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CURRICULUM VITAE Name Lawrence S. Lee Office Address University Heart Surgeons University of Tennessee Graduate School of Medicine 1940 Alcoa Highway, Suite E-260 Knoxville, Tennessee 37920 Office Phone 865-305-6955 Education 2005 M.D. Medicine University of Pennsylvania School of Medicine Philadelphia, PA 2001 B.S. magna cum laude Phi Beta Kappa Biology Haverford College Haverford, PA Postdoctoral Training 2013-2015 Resident Thoracic Surgery Brigham and Women’s Hospital Harvard Medical School Boston, MA 2010-2013 Resident Surgery Brigham and Women’s Hospital Harvard Medical School Boston, MA 2007-2010 Research Fellow Cardiac Surgery Brigham and Women’s Hospital Harvard Medical School Boston, MA 2005-2007 Resident Surgery Brigham and Women’s Hospital Harvard Medical School Boston, MA Academic Appointments 2015- Assistant Professor Surgery University of Tennessee Graduate School of Medicine 2005-2015 Clinical Fellow Surgery Harvard Medical School 1 Board Certification 2016 American Board of Thoracic Surgery Certificate # 8221 2013 American Board of Surgery Certificate # 58458 State Licensure 2015 Tennessee License # 52780 2007 Massachusetts License # 230898 Honors and Prizes 2015 - 2016 Guardian Angel Award University of Tennessee Medical Center Three time recipient. Awarded when a patient identifies a particular physician for excellent and compassionate medical care. 2010 Richard C. Lillehei/Earl Bakken Prize Lillehei Surgical Society, University of Minnesota Awarded for academic excellence and leadership potential 2009 John A. Mannick Research Award Brigham and Women’s Hospital, Harvard Medical School Awarded for academic and research excellence 2008 NIH T32 Harvard Longwood Cardiovascular Surgery Research Grant Awarded to allow for funding of laboratory research for heart failure 2008 Heart Failure Society of America Research Fellowship (awarded but declined) Awarded to allow for funding of laboratory research for heart failure 2007 Warren Whitman Fellowship Harvard Medical School Awarded for academic excellence and to allow funding for laboratory research 2007 Massachusetts Chapter ACS Annual Resident Research Competition, 2nd place Awarded for excellence in research 2004 University of Pennsylvania Medical Student Representative to the ACS Clinical Congress 2002 NIH - NIDDK Research Fellowship 2000 Howard Hughes Medical Institute Interdisciplinary Scholarship Awarded for academic excellence and to allow for funding of laboratory research 2 Research Experience 2007-2010 Postdoctoral Research Fellow Cardiac Surgery Research Laboratory, Harvard Medical School Advisor: Frederick Chen, M.D., Ph.D. Performed large animal (ovine) studies to investigate the effects of adjustable ventricular restraint therapy as a novel surgical treatment for heart failure 2004-2005 Research Fellow Surgical Oncology Research Laboratory, University of Pennsylvania School of Medicine Advisor: Douglas Fraker, M.D. Performed in vivo and in vitro experiments investigating the mechanism of action of isolated limb perfusion chemotherapy for extremity melanoma and sarcoma 2002 Thoracic Oncology Research Laboratory, University of Pennsylvania School of Medicine Advisor: Larry Kaiser, M.D. Analyzed gene expression and regulation in lung adenocarcinoma and mesothelioma using real time quantitative PCR and genomic profiling algorithms Formal Teaching Activities 2016 Instructor Thoracic Trauma University of Tennessee Large animal simulation session for general surgical residents 2015 Instructor Minimally Invasive Esophagectomy University of Tennessee Large animal simulation session for general surgical residents 2009 Preceptor Advanced Clinical Anatomy Harvard Medical School Advanced anatomy course for 4th year medical students 2009 Preceptor Human Body Anatomy Harvard Medical School 1st year medical student anatomy course 2008 Preceptor Introduction to Clinical Medicine Harvard Medical School 2nd year medical student course focusing on physical exam and patient interaction skills Publications Peer reviewed publications 1. Lee L, Singhal S, Brinster C, Marshall B, Kochman M, Kaiser L, Kucharczuk J. Current management of esophageal leiomyoma. J Am Coll Surg 2004; 198(1):136-146. 2. Brinster C, Singhal S, Lee L, Marshall B, Kochman M, Kaiser L, Kucharczuk J. Evolving options 3 in the management of esophageal perforation. Ann Thorac Surg 2004; 77:1475-1483. 3. Lee L, Nance M, Kaiser L, Kucharczuk J. Familial massive leiomyoma with esophageal leiomyomatosis: an unusual presentation in a father and his two daughters. J Ped Surg 2005; 40(5):e29-e32. 4. Lee L, Canter R, Fraker D. Intraoperative jugular venous sampling aids detection of an undescended parathyroid adenoma. World J Surg 2006; 30(4):620-623. 5. Ghanta R, Rangaraj A, Umakanthan R, Lee L, Laurence R, Fox J, Bolman R, Cohn L, Chen F. Adjustable, physiologic ventricular restraint improves LV mechanics and reduces dilatation in a chronic ovine model of heart failure. Circulation Mar 2007; 115:1201-1210. 6. Ghanta R, Lee L, Umakantahn R, Laurence R, Fox J, Bolman R, Cohn L, Chen F. Real time adjustment of ventricular restraint therapy in heart failure. Eur J Cardiothorac Surg Dec 2008; 34:1136-1140. 7. Lee LS, Daniel J. Highlights from the 11th annual scientific meeting of the international society for minimally invasive cardiothoracic surgery. J Thorac Cardiovasc Surg 2008; 136:1107-1009. 8. Umakanthan R, Ghanta R, Rangaraj A, Lee L, Laurence R, Fox J, Mihaljevic T, Bolman R, Cohn L, Chen F. Cardioscopic Tricuspid Valve Repair in a Beating Ovine Heart. Heart Surg Forum Apr 2009;12(2):E90-4. 9. Lee LS, Ghanta RK, Mokashi SA, Coelho-Filho O, Kwong RY, Bolman RM 3rd, Chen FY. Ventricular restraint therapy for heart failure: the right ventricle is different from the left ventricle. J Thorac Cardiovasc Surg. 2010 Apr;139(4):1012-8. 10. Schmitto JD, Mokashi SA, Lee LS, Laurence R, Schotola H, Coelho-Filho O, Rajab TK, Kwong R, Bolman RM 3rd, Quintel M, Cohn LH, Chen FY. A novel, innovative ovine model of chronic ischemic cardiomyopathy induced by multiple coronary ligations. Artif Organs. 2010 Nov;34(11):918-22. 11. Mokashi SA, Schmitto JD, Lee LS, Rawn JD, Bolman RM 3rd, Shekar PS, Couper GS, Chen FY. Ventricular assist device in patients with prosthetic heart valves. Artif Organs. 2010 Nov;34(11):1030-4. 12. Mokashi SA, Guan J, Wang D, Tchantchaleishvili V, Brigham M, Lipsitz S, Lee LS, Schmitto JD, Bolman RM 3rd, Khademhosseini A, Liao R, Chen FY. Preventing cardiac remodeling: the combination of cell-based therapy and cardiac support therapy preserves left ventricular function in rodent model of myocardial ischemia. J Thorac Cardiovasc Surg. 2010 Dec;140(6):1374-80. 13. Schmitto JD, Lee LS, Mokashi SA, Bolman RM 3rd, Cohn LH, Chen FY. Functional mitral regurgitation. Cardiol Rev. 2010 Nov-Dec;18(6):285-91. 14. Schmitto JD, Mokashi SA, Lee LS, Popov AF, Coskun KO, Sossalla S, Sohns C, Bolman RM 3rd, Cohn LH, Chen FY. Large animal models of chronic heart failure (CHF). J Surg Res. 2011 Mar;166(1):131-7. 15. Lee LS, Kwon MH, Cevasco M, Schmitto JD, Mokashi SA, McGurk S, Cohn LH, Bolman III RM, Chen FY. Postoperative recurrence of mitral regurgitation following annuloplasty for functional mitral regurgitation. Ann Thorac Surg 2012 Oct;94(4):1211-6. 16. Lee LS, Ghanta RK, Mokashi SA, Coelho-Filho O, Kwong RY, Kwon M, Guan J, Liao R, Chen FY. Optimized ventricular restraint therapy: adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2013 Mar;145(3):824-31. 17. Cevasco M, Mick SL, Kwon M, Lee LS, Chen EP, Chen FY. True external diameter better predicts hemodynamic performance of bioprosthetic aortic valves than the manufacturers' stated size. J Heart Valve Dis 2013 May;22(3):377-82. 18. Kwon MH, Lee LS, Cevasco M, Couper GS, Shekar PS, Cohn LH, Chen FY. Recurrence of mitral regurgitation after partial versus complete mitral valve ring annuloplasty for functional mitral regurgitation. J Thorac Cardiovasc Surg 2013 Sep;146(3):616-22. 4 19. Mokashi SA, Lee LS, Schmitto JD, Ghanta RK, McGurk S, Laurence RG, Bolman RM 3rd, Cohn LH, Chen FY. Restraint to the left ventricle alone is superior to standard restraint. J Thorac Cardiovasc Surg 2013 Jul;146(1):192-7. 20. Cevasco M, Kwon M, Fiedler A, Lee LS, Shiao J, Shah RV, Worthington AH, Fox JA, Kwong RY, Chen FY. Right heart failure: an ischemic model and restraint therapy for treatment. Ann Thorac Surg 2014 Apr;97(4):1356-62. 21. Lee LS and Shekar PS. Current state-of-the-art device therapy for advanced heart failure. Croat Med J 2014 Dec;55(6):577-586. Book chapters 1. Chen FY, Lee LS, Cohn LH. (2009). Valvular operations. In: AG Little, WH Merrill (Eds.), Complications in cardiothoracic surgery: avoidance and treatment, 2nd edition, pp. 375-391. 2. Lee LS, Chen FY, Cohn LH. (2009). Management of native valve endocarditis. In: FW Sellke, PJ del Nido, SJ Swanson (Eds.), Sabiston & Spencer's surgery of the chest, 8th edition, pp. 12591266. 3. Lee LS, Tchantchaleishvili V, Chen FY. (2010). Visualization of cardioplegia delivery. In: D Chambers, G Szabo, B Podesser (Eds.), New solutions for the heart- an update in advanced perioperative protection. 4. Shekar PS, Lee LS, Cohn LH. (2015). Minimally invasive aortic valve surgery. In: LH Cohn (Ed.), Cardiac surgery in the adult, 5th edition (in press). Presentations 1. "Wrap tightness determines rate and degree of reverse ventricular remodeling with ventricular restraint therapy." Massachusetts Chapter American College of Surgeons 54th Annual Meeting, Boston, MA, December 2007. 2. "Wrap tightness determines reverse remodeling with ventricular restraint therapy." International Society of Minimally Invasive Cardiothoracic Surgery Annual Meeting, Boston, MA, June 2008. 3. "Quantitative ventricular restraint: a novel therapy for heart failure." Brigham and Women's Hospital Cardiovascular Interdisciplinary Fellows Annual Conference, Boston, MA, June 2009. 4. "Ventricular restraint: are the right and left really that different?" Western Thoracic Surgical Association 35th Annual Meeting, Banff, Canada, June 2009. 5. "Ventricular restraint therapy: are the right and left ventricles really different?" Brigham and Women's Hospital 15th Annual Mannick Research Award Day, Boston, MA, October 2009. 6. "Optimized ventricular restraint therapy for heart failure" Harvard Surgery Inaugural Research Day, Boston, MA, May 2012 7. "Cardiac Surgery: past its prime or more relevant than ever?" Brigham and Women's Hospital Department of Surgery Grand Rounds, Boston, MA, February 2013 8. “Surgical Options for Heart Rhythm Disorders” UTMC Outreach O’Connor Day Center, Knoxville, TN, March 2016 9. “Convergent Hybrid Atrial Ablation” UTMC Cardiovascular ICU Nursing Lecture Series, Knoxville, TN, April 2016 5