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G-Protein Coupled Receptor Signaling: Overview M1, H1, V2R, OXTR, AT1R, PAR All s PCR G β-Arrestin RhoA PI3K Akt β-Arrestin AP2 clathrin Src Ras Raf Gαq β,γ Gα12/13 β,γ Rac PKC β,γ VEGFR, PDGFR, EGFR RTK Gαi Gαi β,γ Ion CDC42 PI3K PLCβ [cAMP] IP3 DAG PAK ROCK LATS1/2 MLK Ras JNK p90RSK p38 Actin Remodeling LATS1/2 Erk Glycogen and Fatty Acid Synthesis Bad mTOR Survival Protein Synthesis YAP/TAZ p53 GSK-3 CREB β-catenin Raf Bcl-2 WASP PAK JNK Ras Raf Akt PKA GSK-3β Stat3 CDC42 SOS PKC PI3K Channels AC Axin Src β,γ GTP GTP RhoA β,γ GDP Gαs β,γ GTP PLCβ CXCR4, GABA-B, LPA GDP Gα12/13 β,γ GTP Erk Bad Gαs GDP GDP Gαq β1-Adrenergic R Wnt Ligand/Frizzled Transactivation GRK Ca2+ Receptor Internalization GPR55, SDF-1, PAR, S1P MMPs Examples Inactive IKK NF-κB Bcl-xL YAP/TAZ Erk p53 c-Fos c-Jun YAP/TAZ CREB NF-κB Erk us cle Nu c-Myc Pathway Diagram Key Direct Stimulatory Modification Multistep Inhibitory Modification Separation of Subunits or Cleavage Products Direct Inhibitory Modification Tentative Stimulatory Modification Joining of Subunits Translocation Multistep Stimulatory Modification Tentative Inhibitory Modification Transcriptional Stimulatory Modification Transcriptional Inhibitory Modification Transcription Factor pro-apoptotic G-protein Caspase pro-survival Acetylase Kinase Receptor GAP/GEF Deacetylase Phosphatase Enzyme GTPase Ribosomal subunit Select Reviews This pathway diagram has been assembled by key opinion leaders in the field of G-Protein Coupled Receptor Signaling in collaboration with Cell Signaling Technology (CST) scientists. CST Pathways are reviewed and updated frequently to provide succinct and current overviews of the subject area. We would like to thank Dr. Jonathan Violin, Trevena Inc., King of Prussia, PA for reviewing this diagram. © 2014 Cell Signaling Technology, Inc. Cell Signaling Technology® and CST™ are trademarks of Cell Signaling Technology, Inc. www.cellsignal.com/gpcr 14PSTREFMNONE0210ENG_00 Entschladen, F., Zänker, K.S., and Powe, D.G. (2011) Cell Cycle 10, 1086−1091. | Audet, M. and Bouvier, M. (2012) Cell 151, 14−23. | Lappano, R. and Maggiolini, M. (2012) Acta. Pharmacol. Sin. 33, 351−362. | O’Havre, M., Degese, M.S., and Gutkind, J.S. (2014) Curr. Opin. Cell Biol. 27C, 126−135. | Lappano, R. and Maggiolini, M. (2011) Nat. Rev. Drug Discov. 10, 47−60. | Yu, F.X. and Guan, K.L. (2013) Genes Dev. 27, 355−371. | Smrcka, A.V. (2008) Cell. Mol. Life Sci. 65, 2191−2214. | Kahn, S.M., Sleno, R., Gora, S., Zylbergold, P., Laverdure, J.P., Labbé, J.C., Miller, G.J., and Hérbert, T.E. (2013) Pharmacol. Rev. 65, 545–577. | Shukla, A.K., Xiao, K., and Lefkowitz, R.J. (2011) Trends Biochem. Sci. 36, 457−469. | Raiagopal, S., Raiagopal, K., and Lefkowitz, R.J. (2010) Nat. Rev. Drug Discov. 9, 373−386.
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