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DENDRITIC CELLS

Have a strategic location in mucosal tissues

Associated with routes of pathogen entry

Effects depend on location
Microbiology: A Clinical Approach
Approach, ©
byGarland
Tony Srelkauskas
Science © Garland Science
ISBN: 978-0-8153-6514-3
DENDRITIC CELLS:
Skin and Mucous Membranes

Dendritic cells in the skin are called
Langerhans cells

Located in basal layers of the epidermis

Connected to each other forming a network

Renewed by progenitor cells in the skin
Microbiology: A Clinical Approach
Approach, ©
byGarland
Tony Srelkauskas
Science © Garland Science
ISBN: 978-0-8153-6514-3
DENDRITIC CELLS:
Skin and Mucous Membranes


Activated by the capture of antigen

After activation, they move to regional lymph nodes.

This can trigger the adaptive immune response.
Have the same function in skin and mucous
membranes


Replaced by bone marrow-derived cells in mucous
membranes
In mucous membranes, cells are replaced by bone
marrow-derived cells.
Microbiology: A Clinical Approach
Approach, ©
byGarland
Tony Srelkauskas
Science © Garland Science
ISBN: 978-0-8153-6514-3
Microbiology: A Clinical Approach [9780815365143] © Garland Science