Download Slide 1 - Augusta University

SOUTHEASTERN EXPLORATORY SICKLE CELL CENTER OF
EXCELLENCE
NCMHD Southeastern Exploratory Sickle
Cell Center of Excellence
Principal Investigators:
Abdullah Kutlar, MD
Robert Gibson, PhD
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Participating Institutions:
Medical College of GA
Morehouse SOM
University of Florida
Components of the Center
•
•
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Administrative Core
Research Core
Training and Education Core
Community Engagement/Outreach Core
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Administrative Core
• Oversee and provide
administrative assistance
for the Center
• Serve as a central
communication point
• Coordinate research
activities
• Financial responsibility for
grant administration
Annual Health Disparity Conference
 Increase community involvement and participation of
patients and their families
 Educate health care providers and members of the
community regarding health disparities
 Create opportunities for communication and synergy
across various health disparity research activities at
MCG as well as the University of Florida and
Morehouse School of Medicine
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Research Core
• Dr. Dorothy
Tuan, PI
Research Project 1
Abdullah Kutlar, PI
• Mu Opioid Polymorphisms as Genetic Modifiers
of Pain and Opioid Use in SCD
 Determine variations of the Mu Opioid gene on pain
and perception of pain in patients with sickle cell
disease (Dr. Xiaoling Wang; Dr. Ferdane Kutlar)
 Using a pain algometer, test the patient’s pain
threshhold (Dr. Roger Fillingim, UFL)
 Patients to complete pain diaries; determine
frequency and dose of pain medications and
correlate with Mu Opioid gene (Dr. Steffen Meiler)
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Research Project 2
Dr. Dorothy Tuan, PI
• An NF-Y mediated GATA switch mechanism in
g-globin gene reactivation by HU
To determine the mechanism by which
hydroxyurea (the only drug currently
approved by the FDA for use in sickle cell
disease) helps to alleviate complications of
the disease
This knowledge will ultimately allow new
drugs to be developed giving patients a
choice in treatment options
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Research Project 3
Dr. Tohru Ikuta, PI
• Mechanisms of HU for SCD
To determine intracellular signaling
pathways that play a critical role in HUinduced Hb F expression
To determine whether HU-induced Hb F
expression is further increased by
combining a cAMP-dependent PDE
inhibitor
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Research Training/Education Core
Dr. Thomas Adamkiewicz, PI
(Morehouse School of Medicine)
Research Training/Education Core
Dr. Thomas Adamkiewicz, PI (Morehouse)
• Develop ongoing education programs for the
present and future family medicine physicians
as well as other providers of care for patients
with SCD (Dr. Paul Forney; Dr. Joseph Hobbs)
• Use of information technology to
identify those that would most benefit
from education
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Community Engagement/
Outreach Core
Dr. Robert Gibson, PI
Community Engagement/Outreach Core
Dr. Robert Gibson, PI
• Promoting Health Care Transition/Health Literacy for
Young People with SCD
(Dr. Robert Gibson)
• Outcomes of the Implementation of a Clinical Pathway
for Uncomplicated Sickle Cell Vaso–Occlusive Crisis
(Dr. Matthew Lyon)
• The Creation and Evaluation of an Advanced Medical
Home for adults with SCD
(Dr. Richard Lottenberg, UFL)
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia
Anticipated Benefits/Outcomes
• Improvement in care for adult sickle cell
patients
Evidence based care (protocols)
Medical Home (involvement of PCPs)
Improved outcomes/patient satisfaction in ED
encounters
Transition from pediatric to adult care
Availability of SCD clinical trials for SCD patients in
the Albany area (infrastructure through Phoebe
Sickle Cell Clinic)
Supported by: Georgia Department of Human Resources, National Center for Minority Health
and Health Disparity (NCMHD), and the Medical College of Georgia