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CURRICULUM VITAE
Jen-Kun Lin, Ph. D.
Education:
1958- B.S. ( Pharmacy ), National Taiwan University, College of Medicine,
Taipei, Taiwan, Republic of China.
1961- M.S. ( Biochemistry ), National Taiwan University, College of
Medicine, Taipei, Taiwan, Republic of China.
1968- Ph. D. ( oncology ), McArdle Laboratory for Cancer Research,
Medical Center, University of Wisconsin, Madison,
Wisconsin, USA (Thesis Advisor: Prof. James A Miller
and Prof. Elizabeth C. Miller).
Professional Experience:
1960-1963:
Teaching Assistant, Institute of Biochemistry, College of
Medicine, National Taiwan University, Taipei.
1963-1965:
Instructor, Institute of Biochemistry, College of Medicine,
National Taiwan University, Taipei.
1965-1968: Research Assistant, Department Of Oncology, University of
Wisconsin, Madison, Wisconsin.
1968-1969: Research Associate, McArdle Laboratory for Cancer Research
Medical Center, University of Wisconsin, Madison, Wisconsin.
1969-1973: Associate Professor, Institute of Biochemistry, College of
Medicine National Taiwan University, Taipei.
1973-present: Professor, Institute of Biochemistry, College of Medicine,
1975-1976:
1975-1976:
1979-1983:
1984:
National Taiwan University, Taipei.
Visiting Professor, Department of Oncology, Medical Center,
University of Wisconsin, Madison, Wisconsin.
DHHS, PHS, NIH Forgaty International Research Fellow
( Sponsored by Professors James A. Miller and Elizabeth C.
Miller at McArdle Laboratory for Cancer Research, University
of Wisconsin ).
Director of students, College of Medicine, National Taiwan
University.
Visiting Scientist, Laboratory of Molecular Oncology, NCI,
NIH, USA.
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1986-1993:
Chairman, Institute of Biochemistry, College of Medicine,
1993-1995:
National Taiwan University.
Director, Division of Life Sciences, National Science Council,
Taipei, Taiwan, ROC.
Membership in Learned Societies ( Present and Past ):
Sigma Xi Society
American Association for the Advancement of Science
American Association for Cancer Research, Corresponding Member since
1977
The Formosan Medical Association ( elected as reviewer, 1984-present )
Chinese Biochemical Society ( elected as President, 1985-1987)
Chinese Pharmaceutical Society ( elected as Council Member, 1980-present )
Chinese Mycology Society
Chinese Clinical Biochemical Society ( elected as Council Member, 19881991 )
Chinese Oncology Society ( elected as Council Member, 1983-1995)
Chinese Toxicology Society ( elected as Council, 1986-present; elected as
President, 1990-1995 ).
New York Academy of Sciences ( Member, 1990-present )
Research Interests:
1. Molecular mechanism of chemical carcinogenesis; The formation and
structure of carcinogen-nucleic acid adducts; Bio-transformation of aflatoxins
in rodent liver.
2. Naturally occurring amines as precursors of carcinogenic N-nitroso
compounds.
3. Discovery of dabsyl chloride and development of dabsylation for the
determination of amino compounds with TLC and HPLC. Microdetermination
of amino acids at picomole level in various biological specimens with dabsyl
chloride.
4. Chemopreventive action of retinoids and carotenoids with special reference to
crocetin, crocein , tea polyphenols and plant pigments.
5. The possible role of cellular oncogene in tumor promotion.
6. Molecular and biochemical mechanisms of anticarcinogenesis of curcumin.
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Resveratrol, apigenin, and tea polyphenols including catechins and
theaflavins.
Scientific Advisory Committee:
1978-1981:
1982-1985:
Chairman, Division of Environmental Carcinogenesis, Cancer
Research Promoting Committee, National Science Council,
ROC.
Member, Scientific Advisory Council on Planning, National
Science Council, ROC.
1980-1993:
Chief Editor, Medical Science, Proceedings of National
Science Council, Basic Science, ROC.
1986-present: Editorial Board, Toxicity Assessment.
1990-1995: Editor, J. Genetics and Molecular Biology, ROC.
1993-1995: Associate Editor, J. Biomedical Science, NSC.
1994-present:
International Editorial Board, Japanese Journal of Cancer
Research.
Awards and Honors:
Outstanding research thesis award of the Formosan Medical Association
(Two times, 1962, 1971 )
Chung-Sun Science Award, Chung Sun Science & Literature Foundation
(1982 ).
Outstanding Professorship Award of the Ministry of Education ( 1984-1985 ).
Academic Award of the Ministry of Education in Medical Science ( 1986 ).
Outstanding Academic Research Award of the National Science Council
(1985-1987; 1987-1989; 1989-1991; 1991-1993 ).
Listed in Who's Who in ROC ( 1988-present ).
Listed in Who's Who in the world ( 9th edition, 1989-1990; up-to now)
Selected as Man of the Year 1995 by the American Biographical Institute
And Its Board of International Research.
Outstanding Academic Research Award of the Chinese Oncology
Society (1997).
Recipient of the Foundation for the Advancement of Outstanding Scholarship
(1995-2000).
Recipient of the King-Yi Foundation for the Outstanding Professorship of
National Taiwan University (2000-2001).
Recipient of the ISI Honors Excellence in Taiwanese Research (2001)
(Among 1989-1999, three of our published papers have been selected and
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recognized as high impact papers by ISI the company produces Science
Citation Index (SCI) and Current Contents, see attachment for details).
Books:
1.林仁混編著 (1975),癌-人類的大敵, 科學月刊社出版.
2.許世明, 林仁混編譯 (1974),生化學 (上,下冊), 合記書局出版.
3.林仁混等編譯 (1977), 分子生化學 (上,下冊), 合記書局出版.
4.黃志清, 林仁混編著 (1978), 生命之基石-巨分子, 合記書局出版.
5.Esther H. Chang, Jen-Kun Lin and P. C. Huang (ed.) (1985) Molecular
Biology of Neoplasia. Academia Sinica, Taipei.
6.呂峰洲, 林仁混合著 (1991), 基礎酵素學, 聯經醫學叢書-7,
聯經出版社出版.
7.林仁混著 (1991), 生化學通論-人類疾病之生化觀, 聯經醫學叢書-8,
聯經出版社出版.
8.林仁混著 (1994), 食物與癌症, 聯經醫學叢書,聯經出版社出版.
9.林仁混著 (1995), 致癌基因與分子醫學, 聯經醫學叢書,聯經出版社出版.
10.Jen-Kun Lin (1995),Biochemical Mechanisms of Carcinogenesis and
Anti-carcinogenesis,A collection of 60 selected papers (499 pages).
11.Jen-Kun Lin (2001), Cancer Chemoprevention by Phytopolyphenols and
Apoptosis, A collection of 72 selected papers (1996-2001)(719 pages).
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PUBLICATIONS ( 2004-2008 )
Refereed Journals ( Papers published in International Journals ):
* : indicates corresponding author.
1.
Chen, W. J. and Lin, J. K.* Mechanisms of cancer chemoprevention by hop bitter acids (the Beer Aroma)
through induction of apoptosis mediated by fas and caspase cascades. J. Agric. Food Chem. 52(1); 55-64,
2004.
2.
Way, T. D., Kao, M. C., and Lin, J. K.* Apigenin induces apoptosis through proteasomal degradation of
HER2/neu in HER2/neu overexpressing breast cancer cells via the phosphatidyl-3’-kinase/Akt-dependent
pathway. J. Biol. Chem. 279 (6); 4479-4489, 2004.
3.
Chen, W. J. and Lin, J. K.* Induction of G1 arrest and apoptosis in human Jurkat T cells by
pentagalloylglucose through inhibiting proteasome activity and elevating p27Kip1, p21Cip/WAF1 and Bax
proteins. J. Biol Chem. 279(14); 13496-13505, 2004.
4.
Lee, H. H., Ho, C. T., and Lin, J. K.* Theaflavin-3,3’-digallate and penta-O-galloyl-D-glucose inhibit rat
liver microsomal 5--reductase activity and expression of androgen receptor in LNCaP cancer cells.
Carcinogenesis, 25(7); 1109-1118, 2004.
5.
Lin, Y. P., Zhu, B. Z., Yang, M. C., Frei, B., Pan, M. H., Lin, J. K. and Wang, Y. J. Bcl-2 overexpression
inhibits tetrachlorohydroquinone-induced apoptosis in NIH3T3 cells: A possible mechanism for tumor
promotion. Mol. Carcinogenesis 40; 24-33, 2004.
6.
Way, T. D., Lee, H. H., Kao, M. C. and Lin, J. K.* Black tea polyphenol theaflavins inhibit aromatase activity
and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase
suppression. Eur. J. Cancer 40; 2165-2174, 2004.
7.
Chen, C. N., Weng, M. S., Wu, C. L. and Lin, J. K.* Comparison of the radical scavenging activity, cytotoxic
effects, and apoptosis induction in human melanoma cells by Taiwanese propolis. ECAM (Evidence based
Contemporary Alternative Medicine), 1; 175-185, 2004.
8.
Lin, J. K*. Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of
cancer chemoprevention by Curcumin. Arch Pharm Res. 27(7):683-92, 2004.
9.
Hsu, P. C., Huang, Y. T., Tsai, M. L., Wang, Y. J., Lin, J. K., and Pan, M. H. Induction of apoptosis by
shikonin through coordinative modulation of the Bcl-2family, p27, and p53, release of cytochrome c, and
sequential activation of caspases in human colorectal carcinoma cells. J Agric Food Chem.
52(20):6330-6337,2004.
10. Lin, J. K. Cancer chemoprevention by phytopolyphenols including flavanoids and flavonoids through
modulating signal transduction pathways. In: Phytochemicals: Mechanisms of Action, Meskin, M. S.,
Bidlack, W. R., Davies, A. J., Lewis, D. S., and Randolph, R. K.(eds.), CRC Press, Boca Raton, 2004, pp
79-106.
11. Lin, J. K. Biochemical and molecular mechanisms of cancer chemoprevention by tea and tea polyphenols. In:
Phytochemicals in Health and Disease, Bao, Y., and Fenwick, R.(eds.), Marcel Dekker, Inc. New York, 2004,
213-226.
12. Kuo, K. L., Meng, M. S., Chiang, C. T., Tsai, Y. J., Lin-Shiau, S. Y., and Lin, J. K*. Comparative studies on
the hypolipidemic and growth suppression effects of oolong, black, puerh and green tea leaves in rats. J. Agric.
Food Chem. 53(2), 480-489, 2005.
13. Huang, S. C., Ho, C. T., Lin-Shiau, S. Y., and Lin, J. K.* Carnosol inhibits the invasion of B16/F10 mouse
melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappaB and
c-Jun. ., Biochem. Pharmacol. 69(2): 221-232, 2005.
14. Lin, J. K*., Pan, M. H., Liang, Y. C., Lin-Shiau, S. Y. and Ho. C. T. New momentum on the action
mechanisms of black tea polyphenols, the theaflavins. In: Phenolic Compounds in Foods and natural Health
Products , Shahidi, F., and Ho, C. T. (eds.) ACS Symposium Series 909, American Chemical Society,
Washington, D. C. 2005, pp197-209.
15. Way, T. D., Kuo, M. C., and Lin, J. K.* Degradation of HER2/neu by apigenin induces apoptosis through
cyctochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells. FEBS Lett.
579(1), 145-152, 2005.
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16. Liao, C. H., Ho, C. T. and Lin, J. K.* Effects of garcinol on free radical generation and NO production in
embryonic rat cortical neurons and astrocytes. BBRC 329: 1306-1314, 2005.
17. Ho, Y. S., Chen, C. H., Wang, Y. J., Pestell R. G., Albanese, C., Chen, R. J., Chang, M. C., Jeng, J. H., Lin, S.
Y., Liang, Y. C., Tseng, H., Lee, W. S., Lin, J. K., Chu, J. S., Chen, L. C., Lee, C. H. Tso, W. L., Lai, Y.
C.,and Wu, C. H. Tabacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
induces cell proliferation in normal human bronchial epithelial cells through NF-kappaB activation and cyclin
D1 up-regulation. Toxicol. Appl. Pharmacol. 205(2): 1815-1827, 2005.
18. Chen, Y. W., Huang, S. C., Lin-Shiau, S. Y., and Lin, J. K.* Bowman-Birk inhibitor abates proteasome
function and suppresses the proliferation of MCF7 breast cancercells through accumulation of MAP kinase
phosphatase-1. Carcinogenesis, 26(7): 1296-1306, 2005.
19. Weng, M. S., Ho, Y. S., and Lin, J. K.* Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through
inducing p21waf1/cip1 expression: involvement of p38mitogen activated protein kinase. Biochem. Pharmacol.
69(12): 1815-1827, 2005.
20. Liao, C. H., Sang, S., Ho, C. T., and Lin, J. K.* Garcinol modulate tyrosine phosphorylation of FAK and
subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human
colon cancer cells. J. Cell. Biochem. 96(1), 155-169, 2005.
21. Chiu, F. L., and Lin, J. K.* HPLC analysis of naturally-occurring methylated catechins, 3”- and 4”methyl-epigallocatechin gallate, in various fresh tea leaves and commercial teas and their potent inhibitory
effects on inducible nitric oxide synthase in macrophages. J. Agric Food Chem. 53(18), 7035-7042, 2005.
22. Pan, M. H., Sin, Y. H., Lai, C. S., Wang, Y. J., Lin, J. K., Wang, M., and H., C. T. Induction of apoptosis by
5-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione through reactive oxygen species production,
GADD153 expression and caspase activation in human epidermal carcinoma cells. J. Agric. Food Chem. 53,
9039-9049, 2005.
23. Way, T. D., and Lin. J. K.* Role of HER2/HER3 co-receptor in breast carcinogenesis. Future Oncology, 1,
841-849, 2005.
24. Hsu, K. Y., Lin, H. J., Lin, J. K., Kuo, W. S., and Ou, Y. H*. Mutagenicity study of butachlor and its
metabolites using Salmonrlla typhimurium. J. Microbiol. Immunol. Infect. 38(6), 409-416, 2005.
25. Chiang, C. T., Weng, M. S., Lin-Shiau, S. Y., Kuo, K. L., and Lin, J. K.*Pu-erh tea supplementation
suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as
demonstrated in human hepatoma HepG2 cells. Oncol. Res. 16(3); 119-128, 2005.
26. Lin, J. K.* and Lin-Shiau S. Y. Mechanisms of hypolipidemic and anti-obesity effects of tea and tea
polyphenols. Mol. Nutr. Food Res. 50(2), 211-217, 2006.
27. Hua, K. T., Way, T.D., and Lin, J. K.* Pentagalloylglucose inhibits estrogen receptor alpha by
lysosome-dependent depletion and modulates ErbB/PI3K/Akt pathway in human breast cancer MCF-7 cells.
Mol. Carcinog. 45(8); 551-560,2006.
28. Chen, C. N., Wu, C. L., and Lin, J. K.* Apoptosis of human melanoma cells induced by the novel compounds
propolin A and propolin B from Taiwanese propolis. Cancer Lett. 245 (1-2); 218-231, 2007.
29. Chen, K. H., Weng, M. S. and Lin, J. K.*Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2
expression through inhibition of p38MAPK… JNK and AKT activation in human lung carcinoma cells.
Biochem. Pharmacol. 73(2); 215-227, 2007.
30. Weng, M. S., Ho, C. T., Ho, Y. S., and Lin, J. K.* Theanaphthoquinone inhibits fatty acid synthase expression
in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErB-2 signaling. Toxicol. Appl.
Pharmacol. 218(2); 107-18, 2007.
31. Pan, M.H., Lin, C. C., Lin, J. K.*, and Chen, W. J.* Tea polyphenol (-)-epigallocatechin 3-gallate suppresses
heregulin-beta-induced fatty acid synhthase expression in human breast cancer cells by inhibiting
phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. J. Agric. Food
Chem. 55(13); 5030-7, 2007.
32. Weng, M. S., Liao, C. H., Chen, C. N., Wu, C. L., and Lin, J. K.* Propolin H from Taiwanese propolis
induces G1 arrest in human lung carcinoma cells. J. Agric. Food Chem. 55(13); 5289-98, 2007.
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33. Huang, W. J., Huang, C. H., Wu, C. L., Lin, J. K., Chen, Y. W., Lin, C. L., Chuang, S. E., Huang, C. Y. and
Chen, C. N. Propolin G, a prenylflavone, isolated from Taiwanse propolis, induces caspase-dependent
apoptosis in brain cancer cells. J. Agric. Food Chem. 55(18); 7366-76, 2007.
34. Chiang, C. T., Way, T. D., and Lin, J. K.* Sensitizing HER2-overexpressing cancer cells to luteolin-induced
apoptosis through suppressing p21WAF1/CIP1 expression with rapamycin. Mol. Cancer Therapeut., 6
(7);2127-38, 2007.
35. Lin, C. L., Chen, T.F., Chiu, M. J., Way, T. D., and Lin, J. K.* Epigallocatechin gallate (EGCG) suppresses
β-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3β activation.
Neurobiology of Aging, 30; 81-92, 2009 (This paper was accepted by May 11, 2007 and on the Web Site
since).
36. Lin, C. L., Huang, S. C., and Lin, J. K. Theaflavins attenuate hepatic lipid accumulation through activating
AMPK in human HepG2 cells. J. Lipid Res.,48 (11);2334-43, 2007.
37. Chiu, F. L., and Lin , J. K. Downregulation of androgen receptor expression by luteolin causes inhibition of
cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts. Prostate
68(1);61-71, 2008.
38. Chiang, C. T., Way, T. D.,Tsai, S. J. and Lin J. K. Diosgenin,a naturally occurring steroid, suppresses fatty
acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK
phosphorylation. FEBS Lett.,581 (30) 5735-42, 2007.
39. Huang, W. J., Huang, C. H., Wu, C. L., Lin, J. K., Chen, Y. W., Lin, C. L., Chuang, S. E., Huang, C. Y., and
Chen, C. N. Propolin G, a phenylflavone, isolated from Taiwanesepropolis, induces caspase-dependent
apoptosis in human cancer cells. J. Agric. Food Chem. 55 (18), 7366-76, 2007.
40. Lee J. C., Tsai, C. Y., Kao, J. Y., Kao, M. C., Tsai, S. C., Chang, C. S., Huang, L. J., Huo, S. C., Lin, J. K., and
Wei, T. D. Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of
Fas-ligand expression in human melanoma cells. Mol. Nutr. Food Res. 52(6), 655-63, 2008.
41. Chiu, F. L. and Lin, J. K. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK
pathways in LPS-stimulated mouse macrophages. FEBS Lett. 582(16), 2407-12.2008
42. Chen, C. M., Lin, J. K., Liu, S. H., and Lin-Shiau, S. Y. Novel regimen through combination of memantine and
tea polyphenols for neuroprotection again brain excitotoxicity. J. Neurosci. Res. 86(12);2696-704, 2008.
43. Lin, C. L. and Lin J. K. Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling
blockade in human hepG2 hepatoma cells. Mol. Nutr. Food Res. 52(8); 930-9, 2008..
44. Chen, S. H., Lin, J. K., Liang, Y. C., Pan, M. H., Liu, S. H., and Lin-Shiau, S. Y. Involvement of activating
transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate /Cu
complex. Eur. J Pharmacol. 594 (1-3); 9-17,2008.
45. Syu, K. Y., Lin, C. L., Huang, S. C. and Lin, J. K. Determination of theanine, GABA, and other amino acids in
green, oolong, black and puerh teas with dabsylation and high performance liquid chromatography. J. Agric.
Food chem.. 56(17);7637-43, 2008.
46. Huang, HC., Huang, C. Y., Lin-Shiau, S.Y., and Lin, J. K. Ursolic acid inhibits IL-1bata or TNF-alpha induced
C6 glioma invasion through suppressing the association ZIP/p62 with PKC –zeta and down-regulating the
MMP-9 expression. Mol. Carcinog 2008, Oct.30 (Epub ahead of print).
47. Huang, H.C., Way, T. D., Lin, C. L., and Lin, J. K. EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells
through down-regulation of the Skp2 protein. Endocrinology 149(12); 5972-83, 2008.
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