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List of Ph.D. Students, Program Molecular Oncology
(last update: May 2010)
Since 2010
Giridhar Shivalingaiah
Bindreither Daniel
Tymoszuk Piotr
Supervisor: Stephan Geley
Supervisor: Reinhard Kofler
Supervisor: Wolfgang Doppler
Since 2009
Rachez Glory
Heidegger Isabel-Maria
Peschel Ines-Anna
Datta Sebak
Demir Ummuhan
Wallner Stephanie
Spilka Rita
Supervisor: Ludger Hengst
Supervisor: Helmut Klocker
Supervisor: Ludger Hengst
Supervisor: Wolfgang Doppler
Supervisor: Helmut Klocker
Supervisor: Dominik Wolf
Supervisor: Wolfgang Doppler
Since 2008
Pircher Andreas
Supervisor: Wolfgang Hilbe
List of Publications: (Pircher et al., 2010) (Pircher et al., 2008)
Martowicz Agnieska
Supervisor: Günther Gastl
Koller Johann-Benedikt
Supervisor: Wolfgang Doppler
Rudzki Jakob Daniel
Supervisor: Günther Gastl
Baumgartner Florian
Supervisor: Andreas Villunger
List of Publications: (Labi et al., 2008b) (Manzl et al., 2009)
Hannesdottir Lára
Supervisor: Wolfgang Doppler
Since 2007
Ehehalt Daniela
Supervisor: Pidder Jansen-Dürr
Podmirseg Silvio
Supervisor: Ludger Hengst
Bock Florian
Supervisor: Andreas Villunger
List of Publications: (Krumschnabel et al., 2009) (Manzl et al., 2009) (Shi et al., 2009)
Mikolcevic Petra
Supervisor: Stephan Geley
List of Publications: (Barisic et al., 2010)
Since 2006
Barisic Marin
Supervisor: Stephan Geley
List of Publications: (Barisic et al., 2010)
Bu Huajie
Supervisor: Helmut Klocker
Carlet Michela
Supervisor: Reinhard Kofler (Wasim et al., 2010)
List of Publications: (Gruber et al., 2009) (Mansha et al., 2010)
List of Publications:
Haffner Michael
Supervisor: Wolfgang Doppler
List of Publications: (Haffner et al., 2008) (Haffner et al., 2009) (Haffner et al., 2006)
(Laimer et al., 2007) (Jurgeit et al., 2007) (Haffner et al., 2007)
Graduated
Wolf Frank
List of Publications: (Wolf and Geley, 2006; Wolf et al., 2007; Wolf et al., 2006)
Erlacher Miriam
List of Publications:(Erlacher et al., 2005a; Erlacher et al., 2006; Erlacher et al.,
2005b; Heiser et al., 2004; Labi et al., 2008a; Labi et al., 2006; Teis et al., 2006)
Zitt Marion
List of Publications: (Bodner et al., 2005; Bonatti et al., 2004; Goebel et al., 2005;
Haffner et al., 2009; Kirchmayr et al., 2005; Muller et al., 2004; Oberwalder et al.,
2008; Varga et al., 2004; Zitt et al., 2006a; Zitt et al., 2007; Zitt et al., 2006b)
Ecker Karin
List of Publications: (Ecker et al., 2009)
Massoner Petra
List of Publications: (Jurgeit et al., 2007) (Massoner et al., 2009) (Massoner et al.,
2008)
Auer Doris
List of Publications: (Marth et al., 2007) (Braun et al., 2007) (Braun et al., 2009) (Auer
et al., 2008b) (Auer et al., 2008a)
Gruber Georg
List of Publications: (Gruber et al., 2009) (Mansha et al., 2010)
Parajuli Nirmala
List of Publications: (Haffner et al., 2008) (Parajuli and Doppler, 2009) (Parajuli et al.,
2010)
Desiniotis Andreas
List of Publications: (Desiniotis et al., 2010)
Mansha Muhammad
List of Publications: (Rainer et al., 2009) (Wasim et al., 2010) (Mansha et al., 2010)
Wasim Muhammad
List of Publications: (Rainer et al., 2009) (Mansha et al., 2010) (Wasim et al., 2010)
Dreier Kerstin
References Ph.D. students Program Molecular Oncology
Auer, D., Hubalek, M., Fleischer, M., Roessler, J., and Daxenbichler, G. (2008a). The growthpromoting action of individual women's sera on mammary carcinoma cells. Anticancer Res
28, 2213-2217.
Auer, D., Reimer, D., Porto, V., Fleischer, M., Roessler, J., Wiedemair, A., Marth, C., MullerHolzner, E., Daxenbichler, G., and Zeimet, A.G. (2008b). Expression of coxsackie-adenovirus
receptor is related to estrogen sensitivity in breast cancer. Breast Cancer Res Treat.
Barisic, M., Sohm, B., Mikolcevic, P., Wandke, C., Rauch, V., Ringer, T., Hess, M., Bonn,
G., and Geley, S. (2010). Spindly/CCDC99 Is Required for Efficient Chromosome
Congression and Mitotic Checkpoint Regulation. Mol Biol Cell.
Bodner, J.C., Zitt, M., Ott, H., Wetscher, G.J., Wykypiel, H., Lucciarini, P., and Schmid, T.
(2005). Robotic-assisted thoracoscopic surgery (RATS) for benign and malignant esophageal
tumors. The Annals of thoracic surgery 80, 1202-1206.
Bonatti, H., Hoeller, E., Kirchmayr, W., Muhlmann, G., Zitt, M., Aigner, F., Weiss, H., and
Klaus, A. (2004). Ventral hernia repair in bariatric surgery. Obesity surgery 14, 655-658.
Braun, S., Auer, D., and Marth, C. (2009). The prognostic impact of bone marrow
micrometastases in women with breast cancer. Cancer Invest 27, 598-603.
Braun, S., Vogl, F.D., Schneitter, A., Egle, D., Auer, D., Lang, M., and Marth, C. (2007).
Disseminated tumor cells: Are they ready for clinical use? Breast (Edinburgh, Scotland) 16
Suppl 2, 51-54.
Desiniotis, A., Schafer, G., Klocker, H., and Eder, I.E. (2010). Enhanced antiproliferative and
proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor
and cAMP-dependent protein kinase A. Int J Cancer 126, 775-789.
Ecker, K., Lorenz, A., Wolf, F., Ploner, C., Bock, G., Duncan, T., Geley, S., and Helmberg,
A. (2009). A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptorinteracting protein. Journal of molecular endocrinology 42, 105-117.
Erlacher, M., Knoflach, M., Stec, I.E., Bock, G., Wick, G., and Wiegers, G.J. (2005a). TCR
signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the
stage of development. European journal of immunology 35, 3287-3296.
Erlacher, M., Labi, V., Manzl, C., Bock, G., Tzankov, A., Hacker, G., Michalak, E., Strasser,
A., and Villunger, A. (2006). Puma cooperates with Bim, the rate-limiting BH3-only protein
in cell death during lymphocyte development, in apoptosis induction. The Journal of
experimental medicine 203, 2939-2951.
Erlacher, M., Michalak, E.M., Kelly, P.N., Labi, V., Niederegger, H., Coultas, L., Adams,
J.M., Strasser, A., and Villunger, A. (2005b). BH3-only proteins Puma and Bim are ratelimiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.
Blood 106, 4131-4138.
Goebel, G., Zitt, M., Zitt, M., and Muller, H.M. (2005). Circulating nucleic acids in plasma or
serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias.
Disease markers 21, 105-120.
Gruber, G., Carlet, M., Turtscher, E., Meister, B., Irving, J.A., Ploner, C., and Kofler, R.
(2009). Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of
glucocorticoid-induced leukemia apoptosis. Leukemia 23, 820-823.
Haffner, M.C., Berlato, C., and Doppler, W. (2006). Exploiting our knowledge of NF-kappaB
signaling for the treatment of mammary cancer. Journal of mammary gland biology and
neoplasia 11, 63-73.
Haffner, M.C., Jurgeit, A., Berlato, C., Geley, S., Parajuli, N., Yoshimura, A., and Doppler,
W. (2008). Interaction and functional interference of glucocorticoid receptor and SOCS1. J
Biol Chem 283, 22089-22096.
Haffner, M.C., Kronberger, I.E., Ross, J.S., Sheehan, C.E., Zitt, M., Muhlmann, G., Ofner, D.,
Zelger, B., Ensinger, C., Yang, X.J., et al. (2009). Prostate-specific membrane antigen
expression in the neovasculature of gastric and colorectal cancers. Hum Pathol 40, 1754-1761.
Haffner, M.C., Petridou, B., Peyrat, J.P., Revillion, F., Muller-Holzner, E., Daxenbichler, G.,
Marth, C., and Doppler, W. (2007). Favorable prognostic value of SOCS2 and IGF-I in breast
cancer. BMC cancer 7, 136.
Heiser, D., Labi, V., Erlacher, M., and Villunger, A. (2004). The Bcl-2 protein family and its
role in the development of neoplastic disease. Experimental gerontology 39, 1125-1135.
Jurgeit, A., Berlato, C., Obrist, P., Ploner, C., Massoner, P., Schmolzer, J., Haffner, M.C.,
Klocker, H., Huber, L.A., Geley, S., et al. (2007). Insulin-like growth factor-binding protein-5
enters vesicular structures but not the nucleus. Traffic (Copenhagen, Denmark) 8, 1815-1828.
Kirchmayr, W., Muhlmann, G., Zitt, M., Bodner, J., Weiss, H., and Klaus, A. (2005).
Gallstone ileus: rare and still controversial. ANZ journal of surgery 75, 234-238.
Krumschnabel, G., Sohm, B., Bock, F., Manzl, C., and Villunger, A. (2009). The enigma of
caspase-2: the laymen's view. Cell death and differentiation 16, 195-207.
Labi, V., Erlacher, M., Kiessling, S., Manzl, C., Frenzel, A., O'Reilly, L., Strasser, A., and
Villunger, A. (2008a). Loss of the BH3-only protein Bmf impairs B cell homeostasis and
accelerates gamma irradiation-induced thymic lymphoma development. The Journal of
experimental medicine 205, 641-655.
Labi, V., Erlacher, M., Kiessling, S., and Villunger, A. (2006). BH3-only proteins in cell
death initiation, malignant disease and anticancer therapy. Cell death and differentiation 13,
1325-1338.
Labi, V., Grespi, F., Baumgartner, F., and Villunger, A. (2008b). Targeting the Bcl-2regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? Cell
death and differentiation 15, 977-987.
Laimer, K., Spizzo, G., Obrist, P., Gastl, G., Brunhuber, T., Schafer, G., Norer, B., Rasse, M.,
Haffner, M.C., and Doppler, W. (2007). STAT1 activation in squamous cell cancer of the oral
cavity: a potential predictive marker of response to adjuvant chemotherapy. Cancer 110, 326333.
Mansha, M., Carlet, M., Ploner, C., Gruber, G., Wasim, M., Wiegers, G.J., Rainer, J., Geley,
S., and Kofler, R. (2010). Functional analyses of Src-like adaptor (SLA), a glucocorticoidregulated gene in acute lymphoblastic leukemia. Leuk Res 34, 529-534.
Manzl, C., Krumschnabel, G., Bock, F., Sohm, B., Labi, V., Baumgartner, F., Logette, E.,
Tschopp, J., and Villunger, A. (2009). Caspase-2 activation in the absence of PIDDosome
formation. The Journal of cell biology 185, 291-303.
Marth, C., Egle, D., Auer, D., Rossler, J., Zeimet, A.G., Vergote, I., and Daxenbichler, G.
(2007). Modulation of CA-125 tumor marker shedding in ovarian cancer cells by erlotinib or
cetuximab. Gynecologic oncology 105, 716-721.
Massoner, P., Colleselli, D., Matscheski, A., Pircher, H., Geley, S., Jansen Durr, P., and
Klocker, H. (2009). Novel mechanism of IGF-binding protein-3 action on prostate cancer
cells: inhibition of proliferation, adhesion, and motility. Endocr Relat Cancer 16, 795-808.
Massoner, P., Haag, P., Seifarth, C., Jurgeit, A., Rogatsch, H., Doppler, W., Bartsch, G., and
Klocker, H. (2008). Insulin-like growth factor binding protein-3 (IGFBP-3) in the prostate and
in prostate cancer: local production, distribution and secretion pattern indicate a role in
stromal-epithelial interaction. Prostate 68, 1165-1178.
Muller, H.M., Oberwalder, M., Fiegl, H., Morandell, M., Goebel, G., Zitt, M., Muhlthaler,
M., Ofner, D., Margreiter, R., and Widschwendter, M. (2004). Methylation changes in faecal
DNA: a marker for colorectal cancer screening? Lancet 363, 1283-1285.
Oberwalder, M., Zitt, M., Wontner, C., Fiegl, H., Goebel, G., Zitt, M., Kohle, O., Muhlmann,
G., Ofner, D., Margreiter, R., et al. (2008). SFRP2 methylation in fecal DNA-a marker for
colorectal polyps. International journal of colorectal disease 23, 15-19.
Parajuli, N., and Doppler, W. (2009). Precision-cut slice cultures of tumors from MMTV-neu
mice for the study of the ex vivo response to cytokines and cytotoxic drugs. In Vitro Cell Dev
Biol Anim 45, 442-450.
Parajuli, N., Muller-Holzner, E., Bock, G., Werner, E.R., Villunger, A., and Doppler, W.
(2010). Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide
synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice. Int J
Cancer 126, 896-908.
Pircher, A., Kahler, C.M., Skvortsov, S., Dlaska, M., Kawaguchi, G., Schmid, T., Gunsilius,
E., and Hilbe, W. (2008). Increased numbers of endothelial progenitor cells in peripheral
blood and tumor specimens in non-small cell lung cancer: a methodological challenge and an
ongoing debate on the clinical relevance. Oncol Rep 19, 345-352.
Pircher, A., Ploner, F., Popper, H., and Hilbe, W. (2010). Rationale of a relaunch of gefitinib
in Caucasian non-small cell lung cancer patients. Lung Cancer.
Rainer, J., Ploner, C., Jesacher, S., Ploner, A., Eduardoff, M., Mansha, M., Wasim, M.,
Panzer-Grumayer, R., Trajanoski, Z., Niederegger, H., et al. (2009). Glucocorticoid-regulated
microRNAs and mirtrons in acute lymphoblastic leukemia. Leukemia 23, 746-752.
Shi, M., Vivian, C.J., Lee, K.J., Ge, C., Morotomi-Yano, K., Manzl, C., Bock, F., Sato, S.,
Tomomori-Sato, C., Zhu, R., et al. (2009). DNA-PKcs-PIDDosome: a nuclear caspase-2activating complex with role in G2/M checkpoint maintenance. Cell 136, 508-520.
Teis, D., Taub, N., Kurzbauer, R., Hilber, D., de Araujo, M.E., Erlacher, M., Offterdinger, M.,
Villunger, A., Geley, S., Bohn, G., et al. (2006). p14-MP1-MEK1 signaling regulates
endosomal traffic and cellular proliferation during tissue homeostasis. The Journal of cell
biology 175, 861-868.
Varga, M., Obrist, P., Schneeberger, S., Muhlmann, G., Felgel-Farnholz, C., Fong, D., Zitt,
M., Brunhuber, T., Schafer, G., Gastl, G., et al. (2004). Overexpression of epithelial cell
adhesion molecule antigen in gallbladder carcinoma is an independent marker for poor
survival. Clin Cancer Res 10, 3131-3136.
Wasim, M., Carlet, M., Mansha, M., Greil, R., Ploner, C., Trockenbacher, A., Rainer, J., and
Kofler, R. (2010). PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic
leukemia, interferes with glucocorticoid-induced apoptosis. The Journal of steroid
biochemistry and molecular biology.
Wolf, F., and Geley, S. (2006). A simple and stable auto focusing protocol for long
multidimensional live cell microscopy. Journal of microscopy 221, 72-77.
Wolf, F., Sigl, R., and Geley, S. (2007). '... The end of the beginning': cdk1 thresholds and
exit from mitosis. Cell cycle (Georgetown, Tex 6, 1408-1411.
Wolf, F., Wandke, C., Isenberg, N., and Geley, S. (2006). Dose-dependent effects of stable
cyclin B1 on progression through mitosis in human cells. The EMBO journal 25, 2802-2813.
Zitt, M., Muhlmann, G., Weiss, H., Kafka-Ritsch, R., Oberwalder, M., Kirchmayr, W.,
Margreiter, R., Ofner, D., and Klaus, A. (2006a). Assessment of risk-independent follow-up
to detect asymptomatic recurrence after curative resection of colorectal cancer. Langenbeck's
archives of surgery / Deutsche Gesellschaft fur Chirurgie 391, 369-375.
Zitt, M., Zitt, M., and Muller, H.M. (2007). DNA methylation in colorectal cancer--impact on
screening and therapy monitoring modalities? Disease markers 23, 51-71.
Zitt, M., Zitt, M., Muller, H.M., Dinnewitzer, A.J., Schwendinger, V., Goebel, G., De Vries,
A., Amberger, A., Weiss, H., Margreiter, R., et al. (2006b). Disseminated tumor cells in
peripheral blood: a novel marker for therapy response in locally advanced rectal cancer
patients undergoing preoperative chemoradiation. Diseases of the colon and rectum 49, 14841491.
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