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BIOSYNTHESIS OF NONESSENTIAL AMINO ACIDS
AMINOTRANSFERASE FROM MAJOR PATHWAY INTERMEDIATES
oxaloacetate
α-ketoglutarate
aspartic acid
glutamic acid
pyruvate
alanine
AMIDATIONS
ATP + NH 3
ADP + P i
glutamic acid
ATP+ glutamine
glutamine
glutamic acid
aspartic acid
+ AMP + P P i
asparagine
α-KETOGLUTARATE FAMILY
ATP
glutamate
ADP
Pi
NAD(P)H/H + NAD(P) +
glutamate-5-phosphate
glutamic acid
H 2O
NAD(P)H/H + NAD(P) +
∆ 1-pyrroline-5-carboxylate
glutamate-5-semialdehyde
α-ketoglutarate
urea cycle
glutamate-5-semialdehyde
ornithine
arginine
3-PHOSPHOGLYCERATE FAMILY
NAD +
3-phosphoglycerate
tetrahydrofolate
NADH/H +
α-ketoglutarate
glutamic acid
3-phosphohydroxypyruvate
H 2O
3-phosphoserine
5,10-methylene tetrahydrofolate
serine
+ H 2O
glycine
serine
homocysteine
H 2O
serine
NH 4+
H 2O
cystathionine
cysteine + α-ketobutyrate
TYROSINE
O2
Pi
+ tetrahydrobiopterin
phenylalanine
dihydrobiopterin
tyrosine
+ H 2O
proline
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