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10th Postgraduate Research Symposium Presentation Topic : Modeling Human Vaccinating Behaviors On a Disease Diffusion Network PhD Student : Supervisor : Shang XIA Prof. Jiming LIU Department of Computer Science August 31, 2009 Content: 1 2 3 4 5 Page 1/15 Research Motivation & Objectives Disease Diffusion Dynamics Individual Behaviors and Interactions AOC Modeling for Local-Global Relationship Conclusions Research Background In recent years, the emergence of vital epidemic which spreads all over the world have greatly endangered the public health and cause great social impacts. SARS, • 2002.11 ~ 2003.07 • 8,096 known infected cases and 774 deaths worldwide Bird Flu, (H5N1) • Recent Years • 65 outbreaks in 2006; 55 in 2007; 11 in 2008. Swine Flu, (H1N1) • 2009.04 ~ Now • 177,699 infected cases and 1,126 deaths (Aug. 6th) • Swine Flu Spreading Map Page 2/15 Swine Flu World Wide Spreading 04/24/2009 05/04/2009 06/16/2009 07/06/2009 Data Source: Page 3/15 [1] WHO, ECDC, CPC, HPA (UK), governments [2] BBC Website: http://news.bbc.co.uk/2/hi/uk_news/8083179.stm 05/26/2009 07/30/2009 Research Motivation Disease Diffusion on Human Social Contact Network. Human is the host of many severe infectious disease. Human’s traveling and interaction spread infection worldwide. Disease Diffusion changes human’s behavioral pattern. Decision making for vaccination or not. Individual changes its social interactions. Human’s contact pattern and demography features characterize disease diffusion dynamics. Human social contact is the medium of disease diffusion. Human demographical characteristics influence disease infection. Page 4/15 Complex Social Disease Diffusion System Research Objectives Global Disease Diffusion Dynamics Relationship ? Local Individual Reaction Pattern Disease Infection Model Human Interaction Network Disease Diffusion Dynamics Human Behavioral Mechanism Local-Global Relationship Problem Page 5/15 Disease Infection Model SIV Percolation Model Individual States in Network Susceptible Individual Infected Individual Vaccinated Individual Individual States Transition wij6 wij7 Neighbor Infections. Infected individuals die or recover. Vaccination escape potential infection. Epidemic Transmission in Network Random Selection for a neighbor susceptible. Selection Probability in terms of contact patterns. Page 6/15 wij4 wij5 wij3 wij9 wij2 wij1 wij8 PTrans (i j ) wij w kAll ik Human Social Contact Network (1) Scale Free Network Short Range Routine Mobile Trajectory from home to workplace; Regular shopping in nearby supermarket; Visiting familiar friends or customers. Social Contact Network Long Range Chance Traveling Enjoying vacations abroad; Business trip to other regions; Human Mobility Dynamics Page 7/15 Human Social Contact Network (2) Heterogeneity in contact pattern Degree Distribution: Neighbor Contacts Edge Weight: Contact Frequency Heterogeneity in demography difference Disease - Independent host parameters Ages, Gender, Occupation and so on. Disease - Dependent host parameters Current health status, Susceptibility, Disease transmission rate, etc. Heterogeneity in community structure Community structure by contact pattern. Community structure by demography characteristics Page 8/15 Individual Behavioral Mechanism (1) Individual Vaccination Dilemma Herd Immunity Dilemma: The individual incentive to vaccinate disappears at high coverage levels. So the individual incline to persuade other instead of itself to adopt the vaccination. Risk of Vaccination Self-Interest Decision Risk of Infection Self-Trust Experience Group Psychology Irrational Predictions Page 9/15 Individual Behavioral Mechanism (2) Individual Decision Making Dynamics Perceived Payoff for Vaccination or not Records of History Decision Making Environment Estimation PV PN ? Environment Evaluation Individuals’ Biased Preference W1 W2 History Experience W3 Individual Biased Preference Rules Decision Making Mechanism Y Vaccination Choice Page 10/15 N Non-vaccination Choice Local - Global Relationship Modeling Autonomy Oriented Computing “ AOC emphasize the modeling of autonomy in the entities of a complex system and the self-organization of them in achieving a specific goal ” -- By Liu (2005) AOC Modeling Framework Natural System Identification Artificial System Construction Performance Measurement Page 11/15 AOC Modeling Natural System Identification Disease Infection Model Individual Contact Network Multi-Agent System Artificial System Construction Individual Interaction Patterns Individual Behaviors Mechanism Autonomous Entities & Self-Organization Performance Measurement Vaccination Patterns Disease Diffusion Dynamics Page 12/15 Local-Global Relationship Result Evaluation Criteria Social Vaccination Dynamics The proportion of vaccinated individuals. The Efficacy of Vaccination. •The proportion of vaccinated individuals which are infected by its infectious neighbors. •The proportion of non-vaccinated individuals which are also infected. Disease Diffusion Dynamics The proportion of infected individuals in the whole population. The mass outbreak in a certain community. Page 13/15 Conclusion Individual State Transition Population Immunization Patterns Epidemic Spreading Dynamics Disease Diffusion Dynamics Global Epidemic Spreading Dynamics Global Dynamics Disease Diffusion Dynamics Social Contact Network Entities Infection Model Decision Making Local Behaviors Local-Global Relationship Individual State Change Social Contact Network Individual Vaccination Choice Individual Decision Making Local Interaction History Records History Records Environment Evaluation Individual Decision Making Disease Infection Individual State Transition Page 14/15 Vaccination Dynamics Individual Vaccination Decision Environment Evaluation Q&A Thank You Very Much!