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RCSI and Almac Discovery enter research collaboration to
target therapy-resistant cancer tumours
February 15, 2017 By firstwordpharma
Tag: research collaboration , tumour cells
RCSI (Royal College of Surgeons in Ireland) and Almac Discovery, a biopharmaceutical
company focused on discovering and identifying innovative therapeutics for the treatment of
cancer, have today announced a major research collaboration that aims to gain a new
understanding of how to target tumour cells that are resistant to cancer therapies and cause
cancer to spread to other parts of the body. The project will explore the potential of a drug,
based on initial research by RCSI’s Professor Tracy Robson and developed by Almac
Discovery, which is currently undergoing a Phase I dose escalation trial for patients with
solid tumours. It is expected that the trial will be expanded in a biomarker selected patient
population within ovarian cancer, however the drug, ALM201, has the potential to treat a
range of other cancers.
Ovarian cancer ranks among the top ten diagnosed and top five deadliest cancers in most
countries. Unfortunately approximately 80% of patients present with advanced disease,
therefore it is critical that clinicians are provided with as many treatment options as possible
which can target this disease, both as a monotherapy and in combination with existing
therapies.
The research team at RCSI, led by Professor Robson, Head of Molecular & Cellular
Therapeutics, will investigate a certain type of cell that is present in all tumours, known as
cancer stem cells. These cancer stem cells are resistant to both radiotherapy or
chemotherapy and can facilitate the spread of cancer around the body. The research will
focus on how a novel protein, called FKBPL, which occurs naturally in the body and has a
unique ability to target cancer stem cells, can transform them into more ‘normal’ tumour
cells. These cells can then be more easily killed by chemotherapy and radiotherapy,
therefore reducing the risk of cancer reoccurrence in the patient.
Professor Robson, said: “Cancer stem cells are a major barrier to successful radiotherapy
and chemotherapy and can result in failure of these treatments. Our initial data
demonstrates that ALM201 can transform these cells so they are no longer resistant to these
therapies. This is a promising development and will complement the anti-angiogenic activity
already demonstrated for this drug. This means that ALM201can block the formation of
tumour blood vessels that would otherwise allow cancer to continue to grow. The funding
provided by Almac will enable us to carry out further research in order to fully understand the
mechanism behind its anti-cancer stem cell activity. This research is a key step on the
journey to making this treatment available to patients for whom all other forms of therapy
have failed.”
Stephen Barr, President and Managing Director, Almac Discovery added: “ALM201
continues to surprise us as we uncover the complexities of its effects. The interaction of
ALM201 with cancer stem cells, if proven with this research, opens up potential further
treatment options for cancer patients that can be explored in the clinic.”
RCSI is ranked in the top 250 institutions worldwide in the Times Higher Education World
University Rankings (2016-2017). It is an international not-for-profit health sciences
institution, with its headquarters in Dublin, focused on education and research to drive
improvements in human health worldwide.
Almac Discovery is a research driven oncology company dedicated to the discovery and
development of novel and innovative approaches to the treatment of cancer. Almac
Discovery focuses on the discovery to preclinical stage seeking to partner programmes at an
early time point with the pharmaceutical industry. Exceptionally the company will undertake
clinical development to an early stage before partnering. Almac Discovery is part of the
Almac Group.