative and inflammatory stress, which occur with aging,
anxiety, infection, toxicity
Pharm Des. 2014;20(29):4605-7
Curr
Mind-Body Factors that Disrupt the
Psychoneuroimmuoendocrine System
 chronic infection
 trauma
 lack of sleep
 anxiety and depression
 suppressed anger
 emotional repression
 resignation
Mind-Body Practices that Restore the
Psychoneuroimmuneendocrine System
 conscious breathing
 mindfulness/present moment
awareness
 emotional authenticity
 being able to say “no”
 stretching – yoga, Pilates, Tai
Chi
 sleep
 exercise
 meditation
 chanting, singing
 daily relaxation
•
social connection, support,
love
 visualization of a positive
outcome; reframing
 prayer
 faith/spirituality
 forest bathing, gardening, time
in nature
 self-expression
 laughter
 purpose and meaning
 self-actualization
 creative arts
Healing the Person vs Curing
Cancer
 ideally we heal the whole person while simultaneously
helping to cure cancer
 2 in 5 Canadians will get cancer in their lifetimes and 1
in 4 will die from it – it takes us out
 if we aren’t able to cure it, how can we help patients
heal despite having cancer?
 Mind-Body Medicine presents NDs with opportunities to
facilitate profound healing in people with cancer
What Does It Mean to Be Healed?
 we are relaxed and at peace with “what is” and with our past
 we love and accept ourselves and others and have meaningful
social connections
 we have resolved internal conflict
 we experience self-appreciation, self-forgiveness
 we find meaning, purpose and joy in the moment
 we express ourselves authentically
 we are connected with our spirit and the larger whole
 we share our talents, creativity and resources and envision a
bright future, or are at peace with dying
Cancer as an Opportunity for
Transformation
 after the fact, many cancer patients are grateful for the experience
 gives them permission to live their “unlived life”
 brings the focus back to them, rather than needs of the family or work
 cancer as a dramatic spiritual journey; loss of ego identity; need to
submit, surrender, connect with spirit
 an opportunity to change partners, career, focus and attitude
 can be a time of integration, saying “no”, spiritual renewal
 importance of becoming a “different person” than who you were when
you became sick. Change the thoughts, words, images, beliefs, body
sensations and feelings that promoted the illness
Cancer, Post-traumatic
Growth and Cortisol
 In the aftermath of a traumatic event, such as being
diagnosed with breast cancer, an individual may also
experience beneficial changes in life perspective,
relationships with others, and more.
 These changes are collectively known as post-traumatic
growth.
 There was a significant correlation between post-traumatic
growth and a diurnal cortisol slope.
 This indicates that positive psychological changes and
healthier endocrine functioning in cancer patients can
result in more normal (i.e., steeper diurnal) cortisol patterns
Psychoneuroendocrinology 2014 Jun;44:83-7
How Can You Re-Invent Yourself?
 What is the new story that wants to be lived?
 What beliefs need to change to support the new story?
 Does your environment need changing?
 Who are the people you like to be around, who support
you?
 What are you passionate about? What gives you
meaning? How can you use your gifts?
The Meaning Mandala
Have person draw a large daisy, or 
tree or mandala. On each petal,
branch or section, answer one of the 
following 18 questions:
 What did I come here (this
incarnation) to heal?
Who did I come here to be?
What brings me joy?
 What did I come here to hear?
 What did I come here to feel?
 What did I come here to express?
 Where lies my passion?
 What did I come here to create?
 What did I come here to experience?
 Who did I come here to forgive?
 What did I come here to learn?
 What talents have I come to
 Who did I come here to love?
develop?
 What causes have I come to serve?  What did I come here to enjoy?
 What am I to start or finish?
 What did I come here to see?
 What did I come here to do?
Social Support
 when you can talk to someone about your illness, it
becomes less threatening
 social sharing gives greater sense of control
 social sharing can occur through extended family,
friendships, volunteering for a charity, belonging to a
club or religious/spiritual group, participating in online
forums
 positive involvement with others helps maintain healthy
habits ie Healthy Breast Program facebook group
Social Support cont’d
 social support increases oxytocin, blunts the stress
response
 heightened stress response caused by chronic social
isolation is linked to increased mammary tumor growth in
rodent models of breast cancer
 social isolation and stress-induced changes in
neuroendocrine axis in mice are associated with increased
expression of key metabolic genes in mammary adipocytes
linked with increased glucose metabolism, lipid synthesis,
leptin secretion, and increased proliferation of mammary
cancer cells Cancer Prev Res 2013 Jul;6(7):634-45
Social Support cont’d
 The effect of psychosocial intervention on time of
survival of 86 patients with metastatic breast
cancer was studied prospectively.
 The 1 year intervention consisted of weekly supportive
group therapy with self-hypnosis for pain. Both the
treatment (n = 50) and control groups (n = 36) had
routine oncological care.
 At 10 year follow-up, only 3 of the patients were alive,
and death records were obtained for the other 83.
Survival from the onset of intervention was a mean
37 months in the intervention group compared with
19 months in the control group, a significant
difference. Lancet. 1989 Oct 14;2(8668):888-91.
Components of a Daily
Mind-Body Medicine Program
1. moderate exercise 40-60 min
2. breathing exercises or meditation of 11 min or more
3. yoga/tai chi/Qigong 1 hour
4. relaxation breaks, naps of 10-20 min X 3
5. emotional awareness and expression
6. acceptance, gratitude, focus on positive
7. meaningful work, sense of purpose
8. meaningful, loving social interactions, physical contact
9. healthy boundaries, capacity and permission to say “no”
10. 8 hours quality sleep