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The 11th Japan - Korea Cancer Research Workshop - Cancer Research in Post-genomic Era - December 15-16, 2006 The Westin Chosun Hotel Busan, Korea The 9th Japan-Korea Cancer Research Workshop 2004 Committee Roster Advisors Dr. Tadao Kakizoe, President National Cancer Center, Japan Dr. Tadatsugu Taniguchi, Professor University of Tokyo, Japan Dr. Keun-Young Yoo, President National Cancer Center, Korea Program Dr. Setsuo Hirohashi, Director National Cancer Center Research Institute, Japan Coordinators Dr. Masabumi Shibuya, Professor Institute of Medical Sciences, University of Tokyo, Japan Dr. Jin-Soo Lee, Director Research Institute, National Cancer Center, Korea Dr. Yong-Sung Juhnn, Director Cancer Research Institute Seoul National University, Korea Organizers Dr. Toshikazu Ushijima, Chief Carcinogenesis Division, National Cancer Center Research Institute, Japan Dr. Yasuhito Yuasa, Professor Department of Molecular Oncology Tokyo Medical and Dental University, Japan Dr. Soo-Youl Kim, Head Division of Basic Science Research Institute, National Cancer Center, Korea Dr. Han-Kwang Yang, Professor Cancer Research Institute Seoul National University, Korea -2- Molecular Signature of Cancer Cells and Its Clinical Applications General Information Date & Time December 15 (Fri), 2006 Welcome Party; 19:30-20:30 Shilla(2F), The Westin Chosun Hotel December 16 (Sat), 2006 Science Sessions; 08:15-17:45 Junior Ball Room(Kaya, 2F), The Westin Chosun Hotel Dinner for Participants; 19:00-21:00 Shilla(2F), The Westin Chosun Hotel Venue The Westin Chosun Hotel, Busan Address: 737 Woo 1-dong, Haeundae-gu, Busan, Korea (612-822) TEL: 82-51-749-7000 FAX: 82-51-742-1313 Website: http://twcb.echosunhotel.com/index_en.asp Oral Presentation Each speaker has 25min in total. Poster Presentation A poster board, 165cm in height and 95cm width, is available for the presenters. -3- The 11th Japan - Korea Cancer Research Workshop 2006 PROGRAM December 15, 2006 (Fri) Shilla(2F), The Westin Chosun Hotel 19:30 – 20:30 WELCOME RECEPTION Welcoming Remark by Dr. Jin-Soo Lee Reply by Dr. Masabumi Shibuya December 16, 2006 (Sat) Junior Ball Room(Kaya, 2F), The Westin Chosun Hotel 08:00-08:15 08:15-08:30 Registration Opening Remark by Dr. Toshikazu Ushijima Welcome address by Dr. Han-Kwang Yang Session I. Oncogene and Suppressor Gene in Tumor Development Chairpersons: Dr. Yasuhito Yuasa & Dr. Joo-Bae Park 08:30-08:55 Roles of Nuclear Receptor Coregulators and Their Modification Codes in Regulation of a Metastasis Suppressor Gene Sung Hee Baek Department of Biological Sciences, Seoul National University, Korea 08:55-09:20 LMO3, A Novel Oncogene of Neuroblastoma, Targets Proneural Gene hASH1 for Its Expression and Enhances Cell Growth Akira Nakagawara Division of Biochemistry Chiba Cancer Center Research Institute, Japan 09:20-09:45 Hyperplasia and Spontaneous Tumor Development in the Gynecologic System in Mice Lacking the BRCA1-Delta11 Isoform Sangsoo Kim Radiation Medicine Branch, Research Institute, National Cancer Center, Korea 09:45-10:00 Coffee Break Session II. Oxygenomics and Carcinogenesis Chairpersons: Dr. Toshikazu Ushijima & Dr. Soo-Youl Kim 10:00-10:25 Oxygenomics: A New Approach to Understand Free Radical-induced Carcinogenesis Shinya Toyokuni Department of Pathology and Biology of Diseases, Kyoto University, Japan 10:25-10:50 Novel, Functional Roles of Superoxide-generating Nox family Oxidases in Cancer Development Tohru Kamata Department of Molecular Biology and Biochemistry, Shinshu University, Japan 10:50-11:15 Multi-step Carcinogenesis in -ray Induced Mouse Thymic Lymphomas Ryo Kominami Department of Molecular Genetics, Niigata University, Japan 11:15-11:30 Coffee Break Session III. Targets for Cancer Therapy in Cell Signaling Chairpersons: Dr. Akira Nakagawara & Dr. Yong-Sung Juhnn 11:30-11:55 Geldanamycin-induced Apoptotic Cell Death in Epstein-Barr Virus-positive NK/T Cell Lymphoma by Akt Downregulation Yong-Nyun Kim Pediatric Oncology Branch, Division of Specific Organs Cancer, Research Institute, National Cancer Center, Korea 11:55-12:20 Chasing Targets for EGFR Inhibitor in Lung Cancer Tae-You Kim Division of medical oncology, Seoul National University, Korea 12:20-13:20 LUNCH (Grand Ball Room) 13:20-14:30 POSTER SESSION (Grand Ball Room) Session IV. 14:30-14:55 Clinical Application of Genomics Chairpersons: Dr. Okio Hino & Dr. Jin-Soo Lee Polymorphism of MYH in Japanese Cancer Subjects Haruhiko Sugimura Department of Pathology, Hamamatsu University, Japan 14:55-15:20 Comprehensive Analysis of UGT1A Polymorphisms Predictive for Pharmacokinetics and Treatment Outcome in Non-small Cell Lung Cancer Patients Treated with Irinotecan and Cisplatin Ji-Youn Han Lung Cancer branch, Research Institute, National Cancer Center, Korea 15:20-15:45 The CpG Island Methylator Phenotype is A Strong Prognostic Factor in Neuroblastomas Toshikazu Ushijima Carcinogenesis Division, National Cancer Center Research Institute, Japan 15:45-16:00 Session V. 16:00-16:25 Coffee Break New Approach for Cancer Therapy Chairpersons: Dr. Ryo Kominami & Dr. Han-Kwang Yang MicroRNAs in Cancer V. Narry Kim School of Biological Sciences, Seoul National University, Korea 16:25-16:50 Serum Marker of Asbestos-related Translational Research Mesothelioma - Okio Hino Department of Pathology II, Juntendo University, Japan 16:50-17:15 Intracellular Protein Therapy Inflammation and Apoptosis Daewoong Jo Department of Biomedical Science Chonnam National University, Korea with SOCS3 Inhibits 17:15-17:30 GENERAL DISCUSSION 17:30-17:45 CLOSING REMARKS Dr. Yasuhito Yuasa & Dr. Soo-Youl Kim 19:00- DINNER FOR INVITED SPEAKERS Special Remark by Dr. Setsuo Hirohashi and Dr. Yong-Sung Juhnn Friendship Toast by Dr. Joo-Bae Park Shilla(2F), The Westin Chosun Hotel Poster Session From Japan Processing of the human laminin 2 chain by membrane-type-1 matrix metalloproteinase (MT1-MMP) and its proteolytic fragment potentially supports cancer malignant progression Naohiko Koshikawa, Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Identification of novel target genes of RUNX2 in bone metastasis of breast cancer cells Shingo Maeda, Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research Strategy and mechanism for the prevention of hepatocellular carcinoma (HCC)– phosphorylated RXR might be a critical target for HCC chemoprevention – Masahito Shimizu, Department of Gastroenterology, Gifu University School of Medicine, Roles of prostaglandin E2 receptor EP3 in colon and skin carcinogenesis in mice Mami Takahashi, Cancer Prevention Basic Research Project, National Cancer Center Research Institute Opposing effects of DNA hypomethylation on intestinal carcinogenesis in Apc Min/+ mouse Yasuhiro Yamada, Department of Tumor Pathology, Gifu University School of Medicine Silencing of Tgfbr2 in rat prostate cancers. Satoshi Yamashita, Carcinogenesis Division, National Cancer Center Research Institute Methylation of the calcium channel-related gene, CACNA2D3, is frequent and an independently poor prognostic factor in gastric carcinomas Yasuhito Yuasa, Department of Molecular Oncology, Tokyo Medical and Dental University From Korea Alpha-linolenic acid and genistein : Growth regulatory effect on breast cancer cell Jeong Woo Chon, Carcinogenesis Branch, Research Institute, National Cancer Center The Relationship Between TGase 2 and NF-B in Doxorubicin Resistance Breast Cancer Cells. Dae Seok Kim, Molecular Oncology Branch, Division of Basic Sciences, Research Institute, National Cancer Center Lapatinib increases cytotoxicity against gefitinib-resistant T790M lung cancer cells by inhibiting active heterodimerization of EGFR and HER-2 Hwang-Phill Kim, Cancer Research Institute, Seoul National University College of Medicine Synergistic Effect of Transglutaminase 2 in NF-B activation by TNF- Treatment Jung-Mo Kim, Molecular Oncology Branch, Division of Basic Sciences, Research Institute, National Cancer Center Mechanism of radiosensitization by flavopiridol in head and neck squamous cell carcinoma cell line Suzy Kim, Department of Radiation Oncology, Seoul National University College of Medicine Single Nucleotide Polymorphisms in the VEGF Gene is Ethnically Different in Patients with Breast Cancer Bumi Kwon, Breast Cancer Branch, Research Institute, National Cancer Center Clinical usefulness of circulating angiogenic factors in non-Hodgkins lymphoma Hye Lin Lee, Hematologic Malignancies Branch, Research Institute, National Cancer Center RP1, Ginsenoside, Induces Apoptosis in LnCap and PC3 Cells via Lipid Rafts/Caveolae Alteration. Seung-Hun Lee, Resarch Institute Pediatric Oncology Branch, Research Institute, National Cancer Center Inhibition of epidermal growth factor-induced signaling by mutation of putative caveolin-binding domain in its receptor Ying Chun Li, Pediatric Oncology Branch, Division of Specific Organs Center, Research Institute, National Cancer Center Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing HIFJi-Hong Lim, Department of Pharmacology, Cancer Research Institute, Seoul National University College of Medicine Human papilloma virus type 16 E5 protein promotes the expression of EP4 receptor through upregulation of COX-2 in cervical cancer cells Jung-Min OH, Department of Biochemistry and Molecular Biology, Cancer Research Institute, Seoul National University Effects of ginsenoside Rh2 and its modified form, RP1 on cell viability and changes in lipid rafts in human epidermoid carcinoma A431 cells Eun-Kyung Park, Pediatric Oncology Branch, Division of Specific Organs Cancer, Research Institute, National Cancer Center In vitro characterization of Carbonic Anhydrase 9 (CA9) expression in tumor cells Hye-Jin Shin, Department of Genetic Engineering, Research Institute, National Cancer Center Expression profile and functional study of microRNA in gastric cancer Jieun Yu, Division of Tumor Biology, Cancer Research Institute, Seoul National University College of Medicine Associations between 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 genetic polymorphisms and dietary B vitamins intake with reference to susceptibility to breast cancer: a case-control study Young Mi Yun, Division of Basic Sciences, Research Institute, National Cancer Center