Download Fady Geara, MD, PhD

Fady Geara MD, PhD
Office Phone: +961-1-350000 ext. 5094
Clinic Phone: +961-1- 344839
Email: [email protected]
Present Title & Affiliation
Professor and Chairman, Department of Radiation Oncology,
Founding Director, The Naef K Basile Cancer Institute (2007-2012)
American University of Beirut Medical Center, Beirut, Lebanon
Education
1994
1993
1989-93
1990
1989
1985
American Board of Radiology; Radiation Oncology
University of Paris XI, France, Ph.D. in Radiation Biology (Research conducted at
MDACC, Houston TX)
Clinical and research fellowship in radiation oncology; The University of Texas MD
Anderson Cancer Center, Houston USA
University of Tours, France, Radiation Oncology Diploma.
University of Paris XI, France, Masters of Science Degree in Radiobiology.
University of Paris XI, France, Medical Doctor Degree
Academic Experience & Service

Professor and Chairman, Department of Radiation Oncology, American University of Beirut,
Beirut Lebanon, 2003- present

Founding Director, The Naef K. Basile Cancer Institute at The American University of Beirut
Medical Center, 2007-2012.

Director ad interim, The Naef K. Basile Cancer Institute at The American University of Beirut
Medical Center, 2004-2007.

Associate Professor and Chairman, Department of Radiation Oncology, American University of
Beirut, Beirut Lebanon, 1997- 2003.

Assistant Professor, Department of Radiation Oncology, The University of Texas, M. D.
Anderson Cancer Center, Houston, Texas, 1994-97.

Faculty Associate, Department of Radiation Oncology, The University of Texas, M. D. Anderson
Cancer Center, Houston, Texas, 1993-94.

Clinical Fellow, Radiation Oncology, The University of Texas, M.D. Anderson Cancer Center,
Houston TX, 1991-93.

Visiting Scientist, Experimental Radiation Oncology, The University of Texas, M.D. Anderson
Cancer Center, Houston TX, 1989-91.

Resident in Radiation Oncology, at the Institut Gustave Roussy (Villejuif), University Hospital
Henri Mondor (Creteil), and University Hospital Bretonneau (Tours), France, 1985-89.
Board Certifications
American Board of Radiology; Radiation Oncology
Question item writer for the American Board written examination (1996-1997)
Areas of Interest
Clinical Interest: General Radiation Oncology, Radiation Biology
Procedures: Conformal 3D Radiation therapy, Stereotactic radiosurgery and Radiotherapy; High
dose rate brachytherapy.
Selected Peer-Reviewed Publications
Head and Neck cancer
1. Abboud M, Arabi A, Salti I, Geara F. Outcome of thyroid associated ophthalmopathy treated by
radiation therapy. Radiat Oncol. 2011 May 13;6:46.
2. Abboud M, Haddad G, Kattar M, Aburiziq I, Geara FB. Extraneural metastases from cranial
meningioma: a case report. Radiat Oncol. 2009 Jul 6;4:20.
3. Pignon JP, le Maître A, Maillard E, Bourhis J; MACH-NC Collaborative Group. Meta-analysis of
chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and
17,346 patients. Radiother Oncol. 2009 Jul;92(1):4-14.
4. Hamdan AL, Geara F, Rameh C, Husseini ST, Eid T, Fuleihan N. Vocal changes following
radiotherapy to the head and neck for non-laryngeal tumors. Eur Arch Otorhinolaryngol. 2009
Sep;266(9):1435-9.
5. Farhat FS, Geara F, Natout M, Serhal J, Daya W. Tongue carcinoma in an adult Down's
syndrome patient: a case report. World J Surg Oncol. 2009 Mar 4;7:26.
6. El Saghir NS, Shamseddine A, Geara F, Bikhazi K, Rahal B, Salem Z, Taher A, Tawil A, Khatib
Z, Abbas J, Hourani M, Khalil A, Seoud M. Breast cancer in Lebanon. Increased age-adjusted
incidence rates in younger-aged groups at presentation: implications for screening and for ArabAmerican ethnic groups. Ethn Dis. 2005 Winter;15(1 Suppl 1):S1-11-S1-12.
7. Fady B. Geara, E. Nasr, SL. Tucker, E. Brihi, G. Zaytoun, Z. Salem, N. El Saghir, A.
Shamseddine, P. Issa. Nasopharyngeal carcinoma in the Middle East: Experience of the
American University of Beirut Medical Center. Int J Rad Onc. Biol Phys 2005 Apr 1;61(5):140815.
8. Ang KK, Trotti A, Garden AS, Foote RL, Morrison WH, Geara FB, Klotch W, Peters LJ, Goepfert
H. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in
advanced head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 2001; 51:571-8
9. Meyers C., Geara F. B., Wong P.F, Morrison W.H. Neurocognitive effects of therapeutic
irradiation for base of skull tumors. Int J Radiat Oncol Biol Phys. 2000; 46:51-5.
10. Garden AS, Glisson BS, Ang KK, Morrison WH, Lippman SM, Byers RM, Geara F, Clayman GL,
Shin DM, Callender DL, Khuri FR, Goepfert H, Hong WK, Peters LJ. Phase I/II Trial of Radiation
With Chemotherapy "Boost" for Advanced Squamous Cell Carcinomas of the Head and Neck:
Toxicities and Responses. J Clin Oncol 1999, 17(8): 2390
11. G. Sanguineti, F. B. Geara, A. S. Garden, S. L. Tucker, K.K. Ang, W. H. Morrison, L. J. Peters.
Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional
control. Int. J. Radiat. Oncol. Biol. Phys. 37: 985-996: 1997
12. Fady B. Geara, G. Sanguineti, S. L. Tucker, A. S. Garden, K.K. Ang, W. H. Morrison, L. J.
Peters. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of distant
metastasis and survival. Radiother. Oncol.43: 53-61:1997
13. Fady B. Geara, B. S. Glisson; G. Sanguineti, S. L. Tucker, A. S. Garden, K. Kian Ang, G. L.
Clayman, H. Goepfert, L. J. Peters, W. K. Hong. Induction chemotherapy followed by
radiotherapy versus radiotherapy alone in advanced nasopharyngeal carcinoma: Results of a
matched cohort study. Cancer 79: 1279-1286; 1997
Prostate Cancer
14. G. K. Zagars, F. B. Geara, A. Pollack. A. Von Eschenbach. The T-classification of clinically
localized prostate cancer. An appraisal based on early disease outcome following radiation
therapy. Cancer, 1994; 73:1904-12
15. Fady B. Geara, G. K. Zagars, Alan Pollack. Influence of the presenting symptoms on treatment
outcome for prostate cancer treated by radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.1994,
30:331-37
16. Liebross RH, Pollack A, Lankford SP, Zagars GK, von Eschenbach AC, Geara FB. Transrectal
ultrasound for staging prostate carcinoma prior to radiation therapy: An evaluation based on
disease outcome. Cancer 1999; 85(7): 1577-85
Breast Cancer
17. Abboud M, Saghir NS, Salame J, Geara FB. Complete response of brain metastases from breast
cancer overexpressing Her-2/neu to radiation and concurrent Lapatinib and Capecitabine. Breast
J. 2010;16(6):644-6.
18. Hatoum HA, Jamali FR, El-Saghir NS, Musallam KM, Seoud M, Dimassi H, Abbas J, Khalife M,
Boulos FI, Tawil AN, Geara FB, Salem Z, Shamseddine AA, Al-Feghali K, Shamseddine AI.
Ratio Between Positive Lymph Nodes and Total Excised Axillary Lymph Nodes as an
Independent Prognostic Factor for Overall Survival in Patients with Nonmetastatic Lymph NodePositive Breast Cancer. Ann Surg Oncol. 2009
19. El Saghir NS, Khalil MK, Eid T, El Kinge AR, Charafeddine M, Geara F, Seoud M, Shamseddine
AI. Trends in epidemiology and management of breast cancer in developing Arab countries: a
literature and registry analysis. Int J Surg. 2007 Aug;5(4):225-33.
20. Fady B. Geara, E. Nasr, SL. Tucker, M. Charafeddine, B. Dabaja, T. Eid, J. Abbas, Z. Salem, A.
Shamseddine, P. Issa , N. Saghir. Breast cancer patients with 10 or more involved axillary lymph
nodes treated by multimodality therapy: Influence of clinical presentation on outcome. . Int J
Radiat Oncol Biol Phys. 2007 Jun 1;68(2):364-9.
21. El Saghir NS, Seoud M, Khalil MK, Charafeddine M, Salem ZK, Geara FB, Shamseddine AI.
Effects of young age at presentation on survival in breast cancer.BMC Cancer. 2006 Jul
20;6:194.
22. El Saghir NS, Shamseddine A, Geara F, Bikhazi K, Rahal B, Salem Z, Taher A, Tawil A, Khatib
Z, Abbas J, Hourani M, Khalil A, Seoud M. Breast cancer in Lebanon. Increased age-adjusted
incidence rates in younger-aged groups at presentation: implications for screening and for ArabAmerican ethnic groups. Ethn Dis. 2005;15(1 Suppl 1):S1-11-2.
23. A. Shamseddine, M. Khalifeh, A. Chehal, A. Taher , R. Jalloul, N. Bitar, A. Dandashi, Y. Abou
Mourad, J. Abbas, F. Geara. A Clinical Phase II study of Cisplatinum and Vinorelbine in
Advanced Breast Carcinoma. Am J Clin Onc 2005;28(4):393-8
24. Abulkhair O, Saghir N, Sedky L, Saadedin A, Elzahwary H, Siddiqui N, Al Saleh M, Geara F,
Birido N, Al-Eissa N, Sukhun SA, Abdulkareem H, Ayoub MM, Deirawan F, Fayaz S, Kandil A,
Khatib S, El-Mistiri M, Salem D, Sayd el SH, Jaloudi M, Jahanzeb M, Gradishar WI; MENA
Breast Cancer Regional Guidelines Committee.Modification and implementation of NCCN
guidelines on breast cancer in the Middle East and North Africa region. J Natl Compr Canc Netw.
2010 Jul;8 Suppl 3:S8-S15.
Gynecologic Cancers
25. Lataifeh I, Jaradat I, Seoud M, Youssef B, Barahmeh S, Geara F. Survival outcome after
radiation therapy for patients with early cervical carcinoma undergoing inadequate primary
surgery. Int J Gynecol Cancer. 2014 Jan;24(1):124-9.
26. Fady B Geara, Ali Shamseddine, Ali Khalil, Mirna Abboud, Maya Charafeddine and Muhieddine
Seoud. A phase II randomized trial comparing radiotherapy with concurrent cisplatin or weekly
paclitaxel in patients with advanced cervical cancer. Radiation Oncology 2010, 5:84
27. Seoud M, Khalil A, Geara F, Kaspar H, Abbas J. Long term survival following aggressive surgery
and radiotherapy for pelvic fibromatosis. Int J Gynecol Cancer 2005,15, 1-3
28. M. Seoud, F.B. Geara, A. Shamseddine, Z. Salem, A. Khalil. Short Duration Neoadjuvant
Chemotherapy Followed by Radiotherapy for Advanced Carcinoma of The Cervix: Results and
Prognostic Variables. Eur J Gynaecol Oncol. 2003;24(2):163-8
Basic Science
29. Fady B. Geara, L. J. Peters, K. K. Ang, J.L. Wike, W.A. Brock. Prospective comparison between
in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int. J.
Radiat. Oncol. Biol. Phys. 1993, 27:1173-1179
30. S. L. Tucker, F.B. Geara, L.J. Peters, W.A. Brock. How much could the radiotherapy dose be
altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?
Radiother. Oncol. 1996, 38:103-113
31. Fady B. Geara, L. J. Peters , K. K. Ang, A.S. Garden, S. L. Tucker, L. Levy, B. W. Brown.
Comparison between normal tissue reactions and local tumor control in head and neck cancer
patients treated by definitive radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.1996, 35:455-462.
32. W.A. Brock, S. L. Tucker, F.B. Geara, I. Turesson, J. Wike, J. Nyman, L.J. Peters. Fibroblast
radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer.
Int. J. Radiat. Oncol. Biol. Phys.1995, 32:1371-79
33. Fady B. Geara, Lester J. Peters, K. Kian Ang, Jennifer L. Wike, William A. Brock. Radiosensitivity
measurement of keratinocytes and fibroblasts from radiotherapy patients. Int. J. Radiat. Oncol.
Biol. Phys., 1992, 24: 287-293.
34. Fady B. Geara, Lester J. Peters, K. Kian Ang, Jennifer L. Wike, Susan Sivon, Roland
Guttenburger, David Callender, Edmond P. Malaise, William A. Brock. Intrinsic radiosensitivity of
human fibroblasts and lymphocytes after high- and low-dose rate irradiations. Cancer Res., 1992,
52: 6348-6352.
35. Fady Geara, T. Girinski, N. Chavaudra, J.M. Cosset, B. Dubray, W.A. Brock, E.P. Malaise
Estimation of clonogenic cell fraction in primary culture derived from squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys., 1991, 21; 661-665
36. Taddei PJ, Jalbout W, Howell RM, Khater N, Geara F, Homann K, Newhauser WD. Analytical
model for out-of-field dose in photon craniospinal irradiation. Phys Med Biol. 2013 Nov
7;58(21):7463-79.
37. El-Khatib M, Geara F, Haddadin MJ, Gali-Muhtasib H..Cell death by the quinoxaline dioxide DCQ
in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21.
Radiat Oncol. 2010;5:107.
38. Buchholz, Th, Xifeng Wu, Abu Hussain, SL.Tucker, G. B. Mills, B. Haffty, S Bergh, M. Story, F.
B. Geara, W A. Brock. Evidence of Haplotype Insufficiency in Human Cells Containing a
Germline Mutation in BRCA1 or BRCA2. Int J Cancer. 2002; 97:557-61.
39. Haykal J, Geara F, Haddadin MJ, Smith CA, Gali-Muhtasib H.The radiosensitizer 2-benzoyl-3phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma
cells. Radiat Oncol. 2009 Jul 14;4:25.
40. Joelle M Haykal, MS; Pamela E Fernainy, MS; Wafica S Itani, MS; Makhluf J Haddadin, PhD;
Fady B Geara, MD; Colin A Smith, PhD; Hala Gali-Muhtasib. Radiosensitization of EMT6
mammary carcinoma cells by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline1,4-dioxide.
Radiotherapy Oncology 2008 Mar;86(3):412-8.
41. W. Itani, F. Geara, J. Haykal, M. Haddadin, H. Gali-Muhtasib. Radiosensitization by 2-benzoyl -3phenyl-6, 7-dichloroquinoxaline 1, 4-dioxide under oxia and hypoxia in human colon cancer cells.
Radiation Oncology 2007, 2:1 doi: 10.1186/1748-717X-2-1
42. W. Itani, F. Geara, J. Haykal, M. Haddadin, H. Gali-Muhtasib. Radiosensitization by DCQ under
oxia and hypoxia in human colon cancer cells. Radiation Oncology Journal, MS:
7869650821155456
43. Prithivirajsingh S, Story MD, Bergh SA, Geara FB, Ang KK, Ismail SM, Stevens CM, Buchholz
TA, Brock WA. Accumulation of the Common Mitochondrial Deletion Induced by Ionizing
Radiation. FEBS Lett. 2004;571(1-3):227-32
44. HG Muhtasib, M. Sidani, F. Geara, J.Al-Hmaira, M. Assaf-Diab, M. J. Haddadin, G. Zaatari.
Quinoxaline 1,4-dioxides are Novel Angiogenesis Inhibitors that Potentiate Antitumor Effects of
Ionizing Radiation. Int J Oncol. 2004;24(5):1121-31.
45. Alsbeih G. Story MD, Maor MM, Geara FB, Brock WA. Chromosomal fragility and family history
of radiosensitivity as indicators for radiotherapy dose modifications. Radiother Oncol.
2003;66(3):341-4.
46. Fady B. Geara, Ritsuko Komaki, Susan L. Tucker, Isaac Rosen, Elizabeth L. Travis, James D.
Cox. Factors Influencing the Development of Lung Fibrosis after Chemoradiation for Small Cell
Carcinoma of the Lung: Evidence for Inherent Interindividual Variation. Int. J. Radiat. Oncol. Biol.
Phys.; 41: 279-286. 1998
General radiation oncology
47. Fady Geara, J. P. Le Bourgeois, P. Piedbois, J.M. Pavlovich, J.J.Mazeron. Radiotherapy in the
management of cutaneous epidemic Kaposi's sarcoma. Int. J. Radiat. Oncol. Biol. Phys., 1991,
21; 1517-1522
48. Fady B. Geara, K. Kian Ang. Radiation treatment of malignant melanoma; in Surgery Clinics of
North America, 76:1383-1398; 1996
49. Foray N, Badie C, Alsbeih G, Lambin P, Geara F, Taghian AG, Deschavanne P, Gueulette J,
Courdi A, Chavaudra N, Fertil B. Edmond-philippe malaise (1930-2013): a lifetime of
perseverance leads to the cellular definition of intrinsic radiosensitivity. Int J Radiat Oncol Biol
Phys. 2014 Apr 1;88(5):1215-7.
50. Belkacémi Y, Boussen H, Turkan S, Tsoutsou PG, Geara F, Gligorov J. Fight against cancer
around the Mediterranean area: "Many hands make light work!" Crit Rev Oncol Hematol. 2012
S1040-8428(12) dyskeratosis congenita. Bone Marrow Transplant. 2012
51. Jazieh AR, Bamefleh H, Demirkazik A, Gaafar RM, Geara FB, Javaid M, Khader J, Khodadad K,
Omar W, Saadeddin A, Sabe HA, Shadmehr MB, El Sherif A, Uddin N, Jahanzeb M, Ettinger D;
MENA Lung Cancer Regional Guidelines Committee. Modification and implementation of NCCN
guidelines on non-small cell lung cancer in the Middle East and North Africa region. J Natl Compr
Canc Netw. 2010 Jul;8 Suppl 3:S16-21.
52. El Saghir NS, El-Asmar N, Hajj C, Eid T, Khatib S, Bounedjar A, Ajarim D, Shamseddine A,
Geara F, Jazieh A, Azim HA, Abdelkader Y, Kattan J, Abulkhair O. Survey of utilization of
multidisciplinary management tumor boards in Arab countries. Breast. 2011; Suppl 2:S70-4.
Lymphoma
53. Kharfan-Dabaja MA, Otrock ZK, Bacigalupo A, Mahfouz RA, Geara F, Bazarbachi A.
A reduced intensity conditioning regimen of fludarabine, cyclophosphamide, antithymocyte
globulin, plus 2 Gy TBI facilitates successful hematopoietic cell engraftment in an adult with
54. Azar C, Soweid A, Berro Z, Salem ZM, Geara FB, Kattar MM, Hashash JG, Barada KA.
Duodenal mucosa-associated lymphoid tissue lymphoma successfully treated by radiation
therapy. Clin Lymphoma Myeloma. 2007 May;7(6):428-31.
55. El-Zahabi L MN, Jamali FR, El-Hajj II, Naja MO, Salem Z, Shamseddine A, El Saghir NS, Zaatari
G, Geara FB, Soweid AM. The value of EUS in predicting the response of gastric malt lymphoma
to helicobacter pylori eradication. Gastrointestinal Endoscopy Journal. 2006
56. Muwakkit S, Geara F, Nabbout B, Farah R, Shabb N.S, Hajjar T, Khogali M. Treatment of
pediatric hodgkin’s disease with chemotherapy alone or combined modality therapy. Radiat
Oncol Invest 1999; 7 (6): 365-373
57. Fady Geara. Radiotherapy for gastrointestinal lymphomas: indications and techniques. Cancer
Radiother 1999; 3(2): 141-8