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ENERGY PRODUCTION FOR CELLULAR EVENTS FABINYI BIANKA MITOCHONDRION • Outer membrane • Porin: water channels • Allows ions and molecules to pass under 5000 Da • Inner membrane • Enzyme complexes • Transport proteins • Restricted permeability • Matrix • Proteins, enzymes, DNA • Citric acid cycle • Β-oxidation GLYCOLYSIS • In cytosol • Anaerobic: pyruvate -> lactate • glucose + 2Pi + 2ADP -> 2lactate + 2ATP + 2H2O • Cori cycle • Aerobic: • glucose + 2Pi + 2ADP + 2NAD+ -> 2pyruvate + 2ATP + 2H2O + 2NADH + 2H+ • NADH -> 4-6 ATP • Sum: 36-38 ATP CITRIC ACID CYCLE • In mitochondria • acetyl-CoA + 3NAD+ + FAD + GDP + Pi + 2H2O -> 2CO2 + 3NADH + 3H+ +FADH2 + GTP + CoA • NADH -> 3 ATP, FADH2 -> 2ATP • Precursors for amino acids OXIDATIVE PHOSPHORYLATION • Mitochondria’s inner membrane • Impermeabel to ions • ½ O2 + 2H+ + 2e- -> H2O • Chemiosmotic theory -> proton gradient • 4 complexes • Cytochromes – Heme group SOURCES • https://biochemistry3rst.files.wordpress.com/2014/03/glycolysis-cycle-3.jpg • http://www.humpath.com/IMG/jpg_citric_acid_cycle_noi_wkp_0807_a.jpg • https://fastly.kastatic.org/ka-perseus-images/fe1296eb6182efc88ea25a88f0a02638a7339410.png • https://upload.wikimedia.org/wikipedia/commons/0/07/Cytochrome_c.png • http://www.livescience.com/images/i/000/075/701/i02/mitochondriondiagram.jpg?1430372329?interpolation=lanczos-none&downsize=640:* • https://en.wikipedia.org/wiki/Mitochondrial_matrix • https://en.wikipedia.org/wiki/Cori_cycle • https://en.wikipedia.org/wiki/Citric_acid_cycle • https://en.wikipedia.org/wiki/Glycolysis • Ádám Veronika: Orvosi Biokémia • Darvas Zsuzsa: Sejtbiológia
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