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Program for the Chabner Symposium, Liberty Hotel, November 5-6, 2012 (as of September 11, 2012) November 5, 2012 (6.75 CME credits – Day 1) 7:45am Welcome Daniel Haber, MD, PhD Massachusetts General Hospital Cancer Center, Harvard Medical School 1st Session: Modifiers of Gene Expression Convener – Daniel Haber 8:00-8:45a Ari Melnick, MD, Center on the Microenvironment and Metastasis, Cornell University IDH and TET 2 Mutations in Human Leukemia 8:45-9:30a William Kaelin, MD, Dana-Farber Cancer Institute, Harvard Medical School IDH 1 as an Oncogene 9:30-10:15a James Bradner, MD, Dana-Farber Cancer Institute, Harvard Medical School Bromodomain Inhibitors 10:15-10:30a Break 2nd Session: Signaling Inhibitors: Insights into Resistance Convener - Jeff Clark, MD Massachusetts General Hospital Cancer Center, Harvard Medical School 11:30-11:15a Matthew Smith, MD, PhD, Massachusetts General Hospital Cancer Center, Harvard Medical School Role of VEGFR and MET in Prostate Cancer and Bone Metastases 11:15-12:00p Jose Baselga, MD, PhD, Memorial Sloan-Kettering Cancer Center PI3 Kinase Inhibitions in Clinical Development 12:00-1:00p Lunch 3rd Session: Tumor Quiescence, Drug Response in Vitro, and Drug Resistance Convener - Donald Kufe, MD Dana-Farber Cancer Institute, Harvard Medical School 1:00-1:45p Sridhar Ramaswamy, MD, Massachusetts General Hospital Cancer Center, Harvard Medical School Targeting Quiescent Cancer Cells 1:45-2:30p Cyril Benes, PhD, Massachusetts General Hospital Cancer Center, Harvard Medical School Cell Line Screening 2:30-3:15p Michael Birrer, MD, PhD, Massachusetts General Hospital Cancer Center, Harvard Medical School Prospects for Targeted Therapy in Ovarian Cancer 3:15-3:30p Break 3:30-4:15p Ryan Corcoran, MD, Massachusetts General Hospital Cancer Center, Harvard Medical School Resistance to RAF Inhibition in BRAF Mutant Colorectal Cancer DF/HCC Junior Faculty Forum (non-CME) Page 1 of 3 Program for the Chabner Symposium, Liberty Hotel, November 5-6, 2012 (as of September 11, 2012) 4:15-5:15p David Sykes – Identifying Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia Andrew Elia – Proteomic Approaches to Study Ubiquitination and Protein Stability Julie Losman Rizwan Haq - 5:30 – 6:30p Evening reception Page 2 of 3 Program for the Chabner Symposium, Liberty Hotel, November 5-6, 2012 (as of September 11, 2012) November 6, 2012 (3.75 CME credits – Day 2) 4th Session: Clinical Breakthroughs Convener: Bruce A. Chabner, MD Massachusetts General Hospital Cancer Center, Harvard Medical School 8:00-8:45a Alice Shaw, MD, PhD, Massachusetts General Hospital Cancer Center, Harvard Medical School ROS 1 kinase, a Target for Lung Cancer 8:45-9:30a Frank Haluska, MD, PhD, Ariad Pharmaceuticals Development of a Novel BCR-ABL Inhibitor for CML 9:30-10:15a Carl June, MD, University of Pennsylvania Smart T-Cell Vaccines 10:15-10:30a Break 10:30-11:15a Xandra Breakefield, PhD, Massachusetts General Hospital Cancer Center, Harvard Medical School Exosomes as Biomarkers of the Genetic Status of Brain Tumors 11:15-12:00p Suzanne Topalian, MD, Johns Hopkins University AntiPD1 12:00p Closing Remarks Bruce Chabner Page 3 of 3