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List of Ph.D. Students, Program Molecular Oncology (last update: May 2010) Since 2010 Giridhar Shivalingaiah Bindreither Daniel Tymoszuk Piotr Supervisor: Stephan Geley Supervisor: Reinhard Kofler Supervisor: Wolfgang Doppler Since 2009 Rachez Glory Heidegger Isabel-Maria Peschel Ines-Anna Datta Sebak Demir Ummuhan Wallner Stephanie Spilka Rita Supervisor: Ludger Hengst Supervisor: Helmut Klocker Supervisor: Ludger Hengst Supervisor: Wolfgang Doppler Supervisor: Helmut Klocker Supervisor: Dominik Wolf Supervisor: Wolfgang Doppler Since 2008 Pircher Andreas Supervisor: Wolfgang Hilbe List of Publications: (Pircher et al., 2010) (Pircher et al., 2008) Martowicz Agnieska Supervisor: Günther Gastl Koller Johann-Benedikt Supervisor: Wolfgang Doppler Rudzki Jakob Daniel Supervisor: Günther Gastl Baumgartner Florian Supervisor: Andreas Villunger List of Publications: (Labi et al., 2008b) (Manzl et al., 2009) Hannesdottir Lára Supervisor: Wolfgang Doppler Since 2007 Ehehalt Daniela Supervisor: Pidder Jansen-Dürr Podmirseg Silvio Supervisor: Ludger Hengst Bock Florian Supervisor: Andreas Villunger List of Publications: (Krumschnabel et al., 2009) (Manzl et al., 2009) (Shi et al., 2009) Mikolcevic Petra Supervisor: Stephan Geley List of Publications: (Barisic et al., 2010) Since 2006 Barisic Marin Supervisor: Stephan Geley List of Publications: (Barisic et al., 2010) Bu Huajie Supervisor: Helmut Klocker Carlet Michela Supervisor: Reinhard Kofler (Wasim et al., 2010) List of Publications: (Gruber et al., 2009) (Mansha et al., 2010) List of Publications: Haffner Michael Supervisor: Wolfgang Doppler List of Publications: (Haffner et al., 2008) (Haffner et al., 2009) (Haffner et al., 2006) (Laimer et al., 2007) (Jurgeit et al., 2007) (Haffner et al., 2007) Graduated Wolf Frank List of Publications: (Wolf and Geley, 2006; Wolf et al., 2007; Wolf et al., 2006) Erlacher Miriam List of Publications:(Erlacher et al., 2005a; Erlacher et al., 2006; Erlacher et al., 2005b; Heiser et al., 2004; Labi et al., 2008a; Labi et al., 2006; Teis et al., 2006) Zitt Marion List of Publications: (Bodner et al., 2005; Bonatti et al., 2004; Goebel et al., 2005; Haffner et al., 2009; Kirchmayr et al., 2005; Muller et al., 2004; Oberwalder et al., 2008; Varga et al., 2004; Zitt et al., 2006a; Zitt et al., 2007; Zitt et al., 2006b) Ecker Karin List of Publications: (Ecker et al., 2009) Massoner Petra List of Publications: (Jurgeit et al., 2007) (Massoner et al., 2009) (Massoner et al., 2008) Auer Doris List of Publications: (Marth et al., 2007) (Braun et al., 2007) (Braun et al., 2009) (Auer et al., 2008b) (Auer et al., 2008a) Gruber Georg List of Publications: (Gruber et al., 2009) (Mansha et al., 2010) Parajuli Nirmala List of Publications: (Haffner et al., 2008) (Parajuli and Doppler, 2009) (Parajuli et al., 2010) Desiniotis Andreas List of Publications: (Desiniotis et al., 2010) Mansha Muhammad List of Publications: (Rainer et al., 2009) (Wasim et al., 2010) (Mansha et al., 2010) Wasim Muhammad List of Publications: (Rainer et al., 2009) (Mansha et al., 2010) (Wasim et al., 2010) Dreier Kerstin References Ph.D. students Program Molecular Oncology Auer, D., Hubalek, M., Fleischer, M., Roessler, J., and Daxenbichler, G. (2008a). The growthpromoting action of individual women's sera on mammary carcinoma cells. Anticancer Res 28, 2213-2217. Auer, D., Reimer, D., Porto, V., Fleischer, M., Roessler, J., Wiedemair, A., Marth, C., MullerHolzner, E., Daxenbichler, G., and Zeimet, A.G. (2008b). Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer. Breast Cancer Res Treat. Barisic, M., Sohm, B., Mikolcevic, P., Wandke, C., Rauch, V., Ringer, T., Hess, M., Bonn, G., and Geley, S. (2010). Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation. Mol Biol Cell. Bodner, J.C., Zitt, M., Ott, H., Wetscher, G.J., Wykypiel, H., Lucciarini, P., and Schmid, T. (2005). Robotic-assisted thoracoscopic surgery (RATS) for benign and malignant esophageal tumors. The Annals of thoracic surgery 80, 1202-1206. Bonatti, H., Hoeller, E., Kirchmayr, W., Muhlmann, G., Zitt, M., Aigner, F., Weiss, H., and Klaus, A. (2004). Ventral hernia repair in bariatric surgery. Obesity surgery 14, 655-658. Braun, S., Auer, D., and Marth, C. (2009). The prognostic impact of bone marrow micrometastases in women with breast cancer. Cancer Invest 27, 598-603. Braun, S., Vogl, F.D., Schneitter, A., Egle, D., Auer, D., Lang, M., and Marth, C. (2007). Disseminated tumor cells: Are they ready for clinical use? Breast (Edinburgh, Scotland) 16 Suppl 2, 51-54. Desiniotis, A., Schafer, G., Klocker, H., and Eder, I.E. (2010). Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A. Int J Cancer 126, 775-789. Ecker, K., Lorenz, A., Wolf, F., Ploner, C., Bock, G., Duncan, T., Geley, S., and Helmberg, A. (2009). A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptorinteracting protein. Journal of molecular endocrinology 42, 105-117. Erlacher, M., Knoflach, M., Stec, I.E., Bock, G., Wick, G., and Wiegers, G.J. (2005a). TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development. European journal of immunology 35, 3287-3296. Erlacher, M., Labi, V., Manzl, C., Bock, G., Tzankov, A., Hacker, G., Michalak, E., Strasser, A., and Villunger, A. (2006). Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. The Journal of experimental medicine 203, 2939-2951. Erlacher, M., Michalak, E.M., Kelly, P.N., Labi, V., Niederegger, H., Coultas, L., Adams, J.M., Strasser, A., and Villunger, A. (2005b). BH3-only proteins Puma and Bim are ratelimiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 106, 4131-4138. Goebel, G., Zitt, M., Zitt, M., and Muller, H.M. (2005). Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias. Disease markers 21, 105-120. Gruber, G., Carlet, M., Turtscher, E., Meister, B., Irving, J.A., Ploner, C., and Kofler, R. (2009). Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis. Leukemia 23, 820-823. Haffner, M.C., Berlato, C., and Doppler, W. (2006). Exploiting our knowledge of NF-kappaB signaling for the treatment of mammary cancer. Journal of mammary gland biology and neoplasia 11, 63-73. Haffner, M.C., Jurgeit, A., Berlato, C., Geley, S., Parajuli, N., Yoshimura, A., and Doppler, W. (2008). Interaction and functional interference of glucocorticoid receptor and SOCS1. J Biol Chem 283, 22089-22096. Haffner, M.C., Kronberger, I.E., Ross, J.S., Sheehan, C.E., Zitt, M., Muhlmann, G., Ofner, D., Zelger, B., Ensinger, C., Yang, X.J., et al. (2009). Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. Hum Pathol 40, 1754-1761. Haffner, M.C., Petridou, B., Peyrat, J.P., Revillion, F., Muller-Holzner, E., Daxenbichler, G., Marth, C., and Doppler, W. (2007). Favorable prognostic value of SOCS2 and IGF-I in breast cancer. BMC cancer 7, 136. Heiser, D., Labi, V., Erlacher, M., and Villunger, A. (2004). The Bcl-2 protein family and its role in the development of neoplastic disease. Experimental gerontology 39, 1125-1135. Jurgeit, A., Berlato, C., Obrist, P., Ploner, C., Massoner, P., Schmolzer, J., Haffner, M.C., Klocker, H., Huber, L.A., Geley, S., et al. (2007). Insulin-like growth factor-binding protein-5 enters vesicular structures but not the nucleus. Traffic (Copenhagen, Denmark) 8, 1815-1828. Kirchmayr, W., Muhlmann, G., Zitt, M., Bodner, J., Weiss, H., and Klaus, A. (2005). Gallstone ileus: rare and still controversial. ANZ journal of surgery 75, 234-238. Krumschnabel, G., Sohm, B., Bock, F., Manzl, C., and Villunger, A. (2009). The enigma of caspase-2: the laymen's view. Cell death and differentiation 16, 195-207. Labi, V., Erlacher, M., Kiessling, S., Manzl, C., Frenzel, A., O'Reilly, L., Strasser, A., and Villunger, A. (2008a). Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. The Journal of experimental medicine 205, 641-655. Labi, V., Erlacher, M., Kiessling, S., and Villunger, A. (2006). BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell death and differentiation 13, 1325-1338. Labi, V., Grespi, F., Baumgartner, F., and Villunger, A. (2008b). Targeting the Bcl-2regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? Cell death and differentiation 15, 977-987. Laimer, K., Spizzo, G., Obrist, P., Gastl, G., Brunhuber, T., Schafer, G., Norer, B., Rasse, M., Haffner, M.C., and Doppler, W. (2007). STAT1 activation in squamous cell cancer of the oral cavity: a potential predictive marker of response to adjuvant chemotherapy. Cancer 110, 326333. Mansha, M., Carlet, M., Ploner, C., Gruber, G., Wasim, M., Wiegers, G.J., Rainer, J., Geley, S., and Kofler, R. (2010). Functional analyses of Src-like adaptor (SLA), a glucocorticoidregulated gene in acute lymphoblastic leukemia. Leuk Res 34, 529-534. Manzl, C., Krumschnabel, G., Bock, F., Sohm, B., Labi, V., Baumgartner, F., Logette, E., Tschopp, J., and Villunger, A. (2009). Caspase-2 activation in the absence of PIDDosome formation. The Journal of cell biology 185, 291-303. Marth, C., Egle, D., Auer, D., Rossler, J., Zeimet, A.G., Vergote, I., and Daxenbichler, G. (2007). Modulation of CA-125 tumor marker shedding in ovarian cancer cells by erlotinib or cetuximab. Gynecologic oncology 105, 716-721. Massoner, P., Colleselli, D., Matscheski, A., Pircher, H., Geley, S., Jansen Durr, P., and Klocker, H. (2009). Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility. Endocr Relat Cancer 16, 795-808. Massoner, P., Haag, P., Seifarth, C., Jurgeit, A., Rogatsch, H., Doppler, W., Bartsch, G., and Klocker, H. (2008). Insulin-like growth factor binding protein-3 (IGFBP-3) in the prostate and in prostate cancer: local production, distribution and secretion pattern indicate a role in stromal-epithelial interaction. Prostate 68, 1165-1178. Muller, H.M., Oberwalder, M., Fiegl, H., Morandell, M., Goebel, G., Zitt, M., Muhlthaler, M., Ofner, D., Margreiter, R., and Widschwendter, M. (2004). Methylation changes in faecal DNA: a marker for colorectal cancer screening? Lancet 363, 1283-1285. Oberwalder, M., Zitt, M., Wontner, C., Fiegl, H., Goebel, G., Zitt, M., Kohle, O., Muhlmann, G., Ofner, D., Margreiter, R., et al. (2008). SFRP2 methylation in fecal DNA-a marker for colorectal polyps. International journal of colorectal disease 23, 15-19. Parajuli, N., and Doppler, W. (2009). Precision-cut slice cultures of tumors from MMTV-neu mice for the study of the ex vivo response to cytokines and cytotoxic drugs. In Vitro Cell Dev Biol Anim 45, 442-450. Parajuli, N., Muller-Holzner, E., Bock, G., Werner, E.R., Villunger, A., and Doppler, W. (2010). Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice. Int J Cancer 126, 896-908. Pircher, A., Kahler, C.M., Skvortsov, S., Dlaska, M., Kawaguchi, G., Schmid, T., Gunsilius, E., and Hilbe, W. (2008). Increased numbers of endothelial progenitor cells in peripheral blood and tumor specimens in non-small cell lung cancer: a methodological challenge and an ongoing debate on the clinical relevance. Oncol Rep 19, 345-352. Pircher, A., Ploner, F., Popper, H., and Hilbe, W. (2010). Rationale of a relaunch of gefitinib in Caucasian non-small cell lung cancer patients. Lung Cancer. Rainer, J., Ploner, C., Jesacher, S., Ploner, A., Eduardoff, M., Mansha, M., Wasim, M., Panzer-Grumayer, R., Trajanoski, Z., Niederegger, H., et al. (2009). Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia. Leukemia 23, 746-752. Shi, M., Vivian, C.J., Lee, K.J., Ge, C., Morotomi-Yano, K., Manzl, C., Bock, F., Sato, S., Tomomori-Sato, C., Zhu, R., et al. (2009). DNA-PKcs-PIDDosome: a nuclear caspase-2activating complex with role in G2/M checkpoint maintenance. Cell 136, 508-520. Teis, D., Taub, N., Kurzbauer, R., Hilber, D., de Araujo, M.E., Erlacher, M., Offterdinger, M., Villunger, A., Geley, S., Bohn, G., et al. (2006). p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. The Journal of cell biology 175, 861-868. Varga, M., Obrist, P., Schneeberger, S., Muhlmann, G., Felgel-Farnholz, C., Fong, D., Zitt, M., Brunhuber, T., Schafer, G., Gastl, G., et al. (2004). Overexpression of epithelial cell adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor survival. Clin Cancer Res 10, 3131-3136. Wasim, M., Carlet, M., Mansha, M., Greil, R., Ploner, C., Trockenbacher, A., Rainer, J., and Kofler, R. (2010). PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis. The Journal of steroid biochemistry and molecular biology. Wolf, F., and Geley, S. (2006). A simple and stable auto focusing protocol for long multidimensional live cell microscopy. Journal of microscopy 221, 72-77. Wolf, F., Sigl, R., and Geley, S. (2007). '... The end of the beginning': cdk1 thresholds and exit from mitosis. Cell cycle (Georgetown, Tex 6, 1408-1411. Wolf, F., Wandke, C., Isenberg, N., and Geley, S. (2006). Dose-dependent effects of stable cyclin B1 on progression through mitosis in human cells. The EMBO journal 25, 2802-2813. Zitt, M., Muhlmann, G., Weiss, H., Kafka-Ritsch, R., Oberwalder, M., Kirchmayr, W., Margreiter, R., Ofner, D., and Klaus, A. (2006a). Assessment of risk-independent follow-up to detect asymptomatic recurrence after curative resection of colorectal cancer. Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie 391, 369-375. Zitt, M., Zitt, M., and Muller, H.M. (2007). DNA methylation in colorectal cancer--impact on screening and therapy monitoring modalities? Disease markers 23, 51-71. Zitt, M., Zitt, M., Muller, H.M., Dinnewitzer, A.J., Schwendinger, V., Goebel, G., De Vries, A., Amberger, A., Weiss, H., Margreiter, R., et al. (2006b). Disseminated tumor cells in peripheral blood: a novel marker for therapy response in locally advanced rectal cancer patients undergoing preoperative chemoradiation. Diseases of the colon and rectum 49, 14841491.