Download Dr. MUHAMMAD FARAZ ARSHAD MALIK

Present address
Madian Manzil,
HOUSE # 22,
STREET # 43,
G6-1/1, Islamabad
,PAKISTAN
Phone
+92 -300-9656522,
+92-333-5524301
E-mail: [email protected]
[email protected]
Dr. MUHAMMAD FARAZ ARSHAD MALIK
Objective
Summary of
qualification
s
Facilitating people with science in an urge of learning
PhD Thesis (Molecular Genetics)
2005 –2010 COMSATs Institute of Information Technology, Pakistan
• Advances in Biosciences Research
• Research Techniques
• Advances in Molecular Biology
M.Phil. (Molecular Biology)
2002 – 2003 University of the Punjab, Pakistan
• General molecular biology
• Molecular virology
• Recombinant DNA technology
• Immunology
• Toxicology
• Instrumentation
• Bioinformatics and computation
• Gene expression
Doctor of veterinary medicine (DVM)
1997 – 2001 University of Agriculture, Faisalabad, Pakistan.
Current
Status
Research
Assistant Professor at Department of Biosciences, COMSATs, Institute of Information Technology,
Islamabad, Pakistan.
Postdoctoral Fellowship one year at Uni. of Cardiff in year 2012-2013
and Job
Experience
Worked as Research Fellow at Institute of Cancer Research, Department of oncology, Uni. of Turin,
Italy in 2011.
Worked as Research fellow for half Year at Metastasis and Angiogenesis Research group (MARG),
Department of surgery, University Hospital Wales, Cardiff, UK in 2008
One Year employment as Research officer in Forensic Case Work Lab, University of Punjab.
Two years research experience as Research scholar in Forensic Research Lab, Uni. Of the Punjab
Professional
Skills
DNA Extraction from biological materials using organic and inorganic method.
Polymerase Chain reaction trouble shootings and its associated research work
Gel electrophoresis both Agarose gel electrophoresis and Poly-acrylamide gel electrophoresis PAGE.
Sequencing and Real Time Polymerase Chain Reaction and data analysis
Quantification of the DNA either using gel electrophoresis techniques or by using Quaint Blot Kit.
Preparing samples for the Genetic Analyzer ABI 310/3100 system.
Genotyping and allele scorings in the data.
Cloning and its related experimentation, (including isolation of plasmid, orientation confirmation)
Expressional analysis of desired gene via a range of Invitro assay.
Expressional analysis at protein as well as transcript levels
Immunohisto staining and Immuno fluorescent microscopy usage
Mutation Detection Techniques for gene of interest (SSCP)
ELISA, Two Dimensional Gel Electrophoresis
Western blot technique.
Computer
skills
Genescan and Genotyper 3.7 for ABI3100 Sequencer
Primer designing using Primer #3 software and for Real Time PCR Probe designing.
Workshops
/seminars
Presented paper in annual SARS (society of Academics and Surgeon) meeting (2012) London, UK.
Stem Cell workshop jointly organized by COMSTECH and Center Of Excellence In Molecular Biology,
Lahore, Pakistan. (2003).
Two Forensic training workshop jointly organized by Forensic Laboratory, Indianapolis, Marion County
USA and Center Of Excellence In Molecular Biology, Lahore, Pakistan. (2002)
Poster Presentation in Two International Conferences
Fraz A Malik, Sanders AJ, Kiayani MA, Jiang WG, Expression analysis of KAI1 gene in in vitro breast
cancer cell lines. Cancer Research Institute UK. 2008
Fraz A Malik, Andy Sanders, Lin Ye, Anthony Douglas-Jones, RobertE Mansel, Wen G Jiang .Expression
of Sonic Hedgehog in Breast Cancer Cells and Mammary Tissues and Its Correlation With
Aggressiveness, American Cancer Society, 2008.
List of Publications
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Malik FA, Kayani MA, Ansar M, Obaid Ullah, Shafeeq M, Chohan S, Abbas Y,Shazad S, Raza
A, Rehman R, Raiz F, Hussan M, Zia ur Rehaman, Zahoor Ahmad. Development of 19-plex Y
Str system and polymorphism studies in Pakistani population. ACAD XJTU 20; 267-273, 2008
Non ISI
Malik FA, Ashraf S, Kayani MA, Jiang WG, Mir A, Ansar M, Baloch IA, Sadiq R. Contribution
of BRCA1 germline mutation in patients with sporadic breast cancer. Int Semin Surg Oncol now
named as as World Journal of Surgical Oncology. 29; 5:21, 2008.
IF= 0.87
Malik FA, Kayani MA, Iqbal H, Jiang WG, Sadiq R. Screening of coding region of metastasis
suppressor genes KISS1 and KAI-1 for germ line mutations in breast cancer patients. Gene Ther
Mol Biol Vol 12, 239-246, 2008.
IF=0.724
Malik FA, Sanders AJ, Mansel R, Jiang WG. Transcriptional and translational modulationof
KAI1 expression in ductal carcinoma of the breast and the prognostic significance. Intern. J. of
Mol. Med. 23: 273-8 2008.
IF=1.573
MalikFA, Sanders AJ and Jiang WG: KAI-1/CD82,the molecule and clinical implication in
cancer and cancer metastasis. Journal of histology and histopathology. 24: 519-530, 2009.
IF=2.480
Malik FA, Sanders AJ, Kayani MA, Jiang WG. Effect of expressional regulation of KAI1 on
growth, adhesion, migration and invasion of breast cancer cell lines. Can. Gen. and Proteomics 6;
205-214, 2009 ISI Indexed
Masood, N; Mahjabeen, I; Baig, RM; Malik, FA and MA Kayani.2010. Association of GSTM1
and GSTT1 gene deletions with risk of head and neck cancer in Pakistan: a case control study.
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Asian Pacific J Cancer Prev. 11: 1-6.
IF: 0.659
Masood, N; Malik, FA and MA Kayani. 2011. Expression of xenobiotic metabolizing genes in
head and neck cancer tissues. Asian Pacific J Cancer Prev. 12. 377-382.
IF: 0.659
Masood, N; Malik, FA and MA Kayani. 2011. Expression of xenobiotic metabolizing genes in
head and neck cancer tissues. Asian Pacific J Cancer Prev. 12. 377-382.
IF: 0.659
MasoodN, Malik FA, Kayani MA. 2011. Glutathione S-Transferase Gene Deletions in Sporadic
Breast Cancer. Asian Pacific J Cancer Prev. 12(7): 1749-1752.
IF: 0.659
Nazir M, Kayani M, Malik FA, Masood N, Kayani MA. 2011. Lack of germ line changes in
KISS1 & KAI1 genes in sporadic head and neck cancer patients of Pakistani origin. Asian Pacific
J Cancer Prev. 12(10).2353-2357.
IF: 0.659
Mahjabeen I; Baig R; Masood N; Sabir, M; Malik FA; Kayani MA. 2011. Sequence variations of
OGG1 gene in head and neck cancer patients of Pakistan.Asian Pacific J Cancer Prev.
12(10):2359-2363.
IF: 0.659
Baig R; Mahjabeen I; Sabir, M; Masood N; Hafeez S; Malik FA; Kayani MA. 2011. Genetic
Changes in PTEN gene and their association with breast cancer in Pakistan. Asian Pacific J
Cancer Prev. 12(10):2365-2370.
IF: 0.659
Kayani M, Kayani MA, Malik FA,Faryal R. 2011. Role of miRNAs in Breast cancer. Asian
Pacific J Cancer Prev. 12(12): 3175-3180.
IF: 0.659
Moeez S; Malik, FA; Kayani, MA; Rashid R; Zahid A; Khan A. 2011. Expressional alterations
and transcript isoforms of metastasis suppressor genes (KAI1 & KiSS1) in breast cancer patients.
Asian Pacific J Cancer Prev. 12(10): 2785-2791.
IF: 0.659
Sabir M, Baig RM, Mahjabeen I, Saeed M, Malik FA and Kayani MA. 2012. RB1/105 gene
alterations and head and neck carcinogenesis. 39(10):9573-81. Molcular Biology Reports.
IF: 2.929
Mahjabeen I, Masood N, Baig RM, Sabir M, Inayat U, Malik FA, Kayani MA. 2012. Novel
mutations of OGG1 Base excision repair pathway gene in laryngeal cancer patients. Familial
Cancer. 11:587-593.
IF: 1.302
Akram M, Malik FA, Kayani MA. 2012. Mutational Analysis of the MTHFR gene in breast
cancer patients of Pakistani population. Asian Pacific Journal of Cancer Prevention. 13(4): 15991603. IF: 0.659
Masood N, Malik FA, Kayani MA. 2012. Unusual intronic variant in GSTP1 in head and neck
cancer in Pakistan. Asian Pacific Journal of Cancer Prevention.13(4):1683-6.
IF: 0.659
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Baig RM, Mahjabeen I, Sabir M, Masood N, Ali K, Malik FA, Kayani MA. 2013. Mutational
spectrum of Gelsolin and its down regulation is associated with breast cancer. Disease Markers.
34: 71-80. IF:1.642
Mahjabeen I, Masood N, Baig RM, Sabir M, Inayat U, Malik FA and Kayani MA. 2013. Genetic
variations in XRCC1 gene in sporadic head and neck cancer (HNC) patients.DOI
10.1007/s12253-012-9567-z. Pathology and Oncology Research.
IF: 1.366
Abstracts Published in international Conferences
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Malik FA, Sanders AJ, Kiayani MA, Jiang WG, Expression analysis of KAI1 gene in in vitro
breast cancer cell lines. Cancer Research Institute UK. 2008
• Malik FA, Sanders AJ, Ye L, Douglas-Jones A, Mansel R, Wen G Jiang .Expression of Sonic
Hedgehog in Breast Cancer Cells and Mammary Tissues and Its Correlation With
Aggressiveness, San Antonio Breast Cancer Symposium Abstracts in 2008 American Association
for Cancer Research (ACCR).
• FA Malik FA, L Ye, WG Jiang. Expression of semaphorin (sema4d) and plexin b in breast
cancer is associated with poorer prognosis, and the potential linkage with oestrogen receptor.
Annual meeting (2012) of Society of Academics and Research in Surgery (SARS) in UK.
Manuscripts in Pipeline for write up or revision phase
• Malik FA, Ye L, Jiang W G. Role of PlexinB family in cancer progression. J of Histol. and
Histopathol. (Accepted will be given Issue and page number)
• Malik FA, Ye L, Jiang W G. Involvement of CD44 in bone metastasis Frontiers in Biosciences
(submitted)
• Malik FA, Ye L, Jiang W G. Expression of sema3C in breast cancer patients and cancer cell lines
for disease progression. (write up from Postdoctoral research)
• Malik FA, Ye L, Jiang W G. Sema4D and PlexinB1 role in breast cancer cohort and cancer cell
lines (write up phase from Postdoctoral research)
• Malik FA, Jiang W G. A Book chapter on ‘Peritoneal Metastasis’.