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Milica Medved, Ph.D.
The University of Chicago
Department of Radiology, MC 2026
5841 S. Maryland Avenue
Chicago, IL 60637
Office: (773) 702-4711
Fax: (773) 834-3193
Email: [email protected]
ACADEMIC APPOINTMENTS
2001-2004
Research Associate, Department of Radiology, University of Chicago
2004-2005
Research Associate (Instructor), Department of Radiology, University of Chicago
2005-2014
Research Associate (Assistant Professor), Department of Radiology, University of
Chicago
2015Research Associate (Associate Professor), Department of Radiology, University of
Chicago
OTHER APPOINTMENTS
2009MRI Physicist, Human Imaging Research Office (HIRO), Imaging Research
Institute, University of Chicago
2014Technical Director for Body Imaging, MRI Research Center, University of Chicago
ACADEMIC TRAINING
1990
1995
1997
2000
Diploma
B.S.
M.S.
Ph.D.
Mathematical Academy, Belgrade, Serbia
Physics, University of Belgrade, Belgrade, Serbia
Physics, University of Chicago, Chicago, Illinois
Physics, University of Chicago, Chicago, Illinois
CERTIFICATION
2014
Diplomat
American Board of Medical Physics (MRI Physics)
SCHOLARSHIP
(a) Peer-reviewed publications in the primary literature, exclusive of abstracts:
1. Milica Medved, Damien Dawson, Heinrich M. Jaeger, and Sidney R. Nagel, “Convection in
horizontally vibrated granular material”, Chaos, 9, 1054-1500, 1999.
2. Milica Medved, Heinrich M. Jaeger and Sidney R. Nagel, “Modes of response in horizontally
vibrated granular matter”, Europhysics Letters, 52 (1), 66-72, 2000.
3. Milica Medved, Heinrich M. Jaeger, and Sidney R. Nagel, “Convection in a fully immersed
granular slurry”, Physical Review E, 63 (6), 061302, 2001.
4. Milica Medved, “Connections between response modes in a horizontally driven granular
material”, Physical Review E, 65 (2), 021305, 2002.
5. Weillang Du, Yiping Du, Ulrich Bick, Xiaobing Fan, Peter MacEneany, Marta Zamora, Milica
Medved and Greg Karczmar, “Breast MR Imaging with High Spectral and Spatial Resolutions:
Preliminary Experience”, Radiology, 224(2):577-585, 2002.
6. M. Medved, W. Du, M. A. Zamora, X. Fan, O. I. Olopade, P. MacEneaney, G. Newstead and G.
S. Karczmar, “The effect of varying spectral resolution on the quality of HiSS MR images of the
breast”, Journal of Magnetic Resonance Imaging, 18(4):442-448, 2003.
7. Xiaobing Fan, Milica Medved, Jonathan N. River, Marta A. Zamora, Claire Corot, Philippe
Robert, Philippe Bourinet, Martin Lipton and Gregory S. Karczmar, “New model for analysis of
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dynamic contrast-enhanced MRI data distinguishes metastatic from non-metastatic rodent
prostate tumors”, Magnetic Resonance in Medicine, 51:487-494, 2004.
8. Amy C. Peterson, Susan Swiger, Walter M. Stadler, Milica Medved, Gregory Karczmar, and
Thomas F. Gajewski, “Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced
melanoma”, Clinical Cancer Research, 10:4048-4054, 2004.
9. Milica Medved, Gillian Newstead, Xiaobing Fan, Weiliang Du, Yiping Du, Peter MacEneaney,
Rita Culp, Frederick Kelcz, Olufunmilayo Olopade, Marta Zamora, and Gregory Karczmar,
“Fourier components of inhomogeneously broadened water resonances in breast – a new source
of MRI contrast”, Magnetic Resonance in Medicine, 52:193-196, 2004.
10. Milica Medved, Greg Karczmar, Cheng Yang, James Dignam, Thomas Gajewski, Hedy Kindler,
Everett Vokes, Peter MacEneaney and Walter Stadler, “Semi-quantitative analysis of dynamic
contrast enhanced MRI in cancer patients: variability and changes in tumor tissue over time”,
Journal of Magnetic Resonance Imaging, 20:122-128, 2004.
11. C. Yang, G. Karczmar, M. Medved and W. Stadler, “Estimating the Arterial Input Function Using
Two Reference Tissues in Dynamic Contrast-Enhanced MRI Studies. 1. Fundamental Concepts
and Simulations”, Magnetic Resonance in Medicine, 52:1110-1117, 2004.
12. M. Medved, G. Newstead, H. Abe, M. A. Zamora, O. I. Olopade, G. S. Karczmar, “High spectral
and spatial resolution MR imaging of breast lesions: preliminary clinical experience”, American
Journal of Roentgenology, 186(1):30-37, 2006.
13. X. Fan, M. Medved, S. Foxley, J. N. River, M. A. Zamora G. S. Karczmar, C. Corot, P. Robert,
and P. Bourrinet, “Multi-slice DCE-MRI data using P760 distinguishes between metastatic and
non-metastatic rodent prostate tumors”, Magnetic Resonance Materials in Physics, Biology and
Medicine, 19(1):15-21, 2006.
14. X. Fan, H. Abe, M. Medved, S. Foxley, S. Arkani, M. A. Zamora, O. I. Olopade, G. M. Newstead,
G. S. Karczmar, “Fat suppression with spectrally selective inversion vs. high spectral and spatial
resolution MRI of breast lesions: Qualitative and quantitative comparisons”, Journal of Magnetic
Resonance Imaging, 24(6):1311-15, 2006.
15. X. Fan, M. Medved, G. S. Karczmar, C. Yang, S. Foxley, S. Arkani, W. Recant, M. A. Zamora, H.
Abe, G. M. Newstead, “Diagnosis of suspicious breast lesions using an empirical mathematical
model for dynamic contrast-enhanced MRI”, Magnetic Resonance Imaging, 25(5):593-603, 2007.
16. C. Yang, Karczmar G. S., M. Medved, W. M. Stadler, “Multiple reference tissue method for
contrast agent arterial input function estimation”, Magnetic Resonance in Medicine, 58(6):126675, 2007.
17. S. Foxley, X. Fan, D. Mustafi, C. Yang, M. A. Zamora, M. Medved and G. S. Karczmar,
“Quantitative analysis of water proton spectral lineshape: a novel source of contrast in MRI”,
Physics in Medicine and Biology, 53(17):4509-4522, 2008.
18. O. M. Hahn, C. Yang, M. Medved, G. S. Karczmar, E. Kistner, T. Karrison, E. Manchen, M.
Mitchell, M. J. Ratain, Walter M. Stadler, “Dynamic contrast-enhanced MRI pharmacodynamic
biomarker study of sorafenib in metastatic renal cell carcinoma”, Journal of Clinical Oncology
26:4572-4578, 2008.
19. S. Foxley, X. Fan, D. Mustafi, C. Haney, M. Medved, A. M. Wood, M. Zamora, E. Markiewicz, and
G. S. Karczmar, “Sensitivity to tumor micro-vasculature without contrast agents in high spectral
and spatial resolution MR images”, Magnetic Resonance in Medicine, 61(2):291-298, 2009.
20. C. Yang, G. Karczmar, M. Medved, A. Oto, M. Zamora, W. Stadler, “Reproducibility Assessment
of a Multiple Reference Tissue Method for Quantitative DCE-MRI Analysis”, Magnetic Resonance
in Medicine, 61(4):851-9, 2009.
21. M. Medved, G. M. Newstead, X. Fan, Y. P. Du, O. I. Olopade, A. Shimauchi, M. A. Zamora, G. S.
Karczmar, “Fourier Component Imaging of Water Resonance in Human Breast Provides Markers
for Malignancy”, Physics in Medicine and Biology, 54(19):5767-79, 2009.
22. M. Medved, G. M. Newstead, H. Abe, O. I. Olopade, A. Shimauchi, M. A. Zamora, G. S.
Karczmar, "Clinical implementation of a multislice High Spectral and Spatial resolution (HiSS)-
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based MRI sequence to achieve unilateral full-breast coverage", Magnetic Resonance Imaging,
28(1):16-21, 2010.
23. M. Medved, M. K. Ivancevic, O. I. Olopade, G. M. Newstead, G. S. Karczmar, “Echo-planar
spectroscopic imaging (EPSI) of the water resonance structure in human breast using Sensitivity
Encoding (SENSE)”, Magnetic Resonance in Medicine, 63(6):1557-63, 2010.
24. S. A. Jansen, X. Fan, M. Medved, H. Abe, C. Yang, M. A. Zamora, S. Foxley, O. I. Olopade, G. S.
Karczmar, G. M. Newstead, “Characterizing early contrast uptake of ductal carcinoma in situ with
high temporal resolution dynamic contrast enhanced MRI of the breast: a pilot study”, Physics in
Medicine and Biology, 55(19):N473-85, 2010.
25. M. Medved, X. Fan, H. Abe, G. M. Newstead, A. M. Wood, A. Shimauchi, K. Kulkarni, M. K.
Ivancevic, L. L. Pesce, O. I. Olopade, G. S. Karczmar, “Non-contrast enhanced MRI for evaluation
of breast lesions: comparison of performance of non-contrast enhanced high spectral and spatial
resolution (HiSS) images versus contrast enhanced fat-suppressed T1-weighted images”,
Academic Radiology, 18(12):1467-74, 2011.
26. M. Wang, C. Wang, K. Young, L. Hao, M. Medved, T. Rajh, H. Fry, L. Zhu, G. Karczmar, C.
Watson, S. Jiang, N. Markovic, V. Stamenkovic, “Cross-linked Heterogeneous Nanoparticles as
Bifunctional Probes”, Chemistry of Materials, 24:2423, 2012.
27. A. M. Wood, M. Medved, I. Bacchus, S. Swaminathan, S. Fischer, M. K. Ivancevic, G. M.
Newstead, O. I. Olopade, G. S. Karczmar, “Classification of breast lesions pre-contrast injection
using water resonance lineshape analysis”, NMR in Biomedicine, 26(5):569-77, 2013.
28. I. Karademir, D. Shen, Y. Peng, S. Liao, Y. Jiang, A. Yousuf, G. Karczmar, S. Sammet, S. Wang,
M. Medved, T. Antic, S. Eggener, A. Oto, “Prostate volumes derived from MRI and volumeadjusted serum prostate-specific antigen: correlation with Gleason score of prostate cancer”,
American Journal of Roentgenology, 201(5):1041-8,2013.
29. W. Weiss, M. Medved, G. Karczmar, M. Giger, “Residual analysis of water resonance signal in
breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study”, Medical
Physics, 41(1):012303, 2014.
30. N. Bhooshan, M. L. Giger, M. Medved, A. M. Wood, Y. Yuan, L. Lan, A. Marquez, H. Li, G. M.
Newstead, G. S. Karczmar, “Potential of computer-aided diagnosis of high spectral and spatial
resolution (HiSS) MRI in the classification of breast lesions”, Journal of Magnetic Resonance
Imaging, 39(1):59-67,2014.
31. S. Wang, Y. Peng, M. Medved, A. N. Yousuf, M. K. Ivancevic, I. Karademir, Y. Jiang, T. Antic, S.
Sammet, A. Oto, G. S. Karczmar, “Hybrid multidimensional T(2) and diffusion-weighted MRI for
prostate cancer detection”, Journal of Magnetic Resonance Imaging, 39(4):781-8,2014.
32. M. Medved, S. Sammet, A. Yousuf, A. Oto, “MRI of prostate and adjacent structures before,
during, and after ejaculation: qualitative and quantitative evaluation”, Radiology, 271(2):45260,2014.
33. M. Medved, F. N. Soylu, C. Yang, G. S. Karczmar, M. K. Ivancevic, A. Oto, “High resolution
diffusion-weighted MR imaging of prostate cancer”, Am J Roentgenol, 203(1):85-90,2014.
(b) Peer-reviewed publications currently in review and in preparation:
1. M. Sadinski, M. Medved, I. Karademir, S. Wang, Y. Peng, Y. Jiang, S. Sammet, G. Karczmar, A.
Oto, “Short-term reproducibility of apparent diffusion coefficient estimated from diffusion weighted
MRI of the prostate”, submitted to AJR.
2. W. Weiss, M. Medved, G. Karczmar, M. Giger, “Preliminary assessment of DISPA analysis of
HiSS MR images in the diagnosis of breast cancer”, submitted to Journal of Medical Imaging.
3. F. Pineda, M. Medved, X. Fan, M. K. Ivancevic, H. Abe, A. Shimauchi, C. A. Sennett, G. M.
Newstead, G. S. Karczmar, “Reproducibility of breast lesion kinetic parameters between 1.5T and
3T DCEMRI”, submitted to JMRI.
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(c) Conference proceedings and abstracts:
Sixty nine (69) conference proceedings and abstracts have been published.
(d) Non-peer-reviewed original articles:
1. G S. Karczmar, G. M. Newstead, M. Medved, A. M. Wood, H. Abe, F. I. Olopade, “High resolution
MR breast imaging”, Medica Mundi, 53(1):20,2009.
(e) Clinical trials that are ongoing and unpublished:
1. “DCE-MRI as Pazopanib Biomarker in Metastatic Renal Cancer” (PI: W. M. Stadler) Role: MR
Physicist, acquisition protocol design, processing methods and software design, data processing.
Status: In progress.
2. “DCE-MRI as Pazopanib Biomarker in Metastatic Renal Cancer” (PI: R. Z. Szmulewitz) Role: MR
Physicist, acquisition protocol design, processing methods and software design, data processing.
Status: In progress.
3. “A Pilot Study to Evaluate Magnetic Resonance Thermal Image-guided Laser-Induced Interstitial
Thermal Therapy for Focal Ablation of Breast Cancer” (PI: H. Abe) Role: MR Physicist,
acquisition protocol design, data acquisition. Status: In progress.
4. “Assessment of breast cancer risk with high spectral and spatial resolution MRI” (PI: G. S.
Karczmar) Role: Co-Investigator.
5. “Quantitative DCEMRI of Pca – Correlation with gold standard” (PI: A. Oto) Role: Co-Investigator.
(f) Patents and patent applications:
1. G. Karczmar, M. Medved, and G. Newstead, US Patent Application 20090185981, “Methods and
apparatus for dynamically allocating bandwidth to spectral, temporal, and spatial dimensions
during a magnetic resonance imaging procedure”
FUNDING
(a) Past:
1. Cancer Research Foundation PI: X. Fan. Title: “The Use of Dynamic Contrast-Enhanced MRI to
Differentiate between Rodent Metastatic and Non-Metastatic Prostate Tumors:
Comparing Low, Medium and High Molecular Weight Contrast Agents”. Total direct
costs: $49,997. Project period 01/01/2003-12/31/2003.
2. Cancer Research Foundation PI: X. Fan. Title: “Using Empirical Mathematical Modelof Dynamic
Contrast-Enhanced MRI for Improved Diagnosis of Breast Cancer”. Total direct costs:
$50,000. Project period 01/01/2004-12/31/2004.
3. ACS PI: G. S. Karczmar. My role: Research Associate. Title: “The use of MR to study tumor
response to hyperoxia”. Total direct costs: $429,000. Project period 01/01/200212/31/2004.
4. ACS PI: G. M. Newstead. My role: Research Associate. Title: “Use of dynamic contrast
enhanced MRI with High Temporal resolution for Diagnosis of DCIS”. Total direct
costs: $99,980. Annual salary recovery of effort: 25%. Project period: 07/01/0306/30/04.
5. US Army Medical Research and Acquisition Activity DAMD 17-02-1-0033. PI: G. S. Karczmar.
My role: MR Physicist. Title: “Angiogenesis and Invasiveness in Prostate Cancer
Detected with High Spectral & spatial Resolution MRI”. Total direct? costs:
$370,189/$550,039. Annual salary recovery of effort: 50%. Project period: 12/24/0101/23/05
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NIH 2 R01 EB003108. PI: G. S. Karczmar. My role: MRI Physicist. Title: “High Spectral and
Spatial Resolution Imaging of Breast Cancer”. Total direct costs: $1,372,500. Project
period: 10/01/03-09/30/07.
NIH 5 R01 CA078803-07. PI: G. S. Karczmar. My role: MRI Physicist. Title: “Fast
Spectroscopic MR Imaging of Breast Cancer”. Total direct? costs: $1,555,806.
Annual recovery of effort: 80%. Project period: 09/01/99-02/29/09.
Philips Medical Systems XX. PI: A. Oto. My role: Co-Investigator. Title: “Optimization of prostate
MRI”. Total direct costs: $101,000. Annual salary recovery of effort: 5% Project
period: 04/02/08-12/31/10.
Philips Medical Systems XX. PI: G. S. Karczmar. My role: MR Physicist. Title: “High Spectral,
Spatial, Temporal Resolution MRI”. Total direct costs: $192,000. Annual recovery of
effort: 10% Project period: 11/01/08-12/31/10.
DOE DE-FG02-08ER64578. PI: M. L. Giger. My role: MR Physicist Tech. Title: “Research
Multi-Modality, Image-Based Markers for Assessing Breast Density & Structure to
Determine Risk of Breast Cancer at the University of Chicago”. Total direct?? costs:
$373,290/$573,000. Annual salary recovery of effort: 20%. Project period: 05/01/0804/30/11.
NIH/NCI P50 CA125183-03. PI: O. I. Olopade. My role: MR Physicist. Title: “SPORE in Breast
Cancer; Project 2: Specificity of MRI with optimal temporal, spatial, and spectral
sampling in early breast cancer”. Total direct costs: $181,398. Annual recovery of
effort: 30%. Project period: 09/27/06-07/31/11.
NIH/NCI R33 CA100996-02. PI: G. S. Karczmar. My role: Title: “Micro-vessel density with High
Spectral/Spatial MRI”. Total direct costs: $1,064,575. Annual recovery of effort: 36%.
Project period: 09/20/07-08/31/11.
Philips Healthcare Exhibit 32. PI: A. Oto/S. Sammet. My role: MR Physicist. Title: “MRI guided
HIFU treatment of prostate in-vivo project”. Total direct costs: $50,000. Annual
recovery of effort: 5%. Project period: 09/01/11-08/31/12.
ITM/NorthShore University NSUHS-UC. PI: G. S. Karczmar. My role: MR Physicist. Title: “Use
of quantitative MRI to identify patients with high risk lesions who can avoid surgery”.
Total direct costs: $43,000. Annual salary recovery of effort: 20%. Project period:
02/13/12-02/12/13. (Is this IDPH?)
NIH 5 P30 CA014599-33. PI: LeBeau. My role: Lab Coordinator, Chief Technician. Title:
“UCCRC-CANCER Center Support Grant; Subproject: MRIS Core Facility”. ComputerAided Diagnosis (CADx) of Breast Calcifications”. Total direct costs: $1,250,000.
Annual salary recovery of effort: 10%. Project period: 09/01/97-03/31/13.
Philips Healthcare C38. PI: A. Oto. My role: Investigator. Title: “Novel approaches to DWI of
the prostate”. Total direct costs: $60,000. Annual salary recovery of effort: 7%.
Project period: 01/01/12-06/30/13
Philips Healthcare C32. PI: A. Oto. My role: MRI Physicist. Title: “MR Guided High Frequency
Ultrasound treatment of prostate in dogs”. Total direct costs: $70,000. Annual salary
recovery of effort: 7%. Project period: 09/01/11-08/31/13.
IDPH. PI: G. S. Karczmar. My role: MR Physicist. Title: “Use of quantitative breast MRI to
identify patients with high risk lesions on core biopsy who could avoid surgery”. Total
direct costs: $200,000. Annual recovery of effort 20%. Project period 01/01/1212/31/13. (overlaps with ITM/NorthShore U)
NIH 1R01 CA133490-01A2. PI: G. S. Karczmar. My role: MR Physicist. Title: “MRI of early
non-invasive rodent mammary cancers”. Total direct? costs: $1,628,974. Annual
recovery of effort: 10%. Project period: 03/01/11-12/31/15.
Philips Healthcare Systems (2-72004) PI: G. M. Newstead. My role: . Data Base License
Agreement (MTA) Total indirect? costs: $148,236. Annual recovery of effort 13.61%.
Project period: 10/01/05-09/30/22.
(b) Current:
1. Human Imaging Research Office (2-50045) Faculty Director: S. Armato. My role: MR Physicist.
Annual recovery of effort 25%.
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European Union, Jacobs University Bremen. PI: G. S. Karczmar and G. M. Newstead My role:
Investigator. Title: “VPH-PRISM Consortium”. Total direct costs: $240,000. Annual
salary recovery of effort: 13.92%. Project period: 01/01/13-12/31/15
NIH R01 CA167785. PI: G. S. Karczmar. My role: Co-Investigator. Title: “Assessment of breast
cancer risk with high spectral and spatial resolution MRI”. Total direct costs:
$1,560,000. Annual salary recovery of effort: 28.50%. Project period: 09/01/201208/31/2017.
NIH R01 CA172801. PI: A. Oto. My role: Co-Investigator. Title: “Quantitative DCEMRI of Pca –
Correlation with gold standard”. Total direct costs: $2,884,102. Annual salary
recovery of effort: 25.67%. Project period: 09/01/2012-08/31/2017.
NIH R44 CA186313. PI: A. Penn. My role: Investigator. Title: “Diffusion Weighted Breast MR
Imaging for Screening Women with Dense Breasts”. Total direct costs: $379,992.
Annual salary recovery of effort: 9.08%. Project period: 09/19/2014-08/31/2016.
(c) Pending:
1. NIH PI: M. L. Giger. My role: Co-Investigator. Title: “Multi-modality Imaging Discovery of DCIS
Breast Lesions”. Total direct costs: $1,250,000. Annual salary recovery of effort:
10%. Project period: 04/01/2014-03/31/2019.
2. NIH PI: M. Medved. My role: PI. Title: “Development of a non contrast enhanced MRI Breast
Cancer Screening protocol”. Total direct costs: $1,620,904. Annual salary recovery
of effort: 45%. Project period: 12/01/2014-11/30/2019.
HONORS, PRIZES, AND AWARDS
1987 – 1990
City Merit Fellowship, Belgrade, Yugoslavia
1990 – 1995
State Merit Fellowship, Serbia, Yugoslavia
1995
Best Bachelor’s Thesis Award, Faculty of Physics,
The University of Belgrade, Belgrade, Yugoslavia
2002
Paul C. Hodges Society Award, Department of Radiology,
The University of Chicago, Chicago, Illinois
2013
JMRI Distinguished Reviewer Award
INVITED SPEAKING:
1. M. Medved, “Current Research in Granular Matter”, Institute for Theoretical Physics, Zemun,
Yugoslavia, January 2001.
2. M. Medved, “dMRI for Early Evaluation of Response to Antiangiogenic Cancer Treatment”, MRI
Center, Clinical Center of Serbia, Belgrade, Yugoslavia, October 2001.
3. Karczmar GS, Foxley S, Medved M, Fan X, Zamora M, “Inhomogeneous broadening of the water
resonance is a novel source of contrast in MRI”, In: 47th ENC Conference, Asilomar CA, April
2006. (presented by Dr. Karczmar)
4. Medved M, Karczmar GS, Newstead GM, “Do we really need contrast agents?”, Sixth
International Congress on MR-Mammography, Jena, Germany, September 2012. (presented by
Dr. Newstead)
5. M. Medved, “Applications of Breast MRI”, Faculty for Physical Chemistry, University of Belgrade,
Belgrade, Serbia, May 2014.
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PROFESSIONAL SOCIETIES:
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American Association of Physicists in Medicine
Sigma Xi Society
International Society for Magnetic Resonance in Medicine
American Physical Society (past)
OTHER PROFESSIONAL ACTIVITIES:
Reviewer
Reviewer
Reviewer
JMRI, Medical Physics, MRI, Archives of Gynecology and Obstetrics (since
2005)
ISMRM Annual Meeting (2003-8, 2014-15)
Grant applications, DOD CDMRP Prostate Cancer Research Program (2007),
Breast Cancer Research Program (2009)
SERVICE:
PhD Committee member in the Graduate Program in Medical Physics (William Weiss, BS; Meredith
Sadinski, BS)
SERVICE (extramural):
Reviewer
Associate Editor
abstract submissions, Conrad Foundation Spirit of Innovation Challenge (2013,
2015)
Journal of Medical Imaging (since 2015)