Download NBD board - Digital Pathology Association

Digital Pathology
Empowering pathologists
Bob van Gemen
October, 2008
1
Royal Philips Electronics
• Founded in 1891
• Headquarters: Amsterdam, The
Netherlands
• One of the largest global diversified
industrial company with sales in 2007 of
EUR 26,793 million
• Multinational workforce of 123,800
employees (January 2008)
• Manufacturing sites in 28 countries, sales
outlets in 150 countries
• R&D expenditures EUR 1,619 mln (2006)
CONFIDENTIAL
Healthcare Incubator
2
Since 1 Jan 2006, there are 3 Incubators within
Philips to further New Business Development
Healthcare
Incubator
Lifestyle
Incubator
Technology
Incubator
CONFIDENTIAL
Healthcare Incubator
2
Strategic Focus Healthcare Incubator
Market Stage
Future
Growth
Emerging
Growth
Established
Sector Road Maps
Current
Emerging
Philips capabilities
CONFIDENTIAL
Healthcare Incubator
Potential Future
Incubation Process at Philips
1. Preseed
2. Seed
3. Alpha 4. Beta 5. Scaling
New BU in IEB
Other Philips
Create value for Philips by
1. finding superior venture opportunities and
2. making them work
CONFIDENTIAL
Healthcare Incubator
Healthcare Incubator scope & selection criteria
Scope
• Involvement of medical profession
• Medically validated solution
required (e.g. FDA approval)
Selection Criteria
• Large market potential
• Strong value proposition
• Capable team
• Strong IPR position
• Link to Philips strategy
• Venture can be run independent of
Philips
• There are synergies with Philips
capabilities or assets
CONFIDENTIAL
Healthcare Incubator
6
Challenges in Pathology
Baby Boomers, age distribution (USA)
Pathology graduates decreasing
50.0
3,000
20,000
40.0
2,500
2,000
Millions
Graduates
15,000
1,500
10,000
30.0
20.0
1,000
Medical
5,000
Pathology
-
10.0
500
-
0.0
1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003
under
5
Year
5-14
15-24
25-34
35-44
45-54
55-64
65-74
75-84
85+
Age group
Lack of consensus
More stains
6% AAGR
2,500
15,000
2,000
70%
1,500
10,000
IHC
H&E
16.8% AAGR
accuracy among
average
pathologists
1,000
H&E
5,000
IHC
500
-
-
2000
CONFIDENTIAL
2001
2002
Year
2003
2004
2005
Healthcare Incubator
7
Pathology
oncology care cycle
Radiology
Clinic initiate
diagnostic procedure
Biopsy
Image
creation
Pathologist
Written report
CONFIDENTIAL
Image-based
diagnostics
Clinic: treatment advice
Healthcare Incubator
Radiologist
PACS, RIS
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Digital Pathology: empowering the pathologist
Scanner
Pathology
Lab
Path.
Information
System
CAD
CDS
Expert
pathologists
PACS
Radiologist
Oncologist
EPR
CONFIDENTIAL
Healthcare Incubator
Medical
Specialist
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Value proposition Digital Pathology in Cancer Dx
Quantification single
IHC
Value
Radiology CDS
Pathology CDS
Morphology based
CAD/CDS
General CDS
PACS
Imaging Mod.
CONFIDENTIAL
Quantification multiple
IHC
Fast Scanner
Healthcare Incubator
Lab Dx
Data acquisition: importance of data processing
• Even though a slide is “small”, imaging of biological specimens requires
100’s of millions of pixels.
• Philips strength from Imaging in Radiology (e.g. whole body CT scan)
• Better handling and viewing due to expertise from Radiology PACS
CONFIDENTIAL
Healthcare Incubator
11
Interesting possible solutions
1
2
3
4
Patient
safety
Advisor
Productivity
QA
Clinical relevant solutions
• follows clinical needs
• development with clinical sites
• scanner independent
Technology basis
• hardware and software
• open system
• enables clinical solutions
CONFIDENTIAL
Pathology PACS (viewer & storage)
Digital scanner
Healthcare Incubator
12
How to optimize the anatomic pathology workflow?
1. Single
batch
Slide production
• Is a more continuous
process more
Diagnosis
efficient?
• What is the optimal
workflow for scanning
slides?
2. Small
batches
• Model with output in
terms of:
3. Continuous
CONFIDENTIAL
1. turn-around-times
2. lab equipment
3. human resources
Healthcare Incubator
Development in collaboration with:
• Pathology departments in 3-4 of the top 10 cancer hospitals in USA
• University Hospitals and Med Schools in USA
• Same in Europe
• Companies with synergistic technology
CONFIDENTIAL
Healthcare Incubator
14
Digital Pathology delivers benefits for Oncology
Care Cycles
Diagnostic turnaround time will be shortened to <24 hours
Short
term
Objective, quantitative read out of (IHC) stains will improve patient safety
Improved reporting of pathology data in EPR increases transparency of
treatment choices for physicians and patients
Application of CAD/CDS will improve overall consensus between
pathologists and improved diagnostic result
Long
term
New, Personalized Healthcare CAD/CDS, developed together with
Pharma, will improve treatment response in breast cancer
New Personalized Healthcare CAD/CDS, developed together with
Pharma, will enable introduction of new, targeted treatment
CONFIDENTIAL
Healthcare Incubator
15
Pathology PACS screen shot: patient list
CONFIDENTIAL
Healthcare Incubator
16
Pathology PACS screen shot: image viewer
CONFIDENTIAL
Healthcare Incubator
17
Pathology PACS screen shot: multiple images
CONFIDENTIAL
Healthcare Incubator
18
Pathology PACS screen shot: 3D rebuild
CONFIDENTIAL
Healthcare Incubator
19
Thank you
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