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Upper GI Key Points Assessment ANATOMY AND PHYSIOLOGY REVIEW The gastrointestinal system includes the GI tract or alimentary canal, consisting of the mouth, esophagus, stomach, small and large intestines, and rectum. The salivary glands, liver, gallbladder, and pancreas secrete substances into this tract to form the GI system. The main function of the GI tract, with the aid of organs such as the pancreas and the liver, is the digestion of food to meet the body’s nutritional needs, and the elimination of waste resulting from digestion. The GI tract is susceptible to many health problems, including structural or mechanical alterations, impaired motility, infection, and cancer. Although the GI tract is continuous from the mouth to the anus, it is divided into specialized regions, each of which has a specific function. The functions of the GI tract include secretion, digestion, absorption, motility, and elimination. The oral cavity includes the buccal mucosa, lips, tongue, hard palate, soft palate, teeth, and salivary glands, and is involved with speech, taste, and mastication. Saliva contains mucin and an enzyme called salivary amylase, also known as ptyalin, which begins the breakdown of carbohydrates. The esophagus is a muscular canal that extends from the pharynx to the stomach functioning to move food and fluids from the pharynx to the stomach. The stomach functions as a food reservoir where the digestive process begins, using mechanical movements and chemical secretions. The intestinal phase begins as the chyme passes from the stomach into the duodenum, causing distention. The exocrine function of the pancreas secretes enzymes needed for digestion of carbohydrates, fats, and proteins. The endocrine part of the pancreas is made up of the islets of Langerhans, with alpha cells producing glucagon and beta cells producing insulin, essential in the regulation of metabolism. The liver performs more than 400 functions in three major categories: storage, protection, and metabolism. The small intestine has three main functions: movement (mixing and peristalsis), digestion, and absorption. The large intestine’s functions are movement, absorption, and elimination. ASSESSMENT TECHNIQUES One tool for assessing GI function is the nutritional-metabolic and elimination pattern assessment found in Gordon’s Functional Health Patterns. Ask questions about changes in appetite, weight, and stool to determine the events related to the current health problem. Collect data about the patient’s age, gender, and culture. Question the patient about previous GI disorders or abdominal surgeries, prescription medications, over-the-counter drugs, smoking, chewing tobacco, and travel history, which may provide clues about the cause of symptoms like diarrhea. The goal of a nutritional assessment is to gather information about how well the patient’s nutritional needs are being met, special diets, and food allergies. Inquire about family history, since some GI disorders have genetic predisposition. Obtain a chronologic account of the current problem and treatments and explore the characteristics associated with each symptom, including the location, quality, quantity, timing, and aggravating or alleviating factors. Physical assessment involves a comprehensive examination of the patient’s nutritional status, mouth, and abdomen. The abdominal examination begins at the patient’s right side and proceeds in a systematic fashion through the right upper quadrant, left upper quadrant, left lower quadrant, and right lower quadrant. The abdomen is assessed in a sequence different from that used for other body systems: inspection, auscultation, percussion, and then palpation, so that palpation and percussion do not increase intestinal activity and bowel sounds. Inspect the skin and note overall contour and symmetry of the abdomen, scarring or discolorations, abdominal distention, bulging flanks, and taut, glistening skin. Auscultation of the abdomen is performed with the diaphragm of the stethoscope because bowel sounds are usually high pitched. Bowel sounds are normally heard as relatively high-pitched irregular gurgles every 5 to 15 seconds, characterized as normal, hypoactive, or hyperactive. Bowel sounds are diminished or absent after abdominal surgery or in the patient with peritonitis or paralytic ileus. Percussion is used to determine the size of solid organs; to detect the presence of masses, fluid, and air; and to estimate the size of the liver and spleen. The purpose of palpation, used by advanced practitioners, is to determine the size and location of abdominal organs and to assess for masses or tenderness. Do not palpate or auscultate any abdominal pulsating mass as it could be a life-threatening aortic aneurysm. Psychosocial assessment focuses on how the GI health problem affects the patient’s life and lifestyle. Emotional stress has been associated with the development or exacerbation of irritable bowel syndrome and other GI disorders. Laboratory tests may include a complete blood count for diagnosis of anemia and infection; coagulation studies, electrolytes, assays of serum enzymes for the evaluation of the liver and pancreas, bilirubin, ammonia, and oncofetal antigens to diagnose and monitor for GI cancer. Stool studies evaluate the function and integrity of the GI tract and detect the presence of infections, protozoa, parasites, and blood in the stool. Radiographic examinations detect structural and functional disorders. The nurse’s role is to properly prepare the patient for the examination, to provide an explanation of the procedure, and to provide the necessary post-procedure care. An upper GI radiographic series is an x-ray visualization from the oral part of the pharynx to the duodenojejunal junction to detect disorders of structure or function of the esophagus, stomach, or duodenum. Instruct the patient to drink plenty of fluids and take a laxative as prescribed to eliminate barium if used during diagnostic testing. Endoscopy is direct visualization of the GI tract using a flexible fiberoptic endoscope to evaluate bleeding, ulceration, inflammation, tumors, and cancer of the esophagus, stomach, biliary system, or bowel. EGD-Esophagogastroduodenoscopy is a visual examination of the esophagus, stomach, and duodenum, during which a physician can inject a sclerotherapy agent into an affected area to stop bleeding. ERCP-Endoscopic retrograde cholangiopancreatography includes visual and radiographic examination of the liver, gallbladder, bile ducts, and pancreas to identify the cause and location of obstruction The priority for care is to check for the return of the gag reflex after an upper endoscopic procedure before offering fluids or food, to avoid aspiration. Assess patients who have endoscopies for bleeding, fever, and severe pain. Monitor vital signs carefully for the patient having any endoscopic procedure and moderate sedation. If an endoscopic procedure on an ambulatory basis is scheduled, remind the patient to have someone available to drive him or her home because of the effects of moderate sedation. Colonoscopy is an endoscopic examination of the entire large bowel, during which tissue biopsy specimens or polyps may be removed through the colonoscope. Proctosigmoidoscopy, often referred to as a sigmoidoscopy, is an endoscopic examination of the rectum and sigmoid colon using a flexible scope to screen for colon cancer, investigate the source of GI bleeding, or diagnose or monitor inflammatory bowel disease. For patients having a colonoscopy, check for passage of flatus before allowing fluids or food. Teach patients to limit caffeine and alcohol in their diets to reduce risk of gastrointestinal health problems. Teach patients having invasive colon diagnostic procedures to follow instructions carefully for the bowel preparation to ensure that the bowel is clear. The 2010 American Cancer Society Screening Guidelines recommend yearly fecal occult blood test, yearly fecal immunochemical test, or stool DNA (sDNA) at unspecified intervals to detect colorectal cancer early when it can be treated. The newest test for detection of colorectal cancer is stool DNA (ColoSure®). This test examines stool DNA to detect changes in the vimetin gene. Most patients with colorectal cancer have genetic changes, that can be detected by this simple test. The 2010 American Cancer Society Screening Guidelines include options to determine the presence of colorectal cancer or polyps for people over 50 years of age: o Double-contrast barium enema every 5 years o Flexible sigmoidoscopy every 5 years o CT colonography (virtual colonoscopy) every 5 years o Colonoscopy every 10 years Chapter 57: Care of Patients with Esophageal Problems Key Points - Print The esophagus moves partially digested food from the mouth to the stomach. Common problems of the esophagus that can interfere with digestion and nutrition are caused by inflammation, structural defects or obstruction, and cancer. Collaborative management requires dietary and lifestyle changes, as well as medical and surgical therapies. GASTROESOPHAGEAL REFLUX DISEASE Gastroesophageal reflux disease (GERD) is the most common upper GI disorder in the United States, occurring most often in middle-aged and older adults. The incidence of GERD is increasing throughout the world. GERD occurs as a result of reflux, or backward flow, of gastrointestinal contents into the esophagus. Reflux produces symptoms by exposing the esophageal mucosa to the irritating effects of gastric or duodenal contents, resulting in inflammation, which may be mild to severe. During the process of healing, the body may substitute Barrett’s epithelium for the normal squamous cell epithelium of the lower esophagus. This new tissue is more resistant to acid and therefore supports esophageal healing, but it is associated with an increased risk of cancer in patients with prolonged GERD. The fibrosis and scarring that accompany the healing process can produce esophageal stricture, which is narrowing of the esophageal opening. The stricture leads to progressive difficulty in swallowing. Dyspepsia, also known as heartburn, is the main symptom of GERD and is described as a substernal burning sensation that tends to move up and down the chest in a wavelike fashion. Other symptoms include eructation or belching, flatulence, and difficult or painful swallowing. For most patients, GERD can be controlled by nutrition therapy, lifestyle changes, and drug therapy. The most important role of the nurse is patient and family education. In the past decade, several noninvasive endoscopic procedures have been approved for the diagnosis and treatment of severe GERD. This nonsurgical procedure has also been approved for patients with Barrett’s esophagus. A very small percentage of patients with GERD require antireflux surgery. A newer drug, omeprazole/sodium bicarbonate (Zegerid), is the first immediate-release drug and is designed for short-term use. Another newer drug, dexlansoprazole (Kapidex), is a dual-release (delayed release) drug that is available in several dosages, but tends to be associated with more side and adverse effects than some of the other drugs. HIATAL HERNIA Hiatal hernias, also called diaphragmatic hernias, involve the protrusion of a portion of the stomach through the esophageal hiatus of the diaphragm into the chest. Most patients with hiatal hernias are asymptomatic, but some may have daily symptoms similar to those with GERD. Patients with hiatal hernias may be managed either medically or surgically based on the severity of symptoms and the risk of serious complications. The primary focus of care after conventional surgery is the prevention of respiratory complications. Remember the following key points when caring for patients with esophageal disorders. Collaborate with the health care team for the patient with impaired swallowing and/or limited nutrition. Remain with the dysphasic patient during meals to prevent or assist with choking episodes. Teach the patient oral exercises and correct positioning aimed at improving swallowing. Stress the importance of recognizing and controlling reflux through dietary management and medications to avoid further esophageal damage. Teach the patient to elevate the head of the bed by 6 inches when sleeping to prevent nighttime reflux. Instruct the patient to sleep in the right side-lying position to minimize the effects of nighttime episodes of reflux. Be sure to frequently monitor the nutritional status of the patient with esophageal cancer. Teach the patient with esophageal cancer to monitor his or her body weight and to notify the health care provider of a loss of 5 pounds or greater. Teach the patient to avoid alcoholic beverages, smoking, and other substances that lead to increased gastroesophageal reflux. Teach the patient to prevent gas bloat syndrome by avoiding drinking carbonated beverages, eating gas-producing foods, chewing gum, and drinking with a straw. Chapter 58: Care of Patients with Stomach Disorders Key Points - Print The most common stomach disorders include gastritis, peptic ulcer disease, and gastric cancer, all of which result in impaired or altered digestion and nutrition. The stomach is part of the upper GI system which is responsible for a large part of the digestive process. Diseases that affect the stomach can be very serious and in some cases life threatening. GASTRITIS Gastritis is defined as inflammation of the gastric mucosa. It can be scattered or localized and can be classified according to cause, cellular changes, or distribution of the lesions. Gastritis can be designated as erosive, causing ulcers, or nonerosive. Prostaglandins provide a protective mucosal barrier that prevents the stomach from digesting itself by a process called acid autodigestion. With a break in the protective barrier, mucosal injury occurs. Inflammation of the gastric mucosa or submucosa after exposure to local irritants or other cause can result in acute gastritis. Chronic gastritis appears as a patchy, diffuse inflammation of the mucosal lining of the stomach, resulting in thinning and atrophy of the walls and lining of the stomach. Helicobacter pylori infection and penetration of the mucosal gel layer of the gastric epithelium is often responsible, although other forms of bacterial gastritis occur less often. Type A gastritis has been associated with the presence of antibodies to parietal cells and intrinsic factor, therefore, most likely related to autoimmune disease. H. pylori infection causes type B gastritis, which is more common. A balanced diet, regular exercise, avoidance of excessive use of aspirin and other NSAIDs, and stress reduction techniques can help prevent gastritis. Symptoms of acute gastritis include mild to severe epigastric discomfort, anorexia, cramping, nausea and vomiting, abdominal tenderness and bloating, hematemesis, or melena. Chronic gastritis causes few symptoms unless ulceration occurs. Methods to detect H. pylori include a blood test to detect IgG or IgM anti-H. pylori antibodies, immune testing using an enzyme-linked immunosorbent assay and immune chromatomography, and breath and stool analyses. Esophagogastroduodenoscopy via an endoscope with biopsy is the gold standard for diagnosing gastritis. Collaborative management is directed toward supportive care for relieving the symptoms and removing the cause of discomfort. Acute gastritis healing is spontaneous, usually occurring within a few days. Surgery, such as partial gastrectomy, pyloroplasty, and/or vagotomy, may be needed for patients with major bleeding or ulceration. Treatment of chronic gastritis varies with the cause. PEPTIC ULCER DISEASE A peptic ulcer is a mucosal lesion of the stomach or duodenum. Three types of ulcers may occur: gastric ulcers, duodenal ulcers, and stress ulcers, which are less common. Most gastric and duodenal ulcers are caused by H. pylori infection, which is transmitted via the fecal-oral route and thought to be acquired in childhood. Peptic ulcer disease results when mucosal defenses become impaired and no longer protect the epithelium from the effects of acid and pepsin. Acid, pepsin, and H. pylori infection play an important role in the development of gastric ulcers. The most common complications are hemorrhage, perforation, pyloric obstruction, and intractable disease, with hemorrhage as the most serious. If perforation into the peritoneal cavity is present, the patient has a rigid, boardlike abdomen accompanied by rebound tenderness. Serologic testing for IgG anti-H. pylori antibody is the most common noninvasive method to confirm H. pylori infection. IgA and IgM anti-H. pylori antibody testing may also be performed. Hemoglobin and hematocrit values may be low, indicating bleeding. A stool specimen may be positive for occult blood if bleeding is present. GI bleeding may be tested using a Nuclear Medicine GI bleeding study. No special preparation is required for this scan. The patient is injected with a contrast medium (usually Tc99m) and the GI system is scanned for the presence of bleeding after a waiting period. The major diagnostic test is esophagogastroduodenoscopy. The primary goals of drug therapy are to (1) provide pain relief, (2) eliminate H. pylori infection, (3) heal ulcerations, and (4) prevent recurrence. Teach patients about complementary and alternative therapies that can reduce stress, including hypnosis and imagery. Teach patients the importance of adhering to H. pylori treatment to prevent the risk for gastric cancer. A new faster-acting form of omeprazole combined with sodium bicarbonate (Zegerid) can be purchased OTC and is prescribed most often for active duodenal ulcers for a 4 to 8 week period. The patient who is actively bleeding has a life-threatening emergency and requires supportive therapy to prevent hypovolemic shock and possible death. Endoscopic therapy via an esophagogastroduodenoscopy (EGD) can assist in achieving homeostasis during an acute hemorrhage by isolating the bleeding artery to embolize (clot) it. o Octreotide (Sandostatin) or terlipressin (Novapressin) may be given IV as adjuvant therapy. o These drugs are synthetic GI hormones (somatostatin analogues) that suppress gastric acid secretion. For patients with persistent, massive upper GI bleeding or those who are not surgical candidates, catheter-directed embolization may be performed. The primary methods of endoscopic therapy are (1) thermal contact using a heater probe or multielectrocoagulation, (2) injection of the bleeding site with diluted epinephrine, and (3) clipping the bleeding vessel with a mechanical clip. Surgical intervention is rare but may be used to treat patients who do not respond to medical therapy or to treat a surgical emergency that develops as a complication. Dumping syndrome is a term that refers to a group of vasomotor symptoms that occur after eating as a result of the rapid emptying of food contents into the small intestine, which shifts fluid into the gut causing abdominal distention. Observe the patient for signs and symptoms of dumping syndrome after gastric surgery and teach them the manifestations and management of this syndrome. Interventions to minimize dumping syndrome include small, frequent meals, avoiding liquids with meals, avoiding foods that cause discomfort, eliminating caffeine, alcohol, and tobacco consumption, receiving B12 injections as appropriate, and lying flat after eating for a short time. Keep these general guidelines in mind when caring for these patients. Refer patients and families to organizations focused on digestive disorders where they can obtain information and support. Identify patients at risk for gastritis and peptic ulcer disease, especially older adults who take large amounts of NSAIDs and those with H. pylori. Teach patients the importance of complying with H. pylori treatment to prevent the risk of gastric cancer. Teach patients with abnormal symptoms, such as abdominal tenderness, abdominal pain that is relieved by food or pain or that becomes worse 3 hours after eating, dyspepsia, melena, and/or distention to consult with their physician immediately for prompt diagnosis and treatment. Teach patients that hematemesis is a medical emergency and that they should go to the emergency department for prompt treatment. Teach patients about various complementary and alternative therapies that are currently used for gastritis and peptic ulcer disease. For patients who have undergone a gastrectomy, collaborate with the dietitian and instruct the patient regarding diet changes to avoid distention and dumping syndrome. Teach the proper administration of antacids and provide the information that antacids can interfere with the effectiveness of certain drugs. Teach the proper administration of H2 antagonists on an empty stomach. Teach the proper administration of antisecretory agents, noting that most cannot be crushed because they are sustained-release or enteric-coated tablets. Chapter 62: Care of Patients with Problems of the Biliary System and Pancreas Key Points - Print The liver, gallbladder, and pancreas secrete enzymes and substances that promote food digestion in the stomach and small intestine. When these organs do not work properly, the person has impaired digestion which may result in inadequate nutrition. Patients with biliary and pancreatic disorders are at high risk for biliary obstruction, a serious and painful complication. Interdisciplinary management of patients with problems of the biliary system and pancreas includes the need to promote nutrition for normal cellular function. GALLBLADDER DISORDERS CHOLECYSTITIS Cholecystitis is an inflammation of the gallbladder that affects many people in affluent countries. It may be either acute or chronic, although most patients have the acute type. Two types of acute cholecystitis are calculous and acalculous cholecystitis. The most common type is calculous cholecystitis, in which chemical irritation and inflammation results from gallstones that obstruct the cystic duct most commonly, gallbladder neck, or common bile duct. Acalculous cholecystitis, inflammation occurring without gallstones, is associated with biliary stasis caused by changes in the regular filling or emptying of the gallbladder. Chronic cholecystitis results when repeated episodes of cystic duct obstruction result in chronic inflammation, most often with calculi. Jaundice, seen as yellow discoloration of the skin and mucous membranes, and icterus, which is yellow discoloration of the sclera, can occur in patients with acute cholecystitis, but is most commonly observed with the chronic form of the disease. Women from 20 to 60 years of age are twice as likely to develop gallstones as men. Obesity, pregnancy, estrogen, birth control pills, and combinations of those factors are major risk factor for gallstone formation, especially in women. Teach patients to avoid losing weight too quickly and keep weight under control to help prevent gallbladder disease. Patients with acute cholecystitis present with abdominal pain, although clinical manifestations vary in intensity and frequency. There are no laboratory tests specific for gallbladder disease, so differential diagnosis rules out diseases causing similar symptoms, such pancreatitis. When the cause of cholecystitis or cholelithiasis is not known or the patient has manifestations of biliary obstruction, such as jaundice, an endoscopic retrograde cholangiopancreatography may be performed. o Some patients have the less invasive and safer magnetic resonance cholangiopancreatography which can be performed by an interventional radiologist. Most patients do not respond to nonsurgical interventions during the acute phase of cholecystitis, therefore, surgery is the treatment of choice. Cholecystectomy is a surgical removal of the gallbladder via laparoscopic cholecystectomy or, far less often, cholecystectomy. A new procedure is natural orifice transluminal endoscopic surgery (NOTES) for removal of or repair of organs. Surgery can be performed on many body organs through the mouth, vagina, and rectum. For removal of the gallbladder, the vagina is used most often because it can be easily decontaminated with Betadine or other antiseptic, and allows easy access into the peritoneal cavity. CANCER OF THE GALLBLADDER Primary cancer of the gallbladder is rare, more common in women than in men, and usually is an adenocarcinoma or squamous cell cancer. The diagnosis of gallbladder cancer is typically made by ultrasonography but computed tomography scan, endoscopic retrograde cholangiopancreatography (ERCP), or magnetic resonance cholangiopancreatography are also used. The prognosis for the patient with cancer of the gallbladder is poor because it is usually diagnosed in late disease. Treatments used include surgery, radiation therapy, and chemotherapy. Surgical intervention is either potentially curative for an early resectable tumor or palliative for advanced disease with metastasis.