Download Dr. Cheppail Ramachandran (MCH) - Florida International University

FF Principal Investigator/Program Director (Last, first, middle): RAMACHANDRAN, Cheppail,
Ph.D.
Rev: 02/01/03
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel in the oreder listed on Form Page 2.
Photocopy this page or follow this format for each person.
NAME
POSITION TITLE
Cheppail Ramachandran
Sr. Research Scientist
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include
postdoctoral training.)
INSTITUTION AND LOCATION
Kerala Agricultural University, India
IARI, New Delhi, India
University of Wales, UK
Agricultural Univ., The Netherlands
Ohio State Univ., Columbus, OH
University of Miami, Miami, FL
DEGREE
BS,MS
Ph.D.
Post-Doc
Post-Doc
Post-Doc
Post-Doc
YEAR
CONFERRED
FIELD OF STUDY
1972-78
1979-83
1983-84
1984
1988-90
1990-93
Agriculture
Cytogenetics
Molecular Cytology
Molecular Biology
Molecular Biology
Molecular Biology of Cancer
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order,
previous employment, experience, and honors.Include present membership on any Federal Government public
advisory committee. List, in chronological order, the titles, all authors, and complete references
to all publications during the past three years and to representative earlier publications pertinent
to this application. If the list of publications in the last three years exeeds two pages, select the
most pertinent publications. DO NOT EXCEED TWO PAGES.
PROFESSIONAL EXPERIENCE AND EMPLOYMENT:
Sept. 1998 – Present
Sr. Research Scientist, Miami Children’s Hospital, Research Institute,
Miami, FL
Jan. 1995 – Aug. 1998:
Research Assistant Professor, Dept. of Radiation Oncology, University
of Miami School of Medicine, Miami, FL
July 1994 - Jan. 1995:
Assistant Professor, Michigan Cancer Foundation, Wayne State
University, Detroit, MI.
Sept. 1993 - July 1994:
Sr. Research Associate, Michigan Cancer Foundation, Detroit, MI.
March 1990 - Aug. 1993:
Research Associate, Division of Experimental Therapeutics, Department
of Radiation Oncology, University of Miami, FL.
Jan. 1988 - Feb. 1990:
Postdoctoral Research Associate, Ohio State University, Columbus, OH.
1982 - 1987:
Assistant Professor, Kerala Agricultural University, Kerala, India.
April 1984 - Nov. 1984:
Visiting Scientist, Agricultural University, Wageningen, The Netherlands.
Jan. 1983 - March 1984:
Postdoctoral Research Fellow, University College of Wales, England.
HONORS AND AWARDS:
Active member of American Society For Neurosciences since 1998.
Active member of American Association for Cancer Research since 1994.
Active member of international Society for Preventive Oncology since 2002
Indian Council of Agricultural Research Senior Fellowship for Ph.D.
Commonwealth Scholarship by Association of Commonwealth Universities, U.K.
Fellowship by the Dutch Organization for Advancement of Pure Research (ZWO).
SELECTED PUBLICATIONS (From a total of 45):
Ramachandran, C., Rabi, T., Fonseca, H.B., Melnick, S.J., Escalon, E. 2003. Novel plant terpenoid
drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines.
Int. J. Cancer 106 (in press).
PHS 398 (Rev. 01/03)
(Form Page 6) Page _5__
Cheppail Ramachandran, Ph.D.
FF
Rabi, T., Ramachandran, C., Fonseca, H.B., Alamo, A., Melnick, S.J., and Escalon, E. 2003. Novel
drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines.
Breast Cancer Research and Treatment (in press)
Toi, M., Imai, A., Ramachandran, C., Melnick, S.J., Fife, R., Carr, R.E., Neeman, I., Kaplan B., and
Lansky, E. 2003. Pomegranate extracts inhibit both induction of angiogenic molecules from tumor
cells and endothelial growth directly. Angiogenesis (in press)
Ramachandran, C., and Wellham, L.L. 2003. Effect of MDR phosphorothioate antisense
oligodeoxynucleotides in multidrug resistant human tumor cell lines and xenografts. Anticancer Res.
23 (in press).
Ramachandran, C., Khatib, Z.A., Escalon, E., Fonseca, H.B., Jhabvala, P., Medina, S., D'Souza, B.,
Ragheb, J., and Morrison, G. 2002. Molecular studies in pediatric medulloblastomas. Brain Tumor
Pathol 19: 15-22.
Ramachandran, C., Fonseca, H.B., Jhabvala, P., Escalon, E., and Melnick, S.J. 2002. Curcumin
inhibits
telomerase activity through human telomerase reverse transcriptase in MCF-7 breast cancer cell line.
Cancer Letters 184: 1-6.
Kim, N.D., Mehta, R., Yu, W., Neeman, I., Livney, T., Amichay, A., Poirier, D., Nicholls, P., Kirby, A.,
Jiang, W., Mansel, R., Ramachandran, C., Rabi, T., Kaplan, B., and Lansky, E. 2001.
Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human
breast cancer. Breast Cancer Research and Treatment 71: 203-217.
Ramachandran, C., Melnick, S.J., Escalon, E., Khatib, Z., Jhabvala, P., Fonseca, H.B., Smith, S.,
Alamo, A. and Medina, S. 2001. Cytogenetical and molecular characterizationof a congenital
mesoblastic nephroma. Pediatr. Dev. Pathol.4: 402-411.
Ramachandran, C., Fonseca, H.B., Jhabvala, P., Melnick, S.J., and Escalon, E. 2001. Inhibition of
human reverse transcriptase (hTERT) and telomerase activity in human epithelial and breast cancer
cell lines. In : Advances in Gene Technology: Cell Death and Aging 12: 109.
Ramachandran, C., Melnick, S.J., Escalon, E., Jhabvala, P., Khatib, Z., Alamo, A. and Smith, S. 2000.
Expression of apoptosis, cell proliferation, and drug resistance genes in pediatric Wilms’ tumors.
Anticancer Res. 20: 3759-3766.
Ramachandran, C., Fonseca, H.B., Jhabvala, P., Melnick, S.J., and Escalon, E. 2000. Effect of
curcumin on caspase 3 and telomerase activity in human mammary epithelial and breast carcinoma
cell lines. In: Advances in Gene Technology: DNA, RNA and Cancer 11: 57.
Ramachandran, C. and Melnick, S.J. 1999. Multidrug resistance in human tumors – Molecular
diagnosis and clinical significance. Molecular Diagnosis 4: 81-94.
Ramachandran, C. and You, W. 1999. Differential sensitivity of human mammary epithelial and breast
carcinoma cell lines to curcumin. Breast Cancer Research and Treatment 54: 269-278.
Ramachandran, C., Kunikane, H., You, W., and Krishan, A. 1997. Phorbol ester-induced
P-glycoprotein phosphorylation and functionality in HTB-123 human breast cancer cell line.
Biochem. Pharmacol. 709-718.
Ramachandran, C., You, W., and Krishan, A. 1997. Bcl-2 and mdr-1 gene expression during
doxorubicin induced apoptosis in murine leukemic P388 and P388/R84 cells. Anticancer Res. 17:
3369-3376.
Kunikane, H., Zalupski,M.M., Ramachandran, C., Kukuruga, M.A., Lucas, R.J., James, R.R., and
Krishan, A. 1997. Flow cytometric analysis of P-glycoprotein expression and drug efflux in human
soft tissue and bone sarcoma. Cytometry (Communications in Clinical Cytometry) 30: 197-203.
Lee, Y-I., Ramachandran, C., Kunikane, H., Wellham, L.L., and Krishan, A. 1995.Modulating effect
of tamoxifen, verapamil, and trifluoperazine on doxorubicin cytotoxicity in human breast cancer cell
line. Cell. Pharmacol. 2: 319-322
Ramachandran, C., Mead, D., Wellham, L.L., Sauerteig, A., and Krishan, A. 1995. Expression of
drug resistance associated MDR-1, GST and topoisomerase II genes during cell cycle traverse.
Biochem. Pharmacol. 49: 545-552.
Isobe, H., Wellham, L.L., Sauerteig, A., Sridhar, K.S., Ramachandran, C., and Krishan, A. 1994.
Doxorubicin retention and chemoresistance in human mesothelioma cell lines. Int. J. Cancer
57:581-585.
Koechli, O.R., Sevin, B.-U., Perras, J.P., Angioli, R., Unteh, M., Steren, A., Ramachandran, C.,
Averette, H.E. 1994. Comparative chemosensitivity profiles in three human breast cancer cell lines
with the ATP-cell-viability-assay. Oncology 51: 552-558.
Ramachandran, C., Yuan, Z.K., Huang, X.L., and Krishan, A. 1993. Doxorubicin resistance in human
melanoma cells: MDR-1 and glutathione S-transferase  gene expression. Biochem. Pharmacol.
45:743-751.
Ramachandran, C., Huang, X.L., Yuan, Z.K., Samy, T.S.A., and Krishan, A.
1993.
Doxorubicin-induced DNA break topoisomerase II activity and gene expression in human melanoma
cells. Biochem. Pharmacol. 45:1367-1371.
Ramachandran, C., Sauerteig, A., Sridhar, K.S., and Krishan, A. 1993. MDR-1 gene expression,
anthracycline retention and cytotoxicity in human lung tumor cells from refractory patients. Cancer
Chemo. Pharmacol. 31:431-441.
Chen, G., Ramachandran, C., and Krishan, A. 1993. Thaliblastine, a plant alkaloid, circumvents
multidrug resistance by direct binding to P-glycoprotein. Cancer Res. 53:2544-2547.
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