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Methods of characterization of cell populations as monoclonal or polyclonal. A: Immunoglobulin light and heavy chain distribution in a B lymphocyte
population. B: Glucose-6-phosphate dehydrogenase (G6PD) isoenzyme studies may be used in some female patients. G6PD isoenzyme inheritance is Xlinked. In heterozygous females, one X chromosome codes for the A isoenzyme and the other for the B isoenzyme. Because one X chromosome is
randomly inactivated in the adult cell, an adult cell will contain only one of the isoenzymes. A polyclonal population will be composed of cells containing
both isoenzymes in approximately equal amounts, whereas a monoclonal population will be composed of cells that express only one isoenzyme.
Source: Chapter 18. Neoplasia: II. Mechanisms & Causes of Neoplasia, Concise Pathology, 3e
Citation: Chandrasoma P, Taylor CR. Concise Pathology, 3e; 1998 Available at: http://mhmedical.com/ Accessed: April 29, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved
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