Download Concepts of Genetics

Chapter 4 Lecture
Concepts of Genetics
Tenth Edition
Extensions of
Mendelian Genetics
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4.1 Alleles Alter Phenotypes in Different
Ways
Wild type
Loss of function
Null
Gain of function
New alleles are produced by mutation
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4.2 Geneticists Use a Variety of Symbols
for Alleles
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4.3 Neither Allele Is Dominant In
Incomplete, or Partial, Dominance
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Figure 4.1
4.4 In Codominance, the Influence of Both
Alleles in a Heterozygote Is Clearly
Evident
(There’s no “blending” of phenotypes)
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4.5 Multiple Alleles of a Gene May Exist in
a Population
4.5.1 The ABO Blood Groups
4.5.2 The A and B Antigens
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Figure 4.2
4.5 Multiple Alleles of a Gene May Exist in
a Population
4.5.3 The Bombay Phenotype
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Figure 4.3
4.5 Multiple Alleles of a Gene May Exist in
a Population
4.5.4 The white Locus in Drosophila
More than 100 alleles
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4.1
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4.6 Lethal Alleles Represent Essential
Genes
4.6.1 Recessive Lethal Mutations
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?
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Figure 4-4
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4.6 Lethal Alleles Represent Essential
Genes
4.6.2 Dominant Lethal Mutations
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4.7 Combinations of Two Gene Pairs With
Two Modes of Inheritance Modify the
9:3:3:1 Ratio
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Figure 4.5
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4.8 Phenotypes Are Often Affected by
More Than One Gene
4.8.1 Epistasis
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Figure 4.6
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Figure 4.7
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Figure 4.8
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Figure 4.9
4.9 Complementation Analysis Can
Determine if Two Mutations Causing a
Similar Phenotype are Alleles
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Figure 4.11
4.10 Expression of a Single Gene May
Have Multiple Effects
Pleiotropy
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4.11 X-Linkage Describes Genes on the
X Chromosome
4.11.1 X-Linkage in Drosophila
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Figure 4.12
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Figure 4.13
4.11 X-Linkage Describes Genes on the
X Chromosome
4.11.2 X-Linkage in Humans
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Table 4.3
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Figure 4.14
4.12 In Sex-Limited and Sex-Influenced
Inheritance, an Individual’s Sex
Influences the Phenotype
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Figure 4.15
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Figure 4.16
4.13 Genetic Background and the
Environment May Alter Phenotypic
Expression
4.13.1 Penetrance and Expressivity
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Figure 4.17
4.13 Genetic Background and the
Environment May Alter Phenotypic
Expression
4.13.2 Genetic Background: Suppression and Position
Effects
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Figure 4.18
4.13 Genetic Background and the
Environment May Alter Phenotypic
Expression
4.13.3 Temperature Effects—An Introduction to
Conditional Mutations
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Figure 4.19
4.13 Genetic Background and the
Environment May Alter Phenotypic
Expression
4.13.4
4.13.5
4.13.6
4.13.7
Nutritional Effects
Onset of Genetic Expression
Genetic Anticipation
Genomic (Parental) Imprinting
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