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Download Biochemistry Topic 3: Coenzymes Coenzymes act on enzymatic
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Biochemistry Topic 3: Coenzymes - Coenzymes act on enzymatic Reactions as a “Cosubstrate” they accept electrons or atoms temporally during the reaction Not catalytically active and not substrate or enzyme specific but each works with more than one enzyme / substrate Can be either called soluble coenzyme (coenzyme cleaves off of the enzyme after the reaction) or prosthetic group (coenzyme is bound to enzyme) Enzyme class Name Oxidoreductase NAD NADP FAD FMN From Type Transfers Used in Nicotinic acid (niacin – vitamin B3) Riboflavin / vitamin B2 Vitamin B2 Soluable (always) H- Prosthetic 2[H] Prosthetic 2[H] Prosthetic 2[H] Lactate dehydrogenase G6P dehydrogenase Succinate dehydrogenase Terminal oxidation Pyruvate dehydrogenase enzyme complex Lipoic acid Thiamine pyrophosphate (TPP) Thiamine / Vitamin B1 Hydroxyalkyl residues Oxoacid dehydrogenases Transferase Biotin Vitamin H Coenzyme A (CoA) Vitamin B5 Hydrolase Lyase Folic acid [CO2] Carboxylase Acyl Residues Acyltransferase CoA transferase Amino group Transamilase Amino Acid residues C1 Groups C1 transferases Thiamine / Vitamin B1 Hydroxyalkyl residues Decarboxylases (4.1.1.n) Transketolase ANY COENZYMES Amino group Amino Acid residues Many lyases Pyridoxal phosphate (PLP) Tetrohydrofolate (THF) Thiamine pyrophosphate (TPP) DOES Vitamin B6 Pyridoxal phosphate (PLP) Vitamin B6 NOT REQUIRE Isomerase Glucose-1,6biphosphate Glucosephosphate mutase ATP Glutamine synthase Ligase
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