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Chapter 12: The Peripheral Vascular System - - - - - - - - - - - Injury to vascular endothelial cells can provoke thrombus formation, atheromas, and the vascular lesions of hypertension An atheroma begins in the intima as lipid-filled foam cells, then fatty streaks. Complex atheromas are thickened asymmetric plaques that narrow the lumen, reducing blood flow, and weaken the underlying media. They have a soft lipid core and a fibrous cap of smooth muscle cells and a collagen-rich matrix. Plaque rupture may precede thrombosis. Atherosclerosis can cause symptomatic limb ischemia with exertion; distinguish this from spinal stenosis, which produces leg pain with exertion that may be reduced by leaning forward (stretching the spinal cord in the narrowed vertebral canal) and less readily relieved by rest Hair loss over the anterior tibiae occurs with decreased arterial perfursion. “Dry” or brown-black ulcers from gangrene may ensue Only about 10% of patients have the classic triad of leg pain with exertion that stops with rest. The low symptom rate may reflect functional declines in walking, even though PAD is present or progressing. Symptom location suggests the site suggests the site of arterial ischemia: ~ Buttock, hip – aortoiliac ~ Erectile dysfunction – iliac-pudendal ~ Thigh – common femoral or aortoiliac ~ Upper Calf – superficial femoral ~ Lower calf – popliteal ~ Foot – tibial or peroneal Abdominal pain, “food fear,” and weight loss suggest intestinal ischemia of the celiac or superior or inferior mesenteric arteries Prevalence of abdominal aortic aneurysms in first-degree relatives is 15% to 28% Lymphedema of the arm and hand may follow axillary node dissection and radiation therapy Prominent veins in an edematous arm suggest venous obstruction In Raynaud’s disease, wrist pulses are typically normal, but spasm of more distal arteries causes episodes of sharply demarcated pallor of the fingers Note that if an artery is widely dilated, it is aneurismal Bounding carotid, radia, and femoral pulses in aortic insufficiency; asymmetric diminished pulses in arterial occlusion from atherosclerosis or embolism An enlarged epitrochlear node may arise local or distal infection or may be associated with generalized lymphadenopathy Lymphadenopathy refers to enlargement of thenodes, with or without tenderness. Try to distinguish between local and generalized lymphadenopathy, respectively, by - - - - - - - - finding either (1) a causative lesion in the drainage area or (2) enlarged nodes in at least two other non-contiguous lymph node regions A diminished or absent pulse indicates partial or complete occlusion proximally; for example, at the aortic or iliac level, all pulses distal to the occlusion are typically affected Chronic aterial occlusion, usually from atherosclerosis, causes intermittent claudication An exaggerated, widened femoral pulse suggest a femoral aneurysm, a pathologic dilatation of the artery An exaggerated, widened popliteal pulse suggests an aneurysm of the popliteal artery. Popliteal and femoral aneurysms are not common They are usually caused by atherosclerosis and occur primarily in men older than 50 years Atheroslerosis (arteriosclerosis obliterans) most commonly obstructs arterial circulation in the thigh. The femoral pulse is then normal, the popliteal decreased or absent The doralis pedis artery may be congenitally absent or may branch higher in the ankle. Search for a pulse more laterally Decreased or absent pedal pulses (assuming a warm environment) with normal femoral and popliteal pulses suggest occlusive disease in the lower popliteal artery or its branches-often seen in diabetes mellitus Sudden arterial occlusion from embolism or thrombosis causes pain and numbness or tingling. The limb distal to the occlusion becomes cold, pale, and pulseless. Emergency treatment is required. If collateral circulation is good, only numbness and coolness may result Coldness, especially when unilateral or associated with other signs, suggests arterial insufficiency from inadequate arterial circulation Edema causes swelling that may obscure the veins, tendons, and bony prominences Conditions such as muscular atrophy can also cause different circumferences in the legs In deep venous thrombosis, the extent of edema suggests the location of the occlusion: the popliteal vein when the lower leg or the ankle is swollen; the iliofemoral veins when the entire leg is swollen Venous distention suggests a venous cause of edema A painful, pale swollen leg, together with tenderness in the groin over the femoral vein, suggests deep iliofemoral vein, suggests deep iliofemoral thrombosis. Only half of patients with deep venous thrombosis in the calf have tenderness and cords deep in the calf. Calf tenderness is nonspecific and may be present without thrombosis Local swelling, redness, warmth, and a subcutaneous cord suggest superficial thrombophlebitis - - - - - Brownish discoloration or ulcers just above the malleolus suggest chronic venous insufficiency Thickened brawny skin suggests lymphedema and advanced venous insufficiency Varicose veins are dilated and tortuous. Their walls may feel somewhat thickened Aterial occlusive disease is much less common in the arms than in the legs. Absent or diminished pulses at the wrist are found in acute embolic occlusion and in Buerger’s disease , or thromboangiitis obliterans Extending the hand fully may cause pallor and a falsely positive Allen Test Persisiting pallor of an Allen test indicates occlusion of the ulnar artery or its distal branches Marked pallor on elevation suggests arterial insufficiency The foot above is still pale, and the veins are just starting to fill- signs of arterial insufficiency Persisting rubor on dependency suggests arterial insufficiency When veins are incompetent, dependent rubor and the timing of color return and venous filling are not reliable tests of arterial insuffiency Rapid filling of the superficial veins while the saphenous vein is occluded indicates incompetent valves in the communicating veins. Blood flows quickly in a retrograde direction from the deep to the saphenous system Sudden additional filling of superficial veins after release of compression indicates incompetent valves in the saphenous vein When both steps are abnormal, the test is positive-positive - - - - - - Chapter 16: The Musculoskeletal System - - - - - Articular disease typically involves swelling and tenderness of the entire joint and limits both active and passive range of motion Extra-articular disease typically involves selected regions of the joint and types of movement Approximately 85% of patients have idiopathic low back pain without a precise underlying cause (this term is preferred to “sprain” or “strain”) For midline back pain, assess for musculoligamentous injury, disc herniation, vertebral collapse, spinal cord metastases, or rarely epidural abscess. For pain off the midline, assess for sacroiliitis, trochanteric bursitis, sciatica, or hip arthritis Radicular gluteal and posterior leg pain in the S1 distribution in sciatica that increases with cough or Valsalva Leg pain that resolves with rest and/or lumbar forward flexion in spinal stenosis - Consider cauda equine syndrome from S2-4 midline disc or tumor if bowel or bladder dysfunction (usually urinary retention and overflow incontinence) In cases of low back pain plus a red flag, there is a 10% probabiliry of serious systemic disease Radicular pain from spinal nerve compression, most commonly C7 followed by C6 Unlike low back pain, usually from foraminal impingement from degenerative joint changes (70% to 75%) rather than disc herniation (20% to 25%) Pain in one joint suggests trauma, monoarticular arthritis, possible tendinitis, or bursitis. Lateral hip pain near the greater trochanter suggests trochanteric bursitis Migratory pattern of spread in rheumatic fever or gonococcal arthritis; progressive additive pattern with symmetric involvement in rheumatoid arthritis Extra-articular pain in inflammation of bursae (burtsitis), tendons (tendinitis), or tendon sheaths (tenosynovitis); also sprains from stretching or tearing of ligaments Severe pain of rapid onset in a red, swollen joint in acute septic arthritis or gout. In children consider osteomyelitis in bone contiguous to a joint Fever, chills, warmth, redness in septic arthritis; also consider gout or possible rheumatic fever Pain, swelling, loss of active and passive motion, “locking,” deformity in articular joint pain; Loss of active but not passive motion, tenderness outside the joint, absence of deformity often in nonarticular pain Stiffness and limited motion after inactivity, sometimes called gelling, in degenerative joint disease but usually lasts only a few minutes or more in rheumatoid arthritis and other inflammatory arthritides Stiffness also with fibromyalgia and polymyalgia rheumatic (PMR) Generalized symptoms are common in rheumatoid arthritis, systemic lupus erythematosus (SLE), PMR, and other inflammatory arthritides. High fever and chills suggest an infectious cause Joint pain and systemic disorders ~ A butterfly rash on the cheeks- Systemic lupus erythematosus ~ The scaly rash and pitted nails of psoriasis – psoriatic arthritis ~ A few papules, pustules, or vesicles on reddened bases, located on the distal extremities – Gonococcal arthritis ~ An expanding erythematous patch early in an illness – Lyme disease ~ Hives- Serum sickness, drug reaction ~ Erosions or scale on the penis and crusted, scaling paules on the soles and palms- Reiter’s syndrome, which also includes arthritis, urethritis, and uveitis - - - - - ~ The maculopapular rash of rubella- arthritis of rubella ~ Clubbing of the fingernails – Hypertrophic osteoarthropathy ~ Red, burning, and itchy eyes (conjunctivitis) – Reiter’s syndrome, Behcet’s syndrome ~ Preceding sore throat – Acute rheumatic fever or gonococcal arthritis ~ Diarrhea, abdominal pain, cramping – Arthritis with ulcerative colitis, regional enteritis, scleroderma ~ Symptoms of urethritis – Reiter’s syndrome or possibly gonococcal arthritis ~ Mental status change, facial or other weakness, stiff neck – Lyme disease with central nervous system involvement Acute involvement of only one joint suggests trauma, septic arthritis, gout Rheumatoid arthritis typically involves several joints, symmetrically distributed Dupuytren’s contracture bowlegs or knock-knees Subcutaneous nodules in rheumatoid arthritis or rheumatic fever; effusions in trauma; crepitus over inflamed joints, in osteoarthritis, or inflamed tendon sheaths Decreased range of motion in arthritis, inflammation of tissues around a joint, fibrosis in or around a joint, or bony fixation (ankylosis). Ligamentous laxity of the ACL in knee trauma Muscle atrophy or weakness in rheumatoid arthritis Palpable bogginess or doughtiness of the synovial membrane indicates synovial membrane indicates synovitis, which is often accompanied by effusion. Palpable joint fluid in effusion, tenderness over the tendon sheaths in tendinitis Warmth- arthritis, tendinitis, bursitis, osteomyelitis Tenderness and warmth over a thickened synovium suggest arthritis or infection Redness over a tender joint suggests septic or gouty arthritis, or possibly rheumatoid arthritis Facial asymmetry associated with TMJ syndrome Typical features of TMJ are unilateral chronic pain with chewing, jaw clenching, or teeth grinding, often associated with stress (may also present as headache) Pain with chewing also in trigeminal neuralgia, temporal arteritis Swelling, tenderness, and decreased range of motion in inflammation or arthritis Dislocation of the TMJ may be seen in trauma Palpable crepitus or clicking in poor occlusion, meniscus injury, or synovial swelling from trauma Pain and tenderness on palpation in TMJ syndrome Scoliosis may cause elevation of one shoulder With anterior dislocation of the shoulder, the rounded lateral aspect of the shoulder appears flattened - - - - - - - - - - Atrophy of supraspinatus and infraspinatus over posterior scapula with increased prominence of scapular spine within 2 to 3 weeks of rotator cuff tear A significant amount of synovial fluid is needed before the joint capsule appears distended Localized tenderness arises from subacromial or subdeltoid bursitis, degenerative changes, or calcific deposits in the rotator cuff Swelling of the supraspinatus suggests a bursal tear that communicates with the articular cavity Tenderness over the “SITS” muscle insertions and inability to lift the arm above the shoulder level are seen in sprains, and tendon rupture of the rotator cuff, most commonly the supraspinatous Tenderness and effusion suggest synovitis of the glenohumeral joint. If the margins of the capsule and synovial membrane are palpable, a moderate to large effusion is present. Minimal degrees of synovitis at the glenohumeral joint cannot be detected on palpation Restricted range of motion in bursitis, capsulitis, rotator cuff tears or sprains, or tendinitis Age 60 years or older and a positive dropped-arm test are the individual findings mostlikely to identify a rotator cuff tear, with likelihood rations (LRs) of 3.2 and 5.0, respectively. The combined findings of supraspinatus weakness, and a positive impingement sign increase the likelihood of a tear to 48.0; when all thee are absent, the LR fails to 0.02, virtually ruling out the diagnosis Localized tenderness or pain with adduction suggests inflammation or arthritis of the acromioclavicular joint. But sensitivity and specificity of tenderness is -95% and 10%; of adduction, -80% and 50% Difficulty with these motions suggests rotator cuff disorder Pain during this maneuver(Neer’s impingement signprevent scapular motion with pt. arm above their head) is a positive test indication possible rotator cuff tear Pain during this maneuver(Hawkin’s impingement signshoulder and elbow at 90degrees palm facing down-rotate arm inward with hand on rotator) is a positive test indicating possible rotator cuff tear Weakness during this maneuver(supraspinatus strength“empty can test”- elevate arms 90degree and invert arms in)is a positive test indication possible rotator cuff tear Weakness during this maneuver(infraspinatus strengthelbows at 90degree rotate in) a positive test indicating possible rotator cuff tear or bicipital tendinitis Pain during this maneuver(forearm supination- elbow 90degree provide resistance to pt supination) is a positive test indication inflammation of the long head of the biceps tendon and possible rotator cuff tear - - - - - - - (“Drop-arm” sign) If the patient cannot hold the arm fully abducted at shoulder level, the test is positive, indicating a rotator cuff tear Swelling over the olecranon process in olecran bursitis; inflammation or synovial fluid in arthritis Tenderness distal to the Epicondyle in lateral epicondylitis (tennis elbow) and less commonly in medial epicondylitis (pitcher’s or golfer’s elbow) The olecranon is displaced posteriorly in posterior dislocation of the elbow and supracondylar fracture Full elbow extension makes intra-articular effusion or hemarthrosis unlikely Guarded movement suggests injury Poor finger alignment is seen in flexor tendon damage Diffuse swelling in arthritis or infections Local swelling from cystic ganglion In osteoarthritis, Heberden’s nodes at the DIP joints, Bouchard’s nodes at the PIP joints In rheumatoid arthritis, symmetric deformity in the PIP, MCP, and wrist joints, with ulnar deviation Thenar atrophy in median nerve compression from carpal tunnel syndrome; hypothenar atrophy in ulnar nerve compression Flexion contractures in the ring, 5th, and 3rd fingers, or Dupuytren’s contractures, arise from thickening of the palmar fascia Tenderness over the distal radius in Colles’ fracture Any tenderness or bony step-offs are suspicious for fracture Swelling and/or tenderness suggests rheumatoid arthritis if bilateral and of several weeks’ duration Tenderness over the extensor and abductor tendons of the thumb at the radial styloid in de Quervain’s tenosynovitis and gonococcal tenosynovitis Tenderness over the “snuffbox” in scaphoid fracture, the most common injury of the carpal bones Poor blood supply puts the scaphoid bone at risk for avascular necrosis Synovitis in the MCPs is painful with this pressure- a point to remember when shaking hands The MCPs are often boddy or tender in rheumatoid arthritis (but rarely involved in osteoarthritis) Pain with compression also in posttraumatic arthritis PIP changes seen in rheumatoid arthritis, Bouchard’s nodes in osteoarthritis Pain at the base of the thumb in the first carpormetacarpal arthritis Hard dorsolateral nodules on the DIP joints, or Heberden’s nodes, common in osteo arthritis; DIP joint involvement in psoriatic arthritis Tenderness and swelling in tenosynovitis, or inflammation of the tendon sheaths - - - - - - - - De Quervain’s tenosynovitis over the extensor and abductor tendons of the thumb as they cross the radial styloid Condition that impair range of motion include arthritis, tenosynovitis, Dupuytren’s contracture Onset of carpal tunnel syndrome often related to repetitive motion with wrists flexed (as in key board use, mailsorting), pregnancy, rheumatoid arthritis, diabetes, hypothyroidism Thenar atrophy may also be present Decreased sensation in the median nerve distribution in carpal tunnel syndrome Decreased grip strength is a positive test for weakness of the finger flexors and/ or intrinsic muscles of the hand Wrist pain and grip weakness in de Quervanin’s tensynovitis Decreased grip strength in arthritis, carpal tunnel syndrome, epicondylitis, and cervical radiculopathy Pain during this maneuver identifies de Quervain’s tenosynovitis from inflammation of the abductor pollicis longus and extensor pollicis brevis tendons and tendon sheaths Weakness on thumb abduction is a positive test- the abductor pollicis longus is innervated only but the median nerve Weak thumb abduction, hand symptom diagrams, and decreased sensation roughly double the likelihood of carpal tunnel disease Aching and numbness in the median nerve distribution is a positive test Numbness and tingling in the median nerve distribution within 60 seconds is a positive test Tinel’s and Phalen’s signs do not reliably predict positive electrodiagnosis of carpal tunnel disease Impaired hand movement in arthritis, trigger finger, Dupuytren’s contracture Neck stiffness signals arthritis, muscle strain, or other underlying pathology that should be pursued Lateral deviation and rotation of the head suggest torticollis, from contraction of the sternocleidomastoid muscle Tenderness of the spinous processes suggests fracture or dislocation if preceded by trauma, underlying infection, or arthritis Tenderness of the facet joints in arthritis, especially btw C5 and C6 Step-offs in spondylolisthesis, or forward slippage of one vertebra, which may compress the spinal cord Vertebral tenderness is suspicious for fracture or infection Tendernessover the sacroiliac joint in sacroliitis Ankylosing spondylitis may produce sacroiliac tenderness Pain on percussion may arise from osteoporosis, infection, or malignancy - - - - - - - - - - Increased thoracic kyphosis occurs with aging. In children a correctable structural deformity should be pursued In scoliosis, there is lateral and rotator curvature of the spine to bring the head back to midline Scoliosis often becomes evident during adolescence, before symptoms appear Unequal shoulder heights seen in scoliosis; Sprengel’s deformity of the scapula (from the attachment of an extra bone or band btw the upper scapula and C7); In “winging” of the scapula (from loss of innervation of the serratus anterior muscle by the long thoracic nerve); and in contra-lateral weakness of the trapezius Unequal heights of the iliac crests, or pelvic tilt, suggest unequal lengths of the legs and disappear when a block is placed under the short leg and foot Scoliosis and hip abduction or adduction may also cause a pelvic tilt “Listing” of the trunk to one side is seen with a herniated lumbar disc Birthmarks, port-wine stains, hairy patches, and lipomas often overlie bony defects such as spina bifida Café-au-lait spots (discolored patches of skin), skin tags, and fibrous tumors in neurofibromatosis Spasm(paravertebral muscles) occurs in degenerative and inflammatory processes of muscles, prolonged contraction from abnormal posture, or anxiety Sciatic nerve tenderness suggests a herniated disc or mass lesion impinging on the contributing nerve root Herniated intervertebral discs, most common at L5-S1 or L4-L5, may produce tenderness of the spinous processes, the intervertebral joints, the paravertebral muscles, the sacrosciatic notch, and the sciatic nerve Rheumatoid arthritis may also cause tenderness of the intervertebral joints Remember that tenderness in the costovertebral angles may signify kidney infection rather than a musculoskeletal problem Limitations in range of motion can arise from stiffness from arthritis, pain from trauma, or muscle spasm such as torticollis It is important to assess any complaints or findings of neck, shoulder, or arm pain or numbness for possible cervical cord or nerve root compression Tenderness at C1-C2 in rheumatoid arthritis suggests possible risk for subluxation and high cervical cord compression Deformity of the thorax on forward bending in scoliosis To measure flexion of the spine, mark the spine at the lumbosacral junction, then 10 cm above and 5 cm below this point. A 4 cm increase btw the two upped marks is normal; the distance btw the lower two marks should be unchanged Persistence of lumber lordosis suggests muscle spasm or ankylosing spondylitis - - - - - - Decreased spinal mobility in osteoarthritis, and ankylosing spondylitis among other condtions Underlying cord or nerve root compression should be considered Note that arthritis or infection in the hip, rectum, or pelvis may cause symptoms in the lumbar spine Most problems of gait appear during the weight-bearing stance phase A wide base suggests cerebellar disease or foot problems Hip dislocation, arthritis, or abductor, weakness can cause the pelvis to drop on the opposite side, producing a waddling gait Lack of knee flexion interrupts the smooth pattern of gait Loss of lordosis may reflect paravertebral spasm;excess lordosis suggests a flexion deformity of the hip Changes in leg length are seen in abduction or adduction deformities and scoliosis Leg shortening and external rotation suggest hip fracture Bulges along the ligament may suggest an inguinal hernia or, on occasion, an aneurysm Enlarged lymph nodes suggest infection in the lower extremity or pelvis Tenderness in the groin area may be from synovitis of the hip joint, bursitis, or possibly psoas abscess Focal tenderness over the trochanter in trochanteric bursitis Tenderness over the posterolateral surface of the greater trochanter in localized tendinitis or muscle spasm from referred hip pain Tenderness in ischiogluteal bursitis of “weaver’s bottom”because of the adjacent sciatic nerve, this may mimic sciatica In flexion deformity of the hip, as the opposite hip is flexed (with the thigh against the chest), the affected hip does not allow full leg extension, and the affected thigh appears flexed Flexion deformity may be masked by an increase, rather than flattening, in lumber lordosis and an anterior pelvic tilt Restricted abduction is common in hip osteoarthritis Restrictions of internal and external rotation are sensitive indicators of hip disease such as arthritis Stumbling or pushing the knee into extension with the hand during heel strike suggests quadriceps weakness Bowlegs (genu varum) and knock-knees (genu valgum) are common Flexion contracture (inability to extend fully) in limb paralysis Swelling over the patella suggests prepatellar bursitis Swelling over the tibial tubercle suggests infrapatellar More medial- anserine bursitis Osteoarthritis if tender bony ridges along the joint margins, genu varum deformity, and stiffness 30 minutes - - - - - - - or less (likelihood ratios: 11.8, 3.4, and 3.0) Crepitus may also be present Meniscus teat with tenderness after trauma more common in medial meniscus MCL(medial collateral ligament) tenderness after injury suspicious for an MCL tear LCL injuries less frequent Tenderness over the tendon or inability to extend the leg suggest a partial or complete tear of the patellar tendon Pain and crepitus suggests roughening of the patellar undersurface that articulates with the femur. Similar pain may occur with climbing stairs or getting up from a chair Pain with compression and with patellar movement during quadriceps contraction suggests chondromalacia, or degenerative patella (the patellofemoral syndrome) Swelling above and adjacent to the patella suggest synovial thickening of effusion in the knee joint Thickening, bogginess, or warmth in these areas indicate synovitis or non-tender effusions from osteoarthritis Prepatellar bursitis (“housemaid’s knee) from excessive kneeling Anserine bursitis from running, valgus knee deformity, fibromyalgias, osteoarthritis A popliteal of the gastrocnemius semimembranosus bursa A fluid wave or bulge on the medial side btw the patella and the femur is considered a positive buldge sign consistent with an effusion When the knee joint contains a large effusion, suprapatellar compression ejects fluid into the spaces adjacent to the patella A palpable fluid wave signifies a positive “balloon sign.” A returning fluid wave into the suprapatellar pouch confirms an effusion Palpable fluid returning into the pouch further confirms the presence of a large effusion A palpable patellar click with compression may also occur, but yields more false positives A defect in the muscles with tenderness and swelling in a ruptured Achilles tendon; tenderness and thickening of the tendon above the calcaneus, sometimes with a protuberant posterolateral bony process of the calcaneus in Achilles tendinitis Absence of plantar flexion is a positive test indicating rupture of the Achilles tendon Sudden severe pain “like a gunshot wound,” an Ecchymosis from the calf into the heel, and a flat-footed gait with absence of “toe-off” may also be present Crepitus with flexion and extension in osteoarthritis A click or pop along the medial joint with valgus stress, external rotation, and leg extension suggests a probable tear of the posterior portion of the medial meniscus. The tear may displace meniscal tissue, causing “locking” on full knee extension - - - - - - - - A McMurray sign and locking make a medialmeniscus tear 8.2 and 3.2 times more likely (Abduction)Pain or a gap in the medial joint line points to ligamentous laxity and a partial tear of the medial collateral ligament. Most injuries are on the medial side (Adducion) Pain or a gap in the lateral joint line points to ligamentous laxity and a partial tear of the lateral collateral ligament (Anterior Drawer Sign- slides from supine knee up) A few degrees of forward movement are normal if equally present on the opposite side A forward jerk showing the contours of the upper tibia is a positive anterior drawer sign, making an ACL tear 11.5 times more likely (Lachman Test) Significant forward excursion indicates an ACL tear (likelihood increases 17.0 if positive test) (Posterior Drawer sign) isolated PCL tears are rare Localized tenderness of the ankle joint in arthritis, ligamentous injury, or infection of the ankle Rheumatoid nodules; tenderness in Achilles tendinitis, bursitis, or partial tear from trauma Bone spurs may be present on the calcneus Focal heel pain on palpation of the plantar fascia suggests plantar fascilitis; seen in prolonged standing or hellstrike exercise, also in rheumatoid arthritis, gout After trauma, inability to bear weight after4 steps and tenderness over the posterior aspects of either malleolus, especially the medial malleolus, is suspicious for ankle fracture (Ottowa ankle rule) Tenderness on compression of the metatarsophalangeal joints is an early sign of rheumatoid arthritis Acute inflammation of the first metatarsophalangeal joint in gout Pain and tenderness at the metatarsals is called metatarsalgia, in trauma, arthritis, vascular compromise Pain of the ankle(tibiotalar) joint during movements of the ankle and the foot helps to localize possible arthritis An arthritic joint is frequently painful when moved in any direction, wheras a ligamentous sprain produces maximal pain when the ligament is stretched. For example, in a common form of sprained ankle, inversion and plantar flexion of the foot cause pain, whereas eversion and plantar flexion are relatively pain free Unequal leg length may explain a scoliosis -