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Download Table S4: Functional description of interactome nodes linked with
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Table S4: Functional description of interactome nodes linked with HH genes produtcs in CT-DE network CT-DE CGN Comm HH gene product Protein-related function Interacting protein in 1st level Protein-realted function Biological function Node shape (border color) A CASP4 apoptosis A A COG1 MRPS6 Golgi apparatus mitochondrial protein A RILPL2 MHC-II presentation A BTG3 T-cell development A ARHGAP1 T-cell development A RNF11 TGF-beta signaling B CEACAM1 T-cell development C HSPA13 apoptosis C CD59 Hassal´s corpuscles C CGN Hassal´s corpuscles GCN1L1 PSMD6 CDK2 MDN1 MTHFD1L SMC1A SNRNP200 EIF2S3 HEATR2 MSH6 SRPRB SSR4 SMC2 SMC4 DCTN1 SMC3 MYCBPAP TMEM147 COPE VDAC1 VDAC3 UMPS CCDC59 CTNNBIP1 PTPLAD1 HIGD1A LSM10 SNRPA1 NUP93 SLC25A1 SLC25A22 UBXN1 COG4 ESR1 C1ORF103 KIAA1377 RIF1 TUBB3 TUBB4 HEXDC CNOT3 E2F1 ATXN1 RHOC CDC42 RHOA UBQLN4 IKBKG CLEC4M SHC1 UBQLN1 UBQLN4 CFTR GRB2 EGFR SMAD4 YWHAH SFN Translation factor activity, nucleic acid binding; regulation of translation ATP-dependent proteolysis ATP binding; histone kinase activity; cyclin-dependent protein kinase activity ATPase binding; protein folding ATP binding; protein homodimerization activity ATP binding; chromatin binding; microtubule motor activity ATP binding; helicase activity GTP binding; GTPase activity; translation initiation factor activity Binding ADP binding; chromatin binding GTP binding Calcium ion binding; gene expression DNA recombination; DNA repair; cell cycle Mitotic chromosome condensation; mitotic sister chromatid segregation; cell cycle Motor activity; signaling protein activity involved in unfolded protein response; cell death ATP binding; microtubule motor activity Protein binding; cell differentiation Endoplasmic reticulum COPI coating of Golgi vesicle; intra-Golgi vesicle-mediated transport Porin activity Porin activity Lyase activity Protein binding; regulation of transcription, DNA-dependent Beta-catenin binding; negative regulation of Wnt receptor signaling pathway Rac protein signal transduction; I-kappaB kinase/NF-kappaB cascade Response to stress Histone pre-mRNA DCP binding; RNA splicing RNA binding; RNA splicing Glucose transport; cytokine-mediated signaling pathway Citrate transmembrane transporter activity; cellular lipid metabolic process L-glutamate transmembrane transporter activity ATPase binding; polyubiquitin binding Protein binding; Golgi vesicle prefusion complex stabilization; protein transport Chromatin binding; estrogen receptor activity; estrogen response element binding Receptor activity Protein binding Protein binding; cytoskeleton GTP binding MHC class I protein binding; cytoskeleton; natural killer cell mediated cytotoxicity Carbohydrate metabolic process; hydrolase activity, hydrolyzing O-glycosyl compounds Protein binding; nuclear-transcribed mRNA catabolic process DNA binding; sequence-specific DNA binding transcription factor activity DNA binding; RNA processing GTPase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade GTP binding; GTPase activity; Thymopoise GTP binding; GTPase activity; actin cytoskeleton organization Polyubiquitin binding; regulation of proteasomal ubiquitin-dependent protein catabolic process I-kappaB kinase/NF-kappaB cascade; T-cell receptor signaling pathway ICAM-3 receptor activity; peptide antigen binding; antigen processing and presentation; cell-cell recognition Ephrin receptor binding; Ras protein signal transduction; MAPK cascade Kinase binding; apoptotic process Polyubiquitin binding; regulation of proteasomal ubiquitin-dependent protein catabolic process PDZ domain binding; ATP-binding; phosphorylation-dependent chloride channel activity SH3/SH2 adaptor activity; T-cell costimulation ATP binding; actin filament binding; nitric-oxide synthase regulator activity DNA binding; chromatin DNA binding Actin binding Negative regulation of cell proliferation; apoptotic process cell process cell process cell process/ATP binding cell process/ATP binding cell process/ATP binding cell process/ATP binding cell process/ATP binding cell process/binding cell process/binding cell process/binding cell process/binding cell process/binding/calcium ion binding cell process/cell cycle cell process/cell cycle cell process/cell death cell process/cytoskeleton cell process/differentiation cell process/endoplasmic reticulum cell process/Golgi apparatus cell process/ion transport cell process/ion transport cell process/lyase activity cell process/protein binding cell process/signaling cell process/signaling cell process/stress response cell process/transcription cell process/transcription cell process/transport cell process/transport cell process/transport ubiquitination cell process/Golgi apparatus cell process/binding cell process/signaling cell process/binding cell process/cytoskeleton cell process/binding cell process/antigen presentation cell process/hydrolase activity cell process/protein binding cell process/transcription cell process/transcription GTPase activity/signaling cell process/T-cell differentiation cytoskeleton ubiquitination cell process/signaling cell process/antigen presentation cell process/signaling apoptosis ubiquitination cell process/ion transport cell process/T-cell development apoptosis cell process/transcription actin/binding apoptosis circle circle circle circle circle circle circle circle circle circle circle circle (light blue border) circle circle circle circle circle circle circle circle circle circle circle circle circle circle circle circle circle circle circle triangle circle circle circle circle circle circle circle (orange border) circle circle circle circle circle (yellow border) circle (light blue border) diamond triangle circle circle (orange border) circle vee triangle circle circle (light blue border) vee circle diamond vee D MORC3 Epigenetic regulator D DLG3 T-cell development D ARHGEF4 T-cell development E GSTO1 stress response E APP cell process F FBXL5 Thymic microenviroment F MCM3AP cell proliferation F USO1 ER-golgi TJP1 ACTB YWHAB YWHAG YWHAZ ESR2 HFLX DYNLL1 ERBB4 GRIN2B LRFN2 NLGN1 DGKI DGKZ KLHDC3 ANXA1 S100A3 ATP2B4 CAMK2A GRIN1 CRIPT KRT31 KRT34 KRT35 KRT82 KRT85 GDA GRIN2A GRIN2C GRIN2D KCNA1 SSTR2 HIST1H2BC ABCA1 CUL2 HLA-B RAC1 UBA5 KIAA1377 EEF1G C7ORF64 SETDB1 KAT5 TRAF6 ACTB YWHAZ SHC1 GRB2 RPOB MYB APC SMAD9 CELSR3 CLSTN1 CRMP1 TMEM216 SDHA RAC1 CDC42 SMAD3 NUDT5 ENY2 ARF6 GAK Calmodulin binding; apoptotic process ATP binding; nitric-oxide synthase binding Enzyme binding Insulin-like growth factor receptor binding Protein binding DNA binding; sequence-specific DNA binding transcription factor activity Official symbol: GTPBP6. GTP binding protein 6 (putative) Actin cytoskeleton organization; activation of pro-apoptotic gene products ATP binding; apoptotic process; epidermal growth factor receptor binding Beta-catenin binding; cell adhesion molecule binding Cell junction Neurexin family protein binding; cell adhesion molecule binding ATP binding; diacylglycerol kinase activity ATP binding; diacylglycerol kinase activity; cell migration Chromatin binding Calcium ion binding Calcium ion binding Calmodulin binding Calmodulin binding; positive regulation of NF-kappaB transcription factor activity Calmodulin binding; PDZ domain binding; cytoplasmic microtubule organization; Structural constituent of cytoskeleton Structural molecule activity; intermediate filament Structural molecule activity; intermediate filament Structural constituent of epidermis; keratin filament Structural molecule activity; keratin filament Guanine deaminase activity Calcium channel activity; cell adhesion molecule binding Extracellular-glutamate-gated ion channel activity Extracellular-glutamate-gated ion channel activity Potassium channel activity G-protein coupled receptor activity DNA binding; defense response to bacterium ATP binding; cholesterol transporter activity Ubiquitin protein ligase binding; induction of apoptosis by intracellular signals MHC class I receptor activity; antigen processing and presentation of peptide antigen via MHC class I T-cell costimulation; actin filament polymerization ATP binding Protein binding Protein binding; translation elongation factor activity Official symbol: RBM48. RNA binding DNA binding; regulation of transcription, DNA-dependent Histone acetyltransferase activity; chromatin modification Histone deacetylase binding; ubiquitin-protein ligase activity ATP binding; nitric-oxide synthase binding Protein binding Ephrin receptor binding; Ras protein signal transduction; MAPK cascade SH3/SH2 adaptor activity; T-cell costimulation Official symbol: POLR1B. Transcription of ribosomal RNA (rRNA) genes and production of rRNA DNA binding; chromatin remodeling; regulation of histone H3-K9 methylation T-cell differentiation in thymus; microtubule binding Transforming growth factor beta receptor; pathway-specific cytoplasmic mediator activity G-protein coupled receptor activity; cell adhesion; calcium ion binding Calcium ion binding; cell adhesion Dihydropyrimidinase activity; cytoskeleton Cilium morphogenesis; cytoskeleton Electron carrier activity; oxidation-reduction process T-cell costimulation; actin filament polymerization GTP binding; GTPase activity; Thymopoise Beta-catenin binding; chromatin DNA binding ADP-ribose diphosphatase activity Transcription coactivator activity; chromatin modification; histone deubiquitination GTPase activity; apoptotic process ATP binding; cell junction; heat shock protein binding apoptosis cell process/ATP binding cell process/binding cell process/binding cell process/binding cell process/transcription cell process/protein binding actin/cytoskeleton apoptosis cell process/adhesion cell process/adhesion cell process/adhesion cell process/ATP binding cell process/ATP binding cell process/binding cell process/binding/calcium ion binding cell process/binding/calcium ion binding cell process/calmodulin binding cell process/calmodulin binding cell process/calmodulin binding cell process/cytoskeleton cell process/cytoskeleton cell process/cytoskeleton cell process/cytoskeleton cell process/cytoskeleton cell process/cytoskeleton cell process/deaminase activity cell process/ion transport cell process/ion transport cell process/ion transport cell process/ion transport cell process/signaling cell process/transcription cell process/transport ubiquitination cell process/antigen presentation cell process/T-cell costimulation cell process/ATP binding cell process/binding cell process/protein binding cell process/transcription cell process/transcription cell process/transferase activity ubiquitination cell process/ATP binding cell process/binding cell process/signaling cell process/T-cell development cell process/transcription cell process/transcription cell process/T-cell differentiation cell process cell process/binding/calcium ion binding cell process/binding/calcium ion binding cell process/cytoskeleton cell process/cytoskeleton cell process/electon transport cell process/T-cell costimulation cell process/T-cell differentiation cell process/transcription cell process/transferase activity ubiquitination apoptosis cell process/ATP binding vee circle circle circle circle circle circle diamond vee circle circle circle circle circle circle circle (light blue border) circle (light blue border) circle (light blue border) circle (light blue border) circle (light blue border) circle circle circle circle circle circle circle circle circle circle circle circle circle circle triangle circle (orange border) circle (light blue border) circle circle circle circle circle circle triangle circle circle circle circle (light blue border) circle circle circle (light blue border) circle circle (light blue border) circle (light blue border) circle circle circle circle (light blue border) circle (light blue border) circle circle triangle vee circle F G TBC1D9B HSPA1A autophagy antigen presentation G ZNHIT3 transcription G YIPF2 ER-golgi C1ORF94 ASD PTP4A3 GABPB1 RSGA GSTK1 MAX EGFR ESR1 YWHAB YWHAG YWHAZ CFTR ATXN1 ESR2 SMAD3 ESR1 NHP2L1 SMC YIPF6 Protein binding Official symbol: ARSD. Member of the sulfatase family; correct composition of bone and cartilage matrix Hydrolase activity; early endosome GA-binding protein transcription factor, beta subunit Official symbol: ZNF24. Regulation of transcription, DNA-dependent Glutathione transferase activity Sequence-specific DNA binding transcription factor activity ATP binding; actin filament binding; nitric-oxide synthase regulator activity Chromatin binding; estrogen receptor activity; estrogen response element binding Enzyme binding Insulin-like growth factor receptor binding Protein binding PDZ domain binding; ATP-binding; phosphorylation-dependent chloride channel activity DNA binding; RNA processing DNA binding; sequence-specific DNA binding transcription factor activity Beta-catenin binding; chromatin DNA binding Chromatin binding; estrogen receptor activity; estrogen response element binding RNA binding; RNA splicing Official symbol: DYM. Normal skeletal development and brain function Endoplasmic reticulum cell process/binding cell process/cytoskeleton cell process/hydrolase activity cell process/transcription cell process/transcription cell process/transferase activity cell process/transcription apoptosis cell process/binding cell process/binding cell process/binding cell process/binding cell process/ion transport cell process/transcription cell process/transcription cell process/transcription cell process/binding cell process/transcription cell process/development cell process/endoplasmic reticulum circle circle circle circle circle circle circle vee circle circle circle circle circle circle circle circle circle circle circle circle
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