Download Public Helth Chemistry

Department of Medical Chemistry
Subject: CHEMISTRY
Year, semester: 1st year/1st semester
Number of teaching hours: 70
Lecture: 46
Seminar: 24
1st week:
Lecture: Chemistry: the science of matter. Quantum theory and the atom.
Electronic structure and the periodic table. Types of chemical bonds. Covalent
bonding and properties of molecules.
Seminar: Atomic structure. Periodic perspective. Ionic and metallic bonds.
Covalent bond: valence bond and molecular orbital theories.
2nd week:
Lecture: Intermolecular forces. Changes of state. Kinetic-molecular theory of
gases and liquids. Solutions and colloids.
Seminar: The gaseous state. Liquid and solid states. Vapor pressures of liquid
solutions and related properties. Freezing point depression. Osmosis.
3rd week:
Lecture: The ionization of water. Ions in aqueous solution. Acids and bases. The
law of chemical equilibrium.
Seminar: The chemistry of water. Electrolytes. Acids and bases: Bronsted
Lowry and Lewis theories. Equilibrium constant expressions. Le Chatelier's
principle. Strength of acids and bases.
4th week:
Lecture: Ions and ionic equilibria. Thermochemistry and thermodynamics.
Seminar: Acid base equilibria. Titration curves. Buffer solutions. Solubility
product. Internal energy and enthalpy. Hess' law. Entropy, free energy and free
enthalpy.
5th week:
Lecture: Chemical kinetics. Electrochemistry. Thermodynamics of redox
reactions.
Seminar: Chemical kinetics at the molecular level. Reaction rates and rate
equations. Reaction mechanisms. Catalysis. Oxidation reduction and
electrochemistry. Electrolysis.
6th week:
1st control test
Lecture: Carbon-carbon bond, carbon-heteroatom bond. Stereochemistry: chiral
molecules, optical activity, relative and absolute configurations. Saturated and
unsaturated hydrocarbons: structure, isomerism and biological significance.
Seminar: Separation of chiral molecules. Electron distribution in organic
compounds. Nomenclature of hydrocarbons. Chemical reactions of saturated and
unsaturated hydrocarbons.
7th week:
Lecture: Alkynes. Aromatic hydrocarbons: structure and chemical reactions.
Organic halogen compounds. Alcohols and phenols: physical and chemical
properties. Biological oxidation of alcohols.
Seminar: Aromatic and heteroaromatic compounds. The mechanism of
nucleophilic substitution. Important alcohols and phenols.
8th week:
Lecture: Aldehydes and ketones: physical and chemical properties. Keto and
enol tautomers. Biological significance of aldehydes, ketones and quinones.
Nitrogen containing compounds. Structure, properties and chemical reactions of
amines. Nitrogen containing heterocyclic compounds.
Seminar: Ethers. Sulfur containing organic compounds. Biologically important
nitrogen containing compounds: dyes sulfa drugs and alkaloids.
9th week:
Lecture: Carboxylic acids: physical and chemical properties. Acidity. Chemical
reactions. Important carboxylic acids. Amino acids and peptides. Structure,
classification, stereochemistry, acid-base behavior of amino acids.
Stereochemistry of peptide bond. Naturally occurring peptides.
Seminar: Carboxylic acid derivatives: esters, thioesters, anhydrides, acyl
halides, amides. Reactions and separations of amino acids. Principle of sequence
analysis.
10th week:
Lecture: Structure and function of proteins. The three-dimensional structure of
proteins. Carbohydrates: structure and stereochemistry. Properties of
monosaccharides and disaccharides.
Seminar: Purification of proteins. Enzymes. Oligosaccharides of glycoproteins.
Heteropolysaccharides
11th week:
2nd control test
Lecture: Lipids: structure, classification and biological functions. Steroids.
Seminar: The structure of biological membranes. Carbohydrate metabolism.
Polysaccharides and their role in energy storing: glycogenolysis.
12th week:
Lecture: Nucleotides and nucleic acids. Structure of nucleosides, nucleotides
and nucleotide coenzymes. Polynucleotides.
Seminar: Structure of DNA and RNA. Determination of DNA sequences.
15th week:
3rd control test
Compulsory literature:
Chemistry, 5th edition, 2008, J. E. McMurry and R. C. Fay, Pearson Education,
Inc. Pearson Prentice Hall
Organic and Bioorganic Chemistry for Medical Students, P. Gergely, 3rd edition,
2008, University of Debrecen, Medical and Health Science Center
Recommended literature:
Organic Chemistry for premedical students, F. Erdődi and C. Csortos, 2010,
University of Debrecen, Medical and Health Science Center