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From: Cell-based Therapy for Acute Organ Injury:Preclinical Evidence and Ongoing Clinical Trials Using Mesenchymal
Stem Cells
Anesthes. 2014;121(5):1099-1121. doi:10.1097/ALN.0000000000000446
Figure Legend:
Immunomodulatory properties of mesenchymal stem cells on innate and adaptive immunity. (A) MSC can modulate innate and
adaptive immune cells by: (1) promoting repolarization of macrophages from type 1 to type 2 phenotype characterized by high levels
of interleukin-10 secretion, which can block polymorphonuclear neutrophil influx into the injured tissue and prevent further damage;
(2) interfering with dendritic cells differentiation, maturation, and function, skewing them toward a regulatory phenotype and
decreasing their capacity to induce activation of T cells; and (3) impairing natural killer cells cytotoxic activity, cytokine production,
and
B release.
studies
suggest
thatSociety
the complex
interplay between
MSC
and natural killer cells may
Dategranzyme
of download:
5/6/2017However, recent
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depend on the surrounding milieu. (B) MSC can suppress T cell activation and proliferation and also decrease their response by