Download Cell Plasticity within the Tumor Microenvironment

Cell Plasticity
within the Tumor
Microenvironment
January 8–12, 2017 | Big Sky, Montana | USA
Scientific Organizers:
Sergei Grivennikov, Fox Chase Cancer Center, USA
Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
During the last decade, it has become unequivocally evident that tumor development is not a cell-autonomous process
but rather depends on the intricate reciprocal interplay of mutant tumor cells with their local and distant environments.
Composition and polarization of cells in the tumor microenvironment depends on genetic as well as environmental
factors and is directly influenced by tumor therapy. Indeed, therapies that aim to shape the local immune milieu
and consecutive signaling pathways in both stromal and tumor/stem cells address the complex pathophysiology of
tumors more adequately and may therefore add substantial benefits for therapy. An absolute pre-requisite for such
an endeavor is a comprehensive understanding of the exact molecular basis of the complex signaling networks in the
tumor microenvironment that control the plasticity of both stromal and tumor cells, thereby shaping the complex
cellular contexture, which ultimately forms a pro- or anti-tumorigenic milieu. Thus, this symposium aims to gather a
comprehensive functional understanding of mediator-dependent cellular and molecular events that are responsible for
the plasticity of both stromal and tumor/stem cells. It will bring together experts in cancer, stromal and immune cells to
synthesize scientific knowledge about the phenomenon of cell plasticity within the tumor microenvironment, to define
molecular and cellular pathways mediating plasticity and to propose approaches to interfere with cell plasticity for
a new generation of effective therapeutic approaches in cancer and chronic injury. Importantly, it will bring together
interdisciplinary groups of scientists or investigators who normally would not have an opportunity to meet (classical
cancer biologists, tumor immunobiologists, stem cell experts and scientists working on stromal cells).
Session Topics:
• Plasticity of Epithelial, Cancer and Stem Cells
• Plasticity and (Cancer) Stem Cell Niche
• Cell Types Contributing to the Plasticity of Tumor Microenvironment
• Plasticity of Immune Cells within the Tumor Microenvironment
• Parallels between Normal Tissue Repair Response and Oncogenesis
• Approaches to Visualize and Study Dynamics of Tumor Microenvironment (“Imaging”)
• Targeting Changing Tumor Microenvironment for Anti-Cancer Therapies
• Therapy Resistance Mediated by Adaptive Responses in Tumor Microenvironment
plus two workshops
Scholarship Application & Discounted Abstract Deadline: September 19, 2016
Abstract Deadline: October 6, 2016
Discounted Registration Deadline: November 8, 2016
Note: Scholarships are available for graduate students and postdoctoral
fellows and are awarded based on the abstract submitted.
Upper image of small breast tumor (blue) in its microenvironment, with blood vessels in green
and macrophages in red, courtesy of Mikala Egeblad, Cold Spring Harbor Laboratory
Meeting Hashtag: #KStme
www.keystonesymposia.org/17A1
www.keystonesymposia.org/meetings | 1.800.253.0685 | 1.970.262.1230
a 501(c)(3) nonprofit educational organization
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Cell Plasticity within the Tumor Microenvironment (A1)
January 8-12, 2017 • Big Sky Resort • Big Sky, Montana, USA
Scientific Organizers: Sergei Grivennikov, Florian R. Greten and Mikala Egeblad
Sponsored by Journal of Molecular Cell Biology (JMCB) and Roche
Abstract & Scholarship Deadline: September 19, 2016 / Abstract Deadline: October 6, 2016 / Discounted Registration Deadline: November 8, 2016
SUNDAY, JANUARY 8
Arrival and Registration
MONDAY, JANUARY 9
Welcome and Keynote Address
*Sergei Grivennikov, Fox Chase Cancer Center, USA
*Florian R. Greten, Institute for Tumor Biology and Experimental
Therapy, Germany
*Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Michael Karin, University of California, San Diego, USA
Tumor-Elicited Inflammation and the Initiation of Colorectal Cancer
Plasticity of Epithelial, Cancer and Stem Cells
*Cédric Blanpain, Universite Libre de Bruxelles, Belgium
*Shelly Peyton, University of Massachusetts, USA
Florian R. Greten, Institute for Tumor Biology and Experimental
Therapy, Germany
Inflammatory Signaling in Intestinal Stem Cell Plasticity
John Cassidy, University of Cambridge, UK
Short Talk: The Development of Tamoxifen Resistance is Linked to
Oct4 Driven Transcriptional Plasticity
Andrew J. Ewald, Johns Hopkins University School of Medicine, USA
Phenotypic Plasticity during Cell Invasion and Metastasis
Kristiaan Lenos, Amsterdam Medical Center, Netherlands
Short Talk: Spatiotemporal Regulation of Stem Cell Function in Colon
Cancer
Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Intestinal Stem Cells in Cancer
Brian Bierie, Whitehead Institute for Biomedical Research, USA
Poster Teaser: Integrin-Beta4 Identifies Cancer Stem Cell-Enriched
Populations of Partially-Mesenchymal Carcinoma Cells
Jessica L. Christenson, University of Colorado, USA
Poster Teaser: The Role of the Androgen Receptor in Triple-Negative
Breast Cancer Progression: Tumor-Intrinsic and Tumor-Extrinsic
Mechanisms
Ryan Carpenter, University of Massachusetts, Amherst, USA
Poster Teaser: Capturing Microenvironmental Regulation of
Metastatic Dormancy and Recurrence
Sara E. Berkey, University of Pittsburgh, USA
Poster Teaser: The IL17+Foxp3+ and exTh17 Foxp3+ Plastic T Cells
Comprise Novel Immunosuppressive Regulatory T Cell Subsets in
Tumors
Oxana Dmitrieva, Fox Chase Cancer Center, USA
Poster Teaser: The Role of IL-1R-Signaling in Tumor Elicited
Inflammation and Colon Cancer
Workshop 1: Plasticity and the Cancer Stem Cell Niche
*Diana Leigh Avery, University of Pennsylvania School of Medicine,
USA
Matrix Mechanics and Composition Dictate Stromal Cell
Differentiation in Lung Tumorigenesis
Ikbale El Ayachi, University of Tennessee Health Science Center,
USA
The Absence of Wnt10b Expression Inhibits Tumor Initiation and
Metastasis Modulating Stroma-Tumor Microenvironment Homeostasis
*Loukia Georgiou Karacosta, Stanford University, USA
Identifying Dynamic EMT Transition States in Lung Cancer Using
Single Cell Multidimensional Analysis
Hazel Quinn, Max Delbruck Centre, Germany
Genetically Interfering with the Tumor Microenvironment via Shh in
Wnt-Met driven Mouse Triple Negative Breast Cancer
Michael Buchert, Olivia Newton-John Cancer Research Institute,
Australia
Insights into the Role of DCLK1 as a Novel Driver of Gastric Cancer
Toni Celia-Terrassa, Princeton University, USA
Pathways Regulating the Evasion of Normal and Cancer Stem Cells
from Interferon-Imposed Constraint
Dejan Maglic, Boston Children's Hospital, USA
The Hedgehog and Hippo Pathways Cooperate in BCC Initiation and
Progression
Hélène Salmon, Icahn School of Medicine at Mount Sinai, USA
The Tumor Microenvironment Controls Tumor Response to
Checkpoint Blockade
Plasticity and the (Cancer) Stem Cell Niche
*Florian R. Greten, Institute for Tumor Biology and Experimental
Therapy, Germany
*Louis Vermeulen, CEMM, Netherlands
Jing Yang, University of California, San Diego, USA
Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis
Cédric Blanpain, Universite Libre de Bruxelles, Belgium
Skin Tumor Stemness and Progression
Ekrem Emrah Er, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Pericytic Spreading of Disseminated Cancer Cells Initiate
Multi-Organ Metastasis
Mathias Florian Heikenwälder, German Cancer Research Center,
DKFZ, Germany
Kupffer-Cell Derived TNF Preferentially Triggers Cholangiocellular
Carcinoma through JNK under Chronic Mitochondrial Dysfunction and
ROS
Poster Session 1
TUESDAY, JANUARY 10
Cell Types Contributing to the Plasticity of the Tumor
Microenvironment
*Jing Yang, University of California, San Diego, USA
*Sandra S. McAllister, Brigham & Women's Hospital/Harvard
Medical School, USA
Thomas Tüting, Otto-von-Guericke University, Germany
Inflammation-Induced Phenotypic Plasticity of Tumor and Immune
Cells as a Mechanism of Disease Progression and Therapy
Resistance in Melanoma
Neta Erez, Tel Aviv University, Israel
Short Talk: Cancer-Associated Fibroblasts Link Tissue Damage with
Tumor-Promoting Inflammation in Breast Cancer
* Session Chair † Invited but not yet accepted Program current as of May 6, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/17A1.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Cell Plasticity within the Tumor Microenvironment (A1)
January 8-12, 2017 • Big Sky Resort • Big Sky, Montana, USA
Scientific Organizers: Sergei Grivennikov, Florian R. Greten and Mikala Egeblad
Sponsored by Journal of Molecular Cell Biology (JMCB) and Roche
Abstract & Scholarship Deadline: September 19, 2016 / Abstract Deadline: October 6, 2016 / Discounted Registration Deadline: November 8, 2016
Brian W. Wong, Vesalius Research Center, Belgium
Endothelial versus Cancer Cell Metabolism
Valerie M. Weaver, University of California, San Francisco, USA
Extracellular Matrix and Tumor Mechanics
Shelly Peyton, University of Massachusetts, USA
Short Talk: Dynamics of Fibronectin Assembly and Tumor Cell Latency
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
The Functional Role of EMT and Exosomes in Pancreatic Cancer
Chen Hao Lo, Moffitt Cancer Center, USA
Poster Teaser: Temporal Dynamics of Macrophage Plasticity in Bone
Metastatic Prostate Cancer
Magdolna Djurec, Spanish National Cancer Research Center, Spain
Poster Teaser: Reprogramming Cancer Associated Fibroblasts as a
Therapeutic Approach against Pancreatic Ductal Adenocarcinoma
Ayse Nihan Kilinc, University of Basel, Switzerland
Poster Teaser: The Contribution of Epithelial-Mesenchymal Plasticity
to Cancer Stemness
Lennart Kester, Hubrecht Institute, Netherlands
Poster Teaser: Clonal Dynamics with Single Cell Resolution in
Different Stages of Colon Carcinoma
Natsuko Kimura, University of Tokyo, Japan
Poster Teaser: Maintenance of Stemness and Niche Environment of
Breast Cancer Cells by FRS2beta, a Feedback Inhibitor for
HER2-ERK Pathway, during Mammary Tumorigenesis
Plasticity of Immune Cells within the Tumor Microenvironment
*Mikala Egeblad, Cold Spring Harbor Laboratory, USA
*Alana L. Welm, Huntsman Cancer Institute, University of Utah
School of Medicine, USA
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre,
Netherlands
Serial Killing of Tumor Cells – Impact of the Microenvironment
Giorgio Trinchieri, NCI, National Institutes of Health, USA
Cancer as a Meta-Organism – Fine-Tuning of Tumor Progression and
Response to Therapy by Microbiota-Regulated Immune Cells
Melissa A. Meyer, Washington University in St. Louis, USA
Short Talk: Tumor-Induced IRF8 Deficiency Interrupts
BATF3-Dependent Dendritic Cells Development
Sergei Grivennikov, Fox Chase Cancer Center, USA
Tumor-Elicited Inflammation and Cytokines at Crossroads in Wound
Healing and Tumor Progression
Poster Session 2
WEDNESDAY, JANUARY 11
Parallels between Normal Tissue Repair Response and
Oncogenesis
*Carla V. Rothlin, Yale University, USA
*Neta Erez, Tel Aviv University, Israel
Erik A. Sahai, Cancer Research UK London Research Institute, UK
Tumor-Stroma Cross-Talk in Metastasis and Therapy Failure
Andreas Trumpp, German Cancer Research Center, Germany
Stratification and Resistance Mechanisms in Pancreatic Cancer
Annelise Snyder, University of Washington, USA
Short Talk: Necroptotic Cell Death within the Tumor Microenvironment
Promotes Tumor Control
Alana L. Welm, Huntsman Cancer Institute, University of Utah School
of Medicine, USA
Ron Kinase in Bone Remodeling and Bone Metastasis
Sheila A. Stewart, Washington University School of Medicine, USA
Short Talk: Inhibition of Stromal p38MAPK Abrogates Breast Cancer
Metastases
Robert F. Schwabe, Columbia University, USA
Fibrosis Promotes the Development of Liver Cancer
Mario A. Shields, Cold Spring Harbor Laboratory, USA
Poster Teaser: Lysyl Oxidases Suppress Pancreatic Cancer
Progression and Inhibit FAK and ERK Signaling
Suzanne M. Ponik, University of Wisconsin-Madison, USA
Poster Teaser: Collagen Matrix Density Drives the Metabolic Profile
Shift of Breast Cancer Cells
Daniel C. Rabe, University of Chicago, USA
Poster Teaser: Exosome Crosstalk between Tumors and
Tumor-Associated Macrophages Drives Pro-Invasive Plasticity
Julia Varga, Georg Speyer Haus, Germany
Poster Teaser: Notch3 Activation in Response to Aberrant Akt
Signaling Contributes to Colorectal Cancer Progression
Workshop 2: Therapy Resistance Mediated by Adaptive
Responses in the Tumor Microenvironment
*Weizhou Zhang, University of Iowa, USA
Saran Kumar, Hebrew University, Israel
Adjacency to Blood Vessels as a Generator of Tumor Cell Metabolic
and Phenotypic Heterogeneities
Mihaela Skobe, Icahn School of Medicine at Mount Sinai, USA
Lymphatic Endothelium Protects Breast Cancer Cells from Death by
Inducing Metabolic Adaptations
Melissa R. Junttila, Genentech, Inc., USA
Identification of a Non-Genomic Resistance Mechanism to
Vemurafenib in a BRAF Mutant Melanoma Model
Peter Chockley, University of Michigan Medical School, USA
EMT Confers Susceptibility to Metastasis-Specific Immune
Surveillance in Lung Cancer
Alex Swarbrick, Garvan Institute of Medical Research, Australia
The Paracrine Hedgehog-FGF Axis Mediates Cancer Stem Cell
Plasticity in Triple Negative Breast Cancer
*Ela Elyada, Cold Spring Harbor Laboratory, USA
Pancreatic Stellate Cell Dynamics in PDAC
Michael Timaner, Technion-Israel Institute of Technology, Israel
Tumor-Associated Mesenchymal Stem Cells Preserve Cancer Stem
Cells Niche in the Tumor Microenvironment Following Chemotherapy
* Session Chair † Invited but not yet accepted Program current as of May 6, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/17A1.
KEYSTONE SYMPOSIA
on Molecular and Cellular Biology
Cell Plasticity within the Tumor Microenvironment (A1)
January 8-12, 2017 • Big Sky Resort • Big Sky, Montana, USA
Scientific Organizers: Sergei Grivennikov, Florian R. Greten and Mikala Egeblad
Sponsored by Journal of Molecular Cell Biology (JMCB) and Roche
Abstract & Scholarship Deadline: September 19, 2016 / Abstract Deadline: October 6, 2016 / Discounted Registration Deadline: November 8, 2016
Approaches to Visualize and Study Dynamics of the Tumor
Microenvironment (“Imaging”)
*Sergei Grivennikov, Fox Chase Cancer Center, USA
*Stefani Spranger, University of Chicago, USA
Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Imaging Reveals Tumor and Stromal Contributions to Formation of
Metastases
Danielle Seinstra, Hubrecht Institute, Netherlands
Plasticity Between Epithelial and Mesenchymal States Unlinks EMT
from Metastasis-Enhancing Stem Cell Capacity
Tracy W. Liu, MD Anderson Cancer Center, USA
Short Talk: Imaging the Dynamics of Tumor NF-kB Transcriptional
Activation and the Microenvironment In Vivo
Matthew F. Krummel, University of California, San Francisco, USA
Imaging and Deconvolving Tumor Antigen Flow in Primary and
Metastatic Tumor Sites
*Sergei Grivennikov, Fox Chase Cancer Center, USA
*Florian R. Greten, Institute for Tumor Biology and Experimental
Therapy, Germany
*Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Robert A. Weinberg, Massachusetts Institute of Technology, USA
The Epithelial-Mesenchymal Transition and Malignant Progression
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
FRIDAY, JANUARY 13
Departure
Poster Session 3
THURSDAY, JANUARY 12
Targeting the Changing Tumor Microenvironment for Anti-Cancer
Therapies
*Sheila A. Stewart, Washington University School of Medicine, USA
*Andrew J. Ewald, Johns Hopkins University School of Medicine, USA
Karin E. de Visser, Netherlands Cancer Institute, Netherlands
EMBO Young Investigator Lecture: Targeting Tumor-Induced
Systemic Inflammation to Fight Metastatic Breast Cancer
Carla V. Rothlin, Yale University, USA
Innate Immune Checkpoints in Anti-Tumor Immunity
Deepak Nagrath, University of Michigan, USA
Short Talk: Targeting Glutamine Synthetase in Tumors Disrupts
Tumor Microenvironment-Regulated Cancer Cell Growth
Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical
School, USA
Systemic Regulation of Tumor and Stromal Cell Plasticity
Lionel J. Apetoh, Centre Georges Francois Leclerc, France
Short Talk: Selective Degradation of the PU.1 Transcription Factor by
Autophagy Represses TH9 Cell Differentiation
Paula D. Bos, Virginia Commonwealth University, USA
Short Talk: Treg-ulation of the Breast Tumor Microenvironment
Weizhou Zhang, University of Iowa, USA
Short Talk: Obesity-Related NLRC4 Inflammasome Activation and
Angiogenesis in Breast Cancer
Therapy Resistance Mediated by Adaptive Responses in the
Tumor Microenvironment
*Karin E. de Visser, Netherlands Cancer Institute, Netherlands
*Erik A. Sahai, Cancer Research UK London Research Institute, UK
Francois Ghiringhelli, Centre de Recherche, INSERM U866, France
Chemotherapy and Reprogramming Immune and Cancer Cells
Stefani Spranger, University of Chicago, USA
Impact of Tumor Cell-Intrinsic Signaling on Anti-Tumor Immune
Responses in the Tumor Microenvironment
Closing Keynote Address
* Session Chair † Invited but not yet accepted Program current as of May 6, 2017. Program subject to change. Meal formats are based on meeting venue.
For the most up-to-date details, visit www.keystonesymposia.org/17A1.