Download Parasympatholytics

Parasympatholytic
CH3
N
O
Atropine
OH
O
•Pharmaceutical chemistry
•Possible Origin
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action: Anti-muscarinic
•Structure-based explanation of Therapeutic uses: Mydriatic for measuring refractive errors of the eyes, (week-2 week duration). Replaced by short acting anticholinergics, Antispasmodic, anti-dote for mushroom poisoning and antisecretory.
•Structure-based explanation of Side effects: dry mouth, blurred vision, Sandy eyes, tachycardia, constipation, restless and confusion.
•Analysis
Parasympatholytic
OH
O
O
Cyclopentolate (Cyclogyl)
H3C
N
•Pharmaceutical chemistry
•Possible Origin
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action:
•Structure-based explanation of Therapeutic uses: short acting for mydriasis (24 hours)
•Structure-based explanation of Side effects:
•Analysis
CH3
Parasympatholytic
CH3
N
O
O
O
Scopolamine
•Pharmaceutical chemistry
•Possible Origin
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action:
•Structure-based explanation of Therapeutic uses: motion sickness, block short-term memory and anti-spasmodic
•Structure-based explanation of Side effects:
•Analysis
OH
Parasympatholytic
O
N
Tropicamide (Mydriacyl)
•Pharmaceutical chemistry
•Possible Origin
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action:
•Structure-based explanation of Therapeutic uses: short acting for mydriasis (6 hours)
•Structure-based explanation of Side effects:
•Analysis
HO
N
H3C
Parasympatholytic
N
H
Nicotine (Nicotinell)
•Pharmaceutical chemistry
•Possible Origin
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action: Ganglionic blocker (N2)
•Structure-based explanation of Therapeutic uses: none
•Structure-based explanation of Side effects: stimulation then paralysis of Ganglionic receptor, high blood pressure, increasing cardiac output, hypotension with
high doses and low GI activity.
•Analysis
N
Parasympatholytic
CH3
+
N
CH3
O
HO
O
CH3
Tubocurarine
O
O
CH3
OH
N
•Pharmaceutical chemistry
CH3
•Possible Origin
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action: Neuromuscular blocker (N1)
•Structure-based explanation of Therapeutic uses: Adjuvant drug in anaesthesia to facilitate intubation.
•Structure-based explanation of Side effects: it sometimes increases histamine release and causes hypotension (allergy). Thus it is rarely used.
•Analysis
Parasympatholytic
CH3
H3C
O
O
H3C
CH3
O
O
+
N
O
Atracurium (Tracrium)
H3C
•Pharmaceutical chemistry
O
•Possible Origin
CH3
•Physiochemical Properties
•Idea of Retro-synthesis
•Molecular pharmacology
•Mechanism of action:
•Structure-based explanation of Therapeutic uses:
•Structure-based explanation of Side effects: well-tolerated
•Analysis
CH3
O
O
+
O
N
O
O
CH3
CH3
O
H3C