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CURRICULUM VITAE - ERIC O. FEIGL Degrees: B.A. and B.S. (cum laude) University of Minnesota, 1954 M.D. University of Minnesota Medical School, 1958 Positions: 1958 - 1959 1959 - 1961 1961 - 1962 1962 - 1964 1962 - 1964 1964 - 1969 1969 - 1972 1981 - 1982 1972 - Intern, Philadelphia General Hospital, Philadelphia, PA Instructor and Postdoctoral Fellow, Department of Physiology, Medical School, University of Pennsylvania, Philadelphia, PA Visiting Scientist, Department of Physiology, University of Gothenburg, Gothenburg, Sweden Officer U.S.P.H.S. and Research Associate, National Heart Institute, N.I.H., Bethesda, MD Instructor, Department of Physiology, Medical School, George Washington University, Washington, D.C. Assistant Professor, Department of Physiology, Medical School, University of Pennsylvania, Philadelphia, PA Associate Professor, Department of Physiology and Biophysics, Medical School, University of Washington, Seattle, WA Visiting Scientist (six-mo. sabbatical), Max Planck Institute for Experimental Cardiology, Bad Nauheim, West Germany Professor, Department of Physiology and Biophysics, Medical School, University of Washington, Seattle, WA Memberships: American Physiological Society Fellow, Cardiovascular Section American Heart Association Fellow, Council on Basic Cardiovascular Sciences American Association for the Advancement of Science Licensed Physician in Washington Fellowships: Postdoctoral Fellowship, N.I.H., 1959-1962 Research Associate, National Heart Institute, 1962-1964 Honors and Awards: Research Career Development Award, N.I.H., 1964-1969 First Annual L. N. Katz Basic Science Research Prize, American Heart Association, 1969 Outstanding Research Award of the International Society for Heart Research, 1985 Carl J. Wiggers Award for Cardiovascular Research, American Physiological Society, 1989 John Shepherd Lecture Award, Maastricht, Netherlands, 1997 Berne Distinguished Lectureship, American Physiological Society, 2003 1 Research Interests: Coronary physiology Neural control of the cardiovascular system Cardiovascular instrumentation Editorial Boards: Associate Editor, American Journal of Physiology: Heart and Circulatory Physiology American Journal of Physiology: Heart and Circulatory Physiology Circulation Research Physiological Reviews Blood Vessels Basic Research in Cardiology Other Responsibilities: 1981 - 1986 1970 -1977, 1984 – 2012 1980 - 1986,1993 – 1999 1981 - 1985 1981 - 1987 1995 - 1999 American Physiological Society Membership Committee Education Committee Steering Committee, Cardiovascular Section Chairman, Cardiovascular Section Long Range Planning Committee Public Affairs Committee Chairman, Public Affairs Committee 1975-1977 1979-1982 1979-1982 1981-1982 1984-1986 1992-1997 1994-1997 National Institutes of Health Review Panel, Instrumentation Section, Artificial Heart Program Physiology Study Section 1969 1976-1977 Veterans Administration Cardiology Study Section 1992-1994 Food and Drug Administration Review Panel on Beta Receptor Blocking Agents Review Panel on Atropine Cardiovascular and Renal Advisory Committee 1970 1971 1971-1974 American Heart Association Basic Science Council Executive Committee Physiology & Pharmacology Research Study Section Circulation Council Executive Committee Program Review Committee 1969-1975 1970-1973 1975 - 1978 1984 – 2005 2 Eric O. Feigl Washington State Heart Association Research Study Section, 1975-1977 Research Funding Committee 1991-1995 1996-1998 National Board of Medical Examiners Physiology Test Committee 1976-1980 Cardiac Muscle Society Secretary-Treasurer President 1969-1971 1971-1973 National Academy of Sciences Cardiovascular Subcommittee for Space Biology and Medicine 1984-1985 University of Pennsylvania Medical School Admissions Committee 1965, 1967 University of Washington Medical School Chairman, Cardiovascular and Respiratory Course (HuBio 540) Principal Investigator, NIH Cardiovascular Training Grant Pharmacology Course (HuBio 543) Planning Committee Chairman, Physiology and Biophysics Teaching Evaluation Committee Chairman, Introduction to Physiology Course (PBio 405) Physiology and Biophysics Curriculum Committee Animal Medicine Advisory Board Dental School Student Progress Committee Accreditation Review Committee Chairman, Cardiovascular Course (HuBio 540) Second year Medical Curriculum Committee Basic Science Teaching Committee Student Progress Committee 3 1976-1986 1975-1990 1979-1985 1982-1985 1987-1997 1985-1987 1986-1987 1988-2002 1994 1998-2013 2001-2013 2004-2006 2007-2013 Eric O. Feigl PERSONS TRAINED IN THE FEIGL LABORATORY Masters Degree: 1. Katherine Kelley Ph.D. Degree: 1. Louis D’Alecy 2. Martha Blair 3. Susanna Cunningham 4. Bruce Ito 5. Keith Kroll 6. G. Alec Rooke 7. Alice Huang 8. Donna Van Winkle 9. Steven Herrmann 10. Jody Miyashiro 11. Kenneth Schenkman 12. D. Richard Van Bibber Postdoctoral Fellows: 1. John Zehr 2. Garrett Gross 3. F. Norman Hamilton 4. David Mohrman 5. James Powell 6. Charles Buffington 7. Allan Roth 8. Stephen Katz 9. Howard Nathan 10. M. Giovanna Trivella 11. Theodore Broten 12. David Fullerton 13. David Stepp 14. Toyotaka Yada 15. Keith Richmond 16. Johnathan Tune 17. Kayoko Ogimoto 18. Martin Farias 4 Eric O. Feigl BIBLIOGRAPHY 1. Feigl EO, Peterson LH and Jones AW. Mechanical and chemical properties of arteries in experimental hypertension. J Clin Invest 42: 1640-1647, 1963. 2. Feigl E and Folkow B. Cardiovascular responses in "diving" and during brain stimulation in ducks. Acta Physiol Scand 57: 99-110, 1963. 3. Feigl EO. Vasoconstriction resulting from diencephalic stimulation. Acta Physiol Scand 60: 372380, 1964. 4. Feigl EO and Fry DL. Intramural myocardial shear during the cardiac cycle. Circ Res 14: 536540, 1964. 5. Feigl EO and Fry DL. Myocardial mural thickness during the cardiac cycle. Circ Res 14: 541545, 1964. 6. Jones AW, Feigl EO and Peterson LH. Water and electrolyte content of normal and hypertensive arteries in dogs. Circ Res 15: 386-392, 1964. 7. Feigl E, Johannson B and Loefving B. Renal vasoconstriction and the 'defense reaction'. Acta Physiol Scand 62: 429-435, 1964. 8. Feigl EO. Sympathetic control of the coronary circulation. Circ Res 20: 262-271, 1967. 9. Feigl EO. Effects of stimulation frequency on myocardial extensibility. Circ Res 20: 447-458, 1967. 10. Feigl EO, Simon GA and Fry DL. Auxotonic and isometric cardiac force transducers. J Appl Physiol 23: 597-600, 1967. 11. Feigl EO. Carotid sinus reflex control of coronary blood flow. Circ Res 23: 223-237, 1968. 12. Feigl EO. Parasympathetic control of coronary blood flow in dogs. Circ Res 25: 509-519, 1969. 13. Feigl EO. Dilemmas of angina pectoris. N Engl J Med 281: 48, 1969. 14. Friedman JN, Cowan MJ, Waldhausen JA and Feigl EO. Myocardial contractile force in hemorrhagic shock. Surg Forum 20: 32-34, 1969. 15. Feigl EO and D'Alecy LG. Cuvette for continuously measuring blood oxygen tension. J Appl Physiol 30: 909-911, 1971. 16. Feigl EO and D'Alecy LG. Normal arterial blood pH, oxygen, and carbon dioxide tensions in unanesthetized dogs. J Appl Physiol 32: 152-153, 1972. 17. D'Alecy LG and Feigl EO. Sympathetic control of cerebral blood flow in dogs. Circ Res 31: 267283, 1972. 18. Zehr JE and Feigl EO. Suppression of renin activity by hypothalamic stimulation. Circ Res 32: Suppl-27, 1973. 19. Feigl EO. Mechanism of Prinzmetal angina. N Engl J Med 289: 46, 1973. 20. Smith FD, D'Alecy LG and Feigl EO. Cannula-tip coronary blood flow transducer for use in closed-chest animals. J Appl Physiol 37: 592-595, 1974. 5 Eric O. Feigl 21. Gross GJ and Feigl EO. Analysis of coronary vascular beta receptors in situ. Am J Physiol 228: 1909-1913, 1975. 22. Feigl EO. Control of myocardial oxygen tension by sympathetic coronary vasoconstriction in the dog. Circ Res 37: 88-95, 1975. 23. Feigl EO. Reflex parasympathetic coronary vasodilation elicited from cardiac receptors in the dog. Circ Res 37: 175-182, 1975. 24. Hamilton FN and Feigl EO. Coronary vascular sympathetic beta-receptor innervation. Am J Physiol 230: 1569-1576, 1976. 25. Blair ML, Feigl EO and Smith OA . Elevation of plasma renin activity during avoidance performance in baboons. Am J Physiol 231: 772-776, 1976. 26. Mohrman DE and Feigl EO. Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation. Circ Res 42: 79-86, 1978. 27. Cunningham SG, Feigl EO and Scher AM. Carotid sinus reflex influence on plasma renin activity. Am J Physiol 234: H670-H678, 1978. 28. Kelley KO, Feigl EO. Segmental -receptor-mediated vasoconstriction in the canine coronary circulation. Circ Res 43: 908-917, 1978. 29. Powell JR and Feigl EO. Carotid sinus reflex coronary vasoconstriction during controlled myocardial oxygen metabolism in the dog. Circ Res 44: 44-51, 1979. 30. Buffington CW, Feigl EO. Adrenergic coronary vasoconstriction in the presence of coronary stenosis in the dog. Circ Res 48: 416-423, 1981. 31. Roth AC, Feigl EO. Diffusional shunting in the canine myocardium. Circ Res 48: 470-480, 1981. 32. Rooke GA, Feigl EO. Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting. Circ Res 50: 273-286, 1982. 33. Feigl EO. Coronary physiology. Physiol Rev 63: 1-205, 1983. 34. Averill DB, Scher AM and Feigl EO. Angiotensin causes vasoconstriction during hemorrhage in baroreceptor-denervated dogs. Am J Physiol 245: H667-H673, 1983. 35. Ito BR and Feigl EO. Technique for producing heart block in closed-chest dogs without electrical recording. Pflugers Arch 397: 160-163, 1983. 36. Buffington CW, Feigl EO. Effect of coronary artery pressure on transmural distribution of adrenergic coronary vasoconstriction in the dog. Circ Res 53: 613-621, 1983. 37. Feigl EO. Parasympathetic control of coronary blood flow. Fed Proc 43: 2881-2883, 1984. 38. Ito BR, Feigl EO. Carotid baroreceptor reflex coronary vasodilation in the dog. Circ Res 56: 486-495, 1985. 39. Reid JV, Ito BR, Huang AH, Buffington CW and Feigl EO. Parasympathetic control of transmural coronary blood flow in dogs. Am J Physiol 249: H337-H343, 1985. 40. Ito BR and Feigl EO. Carotid chemoreceptor reflex parasympathetic coronary vasodilation in the dog. Am J Physiol 249: H1167-H1175, 1985. 6 Eric O. Feigl 41. Kroll K and Feigl EO. Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts. Am J Physiol 249: H1176-H1187, 1985. 42. Katz SA, Roth AC and Feigl EO. Electrode and cuvette for rapid continuous CO2 tension and pH measurement in blood. J Appl Physiol 59: 1660-1664, 1985. 43. Nathan HJ and Feigl EO. Adrenergic vasoconstriction lessens transmural steal during coronary hypoperfusion. Am J Physiol 250: H645-H653, 1986. 44. Combs CA, Smith OA, Astley CA and Feigl EO. Differential effect of behavior on cardiac and vasomotor baroreflex responses. Am J Physiol 251: R126-R136, 1986. 45. Feigl EO, Buffington CW and Nathan HJ. Adrenergic coronary vasoconstriction during myocardial underperfusion. Circulation 75: I1-I5, 1987. 46. Katz SA and Feigl EO. Little carbon dioxide diffusional shunting in coronary circulation. Am J Physiol 253: H614-H625, 1987. 47. Feigl EO. The paradox of adrenergic coronary vasoconstriction. Circulation 76: 737-745, 1987. 48. Huang AH, Feigl EO. Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise. Circ Res 62: 286-298, 1988. 49. Katz SA, Feigl EO. Systole has little effect on diastolic coronary artery blood flow. Circ Res 62: 443-451, 1988. 50. Belanger SF, Katz SA, Huang AH and Feigl EO. Blood oxygen content estimated from PO2, PCO2, and pH. Am J Physiol 255: H1545-H1548, 1988. 51. Feigl EO. EDRF--a protective factor? Nature 331: 490-491, 1988. 52. Van Winkle DM, Feigl EO. Acetylcholine causes coronary vasodilation in dogs and baboons. Circ Res 65: 1580-1593, 1989. 53. Feigl EO. Coronary autoregulation. J Hypertens Suppl 7: S55-S58, 1989. 54. Feigl EO, Neat GW and Huang AH. Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow. J Mol Cell Cardiol 22: 375-390, 1990. 55. Feigl EO, Van Winkle DM and Miyashiro JK. Cholinergic vasodilatation of coronary resistance vessels in dogs, baboons and goats. Blood Vessels 27: 94-105, 1990. 56. Trivella MG, Broten TP and Feigl EO. Beta-receptor subtypes in the canine coronary circulation. Am J Physiol 259: H1575-H1585, 1990. 57. Broten TP, Romson JL, Fulleton DA, Van Winkle DM, Feigl EO. Synergistic action of myocardial oxygen and carbon dioxide in controlling coronary blood flow. Circ Res 68: 531-542, 1991. 58. Feigl EO. Adrenergic control of transmural coronary blood flow. Basic Res Cardiol 85 Suppl 1: 167-176, 1990. 59. Herrmann SC and Feigl EO. Subtraction method for the high-performance liquid chromatographic measurement of plasma adenosine. J Chromatogr 574: 247-253, 1992. 60. Broten TP, Feigl EO. Role of myocardial oxygen and carbon dioxide in coronary autoregulation. Am J Physiol 262 (Heart Circ Physiol 31): H1231-H1237, 1992. 7 Eric O. Feigl 61. Broten TP, Miyashiro JK, Moncada S, Feigl EO. Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation. Am J Physiol 262 (Heart Circ Physiol 31): H1579H1584, 1992. 62. Herrmann SC and Feigl EO. Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia. Circ Res 70: 1203-1216, 1992. 63. Miyashiro JK, Feigl EO. Feedforward control of coronary blood flow via coronary -receptor stimulation. Circ Res 73: 252-263, 1993. 64. Feigl EO. Adenosine coronary vasodilation during hypoxia depends on adrenergic receptor activation. Adv Exp Med Biol 346: 199-205, 1993. 65. Miyashiro JK and Feigl EO. A model of combined feedforward and feedback control of coronary blood flow. Am J Physiol 268: H895-H908, 1995. 66. Feigl EO. No adrenergic constriction in isolated coronary arterioles? Basic Res Cardiol 90: 70-72, 1995. 67. Van Bibber R, Traub O, Kroll K and Feigl EO. EDRF and norepinephrine-induced vasodilation in the canine coronary circulation. Am J Physiol 268: H1973-H1981, 1995. 68. Feigl, EO. Simplify indirect costs on NIH grants. (Editorial) FASEB J 9:1123, 1995. 69. Stepp DW, Van Bibber R, Kroll K, Feigl EO. Quantitative relation between interstitial adenosine concentration and coronary blood flow. Circ Res 79: 601-610, 1996. 70. Schenkman KA, Marble DR, Burns DH and Feigl EO. Myoglobin oxygen dissociation by multiwavelength spectroscopy. J Appl Physiol 82: 86-92, 1997. 71. Stepp DW, Kroll K, Feigl EO. K+ATP channels and adenosine are not necessary for coronary autoregulation. Am J Physiol 273 (Heart Circ Physiol 37): H1299-H1308, 1997. 72. Van Bibber R, Stepp DW, Kroll K and Feigl EO. Role of adenosine in norepinephrine-induced coronary vasodilation. Am J Physiol 273: H557-H565, 1997. 73. Morita K, Tsujioka, K Kimura, A Ogasawara Y, Goto M, Hiramatsu O, Kajiya F, Feigl EO. -Adrenergic vasoconstriction reduces systolic retrograde coronary blood flow. Am J Physiol 273 (Heart Circ Physiol 37): H2746-H2755, 1997. 74. Feigl EO. Neural control of coronary blood flow. J Vasc Res 35: 85-92, 1998. 75. Schenkman KA, Marble DR, Feigl, EO, Burns DH Near-infrared spectroscopic measurement of myoglobin oxygen saturation in the presence of hemoglobin using partial least-squares analysis. Appl. Spectroscopy 53: 325-3331, 1999. 76. Schenkman KA, Marble DR, Burns DH and Feigl EO. Optical spectroscopic method for in vivo measurement of cardiac myoglobin oxygen saturation. Appl. Specgroscopy 53: 332338, 1999. 77. Yada T, Richmond KN, Van Bibber R, Kroll K, Feigl EO. Role of adenosine in local metabolic coronary vasodilation. Am J Physiol 276 (Heart Circ Physiol 45): H1425-H1433, 1999. 78. Richmond KN, Tune JD, Gorman MW, Feigl EO. Role of K+ATP channels in local metabolic coronary vasodilation. Am J Physiol 277 (Heart Circ Physiol 46): H2115-H2123, 1999. 8 Eric O. Feigl 79. Tune, J.D., Richmond, K.N., Gorman, M.W., Feigl EO. Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise. Am. J. Physiol. Heart Circ. Physiol. 278: H74-H84, 2000. 80. Tune, J.D., Richmond, K.N., Gorman, M.W., Feigl, E.O. Role of nitric oxide and adenosine in control of coronary blood flow in exercising dogs. Circulation 101: 2942-2948, 2000. 81. Gorman, M.W., Tune, J.D., Richmond, K.N., Feigl, E.O. Feedforward sympathetic coronary vasodilation in exercising dogs. J. Appl. Physiol. 89: 1892-1902, 2000. 82. Gorman, M.W., Tune, J.D., Richmond, K.N., Feigl, E.O. Quantitative analysis of feedforward sympathetic coronary vasodilation in exercising dogs. J. Appl. Physiol. 89: 1903-1911, 2000. 83. Richmond, K.N., Tune, J.D., Gorman, M.W., Feigl, E.O. Role of K+ATP channels and adenosine in the control of coronary blood flow during exercise. J. Appl. Physiol. 89: 529-536, 2000. 84. Tune, J.D., Richmond, K.N., Gorman, M.W., Feigl, E.O. K+ATP channels, nitric oxide, and adenosine are not required for local metabolic coronary vasodilation. Am. J. Physiol. Heart Circ. Physiol. 280: H868-H875, 2001. 85. Hamilton SE, Hardouin SN, Anagnostaras SG, Murphy GG, Richmond KN, Silva AJ, Feigl EO and Nathanson NM. Alteration of cardiovascular and neuronal function in M1 knockout mice. Life Sci 68: 2489-2493, 2001. 86. Hardouin, S.N., Richmond, K.N., Zimmerman, A., Hamilton, S.E., Feigl, E.O., Nathanson, N.M. Altered cardiovascular responses in mice lacking the M1 muscarinic acetylcholine receptor. Journal of Pharmacology & Experimental Therapeutics. 301: 129-137, 2002. 87. Tune, J.D., Richmond, K.N., Gorman, M.W., Feigl, E.O. Control of coronary blood flow during exericse. Exp. Biol. Med. 227: 238-250, 2002. 88. Maier, S.K., Westenbroek, R.E., Schenkman, K.A., Feigl, E.O., Scheuer, T. Caterall, W.A. An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction of the heart. PNAS 99: 4073-4078, 2002. 89. Gorman, M.W., Marble, D.R., Ogimoto, K., Feigl, E.O. Measurement of adenine nucleotides in plasma. Luminescence 18: 173 -181, 2003. 90. Gorman MW, Ogimoto K, Savage MV, Jacobson KA and Feigl EO. Nucleotide coronary vasodilation in guinea pig hearts. Am J Physiol Heart Circ Physiol 285: H1040-H1047, 2003. 91. Schenkman KA, Beard DA, Ciesielski WA and Feigl EO. Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation. Am J Physiol Heart Circ Physiol 285: H1819H1825, 2003. 92. Beard DA, Schenkman KA and Feigl EO. Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model. Am J Physiol Heart Circ Physiol 285: H1826-H1836, 2003. 93. Feigl EO. Berne's adenosine hypothesis of coronary blood flow control. Am J Physiol Heart Circ Physiol 287: H1891-H1894, 2004. 94. Tune JD, Gorman MW and Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 97: 404-415, 2004. 9 Eric O. Feigl 95. Ejike JC, Arakaki LS, Beard DA, Ciesielski WA, Feigl EO and Schenkman KA. Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility. Am J Physiol Heart Circ Physiol 288: H2062-H2067, 2005. 96. Farias M, III, Gorman MW, Savage MV and Feigl EO. Plasma ATP during exercise: possible role in regulation of coronary blood flow. Am J Physiol Heart Circ Physiol 288: H1586-H1590, 2005. 97. Gorman MW, Farias M, III, Richmond KN, Tune JD and Feigl EO. Role of endothelin in alphaadrenoceptor coronary vasoconstriction. Am J Physiol Heart Circ Physiol 288: H1937-H1942, 2005. 98. Gorman MW, Feigl EO and Buffington CW. Human plasma ATP concentration Clin Chem 53: 318-325, 2007. 99. Virag JA, Rolle LM, Reece J, Hardouin S, Feigl EO, Murry CE. Fibroblast growth factor-2 regulates myocardial infarct repair: effects on cell proliferation, scar contraction, and ventricular function. Am J Pathol 171:1431-1440, 2007. 100. Arakaki LSL, Ciesielski WA, Thackray BD, Feigl EO, Schenkman KA. Simultaneous optical spectroscopic measurement of hemoglobin and myoglobin saturations and cytochrome aa3 oxidation in vivo. Applied Spectroscopy. 64:973-979, 2010. 101. Gorman MW, Rooke GA, Savage MV, Jayasekara MP, Jacobson KA, Feigl EO. Adenine nucleotide control of coronary blood flow during exercise. Am J Physiol Heart Circ Physiol 299: H1981-H1989, 2010. 102. Gorman MW, Feigl EO. Control of coronary blood flow during exercise. Exerc Sport Sci Rev, 40:37-42, 2012. 103. Beard DA, Feigl EO. Understanding Guyton’s venous return curves. Am J Physiol Heart Circ Physiol 301:H629-33, 2011. 104. Beard, DA, Feigl EO. Cross Talk opposing view: Guyton’s venous return curves should not be taught. J Physiol 591(Pt23):5795-7, 2013. 10 Book Chapters 1. Feigl, E.O. Transducer for measuring myocardial wall thickness. In: Methods in Medical Research, Vol. 11, ed. by R.F. Rushmer, Year Book Medical Publishers, Chicago, pp. 24-25, 1966. 2. Feigl, E.O. Mechanical force measurements in biology. In: Methods in Medical Research, Vol. 11, ed. by R.F. Rushmer, Year Book Medical Publishers, Chicago, pp. 122-136, 1966. 3. Feigl, E.O. Myocardial diastolic compliance. In: Factors Influencing Myocardial Contractility, ed. by R. Tanz, Academic Press, New York, pp. 85-91, 1967. 4. Jones, A.W., Peterson, L.H., Feigl, E.O. Vascular alterations in experimental hypertension. In: Baroreceptors and Hypertension, ed. by P. Kezdi, Pergamon Press, New York, pp. 309-315, 1967. 5. Feigl, E.O. Effects of paired stimulation on cardiac muscle during diastole. In: Paired Pulse Stimulation of the Heart, ed. by P.F. Cranefield and B.F. Hoffman, Rockefeller Univ. Press, New York, pp. 155-163, 1968. 6. Feigl, E.O. Neural control of the coronary circulation. In: Myocardial Ischemia, ed. by R.S. Ross and F. Hoffman, Exerpta Medica Press, Amsterdam, pp. 9-23, 1971. 7. Feigl, E.O. Physics of the cardiovascular system. In: Physiology and Biophysics, 20th edition, Vol. II, ed. by T.C. Ruch and H.D. Patton, W.B. Saunders Co., Philadelphia, Chapter 2, 1974. 8. Feigl, E.O. Measurement of blood pressure and blood flow. In: Physiology and Biophysics, 20th edition, Vol. II, ed. by T.C. Ruch and H.D. Patton, W.B. Saunders Co., Philadelphia, Chapter 3, 1974. 9. Feigl, E.O. Cardiac muscle mechanics. In: Physiology and Biophysics, 20th edition, Vol. II, ed. by T.C. Ruch and H.D. Patton, W.B. Saunders Co., Philadelphia, Chapter 4, 1974. 10. Feigl, E.O. The arterial system: arteries and arterioles. In: Physiology and Biophysics, 20th edition, Vol. II, ed. by T.C. Ruch and H.D. Patton, W.B. Saunders Co., Philadelphia, Chapter 8, 1974. 11. Feigl, E.O. The coronary circulation. In: Physiology and Biophysics, 20th edition, Vol. II, ed. by T.C. Ruch and H.D. Patton, W.B. Saunders Co., Philadelphia, Chapter 16, 1974. 12. Feigl, E.O., Mohrman, D.E., Kelley, K.O. Sympathetic coronary vasoconstriction limits myocardial oxygen supply. In: Coronary Heart Disease, 3rd Int. Symp. Frankfurt, ed. by M. Kaltenbach, P. Lichtlen, R. Balcon, and W-D. Bussmann, Georg Thieme Publishers, Stuttgart, pp. 200-205, 1978. 13. Feigl, E.O., Mohrman, D.E. Sympathetic coronary control of oxygen delivery to the heart. In: Primary and Secondary Angina Pectoris, ed. by A. Maseri, G.A. Klassen, and M. Lesch, Grune & Stratton, New York, pp. 187-199, 1978. 14. Feigl, E.O. Baroreceptor reflex control of the coronary circulation. In: Arterial Baroreceptors and Hypertension, ed. by P. Sleight, Oxford Univ. Press, Oxford, pp. 202-209, 1980. 11 15. Averill, D.B., Scher, A.M., Feigl, E.O. Demonstration of the vasomotor action of angiotensin II following haemorrhage in unanaesthetized dogs without functional baroreceptors. In: Arterial Baroreceptors and Hypertension, ed. by P. Sleight, Oxford Univ. Press, Oxford, pp. 180-185, 1980. 16. Feigl, E.O., Rooke, G.A. The problem of catecholamine oxygen wasting in the heart. In: Catecholamines and the Heart, ed. by W. Delius, E. Gerlach, H. Grobecker, and W. Kübler, Springer-Verlag, New York, pp. 177-182, 1981. 17. Feigl, E.O., Buffington, C.W. Adrenergic coronary vasoconstriction with coronary stenosis. In: Transluminal Coronary Angioplasty and Intracoronary Thrombolysis. Coronary Heart Disease IV, ed. by M. Kaltenbach, A. Grüntzig, K. Rentrop, and W-D. Bussmann, Springer-Verlag, New York, pp. 372-377, 1982. 18. Feigl, E.O., Buffington, C.W. Adrenergic control of myocardial blood flow with normal and stenosed coronary vessels. In: Catecholamines in the Non-ischaemic and Ischaemic Myocardium, ed. by Riemersma and Oliver, Elsevier/North-Holland Biomedical Press, pp. 155-165, 1982. 19. Feigl, E.O. Neural control of coronary blood flow. In: Simulation and Imaging of the Cardiac System, ed. by S. Sideman and R. Beyar, Martinus Nijhoff Publishers, Boston, pp. 323-330, 1985. 20. Feigl, E.O. Neural control of the coronary circulation. In: Neurocardiology, ed. by H.E. Kulbertus and G. Franck, Futura Publishing Co. Inc., Mount Kisco, NY, pp. 123-131, 1988. 21. Feigl, E.O. Reflex control of the coronary circulation. In: Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium, ed. by P.M. Vanhoutte, Raven Press, New York, pp. 307-310, 1988. 22. Scher, A.M., and Feigl, E.O. Introduction and physical principles. In: Textbook of Physiology, 21st edition, Vol. II, Circulation, Respiration, Body Fluids, Metabolism, and Endocrinology, ed. by H.D. Patton, A.F. Fuchs, B. Hille, A.M. Scher, and R. Steiner, W.B. Saunders Co., Philadelphia, Chapter 36, pp. 771-781, 1989. 23. Huntsman, L.L., and Feigl, E.O. Cardiac Mechanics. In: Textbook of Physiology, 21st edition, Vol. II, Circulation, Respiration, Body Fluids, Metabolism, and Endocrinology, ed. by H.D. Patton, A.F. Fuchs, B. Hille, A.M. Scher, and R. Steiner, W.B. Saunders Co., Philadelphia, Chapter 39, pp. 820-833, 1989. 24. Feigl, E.O. The arterial system: In: Textbook of Physiology, 21st edition, Vol. II, Circulation, Respiration, Body Fluids, Metabolism, and Endocrinology, ed. by H.D. Patton, A.F. Fuchs, B. Hille, A.M. Scher, and R. Steiner, W.B. Saunders Co., Philadelphia, Chapter 41, pp. 849-859, 1989. 25. Feigl, E.O. The coronary circulation. In: Textbook of Physiology, 21st edition, Vol. II, Circulation, Respiration, Body Fluids, Metabolism, and Endocrinology, ed. by H.D. Patton, A.F. Fuchs, B. Hille, A.M. Scher, and R. Steiner, W.B. Saunders Co., Philadelphia, Chapter 48, pp. 933-951, 1989. 26. Feigl, E.O. Autonomic control of coronary blood flow. In: Regulation of Coronary Blood Flow, ed. by M. Inoue, M. Hori, S. Imai, and R.M. Berne, Springer-Verlag, New York, pp. 47-60, 1991. 12 Eric O. Feigl 27. Feigl, E.O. Vagal control of coronary blood flow. In: Vagal Control of the Heart: Experimental Basis and Clinical Implications, ed. by M.N. Levy and P.J. Schwartz, Futura Publishing, Armonk, NY, Chapter 17, pp. 277-288, 1994. 28. Feigl, E.O. Neural control of coronary blood flow. In: Neurocardiology, ed. by J.A. Armour and J.L. Ardell, Oxford Univ. Press, New York, Chapter 7, pp. 139-164, 1994. 29. Feigl, E.O. Autonomic control of coronary blood flow. In: Nervous Control of the Heart, Vol. 9 in The Autonomic Nervous System, ed. by J.T. Shepherd and S.F. Vatner, Harwood Academic Publishers, Amsterdam, Chapter 9, pp. 227-252, 1996. 30. Feigl, E.O., Schaper, W. Physiology of coronary circulation. In: Cardiology, ed. by M.H. Crawford and J.P. DiMarco, Mosby, London, Section 2, pp. 1.1-1.8, 2001. 13