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The Sagol School of Neuroscience invites you to its new course New Horizons in Clinical Neuroscience In cooperation with the Human Brain Project Venue: Shreman Building, Hall 03, Life Sciences Faculty, Tel Aviv University Date: Sunday; 16:00-18:00 Date Title Lecturer 28.2.2016 The Natural History of Neurodegenerative disease: Can We Modify it? Clinical neuroanatomy Vascular aspects of brain disorders – stroke Epilepsy and EEG Neuroimmunology Systems biology of addiction Neuropsychiatric disorders Clinical aspects of brain imaging Therapeutic strategies Prof. Nir Giladi 13.3.2016 27.3.2016 10.4.2016 1.5.2016 15.5.2016 29.5.2016 19.6.2016 26.6.2016 Dr. Eitan Auriel Prof. Natan Bornstein Prof. Miri Neufeld Prof. Anat Achiron Prof. Alois Saria Prof. Hilik Levkoviyz Prof. Dafna Ben Bashat Dr. Ralph Laufer Lecture 1: The Natural History of Neurodegenerative disease: Can We Modify it? Lecture Description: Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Lewy body dementia, Huntington's disease and motor neuron disease have similar pathophysiologies of protein misfolding, accumulation of protein aggregates and a slow, progressive course of neuronal cell death. In addition, these and other disorders have a long prodromal stage, when the pathological process is slowly progressing but clinically unrecognized. Better characterization of new and highly sensitive biological markers now enables the detection of subjects at risk or in the earliest prodromal stages of the disease. Early detection of neurodegeneration will enable future medicine to apply new concepts of intervention, moving from the current symptomatic and palliative approaches to disease-modifying therapy and even disease prevention. Prof. Nir Giladi, Chairman, Tel Aviv Institute of Neurology, Sieratzki Chair in Neurology, Director of the Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel Aviv University. 1 Lecture 2: Clinical neuroanatomy Lecture Description: Clinical consequences of neurological diseases often depend on the involved anatomical territory in the central or peripheral nervous system. For instance, the characteristics of motor weakness resulting from a spinal lesion differ from those resulting from a root lesion. By the same token, a stroke involving the posterior circulation has a different clinical presentation than one in the anterior circulation. By understanding and applying simple neuroanatomical rules, one can localize the damage along the neuroaxis, the first crucial step toward making the correct clinical diagnosis and initiating treatment. Dr. Eitan Auriel, Department of Neurology, Tel Aviv Medical Center. Lecture 3: Vascular aspects of brain disorders – stroke Lecture Description: Stroke remains the second most common cause of death and the major cause of severe disability, including physical and cognitive–behavioral consequences. In the last two decades, significant advances have been made in the prevention and acute treatment of stroke, as well as in advanced neuroimaging. The most dramatic progress is seen in the widespread introduction of intravenous thrombolysis as standard therapy for acute ischemic stroke and very recently, the positive results of 5 clinical trials with intra-arterial clot retrieval within a short time after the onset of symptoms. Today, we have much better diagnostic tools for various subtypes of stroke, which are enabling us to better tailor new therapeutics and preventive measures to avoid recurrent events. Prof. Natan Bornstein Professor of Neurology at Tel Aviv University, Sackler Faculty of Medicine Head of Stroke Unit at Tel Aviv Medical Center, Sagol School of Neuroscience, Tel Aviv University, Chairman of the Israeli Neurological Association, Vice President of the World Stroke Organization (WSO). Lecture 4: Epilepsy and EEG Lecture Description: Epilepsy is characterized by an enduring tendency for recurrent unprovoked seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition. Advances in the understanding, investigation and treatment of epilepsy are continuing apace. 2 Genome analysis is providing insight into the causes of the individual epilepsy syndromes and is helping to target appropriate treatments. The number of antiepileptic drugs with novel mechanisms of action has risen, adding to the pharmacological armamentarium of epilepsy. Major technical advances have contributed to our ability to map the brain and identify the part responsible for seizure generation, which can then be surgically removed. Neurostimulation for epilepsy continues to evolve rapidly, including the development of implantable devices aimed at interfering with seizure-related processes in the brain. Current therapy aims to prevent seizures; the goal of future research is to intervene with the natural history of the epileptic process and prevent epilepsy and its co-morbidities. Prof. Miri Neufeld, Director of EEG and Epilepsy Unit, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University. Lecture 5: Neuroimmunology Lecture Description: The immune system can target and attack the nervous system to produce autoimmune responses that may result in diseases such as multiple sclerosis, neuromyelitis and lupus cerebritis manifested by motor, sensory and cognitive impairments. Despite the fact that the brain is an immune-privileged site, autoreactive lymphocytes producing proinflammatory cytokines can cause active brain inflammation, leading to myelin and axonal loss. Recent research demonstrates that immune manipulations and restoration of aberrant apoptotic processes can benefit neuroimmunological disorders. Prof. Anat Achiron, Director of the Multiple Sclerosis Center, Sheba Medical Center. Lecture 6: Systems biology of addiction Lecture Description: The diagnostic criteria of substance dependence (addiction), which include tolerance, withdrawal symptoms, increased time spent getting hold of substances, giving up social or occupational activities and a set of additional psychological and physical problems indicate adaptive brain mechanisms with common pathways in complex neural networks. A number of different brain regions appear to be involved and among them, the "reward circuit" has been postulated as a common pathway for all addictive substances. Moreover, numerous studies in molecular and cellular neurobiology have revealed details of biochemical changes that are common to drugs that, on the other hand, differ radically in their pharmacological properties. However, the complexity of these dynamic networks is not yet understood and therefore, the outcome of pharmacological treatments for addiction remains disappointing. Recent attempts have been made to describe the biological systems as 3 theoretical (computational) models; these could provide a better understanding of addiction at the cellular and network levels in the future. Prof. Alois Saria, Center of Psychiatry and Psychotherapy, Department of Psychiatry Unit, Innsbruck University, Innsbruck, Austria Lecture 7: Neuropsychiatric disorders Lecture Description: Psychiatry includes the assessment, treatment, and prevention of complex brain disorders, such as depression, bipolar disorder, anxiety disorders, schizophrenia, and developmental disorders (e.g., autism). Its core mission is to prevent and alleviate the distress and impairment caused by these disorders, which account for a substantial part of the global burden of illness-related disability. Psychiatry is grounded in clinical neuroscience. Its core mission, now and in the future, is best served within this context because advances in assessment, treatment, and prevention of brain disorders are likely to originate from studies of etiology and pathophysiology based in clinical and translational neuroscience. In this lecture I will present and discuss the neuroscientific aspects of psychiatric disorders and suggest new approaches to understanding their neurobiological bases. Prof. Hilik Levkoviyz, Head of Continuing Medical Education (CME), School of Medicine, Deputy Director, Beer Yaakov & Ness Ziona Mental Health Center of the Sackler Faculty of Medicine, Tel Aviv University. Lecture 8: Clinical aspects of brain imaging Lecture Description: • Magnetic resonance imaging (MRI) – basic principles and various methods • Routine clinical protocols • Advanced MRI methods: from localized imaging to network analysis • Applications for patients with brain tumors • Applications for patients with neurological and psychiatric disorders Prof. Dafna Ben Bashat, Dept. of Radiology, Sackler Faculty of Medicine, Functional Brain Center, Tel Aviv Sourasky Medical Center, Sagol School of Neuroscience, Tel Aviv University. 4 Lecture 9: Therapeutic strategies Lecture Description: The development of efficient therapies for central nervous system (CNS) disorders poses several unique challenges. Many CNS diseases are complex multigenic disorders with poorly understood underlying mechanisms. Available small animal models are poor predictors of clinical efficacy. Furthermore, the blood–brain barrier impedes access of potential therapeutic agents to the CNS. Nevertheless, modern genetic and genomic research, together with advances in molecular biology, systems biology and big data analysis are providing a better understanding of disease mechanisms and the identification of novel targets and therapeutic approaches. Examples of novel treatment strategies include targeting common mechanisms of neurodegenerative diseases, stem-cell therapy and genesilencing technology. Dr. Ralph Laufer, TEVA's Discovery and Product Development SVP. 5