Download BSc - III (Chemistry)

B.Sc. (SEMESTER V-VI) CHEMISTRY
SYLLABUS
B.Sc. (Medical ,Non-Medical and Biotechnology)
(SEMESTER V & VI)
(2014-2015)
Paper Code
Title of Paper
No. of
Lectures
Max.
Marks
Time
Allowed
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
65
65
65
50
50
50
3 hrs.
3 hrs.
3 hrs.
Chemistry Practical
100
50
6hrs
SEMESTER-V
BCH 501
BCH 502
BCH 503
PRACTICALS
BCH 504
SEMESTER-VI
BCH 601
BCH 602
BCH 603
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
65
65
65
50
50
50
3 hrs.
3 hrs.
3 hrs.
Chemistry Practical
100
50
6 hrs.
PRACTICALS
BCH 604
1
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 501 : INORGANIC CHEMISTRY
Maximum Marks : 50
(i) University Examination : 40
(ii) Internal Assessment : 10
(2 Hrs./week)
Time : 3 Hours
Pass Marks : 35%
INSTRUCTIONS FOR PAPER-SETTER AND CANDIDATES
In the case of Chemistry, each theory paper will have three sections A, B, C and an additional
section D. The paper-setter will set eight questions from Section A, B and C in such a way that
not less than two and not more than three questions are set from any section, Section D will have
one question only which will consist of 10 objective/very short answer type parts uniformly
covering the whole syllabus. All the questions from sections A, B, C and D will carry the same
marks.
Candidates will attempt five questions, selecting at least one but not more than two from
each section.
SECTION - A
Bioinorganic Chemistry: Metal ions present in the biological system: classification of elements
according to their action in biological system Metalloporphyrins with special reference to
Hemoglobin
and
Myoglobin.
Sodium/Potassium
pump.
Biotechnology of
Mg,
Ca.
Metalloenzyme carboxypeptidases. Nitrogen fixation toxicity of metal ions (Hg, Pb, As) reasons
for toxicity use of chelating agents in medicine.
SECTION - B
Organmetallic Chemistry: Definition, Nomenclature and classification of organ
metallic compounds, EAN Rule. Bonding in Organometallic compounds, classification of
ligands.
2
B.Sc. (SEMESTER V-VI) CHEMISTRY
SECTION - C
Carbonyls: Preparation, properties, structure and bonding of the mononuclear carbonyls. A brief
account of metal ethylene complexes, Homogeneous Hydrogenation preparation, properties,
Bonding, Applications of alkyls of Li, Al, Hg, Sn, Ti, acceptor behaviour of CO. Ferrocene and
its reactions.
Reference :
•
Huhecy, J.E. Inorganic Chemistry, Prentice Hall, 1993.
•
F.A Cotton and Wilkinson ; Inorganic Chemistry.
•
Purcell, K.F. and Kotz, J.C. W.B. Saundes Co, 1977.
•
Lippard, S.J and Berg, J.M. Principles of Bioinorganic Panima Publishing
Company.
3
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 502: ORGANIC CHEMISTRY
Maximum Marks: 50
(i) University Examination : 40
(ii) Internal Assessment : 10
(2 Hrs./week)
Time : 3 Hours
Pass Marks : 35%
INSTRUCTIONS FOR PAPER-SETTER AND CANDIDATES
In the case of Chemistry, each theory paper will have three sections A, B, C and an additional
section D. The paper-setter will set eight questions from Section A, B and C in such a way that
not less than two and not more than three questions are set from any section, Section D will have
one question only which will consist of 10 objective/very short answer type parts uniformly
covering the whole syllabus. All the questions from sections A, B, C and D will carry the same
marks.
Candidates will attempt five questions, selecting at least one but not more than two from
each section.
SECTION – A
Heterocyclic Compounds :Introduction: Molecular orbital picture of pyrrole, furan, thiophene,
pyridine. Classification, Nomenclature, structure aromaticity in 5 and 6 membered rings
containing
heteroatom. Methods of synthesis and reaction on mechanism of electrophilic
substitution of : Furan, Pyrrole (Paal Knorr synthesis, Hantzsch pyrrole synthesis, Knorr
synthesis. thiophene, pyridine, pyrimidine. Indole (Jischer indole synthesis, Madelung synthesis,
Reissert synthesis, Bischler synthesis). Quinoline (Skroup synthesis, Conard – Limpach
synthesis, Doebner-Miller syntghesis, Conard-limpach synthesis, Knorr quinoline synthesis,
Pfitzinger reaction) Isoquinoline (Bischler-Napieralski reaction, Pictet-Spengler reaction,
Someranz – Fritsch reaction),Derivatives of furan – furfural, furoic acid.
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B.Sc. (SEMESTER V-VI) CHEMISTRY
SECTION – B
Organic Compounds of Nitrogen: Preparation of nitroalkanes, nitroarenes. Chemical reactions
of nitroalkanes mechanism of Nucleophilic substitution in nitroarenes and their reaction in
acidic, neutral and alkaline media, Picric acid.Structure and nomenclature of amines, physical
properties, stereochemistry of amines, Distinction between primary, secondary and tertiary
amines. Separation of mixture primary, secondary and tertiary amines, Effect of substituent and
sonlvent on basicity, quarternary salts as phase transfer catalyst, Preparation and properties of amines
(including Gabriel pthalimide synthesis, Hoffmann bromamide degradation, Carbylamine reaction,
Mannich reaction, Hoffmann’s exhaustive methylation, Hoffmann-elimination reaction). Diazonium salts
– preparation and their synthetic applications.
SECTION – C
Amino-acids, peptides, proteins, nucleic acids :Classification, structure and stereochemistry of
amino acids, acid-base behavior, Isoelectric point, Electrophoresis, preparation and reaction of αamino acids, Zwitter ions, Ionic properties. Structure and Nomenclature of peptides & proteins,
classification of proteins, peptide structure determination, end group analysis, selective
Hydrolysis of peptides, classical peptide synthesis, phase peptide synthesis, structure of peptides
& proteins, level of protein structure,
protein denaturation/renaturation, Nucleic acids:
Introduction, constituents of nucleic acids, ribonucleosides, ribonucleotides, double helical
structure of DNA,types of nucleic acids, difference between DNA and RNA.
Reference :
Robert thornton Morrison and Robert neilson voyd, organic chemistry darling Kindersley (india)
pvt. Ltd. (Pearson Education).
I.L. Finar, Organic chemistry (Vol-I) Darling Kindersley (India) Pvt. Ltd. (Pearson Education).
Heterocyclic compounds by Raj. K.Bansal.
5
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 503: PHYSICAL CHEMISTRY
Maximum Marks : 50
(i) University Examination : 40
(ii) Internal Assessment : 10
(2 Hrs./week)
Time : 3 Hours
Pass Marks : 35%
INSTRUCTIONS FOR PAPER-SETTER AND CANDIDATES
In the case of Chemistry, each theory paper will have three sections A, B, C and an additional
section D. The paper-setter will set eight questions from Section A, B and C in such a way that
not less than two and not more than three questions are set from any section, Section D will have
one question only which will consist of 10 objective/very short answer type parts uniformly
covering the whole syllabus. All the questions from sections A, B, C and D will carry the same
marks.
Candidates will attempt five questions, selecting at least one but not more than two from
each section.
SECTION – A
Molecular Spectroscopy:Electromagnetic radiation ,intraction of electromagnetic radiation with molecules and various
types of spectra, Born oppenheimer approximation, absorption and emission spectroscopy,
difference between atomic and molecular spectroscopy, types of spectroscopy, selection rules,
width and intensities of spectral lines.
Rotational Spectroscopy:Selection rules, determination of bond length of diatomic, linear molecules, isotopic substitution.
6
B.Sc. (SEMESTER V-VI) CHEMISTRY
SECTION-B
Vibrational Spectroscopy:Vibrational energy levels of simple harmonic oscillator, anharmonicity, Morse potential,
fundamental frequencies ,overtone, hotbands, degrees of freedom for polyatomic molecules
,modes of vibration, vibrational-rotational spectroscopy, P,Q,R branches, diatomic vibrating
rotator.
Electronic Spectroscopy:Introduction to electronic spectra, Franck Condon Principle ,electronic transition, singlet and
triplet states, selection rules for electronic transitions in molecules.
SECTION -C
Quantum Mechanics:Introduction ,black body and black body radiation ,Kirchhoff’s law, Plank’s radiation law,
photoelectric effect ,heat capacity of solids ,atomic and molecular spectra ,origin ,of quantum
mechanics, relation between quantum and classical mechanics ,Bohr model of atom, defects of
Bohr model of atom, de Broglie relationship, Heisenberg Uncertainty principle, Compton effect,
Schrodinger wave equation, eigen function and value, significance of wave function,
normalized and orthogonal wave function, operators, postulates of quantum mechanics, particle
in one dimensional box quantization of energy levels, zero point energy, separation of variables,
degeneracy.
Chemical bonding:Covalent bonding, valence bond and molecular orbital approaches, LCAO molecular orbital
treatment of H2 + and H2 molecules, valence bond treatment of H2 molecule ,comparison of
LCAO-MO and VB treatment of H2,hybridization of AO, quantum mechanical principle of
hybridization, calculation of wave function of hybrid orbital.
7
B.Sc. (SEMESTER V-VI) CHEMISTRY
Reference books:Physical Chemistry by Puri Sharma Pathania
Physical Chemistry by Gurdeep Raj
Physical Chemistry by Gurthu
Introduction to Electrochemistry by Glasston
Photochemistry by A.Singh,R.Singh
Photochemistry by Gurdeep Raj
Solid State Physics by Gupta Kumar
Physical Chemistry by D.W. Ball
Statistical Thermodynamics by M C Gupta
Physical Chemistry by Atkins
8
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 504: CHEMISTRY PRACTICALS
Maximum Marks : 50
(4 Hrs./week)
(i) University Examination : 40
Time : 6 Hours
(ii) Internal Assessment : 10
Instructions: Practical examination will be conducted in one single day and marks distribution
will be as follows:
Inorganic: 15 (10+5) marks
Organic: 15(10+5) marks
Viva: 5 marks
Notebook: 5 marks
INORGANIC
1.
2.
3.
4.
5.
Preparation of sodium trioxalatoferrate(III)
Preparation of Nickel- DMG complex
Preparation of tetrammine Copper sulphate complex
Preparation of cis-bisoxalatodiaquachromate (III) ion
Preparation of hexaminecobalt (III) cobalt.
ORGANIC
COLUMN CHROMATOGRAPHY
1. Separation of dyes
2. Separation of o- and p- nitrophenols
9
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 601 : INORGANIC CHEMISTRY
Maximum Marks : 50
(i) University Examination : 40
(ii) Internal Assessment : 10
(2 Hrs./week)
Time : 3 Hours
Pass Marks : 35%
INSTRUCTIONS FOR PAPER-SETTER AND CANDIDATES
In the case of Chemistry, each theory paper will have three sections A, B, C and an additional
section D. The paper-setter will set eight questions from Section A, B and C in such a way that
not less than two and not more than three questions are set from any section, Section D will have
one question only which will consist of 10 objective/very short answer type parts uniformly
covering the whole syllabus. All the questions from sections A, B, C and D will carry the same
marks.
Candidates will attempt five questions, selecting at least one but not more than two from
each section.
SECTION - A
Metal Ligand Bonding in transition metal complex : Bonding theories valence bond theory,
Inner and outer Oriental complexes, electroneutrality principle, Back bonding limitations of
V.B.T. crystal field theory. Crystal field splitting in octahedral, tetrahedral, square planer
complexes CFSE in weak and strong fields, pairing energies, factors affecting crystal field
parameters tetragonal and distortions from octahedral geometry, Jahn Taller Theorem. Ligand
field and M.O. Theories (elementary idea only).
SECTION - B
Electronic spectra of transition Metal complexes : Types of electronic transition, selection
rules for d-d transition, spectroscopic ground states, spectrochemical series, orgel energy level
Diagram for d1 and d9 states Discussion of electronic spectrum of [Ti(H2O)6] 3+complexion.
10
B.Sc. (SEMESTER V-VI) CHEMISTRY
SECTION - C
Reaction kinetics and mechanism : The trans effect theories of trans effect, mechanism of trans
effect. Kinetics of sulstitution rxins in square planar complexes. Thermodynamic and kinetic
stability including factors affecting them. Labile and inert complexes. Electron transfer reactions.
Inner sphere, outer sphere, without breaking M-L Bond.
Reference :
Principle of Inorganic chemistry by Puri, Sharma, Kalia, Milestone Publishers, Delhi.
11
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 602: ORGANIC CHEMISTRY
Maximum Marks: 50
(i) University Examination : 40
(ii) Internal Assessment : 10
(2 Hrs./week)
Time : 3 Hours
Pass Marks : 35%
INSTRUCTIONS FOR PAPER-SETTER AND CANDIDATES
In the case of Chemistry, each theory paper will have three sections A, B, C and an additional
section D. The paper-setter will set eight questions from Section A, B and C in such a way that
not less than two and not more than three questions are set from any section, Section D will have
one question only which will consist of 10 objective/very short answer type parts uniformly
covering the whole syllabus. All the questions from sections A, B, C and D will carry the same
marks.
Candidates will attempt five questions, selecting at least one but not more than two from
each section.
SECTION - A
Electromagnetic spectrum : Absorption spectra: Ultraviolet (UV) absorption spectroscopyabsorption laws (Beer Lambert’s law), molar absorptivity, presentation and analysis of UV
spectra, types of electronic transitions, effect of conjugation, concept of chromophore and
auxochrome,
Bathochromic,
hyperchromic
and
hypochromic
shifts,
UV
spectra
of
conjugatedenes and enones.
Infrared (IR) absorption spectroscopy: molecular vibrations, Hooke’s law, selection rules,
intensity and position
of IR bands, measurement of IR spectrum, fingerprint region,
characteristic absorptions of various functional groups and interpretation of IR spectra of simple
organic compounds, problems pertaining to the structure elucidation of simple organic
compounds using UV, IR and PMR spectroscopic techniques.
SECTION – B
12
B.Sc. (SEMESTER V-VI) CHEMISTRY
Nuclear magnetic resonance (NMR) spectroscopy :Proton magnetic resonance (1HNMR)
spectroscopy, nuclear shielding and deshielding, chemical shift and molecular structure, spinspin splitting and coupling constants, areas of signal interpretation of PMR spectra of simple
organic molecules such as ethyl bromide, ethanol, acetaldehyde, 1,1,2-tribromomethane, ethyl
acetate, toluene and acetophenone,
SECTION-C
Organometallic compounds :Organomagnesium compounds:The Grignard reagents-formation,
structure and chemical reactions. Organozinc Compounds- Formation and chemical reactions.
Organolithium compounds : Formation and chemical reactions.
Organosulphur Compounds :Nomenclature, structural
features, methods of formation and
chemical reactions of thiols, thioethers, sulphonic acids, sulphonamides.
Reference :
•
William Kemp ; Organic spectroscopy, palgrave.
•
Organic spectroscopy by Y.R. Sharma.
•
Robert thornton Morrison and Robert neilson boyd, organic chemistry, darling
kinderssley (India) pvt. Ltd. (Pearson Education).
•
I.L. Finar, organic chemistry (volume-I) darling Kindersley (India) pvt.ltd. (pearson
education).
13
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 603: PHYSICAL CHEMISTRY
Maximum Marks : 50
(i) University Examination : 40
(ii) Internal Assessment : 10
(2 Hrs./week)
Time : 3 Hours
Pass Marks : 35%
INSTRUCTIONS FOR PAPER-SETTER AND CANDIDATES
In the case of Chemistry, each theory paper will have three sections A, B, C and an additional
section D. The paper-setter will set eight questions from Section A, B and C in such a way that
not less than two and not more than three questions are set from any section, Section D will have
one question only which will consist of 10 objective/very short answer type parts uniformly
covering the whole syllabus. All the questions from sections A, B, C and D will carry the same
marks.
Candidates will attempt five questions, selecting at least one but not more than two from
each section.
SECTION -A
Solid State:Solids and their classification(crystalline and amorphous solids) law of constancy of interfacial
angles, Hauy’s law of rational indices, space lattice unit cells, Miller indices, ideas of symmetry
symmetry elements and symmetry operations ,point groups, space groups ,seven crystal system
and fourteen bravais lattices, x-ray differaction,
Braggs law ,crystal structures
NaCl,KCl,CsCl,CaF2,ZnS.
SECTION -B
Photochemistry:Characterstics of electromagnetic radiation, difference between thermochemical and
photochemical reactions, Lembert-Beer law and its limitation laws of photochemistry, quantum
yield, determination of quantum yield, examples of low and high quantum
yield,luminescence,chemiluminescence,photosensitization,photoinhibitors,Jablonski diagram
Fluorescence and Phosphorescence.
14
B.Sc. (SEMESTER V-VI) CHEMISTRY
SECTION – C
Conductance:Electrolytic conduction, specific conductance, equivalent conductance, relation between specific
and equivalent conductance ,variation of equivalent and specific conductance with dilution, ionic
mobility, transport numbers, method of determination of transport number by Hittof’s method
and moving boundry method, Debye-Huckel Onsager equation for strong electrolytes.
Electrochemistry:Introduction, galvanic cells ,half reactions and reversible electrodes, electrode potential, Nernst
equation,standard hydrogen electrode, reference electrodes, standard electrode potential,
electrochemical series and its significance, chemical cells, reversible and irreversible cells with
examples, concentration cells ,liquid junction potential, acid base titrations ,applications of EMF
corrosion.
Reference books:Physical Chemistry by Puri Sharma Pathania
Physical Chemistry by Gurdeep Raj
Quantum Chemistry by R.K. Prasad
Quantum Chemistry by Donald A McQuarie
Physical Chemistry by Atkins
Fundamentals of Molecular Spectroscopy by C.N. Banwell
Fundamentals of Quantum Chemistry by J.E.House
Introductry Quantum Chemistry by A K Chandra
Atomic and Molecular Spectroscopy by Gurdeep R. Chatwal and Sham K. Anand.
15
B.Sc. (SEMESTER V-VI) CHEMISTRY
PAPER BCH 604: CHEMISTRY PRACTICALS
Maximum Marks : 50
(4 Hrs./week)
(i) University Examination : 40
Time : 6 Hours
(ii) Internal Assessment : 10
Instructions: Practical examination will be conducted in one single day and marks distribution
will be as follows:
Organic: 15 (10+5) marks
Physical: 15(10+5) marks
Viva: 5 marks
Notebook: 5 marks
ORGANIC
Synthesis of Organic Compounds:
a) Meta dinitrobenzene
b) Para nitroacetanilide
c) Para bromoacetanilide
d) Preparation of Benzoic acid from toluene.
Model preparations on topics of stereochemistry as discussed in the class
PHYSICAL
1. Determination of refractive index of a liquid by Abbe refractometer; hence specific and
molar refraction.
2. To test the validity of Beer Lambert law using a calorimeter and determine unknown
conc. Of a solution
3. Molecular weight determination by Rast’s method
4. PHASE EQUILLIBRIA:
To determine distribution coefficients of iodine between CCl4 and H2O.
5. CONDUCTROMETRIC TITRETIONS
Determination of end point of titration of mixture of strong acid and weak base using
strong base.
16