Download 記錄編號 5653 狀態 NC093FJU00255028 助教查核 索書號 學校名稱

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5653
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NC093FJU00255028
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輔仁大學
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食品營養學系
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492445111
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研
究
生 徐姞屏
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研
究
Gi-Pin Hsue
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稱 葉酸營養狀態與甲醯基四氫葉酸還原酶基因多型性對癌症的影響
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中
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稱 Folate status and methylenetetrahydrofolate reductase gene polymorphism affect on cancer: an overview
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指
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授 許瑞芬
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學 93
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文 中文
別
關
鍵
字 葉酸 甲醯基四氫葉酸還原酶基因多型性 癌症
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中
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關
鍵
字 folate methylenetetrahydrofolate reductase polymorphism cancer
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英
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摘
要 癌症是台灣第一大死因，影響健康甚鉅，並耗損許多醫療資源。適量的葉酸攝取可以防癌。葉酸代謝
( 至修復癌前損傷。然而葉酸補充也可能加速癌細胞增生。葉酸補充可以預防或是促進癌症的關鍵是補
中 。老化、懷孕、感染、飲酒等因素惡化葉酸缺乏狀態。未來可觀察葉酸營養強化政策，對癌症發生的
)
摘 Cancer is the leading cause of death in Taiwan which not only threatens our health but also wastes many med
要 prevent lipid peroxidation and DNA damage. Folate deficiency is related to DNA mutation and aberrant DNA
( stage. Folate supplement could lower incident at early stage of cancer, however, folate supplement might acc
英 DNA methylation or DNA synthesis, thus alters cancer risk. MTHFR enzyme activity was modulated by ade
) develop personal chemopreventive and therapeutic strategies, MTHFR gene variants could serve as a bioche
論
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次
縮寫表(ABBREVIATIONS) VIII 前言 1 第一章 葉酸缺乏的致癌機制 2 一、葉酸缺乏增加雙股DNA錯
化現象 5 (一) DNA甲基化與基因表現及DNA穩定性 5 (二)葉酸缺乏對專一性CpG島高甲基化的影響 5
CpG島甲基化影響 10 四、葉酸介入動物研究 13 (一) 葉酸介入對致癌劑刺激的癌症發生影響 13 (二) 葉
一) 懷孕 19 (二) 飲酒 19 (三) 吸菸 21 (四) 感染 21 (五) 老化 22 八、問題討論與未來研究方向 23 第二章
酸還原? (MTHFR) 基因變異對編碼酵素功能的影響 26 (一) MTHFR酵素結構與作用 27 (二) MTHFR基
MTHFR酵素本身濃度 32 (二) 黃素腺嘌呤二核甘酸 (flavine adenine denucleotide, FAD) 32 (三) SAM 32
長的影響 34 六、 葉酸與MTHFR、環境因子交互作用，產生不同的癌症風險 35 七、 MTHFR基因變
地區人口葉酸營養狀態 48 (二) 國外葉酸強化政策補充概廓 49 二、 葉酸代謝途徑相關營養狀態及MT
54 5. 葉酸相關營養素及MTHFR基因多型性交互作用影響大腸癌 57 6. MTHFR基因多型性與葉酸攝取
葉酸營養狀態與乳癌風險 63 3. 葉酸代謝相關營養素與乳癌風險 64 4. MTHFR基因變異與乳癌風險 65
乏介入性研究 70 三、 葉酸補充人體介入性實驗 71 四、結論與問題討論 74 圖 (FIGURE) 78 表(TABL
參
考
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獻
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