Download Lecture - Venice Arrhythmias

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

page
1
page
2
page
3
page
4
page
5
page
6
page
7
page
8
page
9
page
10
page
11
page
12
page
13
page
14
page
15
page
16
page
17
page
18
page
19
page
20
page
21
page
22
page
23
page
24
page
25
page
26
page
27
page
28
page
29
page
30
page
31
page
32
page
33
page
34
page
35
page
36
page
37
page
38
page
39
page
40
page
41
page
42
page
43
page
44
Document related concepts
no text concepts found
Transcript 
Sami%Viskin,%M.D.%
Tel%Aviv%Medical%Center%
Israel%
2015%
Rejected%by%NEJM,%Lancet,%Ann%Intern%Med%(without%peer%review)%
Accepted%to%the%Journal%of%the%American%College%of%Cardiology%
60%year%old%woman%aOer%receiving%sotalol%
%
d
n
a
%
e
n
i
d
i
n
i
u
q
%
%
s
d
i
g
o
u
v
r
d
%
g
n
! %A
i
g
n
o
l
o
r
QTSp
40%year%old%man%aOer%receiving%ajmaline%%
%
y
d
u
t
s
%
c
i
g
o
l
o
i
s
y
h
p
%
o
r
d
t
e
c
c
e
l
u
d
n
i
%
! %E
s
i
%
F
V
%
f
i
%
D
C
I
%
!
Long%QT%syndrome%is%diagnosed%"in$the$presence$of$
QTc>500$ms$...$when%a%secondary%cause%for%QT%
prolongaUon%is%absent."%$$$$$$$$$$$$$$$$
Brugada%syndrome%is%diagnosed”$in$pa8ents$with$type$1$
ECG…$either$spontaneously$or%aOer%provocaUve%drug%
test$with$a$Class$I$an8arrhythmic$drug.”$
La tachycardie ventriculaire a deux foyers opposes variables.
F. Dessertenne.
Arch Mal Coeur Vaiss 1966;59:263.
Am$Heart$J$1953;45:404L415$
Transient$ventricular$fibrilla8on.$
Sidney$P.$Schwartz.$Am$Heart$J$1953$
Transient$ventricular$fibrilla8on.$
Sidney$P.$Schwartz.$Am$Heart$J$1953$
Raynaud%R,%Brochier%M,%Neel%JL,%Fauchier%JP,%Raynaud%P.%
[Ventricular%tachycardia%with%variable%focus%and%dyskaliemia].%
Arch%Mal%Coeur%Vaiss%1969%%
MoXe%G,%Coumel%P,%Abitbol%G,%Dessertenne%F,%Slama%R.%%
[The%long%QT%syndrome%and%syncope%caused%by%spike%torsades].%%
Arch%Mal%Coeur%Vaiss%1970%%
Krikler%DM,%Curry%PV.%%
Torsade%De%Pointes,%an%atypical%ventricular%tachycardia.%%
BriUsh%Heart%Journal%1976%%
1957 – Jervell-Lange Nielsen
1964- Romano - Ward
1964 – Seltzer
1966 - Schoonmaker
Circula(on+Research+1966%
Right%stellate%ganglionectomy%OR%leO%stellate%sUmulaUon%
!%QT%prolongaUon%
LeO%stellate%ganglionectomy%OR%right%stellate%sUmulaUon%
!%No%change%in%QT%interval%
Cell%1995;80:795S803%
Cell%1995;80:805S811%%
1957 – Jervell-Lange Nielsen
1964- Romano - Ward
1964 – Seltzer
1966 - Schoonmaker
Circula(on+1998%
Eur+Heart+J+2003%
HeartRhythm%2008%
HeartRhythm$2008$
About%264,000%results%(0.35%sec)%
About%107,000,000%(0.46%sec)%
1953%
1989%
1992%
Brugada%&%Brugada,%+JACC+1992%
From%first%descripUon%to%idenUficaUon%of%culprit%geneUc%
mutaUon%in%6%years%(30%years%for%LQTS).%
It’s%the%sodium%channel%
And%it%only%took%6%years%!%
Chen,%+Nature+1998%
Male%predominance%in%
Brugada%syndrome%
Male%predominance%in%
Ashley%Madison%
Mizusawa$$&$Wilde,$Circ*EP-2012$
Brugada syndrome: The ECG changes from day to day
October 6
V1
V2
V3
V2
V3
V2
V3
October 8
V1
October 10
V1
October 15
V1
V2
V3
Baseline%
PostSajmaline%
Baseline%
PostSajmaline%
1992 Brugada & Brugada
1991 Krishnan & Antzelevitch
1996 Miyazaki
1998 Chen
2000 Brugada & Antzelevitch
“AsymptomaUc,%drugSinduced%type%I%Brugada”%is%THE%
most%common%indicaUon%for%ICD%implantaUon%for%
Brugada%syndrome%in%Europe.%%%% % % % %Sacher,%Circula(on%2006%
History+never+looks+like+history+when+you+are+living+through+it.+%
++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++~John+W.+Gardner+(1912E2002)%
%
Related documents