Download Case / Control Flow Diagram for BPH (Benign Prostatetic

[Type here]
Case / Control Flow Diagram for BPH (Benign Prostatetic Hyperplasia)
If you have questions regarding any of the information presented here, please contact either
Sarah Stallings ([email protected]) or Josh Denny ([email protected])
1. Population: Genotyped for eMERGE
Male
Age >= 40
2. Population Exclusions
Prostate, Penile, Urethral, and Bladder Cancer (ICD9 or Tumor Registry or Prob List, ever)
3a. Case
3b. Control
2 or more of any ICD-9 for BPH
Evidence of regular outpatient visits (3 or
more in any 2 year period)
-AND-AND[1 or more of any BPH Meds
NO [BPH ICD-9s
-OR-OR1 or more CPT codes for BPH related
surgeries]
BPH Meds
-ORBPH-related surgery CPT codes]
[Type here]
Case / Control Algorithm for BPH (Benign Prostatetic Hyperplasia)
If you have questions regarding any of the information presented here, please contact either
Sarah Stallings ([email protected]) or Josh Denny ([email protected])
Population:
Include:
eMERGE genotyped
 Gender = Male
 Age ≥ 40
Exclude those with Prostate & Bladder Cancer using ICD-9, Tumor Registry (if available) and
keywords:
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ICD-9: (1 or more of any on separate days):
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233.4-Carcinoma in situ of prostate
233.7-Carcinoma in situ of bladder
233.9-Carcinoma in situ of other and unspecified urinary organs
185 - Malignant neoplasm of prostate
187 - Malignant neoplasm of penis and other male genital organs
187.1 - Malignant neoplasm of prepuce
187.2 - Malignant neoplasm of glans penis
187.3 - Malignant neoplasm of body of penis
187.4 - Malignant neoplasm of penis, part unspecified
187.5 - Malignant neoplasm of epididymis
187.6 - Malignant neoplasm of spermatic cord
187.7 - Malignant neoplasm of scrotum
187.8 - Malignant neoplasm of other specified sites of male genital organs
187.9 - Malignant neoplasm of male genital organ, site unspecified
188 - Malignant neoplasm of bladder
188.0 - Malignant neoplasm of trigone of urinary bladder
188.1 - Malignant neoplasm of dome of urinary bladder
188.2 - Malignant neoplasm of lateral wall of urinary bladder
188.3 - Malignant neoplasm of anterior wall of urinary bladder
188.4 - Malignant neoplasm of posterior wall of urinary bladder
188.5 - Malignant neoplasm of bladder neck
188.6 - Malignant neoplasm of ureteric orifice
188.7 - Malignant neoplasm of urachus
188.8 - Malignant neoplasm of other specified sites of bladder
188.9 - Malignant neoplasm of bladder, part unspecified
189.2 Malign Neopl Ureter
189.3 - Malignant neoplasm of urethra
189.4 Mal Neo Paraurethral Glands
189.8 Mal Neo Urinary Nec
189.9 Mal Neo Urinary Nos
OR
Tumor Registry: Primary site = any of the following:
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C619
C670
C671
Prostate gland
Trigone of Bladder
Dome of Bladder
[Type here]
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C672
C673
C674
C675
C676
C677
C678
C679
Lateral Wall of Bladder
Anterior Wall of Bladder
Posterior Wall of Bladder
Bladder Neck
Uretic Orifice
Urachus
Overlapping Lesion of Bladder
Bladder, NOS
OR
Keyword: (1 or more of any of the following in Problem List):
note these phrases are specific to Vanderbilt –your site may use variations of these phrases /
abbreviations. Please use prostate and bladder cancer related keywords appropriate to your site to
improve the exclusion of cancer patients from the sets.
 'prostate cancer'
 'malignant tumor of prostate'
 'bladder CA'
 'bladder cancer'
]
Case:
Include:
ICD-9 Codes for BPH: (2 or more each of one or more on separate days): 600, 600.0, 600.0*, 600.2,
600.2*, 600.9, 600.9*
AND
[
CPT code for BPH-related surgery (1 or more of any): 52450, 52601, 52630, 52648, 53850, 53852,
OR
BPH MEDICATIONS: (one or more mention found with any of the following included: (form, strength,
amount, route, frequency, or source) – include generic and brand names in query. Use the RXCUI for
ingredient type if that is available at your site):
Generic Names
terazosin
terazosin HCL
doxazosin mesylate
doxazosin
tamsulosin
alfuzosin
silodosin
dutasteride
finasteride
Brand names
Hytrin
Cardura, Cardura XL
Flomax, Jalyn*
Uroxatral
Rapaflo
Avodart, Jalyn*
Propecia, Proscar
RxNorm code (RXCUI for the
Ingredient Term Type)
37798
(236495 precise ingredient CUI)
49276
(39273 precise ingredient CUI)
77492
17300
720825
228790
25025
[Type here]
prazosin
* combination drug
Minipress, Minipress XL
8629
]
Control:
Include:
3 or more outpatient visits in any 2-year period for age ≥40
Exclude:
[
ICD-9 Codes for BPH (1 or more of any): 600, 600.0, 600.0*, 600.2, 600.2*, 600.9, 600.9*, 600
OR
CPT code for BPH-related surgery (1 or more of any): 52450, 52601, 52630, 52648, 53850, 53852
OR
BPH MEDICATIONS: (one or more mention found with any of the following included: (form, strength,
amount, route, frequency, or source) – include generic and brand names in query. Use the RXCUI for
ingredient type if that is available at your site):
Generic Names
terazosin
terazosin HCL
doxazosin mesylate
doxazosin
tamsulosin
alfuzosin
silodosin
dutasteride
finasteride
prazosin
* combination drug
]
Brand names
Hytrin
Cardura, Cardura XL
Flomax, Jalyn*
Uroxatral
Rapaflo
Avodart, Jalyn*
Propecia, Proscar
Minipress, Minipress XL
RxNorm code (RXCUI for the
Ingredient Term Type)
37798
(236495 precise ingredient CUI)
49276
(39273 precise ingredient CUI)
77492
17300
720825
228790
25025
8629