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MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 WORK EXPERIENCE Instructor/Research Engineer June 1987-August 1990 University of Connecticut Health Center Department of Anesthesiology Farmington, CT Research on airway mechanics, flow through airways, mathematical modeling Instructor of Medicine July 2001-June 2002 Yale University School of Medicine Division of Pulmonary, Critical Care & Sleep New Haven, CT Attending Physician West Haven VA Medical Center, PCCM Attending Physician Yale-New Haven Hospital Medical ICU Research on outcomes in older ICU patients and risk factors for delirium Assistant Professor of Medicine July 2002-June 2011 Yale University School of Medicine Division of Pulmonary, Critical Care & Sleep New Haven, CT Pulmonary Faculty Recruitment Selection Committee Pulmonary, Critical Care, Sleep Medicine Faculty Schedule 2006-2011 Attending Physician Yale-New Haven Hospital Medical ICU Attending Physician Yale-New Haven Hospital Neuro ICU Attending Physician Yale-New Haven Hospital Pulmonary Consult Service Attending Physician Yale-New Haven Hospital Winchester Chest Clinic Research on outcomes in older ICU patients and risk factors for delirium Research on pleural effusions and interventional pulmonary procedures Associate Medical Director July 2003-June 2005 Respiratory Care Yale-New Haven Hospital New Haven, CT Responsible for education and clinical training for the respiratory therapists Reviewed respiratory therapy protocols and guidelines with the Directory of Respiratory therapy Director, Pulmonary & Critical Care Fellowship Program Yale University School of Medicine New Haven, CT Fellowship Curriculum Committee, Chair 2009-2012 Fellowship Curriculum Committee, Member 2009-present 4th Year of Fellowship Committee, Chair 2009-present 1 July 2008-present MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Fellowship Research Advisory Committee 2009-present Fellowship Milestone Committee, Chair 2012-present Supervising attending Winchester Chest Fellows Clinic 2014-present Associate Professor of Medicine July 2011-present Yale University School of Medicine Division of Pulmonary, Critical Care & Sleep New Haven, CT Pulmonary, Critical Care, Sleep Medicine Faculty Schedule 2011-present MICU Committee 2012-present Attending Physician Yale-New Haven Hospital Medical ICU Attending Physician Yale-New Haven Hospital Pulmonary Consult Service Attending Physician Yale-New Haven Hospital Winchester Chest Clinic Research on outcomes in older ICU patients and risk factors for delirium Research on pleural effusions and interventional pulmonary procedures Research on sleep in the intensive care unit Associate Director July 2011-June 2013 Winchester Chest Clinic Yale-New Haven Hospital New Haven, CT Responsible for coordinating patient referrals and optimizing clinic flow Redesign of fellow’s clinic Clinic space redesign, committee member Associate Professor of Nursing July 2015-present Yale University School of Nursing New Haven, CT Collaborate with students and faculty at the School of Nursing on a variety of research projects Iona College EDUCATION New Rochelle, Bachelor of Science in Physics NY May 1985 New Jersey Institute of Newark, NJ Master of Science in Biomedical Technology Engineering Thesis Title: “Optimization of the Design of the Harrington Rod” May 1987 Temple University Doctor of Medicine May 1994 Masters of Public Health May 2001 Yale University Philadelphia, PA New Haven, CT 2 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 POSTDOCTORAL TRAINING Yale-New Haven Hospital Yale University School of Medicine Yale University School of Medicine New Haven, CT New Haven, CT Intern and Resident in Internal Medicine Chief Resident in Internal Medicine 1994-1997 Yale University School of Medicine New Haven, CT Fellow in Pulmonary and Critical Care Medicine 1998-2001 1997-1998 BOARD CERTIFICATIONS AND LICENSES American Board of Internal Medicine 1998; Recertified 2009 American Board of Internal Medicine, Pulmonary Medicine 2000, Recertified 2010 American Board of Internal Medicine, Critical Care Medicine 2001, Recertified 2011 Connecticut License Number 035793 GRANTS, HONORS AND AWARDS The Hartford Foundation/NIA July 2000 July 2002 Internal Medicine Subspecialty Fellowship in Aging Project Title: Cognitive Impairment in Elderly Medical Intensive Care Unit Patients Role: Principle Investigator The Chest Foundation T. Franklin Williams Scholar Award July 2002-July 2004 Project Title: The contribution to psychoactive drug use to poor outcomes in older ICU patients Role : Principle Investigator American Lung Association Clinical Research Grant July 2002-July 2004 Project Title: Prevalence of preexisting cognitive impairment and its impact on use of interventions and outcomes in older ICU patients Role: Principle Investigator Project Period: 7/1/2002-6/30/2004 Merck/American Federation Aging Research July 2002-July 2004 Junior Investigator Award in Geriatric Clinical Pharmacology Project Title: Impact of sedative use on outcomes in older intensive care unit patients Role: Principle Investigator National Institute of Health/NIA September 2002-September 2005 3 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Yale Pepper Center Early Research Career Development Award Project Title: Contribution of multiple risk factors to ICU outcomes in older patients Role: Principle Investigator Yale Mentored Clinical Scholar Program (K12 Award)* July 2004-October 2004 Project Title: Impact of psychoactive medications on outcomes in older ICU patients Role : Principle Investigator *This grant was terminated due to concurrent receipt of the K23 NIH/NIA K23 AG 23023-01A1 October 2004-July 2009 Project Title: Impact of psychoactive medications on outcomes in older ICU patients Role : Principle Investigator Percent effort: 75% The Chest Foundation October 2008-October 2009 BI Clinical Research Award in Women’s Pulmonary Health Project Title: Gender differences as they relate to outcome in an older ICU cohort Role : Principle Investigator NIH/NINR R21 NR011066-01A1 September 2009-September 2011 Project Title: Feasibility of measuring sleep in an ICU setting using portable polysomnography Role: Principle Investigator NIH/NHLBI / ARRA Stimulus Funds 5RC1HL100347-02 September 2009-August 2012 Project Title: Risk, Severity, and Outcome of Bacterial Pneumonia in an HIV +/- Veteran Cohort Role: Co-Principle Investigator National Institute of Nursing Research 120NR014126-0 September 2012-July 2017 Project Title: Yale Center for Sleep Disturbance in Acute and Chronic Conditions Role: Mentor for Pilot Project NIH/NIA R01 AG035117-01A1 July 2011-November 2017 Project Title: The MIND USA Project. RCT comparing haloperidol, ziprasidone and placebo for ICU delirium. Role: Site Principle Investigator Yale Claude D. Pepper Older Americans Independence Center July 2014-June 2016 P30AG021342 NIH/NIA Project Title: Characterization of sleep and brain dysfunction markers on EEG in older adults admitted to the MICU Role: Mentor for Research Career Development Award CTSA/YCCI Yale Center for Clinical Investigation UL1 TR000142 KL2 TR000140 NIH 4 October 2014-October 2015 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Project Title: Using noninvasive electroencephalography and cerebral oximetry monitoring to understand brain physiology in critically ill patients with sepsis Role: Mentor for YCCI Career Development Award Donaghue Foundation October 2015-October 2016 Project Title: Nocturnal Ambient Protection Protocol (NAPP) for patient sleep in the ICU Role: Principle Investigator Yale Claude D. Pepper Older Americans Independence Center P30AG021342 NIA Project Title: Critical illness, disability and vulnerability in older adults Role: Mentor for Research Career Development Award July 2015-July 2017 CTSA/YCCI Clinical and Community-Based Scholar Award UL1 TR000142 NIH Project Title: Circadian Misalignment in Critically Ill Patients Role: Mentor for YCCI Career Development Award July 2015-July 2017 National Institute of Health Loan Repayment Program William B. Abrams Award in Geriatric Clinical Pharmacology Fellow American College of Chest Physicians CHEST Foundation Young Investigator Award The Emanuel M. Weinberger Award for Achievement in Rheumatology John Creswell Memorial Award for Outstanding Performance in Medicine 2003-2009 2006 2003 2001 1994 1993 PUBLICATIONS 1. Moslehi F, Ligas JR, Pisani M, Epstein MAF. The Unsteady Form of the Bernoulli Equation for Estimating Pressure Drop in the Airways. Respiration Physiology. 1989; 76: 319-326. PMID:2749031 2. Pisani MA, Redlich CA, McNicoll L, Ely W, Inouye SK. Under recognition of Preexisting Cognitive Impairment by Physicians in Older ICU Patients. Chest 2003; 124:2267-74. PMID:14665510 3. McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel M, Inouye SK. Delirium in the intensive care unit: Occurrence and clinical course in older patients. J Amer Geriatr Soc. 2003; 51:591-8. PMID:12752832 4. Pisani MA, Inouye SK, McNicoll L, Redlich CA. Screening for preexisting cognitive impairment in older intensive care unit patients: Use of proxy assessment. J Amer Geriatr Soc. 2003; 51:689-93. PMID:12752846 5. McNicoll L, Pisani MA, Ely EW, Gifford D, Inouye SK. Detection of delirium in the ICU: Comparison of CAM-ICU with CAM ratings. J Amer Geriatr Soc 2005; 53:495-500. PMID:15743296 5 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 6. Pisani MA, Redlich CA, McNicoll L, Ely EW, Friedkin R, Inouye SK. Short-term outcomes in older intensive care unit patients with dementia. Crit Care Med 2005; 33:1371-76. PMID:15942358 7. D’Ambrosio C, Stachenfeld NS, Pisani MA, Mohsenin V. Sleep, breathing, and menopause: The effect of fluctuating estrogen and progesterone on sleep and breathing in women. Gender Medicine 2005; 2(4):238-245. PMID: 16464735 8. Friedman LN, Nash ER, Byrant J, Henry S, Shi J, D’Amato, J, Khaled GH, Russi MB, Pisani MA, Edberg SC, O’Conner PG, Cain H, Tanoue L, Weissman, DN. High rate of negative tuberculin and QuantiFERON® tests in individuals with histories of past-positive skin tests. Infect Control Hosp Epidemiol 2006; 27:436-41. PMID:16671022 9. Pisani MA, Araujo KLB, Van Ness PH, Zhang Y, Ely EW, Inouye SK. A research algorithm to improve detection of delirium in the intensive care unit. Crit Care. 2006 Aug 18;10(4): R121. PMID:16919169 10. Cosgriff JA, Pisani MA, Bradley EH, O’Leary JR, Fried TR. The association between treatment preferences and trajectories of care at the end-of-life. J. Gen. Intern. Med. 2007; 22(11):1566-71. PMID:17874168 11. Pisani MA, Murphy TE, Van Ness PH, Araujo KLB, Inouye SK. Admission characteristics associated with delirium in older patients in a medical intensive care unit. Arch Intern Med 2007; 167 (15):1629-1634. PMID:17698685 12. Van Ness PH, Murphy TE, Araujo KLB, Pisani MA, Allore HG. The use of missingness screens in clinical epidemiologic research has implications for regression modeling. J Clin Epi 2007 60(12):1239-45. PMID:17998078 13. Pisani MA. Delirium assessment in the intensive care unit: patient population matters. Crit Care. 2008 Apr 7; 12(2):131. PMID:18423059 14. Pisani MA, Murphy TE, Araujo KA, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of ICU delirium in an older population. Crit Care Med, 2009 37(1):177-183. PMID:19050611 15. Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of Delirium Are Associated with 1-year Mortality in an Older Intensive Care Unit Population. Am J Respir Crit Care Med 2010 180 (11): 1092-1097. PMID:19745202 16. Pisani MA, Murphy TE, Araujo KA, Van Ness PH. Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. J Crit Care 2010 Sep:25(3): 540 e1-7. PMID:20413252 17. Akgun KM, Murphy TE, Araujo KLB, Van Ness PH, Pisani MA. Equivalent Treatment of Older Medical Intensive Care Unit Patients Based on Gender. Crit Care Res Prac 2010:404608. Epub 2010 Oct 20. PMID:20981259 18. Vest MT, Murphy TE, Araujo KL, Pisani MA. Disability in activities of daily living, depression, and quality of life among older medical ICU survivors: a prospective cohort study. Health Qual Life Outcomes 2011; Feb 5; 9:9. PMID:21294911 19. McGinnis K, Brandt C, Skanderson M, Justice A, Shahrir S, Butt AA, Brown S, Freiberg M, Gibert G, Goetz M, Kim JW, Pisani MA, Rimland D, Rodriquez-Barradas M, Sico J, Tindle H, Crothers K. Validating Smoking Data from the Veteran’s Affair Health Factor Dataset, an Electronic Data Source. Nicotine & Tobacco Research Sept 12, 2011. PMID:21911825 6 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 20. Murphy TE, Van Ness PH, Araujo, KLB, Pisani MA. Bayesian Time Series Analysis of a Repeated Measures Poisson Outcome with Excess Zeroes. Am J Epidemiology, 2011 Dec 1; 174(11):1230-7. PMID:22025357 21. Van Ness PH, Murphy TE, Araujo KLB, Pisani MA. Multivariate Graphical Methods Provide an Insightful way to Formulate Explanatory Hypotheses from Limited Categorical Data. J Clinical Epi. 2012 Feb; 65(2):179-88. PMID:21889310 22. Pisani MA, Ferrante L. Among patients admitted to ICU, delirium is most common in those with neurological diagnoses, and is associated with adverse health outcomes. Evid Based Nurs. 2012 Nov 21. [Epub ahead of print]. PMID:23171569 23. Akgun KA, Gordon K, Pisani MA, Fried T, McGinnis KA, Tate JP, Butt AA, Gilbert CL, Huang L, Rodriquez-Barradas MC, Rimland D, Justice AC, Crothers K. Risk factors for hospitalization and medical intensive care unit admissions among HIV infected veterans. J Acquir Immune Defic Syndr. 2012 Oct 29. [Epub ahead of print]. PMID:23111572 24. Puchalski JT, Argento AC, Murphy TE, Araujo KLB, Olivia I, Rubinowtiz A, Pisani MA. Etiologies of bilateral pleural effusions. Respir Med. 2013 Feb;107(2):284-91. PMID: 23219348 25. Akgun KA, Tate JP, Pisani MA, Fried T, Butt AA, Gilbert CL, Huang L, Rodriquez-Barradas MC, Rimland D, Justice AC, Crothers K. Medical intensive care unit (MICU) admission diagnoses and outcomes in HIV-infected and uninfected Veterans in the combination antiretroviral era. Crit Care Med. 2013 Mar 15. PMID:23507717 26. Puchalski JT, Argento AC, Murphy TE, Araujo KLB, Pisani MA. The safety of thoracentesis in patients with uncorrected bleeding risk. Ann Am Thorac Soc. 2013 Aug;10(4):336-41. PMID: 23952852 27. Pisani MA, Bramley K, Vest MT, Araujo KLB, Murphy TE. Patterns of benzodiazepine, opiate and antipsychotic drug administration in a medical intensive care unit. Am J Crit Care. 2013 Sep;22(5): e62-e69. PMID:23996429 28. Mannam P, Shinn A, Srivastava A, Neamu R, Walker W, Bohanon M, Merkel J, Kang M, Dela Cruz C, Ahasic A, Pisani M, Trentalange M, West AP, Shadel G, Shen J, Elias J, Lee P. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7): L604-19. PMID:24487387 29. Kookoolis A, Puchalski JT, Araujo KL, Murphy TE, Pisani MA. Mortality of hospitalized patients with pleural effusions. J Pulm Respir Med. 2014 Jun;4(3):184. PMID:25977841 30. Knauert MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KL, Pisani MA. Feasibility study of unattended polysomnography in medical intensive care unit patients. Heart Lung. 2014 SepOct;43(5):445-52. Epub 2014 Jul 12. PMID:25023504 31. Goyal G, Pisani MA, Murphy TE, Araujo KL, Puchalski JT. Advanced diagnostic bronchoscopy using conscious sedation and the laryngeal nerve block: tolerability, thoroughness and diagnostic yield. Lung. 2014 Dec;192(6):905-13. Epub 2014 Jun 28. PMID:24972639 32. Ahasic A, Van Ness P, Murphy TE, Araujo KL, Pisani MA. Functional status after critical illness: Agreement between patient and proxy assessments. Age Ageing. 2014 Oct 16. [Epub ahead of print] PMID:25324334 33. Hoang, Q, Pisani MA, Inzucchi S, Buqu H, Honiden S. The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the 7 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 intensive care unit: A prospective observational study. J Crit Care. 2014 Dec;29(6):1052-6 Epub 2014 Jun 12. PMID:25092614 34. Pisani MA, Araujo KL, Murphy TE. Association of Cumulative Dose of Haloperidol with Delirium in Older Medical Intensive Care Unit Patients. Crit Care Med. 2015 [Epub ahead of print] PMID:25746748 35. Ferrante L, Pisani MA, Murphy TE, Gabbauer EA, Leo-Summers L, Gill TM. Functional trajectories among older persons before and after critical illness. JAMA Intern Med. 2015 Feb 9. [Epub ahead of print] PMID:25665067 36. Hopper K, Fried T, Pisani MA. Healthcare worker attitudes and identified barriers to patient sleep in the medical intensive care unit. Heart Lung. 2015 Mar-Apr;44(2):95-9. [Epub 2015 Feb 14]. PMID:25686516 37. Ferrante L, Pisani MA, Murphy TE, Gabbauer EA, Leo-Summers L, Gill TM. Functional trajectories among older persons before and after critical illness. JAMA Intern Med. 2015 Feb 9. [Epub ahead of print] PMID:25665067 38. Debiasi EM, Pisani, MA, Murphy TE, Katy KL, Kookoolis A, Argento AC, Puchalski JT. Pleural effusions and mortality at 30-days and 1-year. Eur Respir J. 2015 Apr 2. pii: ERJ02171-2014. [Epub ahead of print] PMID:25837039 39. Barakat L, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgun KM, Goetz MB, Butt AA, Rodriquez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes of HIV-infected and uninfected older men hospitalized with community-acquired pneumonia. HIV Medicine. 2015 May 11 [Epub ahead of print] PMID:25959543 40. Chima-Melton C, Murphy TE, Araujo KL, Pisani MA. The impact of race on intensity of care provided to older adults in the medical intensive care unit. J. Racial and Ethnic Health Disparities. 2016 Jun 3(2):365-72 [Epud ahead of print] PMID:27271078 41. Attia EF, McGinnis KA, Feemster LC, Akgun KA, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas M, Pisani MA, Tindle HA, Brown ST, Hoo, GW, Rimland D, Gilbert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD with risk for pulmonary infections requiring hospitalization in HIV-infected Veterans. J Acquir Immune Defic Syndr. 2015 Jul 11. [Epub ahead of print] PMID: 26181820 42. Murphy TE, Araujo KL, Pisani MA. The Authors reply. Crit Care Med. 2015 Dec;43(12): e589-90 PMID: 26575672 43. Argento AC, Murphy T, Pisani M, Araujo K, Puchalski J. Patient-centered outcomes following thoracentesis. Pleura. 2015 Jan-Dec [Epub 2015 Sep 1] PMID: 26767192 44. Pisani MA. The 3D-CAM provides a brief, easy to use, sensitive and specific delirium assessment tool for older hospitalized patients, both with and without dementia. Evid Based Mental Health 2015 Nov;18(4):120. [Epub 2015 Oct 12] PMID: 26459467 45. Murphy TE, Van Ness, PH, Araujo KLB, Pisani MA. An empirical method of detecting timedependent confounding: An observational study of next day delirium in a medical ICU. Int J Stats Med Res. 2016; 5(1):41-47. Jan 8 [Epub ahead of print] PMID:26798411 46. Rowe T, Araujo KL, Van Ness PH, Pisani MA, Juthani-Mehta, M. Outcomes of older adults with sepsis at admission to an intensive care unit. Open Forum Inf Dis 2016 Jan 21; 3(1). PMID:26925430 8 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 47. Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy T, Araujo K, Puchalski J. Comparison of transbronchial and cryobiopsies in evaluation of diffuse parenchymal lung disease. J of Bronchology Interv Pulmonol. 2016 Jan;23(1):14-21. PMID: 26705007 48. Bramley K, Pisani, MA, Murphy TE, Katy KL, Homer R, Puchalski JT. EBUS-guided cautery-assisted forceps biopsies: improved yield, expanded applications. Ann Thor Surg 2016 May;101(5):1870-6. [Epub 2016 Feb 22] PMID:26912301 49. Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LE, Gill TM. Factors associated with functional recovery among older ICU survivors. Am J Respir Crit Care Med. 2016 Aug 1; 194(3):299-307 [Epub 2016 Feb 3] PMID:26840348 50. Han L, Pisani MA, Araujo KLB, Allore HG. Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients. Int J Stats Med Res. 2016 5:8-16 [Epub ahead of print Jan 8] PMID:27123153 51. Kamdar BB, Knauert MP, Jones SF, Parsons EC, Pisani MA. Perceptions and practices regarding sleep in the ICU: A survey of 1,223 critical care providers. Ann Am Thorac Soc. 22 Apr 2016 [Epub ahead of print] PMID:27104770 52. Harris DA, Pensa MA, Redlich CA, Pisani MA, Rosenthal MS. Community-based participatory research is needed to address pulmonary health disparities. Ann Am Thorac Soc Jun 1 2016 [Epub ahead of print] PMID:27249657 53. Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK. Quantifying the severity of a delirium episode throughout hospitalization: the combined importance of intensity and duration. J Gen Int Med. 2016 June 3 [Epub ahead of print] PMID:27259291 54. Ding Q, Redeker NS, Pisani MA, Yaggi HK, Knauert MP. Factors influencing patients’ sleep in the intensive care unit: Patient and clinical staff perceptions. Am J Crit Care. In Press 55. Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: Worth further study. J Thorac Dis. 2016 Sep 8(9):E999-E1002 PMID:27747045 56. Knauert MP, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on Aweighted and C-weighted decibel scales. J Crit Care. 2016 Dec:36:1-7 PMID:27546739 57. Pisani MA, Albuquerque A, Marcantonio ER, Jones RN, Gou RY, Fong TG, Schmitt EM, Tommet D, Aizpurua II, Alsop DC, Inouye SK, Travison TG. Hospital readmission is associated with both acute and sustained delays in functional recovery during the 18 months following elective surgery: The SAGES Study. JAGS. In Press 58. Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshal PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. How and when to assess swallowing in post-extubation ICU patients. Submitted 59. Jin L, Korde A, Zhang J, Ramaswamy A, Hu B, Juan-Guardela B, Herazo-Maya J, Siegfried JM, Stabile L, Pisani MA, Herbst RS, Kaminski N, Elias JA, Puchalski JT, Takyar SS. Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis. Submitted 60. Ferrante LE, Murphy TE, Gahbauer EA, Leo-Summers LE, Gill TM, Pisani MA. Pre-ICU Cognitive status and post-ICU functional outcomes among critically ill older adults. Submitted 9 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 ABSTRACTS (*Oral Presentations) 1. Moslehi F, Ligas JR, Pisani M, Epstein MAF. Wave Mechanics Applications in Respiratory Mechanics. 38th Annual Fall Meeting of the American Physiological Society, 1987. 2. Moslehi F, Ligas JR, Pisani M, Epstein MAF. An Application of Wave Mechanics: Effects of Viscosity and Geometry. FASEB 1988. 3. Epstein MAF, Moslehi F, Pisani M, Ligas JR. One and Two Dimensional Wave Mechanics for Oscillating Flows in Respiration. 6th International Conference on Mechanics in Medicine and Biology, 1988. 4. Moslehi F, Epstein MAF, Ligas JR, Pisani M, Epstein RA. Physiological Flow Impedance as a Fluid Mechanical Field Variable. 10th Annual Conference of the IEEE Engineering in Medicine and Biology Society, 1988. 5. Epstein MAF, Moslehi F, Ligas JR, Pisani M, Epstein RA. Airway Impedance Analysis with Wave Mechanic Models: Effects of Airway Geometry. FASEB. 1989. 6. Epstein MAF, Pisani M, Conard PL, Epstein RA. Airway Acoustic Resonance in Dogs. FASEB Journal. 1990. 7. *Pisani M, Inouye SK. Cognitive impairment in older medical intensive care unit patients: Physician recognition, intensity of care and outcomes. American College of Chest Physicians; Philadelphia, PA. November 2001. 8. *Pisani M, Inouye SK. Preexisting cognitive impairment in older patients admitted to the intensive care unit. Gerontological Society of America; Chicago, IL, November 2001. 9. Pisani MA, Redlich CA, Inouye SK. Detection of preexisting cognitive in a medical ICU using two proxy scales. American Thoracic Society. Am. J. Respir. Crit. Care Med. 2002. 10. *McNicoll L, Pisani M, Zhang Y, Inouye SK. Adverse Hospital Outcomes in Critically Ill Older Patients: The Effect of Delirium. Gerontological Society of America; November 2002. 11. Pisani M, Ely EW, Redlich CA, McNicoll L, Inouye SK. Favorable outcomes of elderly patients with critical illness and preexisting cognitive impairment. American Geriatrics Society, May 2003. 12. Weissman DN, Khaled G, Nash E, Bryant J, Henry S, Shi J, D'Amato J, Pisani MA, Janotka E, Edberg S, O'Connor P, Russi M, Cain H, Tanoue L and Friedman LN. Does Tuberculin Skin Testing (TST) Boost in Vitro Measures of TB-Specific Cell Mediated Immunity? Am. J. Respir. Crit. Care Med. 2003; 167(7): A866. 13. Pisani MA, Redlich CA, Ely W, McNicoll L, Inouye SK. Favorable ICU outcomes in older patients with preexisting cognitive impairment. Am. J. Respir. Crit. Care Med. 2003; 167(7): A252. 14. *Friedman LN, Khaled G, Nash E, Bryant J, Henry S, Shi J, D’Amato J, Janotka E, Edberg S. O’Connor P, Russi M, Cain H, Pisani M, Tanoue L, Weissman DN. High rate of Tuberculosis Skin Test (TST) reversion in screening programs and its association with the Quantiferon-TB (QFN) assay. Am. J. Respir. Crit. Care Med. 2004; 169(7): A259. 15. *McNicoll L, Pisani MA, Inouye SK. One-year outcomes following delirium in older ICU patients. JAGS 52(4), April 2004, A4. 16. Pisani MA, Araujo K, Zhang Y, Lee P, Redlich CA, Inouye SK. Risk Factors for New-Onset Delirium in Older ICU Patients. American Geriatric Society, May 2004. 10 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 17. *Pisani MA, Murphy TE, Araujo KLD, Van Ness PH. Psychoactive medications and the duration of delirium in an ICU population. American Thoracic Society Am. J. Respir. Crit. Care Med. 2007; 175: A21. 18. Pisani MA, Murphy TE, Van Ness PH, Araujo KLB, Inouye SK. Characteristics associated with delirium in patients in a medical intensive care unit. American Thoracic Society Am. J. Respir. Crit. Care Med. 2007; 175: A786. 19. Pisani MA, Van Ness PH, Araujo KLB, Murphy TE. Risk factors for delirium persistence after ICU discharge in an older medical population. Am. J. Respir. Crit. Care Med. 2008; 177: A987. 20. Akgun KM, Araujo KLB, Siner JM, Pisani MA. Association between ICU Delirium and Serum IL-6 Levels. Am. J. Respir. Crit. Care Med. 2008 177: A987. 21. Akgun KM, Araujo KLB, Murphy TE, Pisani MA. Gender Differences in Medical Intensive Care Unit Patients. Am. J. Respir. Crit. Care Med. 2008; 177: A634. 22. Akgun KM, Pisani MA, Butt AA, Gibert CL, Rodriguez-Barradas, MC, Justice AC, Rimland D, Crothers K. Incidence and Mortality of MICU Admission in HIV Infected (HIV+) and NonInfected (HIV-) Veterans. Am. J. Respir. Crit. Care Med. 2010; 181: A5200. 23. Akgun KM, Pisani MA, Fried TR, Butt AA, Gibert CL, Rimland D, Justice AC, RodriguezBarradas, MC, Crothers K. Risk Factors for MICU Admission among HIV+ Patients. Am. J. Respir. Crit. Care Med. 2010; 181: A5199. 24. *Vest M. Araujo KLB, Murphy TE, Pisani MA. Disabilities in activities of daily living and quality of life among older medical ICU survivors. Am. J. Respir. Crit. Care Med. 2010; 181: A5358. 25. Bramley K, Vest M, Araujo KLB, Murphy TE, Pisani MA. Sedative, narcotic and haloperidol drug dosing by nursing shift in a medical ICU. Am. J. Respir. Crit. Care Med. 2010; 181: A4549. 26. Mathur A, Pisani MA, Araujo KLB, Trow T. Risk factors for MICU admission in patients with pulmonary hypertension. Chest 2010; 138: 296A. 27. Argento AC, Pisani MA, Johnson K, Qin L, Puchalski J. Thoracentesis are safe in patients with bleeding tendencies. Am. J. Respir. Crit. Care Med. 2011; 183: A4630. 28. Panico M, Jenq G, Honiden S, Araujo KLB, Pisani MA. Outcomes following a rapid response and the impact on transfer to the intensive care unit. Am. J. Respir. Crit. Care Med. 2011; 183: A4725. 29. *Heavner J, Pisani MA. Carpal tunnel syndrome and hypoxemia: A case of the antisynthetase syndrome. Am. J. Respir. Crit. Care Med. 2011; 183: A5656. 30. Akgun KM, Pisani M, Fried T, Butt AA, Gibert C, Rimland D, Huang L, Justice AC, Rodriguez-Barradas M, Crothers KA. Impact of age on medical intensive care unit admissions in HIV-infected patients. Am. J. Respir. Crit. Care Med. 2011; 183: A6270. 31. Akgun KM, Tate JP, Pisani M, Butt AA, Gilbert C, Rimland D, Huang L, Justice AC, Rodriquez-Barradas MC, Crothers K. Is the VACS index responsive to acute critical illness? 16th Annual Instructional Workshop on HIV Observational Databases (IWHOD) March 2012 Athens, Greece, Abstract #16_173 32. *Akgun KM, Tate JP, Pisani M. Butt AA, Gibert CL, Rimland D, Huang L, Justice AC, Rodriquez-Barradas MC, Crothers K. Prediction of 30-day mortality after MICU admission among HIV-infected patients. Am. J. Respir. Crit. Care Med. 2012; 185: A2549. 11 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 33. Erb CT, Pisani MA, Murphy TE, Araujo KLB, Puchalski JT. The safety, tolerability and outcomes of performing endobronchial ultrasound (EBUS) in obese patients. Am. J. Respir. Crit. Care Med. 2012; 185: A3000. 34. Knauert-Brown MP, Yaggi HK, Redeker NS, Murphy TE, Araujo KLB, Donlon T, Pisani MA. Feasibility of conducting 24-hour polysomnography studies in the medical intensive care unit. Am. J. Respir. Crit. Care Med. 2012; 185: A1617. 35. Knauert-Brown MP, Xu X, Shan P, Qin L, Araujo KLB, Allore HG, Pisani MA, Lee PJ. Alterations in toll-like receptor 4 function secondary to smoking and age. Am. J. Respir. Crit. Care Med. 2012; 185: A1314. 36. Mathews KS, Jenq GY, Siner JM, Long EF, Pisani MA. Short-Stay patients in the intensive care unit: Characterizing patient acuity, throughput and critical care resource utilization. Am. J. Respir. Crit. Care Med. 2012; 185: A6731 37. *Argento AC, Pisani MA, Murphy TE, Araujo KLB, Kookoolis A, Johnson K, Puchalski JT. Impact of thoracentesis on dyspnea and quality of life. Chest 2012; 142:488A 38. Knauert-Brown MP, Yaggi HK, Redeker NS, Murphy TE, Arajuo KLB, Pisani MA. Feasibility of providing medical ICU patients with a four hour nocturnal naptime. Chest 2012; 142:547A. 39. Mathews K, Pisani MA, Jenq GY, Long E. Characterizing the flow of short-stay patients in the intensive care unit. Society for Medical Decision Making October 2012. 40. Mathews K, Jenq GY, Long E, Pisani MA. ICU utilization by “subacute” patients: reasons for admission and opportunities for improvement. Society for Critical Care Medicine January 2013. 41. Ahasic A, Murphy TE, Araujo KLB, Pisani MA. Association between body mass index (BMI) and occurrence of delirium in a cohort of older medical ICU patients. Am. J. Respir. Crit. Care Med. 2013: A40028. 42. Hoang QN, Pisani MA, Inzucchi S, Hu B, Honiden S. The prevalence of previously undiagnosed diabetes and the impact of baseline glycemic control upon outcomes in the medical ICU. Am. J. Respir. Crit. Care Med. 2013: A43818. 43. *Hu X, Puchalski JT, Pisani MA, Carbone C, Michaud GC, Herzog E. Intrathoracic and circulating fibrocytes are elevated in patients with malignant pleural effusions. Am. J. Respir. Crit. Care Med. 2013: A44060. 44. Chima-Okereke C, Murphy TE, Araujo KLB, Pisani MA. Impact of race on the intensity of care provided to older adults in the medical intensive care unit. Am. J. Respir. Crit. Care Med. 2013: A37967. 45. Knauert M, Yaggi HK, Redeker NS, Pisani MA. Medical ICU sleep deprivation: frequent nocturnal room activity. Annual Meeting of the Associated Professional Sleep Societies. June 2013: A0815 46. Murphy E, Pisani MA, Murphy TE, Araujo KL, Kookoolis A, Argento AC, Puchalski JT. Pleural effusions and 30-day mortality. Chest 2013. 47. *Ahasic A, Murphy TE, Araujo KL, Pisani MA. Functional assessment after critical illness. Agreement between patient and proxy assessments. Chest 2013. 48. *Erb C, Pisani MA, Puchalski JT. The Utility of a Silicone Y-Stent in the Secondary Carina for a Life-Altering Bronchoesophageal Fistula. Chest 2013. 49. *Bramley K, Pisani MA, Puchalski JT. Electrocautery knife incisions during EBUS-guided miniforceps biopsies. Chest October 2013. 12 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 50. *Ryu C, Bramley, K, Boffa D, Pisani MA, Puchalski JT. Endobronchial treatment of pulsatile hemoptysis complicating Y-stent management of tracheobronchomalcia. Case Report. Chest 2013. 51. Akgun KM, Tate JP, Pisani M, Butt AA, Gibert C, Fried T, Rimland D, Huang L, Justice AC, Rodriquez-Barradas MC, Crothers K. Hospital readmission and incident skilled nursing facility placement in MICU survivors from a nationally representative cohort of HIV-infected and uninfected veterans: 1996-2010. Am. J. Respir. Crit. Care Med. 2014: A4518. 52. *Ferrante L, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers L, Gill TM. The course of disability in the year immediately before and after an ICU admission in older persons. Am. J. Respir. Crit. Care Med. 2014: 3931. 53. *Ferrante L, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers L, Gill TM. The association between pre-ICU functional trajectory and mortality after ICU admissions in older persons. Am. J. Respir. Crit. Care Med. 2014: 3934. 54. *McGinniss JE, Wong Y, Shinn AA, Bohanon M, Merkel J, Ahasic AA, Pisani MA, Lee PJ, Mannam P. MAP Kinase Kinase 3 (MKK3) Regulates Mitochondrial Turnover and Susceptibility to Sepsis. Am. J. Respir. Crit. Care Med. 2014: A3939. 55. Knauert MP, Jeon S, Pisani MA, Yaggi HK, Redeker NA. Noise as a source of medical intensive care unit sleep disruption. Sleep 2014 56. Rowe T, Araujo KL, Van Ness PH, Pisani MA, Juthani-Mehta M. Outcomes of Older Adults with Sepsis at Admission to an Intensive Care Unit. Infectious Disease Society of America Oct 10, 2014, A46058. 57. Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski JT. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Lung Disease. Am. J. Respir. Crit. Care Med. 2015; 191: A3727 58. Ramaswamy A, Jin L, Zhang B, Hu B, Bramley K, Boffa D, Pisani, MA, Puchalski JT, Takyar S. MiR-1 Levels in Lung Tumor Samples Correlate with Tumor Progression in Human Non-Small Cell Lung Cancer Patients Am. J. Respir. Crit. Care Med. 2015; 191: A5095 59. Ferrante L, Pisani MA, Murphy TE, Gill T. Factors Associated with Functional Recovery After Critical Illness in Older Persons. Am. J. Respir. Crit. Care Med. 2015; 191: A2282 60. Ahasic AM, Murphy TE, Araujo KL, Pisani MA. Obesity and Persistent Delirium: Is There an Association? Am. J. Respir. Crit. Care Med. 2015;191: A4016 61. Ahasic AM, Murphy TE, Araujo KL, Pisani MA. Predictors of Change in Functional Status of Older Patients Before and After Intensive Care Unit Admission. Am. J. Respir. Crit. Care Med. 2015; 191: A2283 62. Pinto S, Pisani MA, Araujo KL, Argento C, Kookoolis, A, Puchalski JT. Impact of Endobronchial Ablation Therapy and Airway Stenting on Dyspnea and Activities of Daily Living in Patients with Central Airway Obstruction. Am. J. Respir. Crit. Care Med. 2015; 191: A3721 63. Akgun KA, Cheung K, Crothers K, Pisani MA, Justice AC, Gilbert CL, Friedberg M, Brandt C, Fried T. Identifying Medical Intensive Care Unit (MICU) Palliative Care Domains with Chart Review. Am. J. Respir. Crit. Care Med. 2015; 191: A4552 64. Erb C, Fares WH, Araujo KA, Murphy TE, McDade KE, Pisani MA, Puchalski JT. A modified approach to the use of ultrasound for subclavian vein catheterization. Am J Resp Crit Care Med. 2015; 191: A5681 13 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 65. *Han L, Allore HG, Araujo KL, Pisani MA. Anticholinergic drug burden and severity of delirium symptoms among older medical patients receiving intensive care. Gerontological Society of America 2015 66. Murphy TE, Araujo KL, Pisani MA. Exploratory Measures for Detecting Time Dependent Confounding in Longitudinal Data. Gerontological Society of America 2015 67. Chauhan Z, Pisani MA, Ahasic AM. Predictors of sleep quality in survivors of critical illness. Soc Crit Care Med 2016. 68. Ahasic A, Pisani MA. Adipokines early in critical illness. Am J Resp Crit Care Med 2016; A8672 69. *Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Frailty is associated with new or worsening disability after critical illness. Am J Resp Crit Care Med 2016 70. Ferrante LE, Gill TM, Murphy TE, Douglas M, Pisani MA. Maximum mobility achieved among older vs. younger patients in an early mobilization program in the MICU. Am J Resp Crit Care 2016. 71. Ramaswamy A, Jin L, Hu B, Boffa D, Pisani MA, Puchalski JT, Takyar S. MiR-1 expression in the vicinity of non-small cell cancer correlates with patient survival. Am J Resp Crit Care Med 2016 72. Israel RA, Lemieux S, Chernova I, Pisani MA. Case of life-threatening amlodipine overdose in an obese male. Chest 2016 73. Hirsh J, Bournival NL, Pisani MA, Puchalski JT. A caustic case of acute calcium tablet aspiration. Chest 2016 74. Han L, Allore HG, Araujo KLB, Pisani MA. Anticholingergic drug burden predicts delirium severity among older medical patients under intensive care. Alzheimer’s Assoc International Conference 2016 Submitted 75. Littlefield A, Chan C, Cooper D, Heavner J, Kurtz J, Pisani M, Clark K, Halpin A, Hough C, Leach N, Maurice L, Moreira S, Roberts N, Schifflett S, Watts L, Heavner M. The correlation between CIWA and modified MINDS score in patients with alcohol withdrawal syndrome. Society for Critical Care Medicine January 2017 Accepted 76. Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Pre-ICU cognitive status and functional outcomes after a critical illness among older adults. Society for Critical Care Medicine January 2017 Accepted 77. Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The combined effects of frailty and cognitive impairment on the course of disability after an ICU admission among older persons. Am J Resp Crit Care Med 2017 Submitted 78. Rentsch C, Tate JP, Steel T, Butt AA, Gibert CL, Huang L, Pisani M, Soo Hoo GW, Crystal S, Rimland D, Justice AC, Crothers K, Akgun KM. Medical intensive care unit (MICU) admission rates by HIV serostatus and alchohol-related diagnosis in the combination antiretroviral era. Am J Resp Crit Care Med 2017 Submitted 79. Knauert M, Redeker N, Yaggi H, Araujo K, Pisani MA. Circadian rhythms in the medical intensive care unit: Measurement via actigraphy. Am J Resp Crit Care Med 2017 Submitted CHAPTERS, BOOK AND REVIEWS 14 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 1. Pisani M, McNicoll L, Inouye SK. Cognitive impairment in the intensive care unit. Clinics in Chest Medicine 2003; 24(4): 727-738. PMID:14710700 2. Pisani MA. Recognition of preexisting cognitive impairment in older intensive care unit patients. Research and Practice in Alzheimer’s Disease 2004; 9: 33-38. 3. Levy CR, Pisani MA, Ely EW. Pulmonary and Critical Care Among Elderly Patients Admitted to the Intensive Care Unit. In: Chest Medicine, eds. George RB, Light RW, Matthay MA, Matthay RA. May 2005 Publisher: Williams & Wilkins. 4. Pisani MA, Ely EW. Monitoring and Treatment of Pain, Anxiety and Delirium in the ICU. In: Clinical Critical Care Medicine, eds. Albert RK, Slutsky A, Ranieri M, Takala J, Torres A. 2006 Publisher: Elsevier, Philadelphia, PA. 5. Siner J, Pisani MA. Mechanical Ventilation and Acute Respiratory Distress Syndrome in Older Patients. Clinics in Chest Medicine, 2007 Dec;28(4):783-91. PMID:17967294 6. Pisani MA. Guest Editor: Respiratory Disease in Older Patients. Clinics in Chest Medicine. 2007, 28 (4). Publisher: Elsevier, Philadelphia, PA. 7. Pisani MA. Delirium in the ICU: An Overview. Pulmonary and Critical Care Updates. Volume 22, Lesson 17 2008. 8. Pisani MA. American College of Chest Physicians Pulmonary and Critical Care Updates. “Delirium in the ICU: An Overview”. Volume 22, Lesson 17. September 2008 9. Pisani MA. Considerations in Caring for the Critically Ill Older Patient. J Intensive Care Med, 2009, 24(2):83-95. PMID:19114416 10. Pisani MA, Ely EW. Respiratory Diseases and Disorders. In: Pacala JT, Sullivan GM, eds. Geriatric Review Syllabus: A core Curriculum in Geriatric Medicine, 7th ed. New York, NY: American Geriatrics Society; 2010 11. Pisani MA. Intensive and Critical Care Medicine. JAMA 2010; 304: 1497. 12. Akgun KA, Pisani MA. Respiratory Diseases and Disorders. In: Medina-Walpole A, Pacala JT, Potter JF, eds. Geriatric Review Syllabus: A Core Curriculum in Geriatric Medicine, 9th ed. New York, NY: American Geriatrics Society; 2016 13. Pisani MA, Ferrante L. Intensive care unit outcomes in older adults. In: The Aging Lungs: Mechanisms and Clinical Sequela, eds. Bucala R, Lee PJ 2016 Publisher World Scientific, Singapore. 14. Pisani MA, Ely EW. Respiratory Diseases and Disorders. In: Flaherty E, Resnick B, eds. Geriatric Nursing Review Syllabus: A Core Curriculum in Advanced Practice Geriatric Nursing. 3rd ed. NY: American Geriatrics Society; 2011 15. Akgun KM, Pisani MA, Crothers K. The changing epidemiology of HIV-infected patients in the intensive care unit. J Intensive Care Med. 2011 May-Jun;26(3):151-64. PMID:21436170 16. Akgun KM, Huang L, Morris A, Justice AC, Pisani MA, Crothers K. Critical illness in HIVinfected patients in the era of combination antiretroviral therapy. Proc. Am. Thorac. Soc 2011 Jun;8(3):301-7. PMID:21653532 17. Mathur A, Sauler M, Pisani MA. Pulmonary Embolism in Older Patients. In: Aging and Lung Disease, ed. Pisani MA. 2012 Publisher: Springer, Humana Press, New York, NY. 18. Pisani MA. Delirium Assessment Tools. In: Current Concepts in Adult Critical Care, eds. Cheng EY, Park PK. February 2012, Society for Critical Care Medicine. 19. Pisani MA. Editor: Aging and Lung Disease: A Clinical Guide. Respiratory Medicine Series. 2012, Publisher: Springer, Humana Press, New York, NY. 15 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 20. Akgun KM, Crothers K, Pisani MA. Epidemiology and management of common pulmonary diseases in older persons. J Gerontol a Biol Sci Med Sci. 2012 Mar;67(3):276-91. PMID:22337938 21. Jones S, Pisani MA. Intensive Care Unit Delirium: An Update. Curr Opin Crit Care. 2012 Apr;18(2):146-51. PMID:22322260 22. Pisani MA. British Medical Journal. “Delirium Monograph”. 2013, 2014, 2015, 2016 23. Akgun KA, Pisani MA. Respiratory Diseases and Disorders. In: Durso SC, Sullivan GM, eds. Geriatric Review Syllabus: A Core Curriculum in Geriatric Medicine, 8th ed. New York, NY: American Geriatrics Society; 2013 24. Pisani MA. Delirium and Dementia: Unraveling the Complex Relationship. In: Brain Dysfunction in Critical Illness, eds. Stevens R, Sharshar T, Ely EW. Publisher: Cambridge University Press; 2013 25. Farshidpanah S, Pisani MA, Ely EW, Watson PL. Sleep in the critically ill patient. In: Principles and Practice of Sleep Medicine 6th edition, eds. Meir Kryger. Publisher Elsevier; 2015 26. Pisani MA, Friese RS, Gehlbach BK, Schwab RJ, Weinhouse GL, Jones SF. Sleep in the ICU: A concise clinical review. Am J Resp Crit Care Med. 2015 Apr 1;191(7):731-38. [Epub ahead of print] PMID:25594808 27. Knauert M, Haspell J, Pisani MA. Sleep loss and circadian disruption in the ICU. Clinics in Chest Medicine. 2015 Sep;36(3):419-29. [Epub ahead of print 2015 Jun 29] PMID: 26304279 28. Oldham M, Pisani MA. Sedation in critically ill patients. In: Sleep and circadian rhythms in the ICU, Critical Care Clinics. 2015 Jul;31(3):563-87. PMID: 26118921 29. Debiasi E, Akgun KA, Pisani MA. Awake or sedated; Trends in the evaluation and management of agitation in the intensive care unit. In: Semin Respir Crit Care Med, eds. Mark Siegel, Wassim Fares. Publisher Thieme; [Epub 2015 Dec 14] PMID: 26595050 30. Akgun KA, Pisani MA. Respiratory Diseases and Disorders. In: Durso SC, Sullivan GM, eds. Geriatric Review Syllabus: A Core Curriculum in Geriatric Medicine, 9th ed. New York, NY: American Geriatrics Society; 2016 COMMITTEES AND MEMBERSHIPS Member, Internship Selection Committee, Yale University School of Medicine, 2001-2004 Member, Internal Medicine, Society for Critical Care Medicine, 2001-present Member, Clinical Problems Assembly, American Thoracic Society, 2001-present Member, Critical Care Assembly, American Thoracic Society, 2001-present Member, Program on Aging Research Career Development Core Planning Committee, Yale University 2003 Member, American Board of Internal Medicine Subspecialty Recertification Project. Infusing Geriatrics into the Subspecialties of Medicine 2003-2004 Member, Women’s Health Network American College of Chest Physicians, 2003-present Member, Chest Foundation Community Service Outreach Program 2005-present Member, Up-to-Date-Integrating Geriatrics into Subspecialties 2006-2007 16 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Grant Reviewer, CHEST Foundation Geriatric Development Research Awards, 2006-2010 Member, Delirium Treatment Protocol Committee, Yale-New Haven Hospital, 2006-present Abstract Reviewer, American College of Chest Physicians Annual Meeting 2006-present Member, Alcohol Withdrawal Treatment Protocol Committee, Yale-New Haven Hospital 2007 Member, Internal Medicine Research Advisory Panel, Yale University, 2007-2012 Member, Yale University Graduate Medical Education Committee, 2008-2011, 2015-present Member, Association of Subspecialty Professors in Internal Medicine, 2008-present Member, Geriatric Section Chief Search Committee, Yale University School of Medicine 2009 Member, Sedation Protocol Committee, Yale-New Haven Hospital 2011-present Member, Executive Committee, Center of Excellence for Delirium in Aging: Research, Training and Educational Enhancement (CEDARTREE), 2011-present Member, Scientific Presentations and Awards Committee, American College of Chest Physicians, 2011-present Member, Safety Advisory Board, SAGES Delirium Program Project Grant 2011-present Grant Reviewer, NIH Clinical and Translational Science Award, (CTSA), Albert Einstein College of Medicine 2012 Co-Chair, Sleep in the ICU Task Force, 2012-present Member, Physician Scientist Recruitment Committee, Yale University School of Medicine 2012present Member, Steering Committee, Women’s Health Network American College of Chest Physicians, 2013-present Member, Scientific Programming Committee, Connecticut Thoracic Society, 2013-present Chair, Scientific Programming Committee, Connecticut Thoracic Society, 2015-present Vice-Chair, Scientific Presentations and Awards Committee, American College of Chest Physicians, 2013-2015 Member, Yale University School of Medicine, Medical Student Thesis Committee 2014 Member, Critical Care Network, American College of Chest Physicians 2014-present Member, Education Assembly, American Thoracic Society, 2015-present Member, Sleep and Neurobiology Assembly. American Thoracic Society, 2014-present Member, Pain, Agitation, Delirium (PAD) Guidelines Revision Committee, 2014-present Member, Intensive Care Unit Alarm Committee, Yale-New Haven Hospital, 2014-present Member, American Board of Internal Medicine, Critical Care Medicine Board Writing Exam Committee, 2015-present Chair, Scientific Presentations and Awards Committee, American College of Chest Physicians, 2015-present Social Media Ambassador, American College of Chest Physicians National Meeting, 2015 Member, Educational Programming Committee, American College of Chest Physicians National Meeting 2015-present Member, BASIL (Better Assessment in Severe Illness) Delirium Expert Panel, 2015-present Member, Social Media Working Group, American College of Chest Physicians, 2016-present JOURNAL SERVICE 17 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Peer Reviewer, JAMA, Archives of Internal Medicine, British Medical Journal, Critical Care Medicine, Intensive Care Medicine, Critical Care, Journal of the American Geriatrics Society, 2001-present Guest Editor, Respiratory Disease in Older Patients, Clinics in Chest Medicine, 2007 Editor, Pulmonary & Critical Care & Sleep Updates (PCCSU), American College of Chest Physicians, 2007-2012 Editorial Board, Heart & Lung: The Journal of Acute and Critical Care, 2013-present Editorial Board, Pleura 2015-present INVITED SPEAKING ENGAGEMENTS, PRESENTATIONS, SYMPOSIA & WORKSHOPS Invited Speaker, “Preexisting cognitive impairment in older patients admitted to the intensive care unit” Gerontological Society of America, Chicago, IL November 2001 Invited Speaker, “Cognitive impairment in older medical intensive care unit patients: Physician recognition, intensity of care and outcomes” American College of Chest Physicians, Philadelphia, PA October 2001 Invited Speaker, Griffin Hospital Geriatric Grand Rounds, “Cognitive impairment in the ICU” 2002 Session Chair, “Sedation in the ICU” American Thoracic Society, Seattle WA, May 2003 Invited Speaker, “Risk factors for poor outcomes in older ICU patients: the contribution of psychoactive drug use” American College of Chest Physicians, Women’s Health Network, Annual Meeting, San Diego, CA October 2003 Invited Speaker, “Cognitive impairment in the ICU, why is it important and how do I recognize it?” American College of Chest Physicians, San Diego, CA October 2003 Invited Speaker, Panel on Sedation in the ICU, “Cognitive Impairment in the ICU, how do I recognize it?” American College of Chest Physicians, Orlando, FL October 2003 Invited Speaker, “Keys to Starting a Clinical Research Career” American College of Chest Physicians Academic Leadership Conference, October 2003-2007 Invited Speaker, “Risk Factors for Poor Outcomes in Older ICU Patients” Connecticut Thoracic Society Research Meeting, New Britain, CT April 2004 Invited Speaker, “Risk factors for poor outcomes in older ICU patients” American Geriatric Society, New Frontiers in Geriatrics: The Jahnigen and Williams Awardees Report on Research Leading to Improved Care by Surgical and Medical Sub-specialists. Las Vegas, NV May 2004 Invited Speaker, “Delirium in Older ICU Patients” Pennsylvania Thoracic Society Annual Meeting, Pittsburgh, PA September 2004 Invited Speaker, “Tips for Succeeding in Academic Medicine” American College of Chest Physicians Academic Leadership Conference, Montreal CN October 2005 Invited Speaker, “How I started a clinical research career” Gerontological Society of America, Chicago, IL 2006 Invited Speaker, “Under recognition of preexisting cognitive impairment by physicians in older patients and its effect on ICU outcomes” American Thoracic Society, San Diego, CA May 2006 18 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Session Chair, “Critical care of the geriatric patient” American Thoracic Society National Meeting, San Diego, CA May 2006 Invited Speaker, “Monitoring sedation and delirium in the ICU” American Thoracic Society National Meeting, San Diego, CA May 2006 Invited Speaker, “Does age impact on outcomes from critical care” American College of Chest Physicians, Salt Lake City, UT October 2006 Session Chair, “Caring for the critically ill geriatric patient” American College of Chest Physicians, Salt Lake City, UT October 2006 Invited Speaker, “Delirium in the ICU: A long way to go” Brown University School of Medicine, Providence, RI 2007 Invited Speaker, “Delirium in the ICU” National Institute of Health/NIA Seminar on Critical Illness in Older Patients, Washington, DC 2007 Invited Speaker, “Psychoactive medications and the duration of delirium in an ICU population” American Thoracic Society, San Francisco, CA May 2007 Invited Speaker, “Delirium in the ICU” Norwalk Hospital, Norwalk, CT 2008 Session Moderator, Poster Discussion: “Non-pulmonary Critical Care” American Thoracic Society, Toronto, CN May 2008 Invited Speaker: “Delirium and the role of sedative medications” German Society of Anesthesiology and Intensive Care Medicine, Berlin, Germany September 2008 Invited Speaker, “Implementation of delirium screening in the ICU” German Society of Anesthesiology and Intensive Care Medicine, Berlin, Germany September 2008 Session Moderator, “Foundation Funding” T. Franklin Williams Scholars Program Annual Alumni Meeting, Austin, TX 2009 Session Moderator, “Top secrets of writing a successful aging related research grant” T. Franklin Williams Scholars Program Annual Alumni Meeting, Austin, TX 2009 Invited Speaker, “Geriatric Research Update” T. Franklin Williams Scholars Program Annual Alumni Meeting, Austin, TX 2009 Invited Speaker, “Clinical Research in Pulmonary & Critical Care” Norwalk Hospital, Norwalk, CT 2009 Invited Speaker, “Gender differences as they relate to outcome in an older ICU cohort” Women’s Health Network Featured Speaker, American College of Chest Physicians, San Diego, CA October 2009 Session Moderator, Poster Discussion Session, “Non-pulmonary critical care” American Thoracic Society, New Orleans, LA May 2010 Invited Speaker, “Delirium in the ICU” Advancing Delirium Science Department of Veterans Affairs, Baltimore, MD June 2010 Invited Speaker, “Career Development in Science” Iona College, New Rochelle, NY September 2010 Invited Speaker, “Delirium and a Research Career” Tufts University School of Medicine, Boston, MA 2010 Invited Speaker, “Delirium in the ICU” St. Mary’s Hospital Grand Rounds, Waterbury, CT 2010 Session Moderator, Poster Discussion Session, “Non-pulmonary critical care” American Thoracic Society, Denver, CO May 2011 19 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Invited Speaker, “Environmental treatments for delirium” French Intensive Care Society Annual Meeting, Versailles, France July 2011 Invited Speaker, “Delirium Assessment Tools” Society for Critical Care Medicine; Current Concepts in Critical Care, Houston, TX January 2012 Session Moderator, Poster Discussion Session, “Pulmonary Infections and Tuberculosis: Case Reports of Note” American Thoracic Society, San Francisco, CA May 2012 Invited Speaker, “Confusion, drugs and decline: Challenges for caring for the older patient in the ICU”. Rhode ICU Collaborative Outcomes Congress, Warwick RI September 2012 Session Moderator, Poster Discussion Session “Non-pulmonary critical care”, American College of Chest Physicians, Atlanta, GA October 2012 Session Moderator, Thematic Poster Session, “Taking it to the house: great cases in critical care”, American Thoracic Society, Philadelphia, PA May 2013 Invited Speaker, “Delirium and the hazards of medication use in older ICU patients” American Thoracic Society, Philadelphia PA May 2013 Invited Speaker, “Delirium: Best practices to identify and prevent” American College of Chest Physicians, Chicago, IL October 2013 Invited Speaker, “Sleep in critically ill patients: Where are we now?” American College of Chest Physicians, Chicago, IL October 2013 Session Chair, “A new frontier: Sleep in the ICU exploration beyond the sleep laboratory” American College of Chest Physicians, Chicago, IL October 2013 Session Moderator, “Non-pulmonary critical care” American College of Chest Physicians, Chicago, IL October 2013 Session Moderator, “Quality improvement in the ICU” American College of Chest Physicians, Chicago, IL October 2013 Session Moderator, “End of Life Care” American College of Chest Physicians, Chicago, IL October 2013 Invited Speaker, Women’s Health Network Featured Lecture, “Women, lung disease and personalized medicine: Ready for prime time?” American College of Chest Physicians, Austin, TX October 2014 Session Moderator, “ICU Infections” American College of Chest Physicians, Austin, TX October 2014 Session Moderator, “Advances in COPD Treatments” American College of Chest Physicians, Austin, TX October 2014 Invited Speaker, Cedartree Visiting Professor Hebrew Senior Life, “Sleep and circadian rhythm alterations in aging and illness”. Harvard University Boston, MA April 2015 Invited Speaker, Beth Israel-Deaconness Hospital, Department of Medicine Visiting Professor: “Addressing challenging clinical research questions in critically ill patients with novel analytical techniques”. Harvard University Boston, MA April 2015 Invited Speaker, “Clinical research questions in older, critically ill patients.” Brigham & Women’s Hospital, Department of Pulmonary & Critical Care, Harvard University, Boston, MA April 2015 20 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Invited Speaker, “Delirium and sleep in the ICU” Tufts University School of Medicine, Division of Pulmonary & Critical Care Medicine 2015 Invited Speaker, “Sleep in the ICU: Absent, Impact, Improvement”, Connecticut Pulmonary Society Annual Meeting, Hartford, CT October 2015 Invited Speaker, “ICU delirium protocols, how to implement screening” American College of Chest Physicians, Montreal, BC October 2015 Session Moderator, “Original investigations in sepsis” American College of Chest Physicians, Montreal, BC October 2015 Session Moderator, Thematic Poster Session “Critical Care Posters” American College of Chest Physicians, Montreal CN, October 2015 Session Moderator, Poster Discussion Session “Non-pulmonary critical care” American College of Chest Physicians, Montreal CN, October 2015 Invited Participant, NIH U13 Conference Sleep, circadian rhythms, and aging: New avenues for improving brain health, physical health and functioning. Bethesda, MD October 2015 Invited Participant, AAMC Women’s Leadership Conference, Austin TX, December Invited Speaker, “Sleep during acute illness” Gaylord Hospital Grand Rounds, Wallingford CT January 2016 Invited Speaker, “Sedation interventions during critical illness: More or Less?” Postgraduate Course American Thoracic Society International Meeting, San Francisco, CA May 12, 2016 Invited Speaker, “Challenging cases of ICU Delirium: Assessment, Management and Prevention”, American College of Chest Physicians, Los Angeles, CA, October 2016 Session Moderator, Poster Discussion Session “Critical Care” American College of Chest Physicians, Los Angeles CA, October 2016 Session Moderator, “Original Investigations in Critical Care-Sepsis” American College of Chest Physicians, Los Angeles, CA October 2016 EDUCATIONAL LECTURES PCCSM Fellowship Summer Lecture Series, “Endocrine disorders in the ICU” 2002 Yale-New Haven Hospital Medical ICU Nursing In-service, “Cognitive impairment in the ICU, Why is it important and how do I recognize it?” 2003 Pulmonary State Chest Conference, “Cognitive impairment in the ICU” 2004 Pulmonary Research in Progress, “Dementia, delirium and psychoactive drugs: challenges of clinical research in the ICU” 2004 Aging Biomedical Research Conference, “Risk factors for poor outcomes in older ICU patients” 2004 Pulmonary Research in Progress, “Delirium in the ICU” 2005 Yale Claude D. Pepper Center Retreat, “T. Franklin Williams Scholar Program” 2005 Yale-New Haven Hospital Medical ICU Nursing In-service, “Delirium in the ICU” 2005 21 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Pulmonary State Chest Conference, “Challenges for caring for the geriatric patient in the ICU” 2006 PCCSM Fellowship Summer Lecture Series, “Study Design, Meta-analysis, RCT's & Medical Decision Making” 2007 PCCSM Fellowship Summer Lecture Series, “Monitoring Pain, Agitation and Delirium in the ICU” 2007 PCCSM Fellowship Summer Lecture Series, “How to Present in State Chest & Journal Club” 2007 Yale University Biomedical Research Seminar, “Delirium and the challenges of clinical research in the ICU” 2007 Pulmonary Research in Progress, “Delirium in the ICU: A long way to go” 2007 Aging Research Seminar, “Delirium and the challenges of clinical research in the ICU” 2007 Yale-New Haven Nursing Education Conference, “Delirium in the ICU: What is all the confusion about?” 2007 Yale University Medical Grand Rounds, “Delirium in the ICU” 2007 Yale Internal Medicine Resident Noon Conference, “Monitoring delirium and sedation in the ICU” 2008 PCCSM Research Conference, “Clinical Research in the ICU” 2009 PCCSM Fellowship Summer Lecture Series, “Delirium and Sedation in the Elderly ICU PCCSM Winchester Fellows Clinic Conference, “Inhaled Anti-cholinergic Risk” 2010 PCCSM Fellowship Summer Lecture Series, “Delirium and Sedation in the ICU” 2010 Greenwich Hospital Resident Lecture, Greenwich CT, “Sarcoidosis” 2010 PCCSM Winchester Fellows Clinic Conference, “Evaluation of ILD-Case Based Conference” 2011 PCCSM Fellowship Summer Lecture Series, “Introduction to Clinical Research” 2011 PCCSM Winchester Fellows Clinic Conference, “Lung volume reduction surgery” 2011 PCCSM Winchester Fellows Clinic Conference, “How to make sense of the patient with isolated restriction” 2011 PCCSM Winchester Fellows Clinic Conference, “Bariatric Surgery-Pre-Operative Evaluation” October 2011 Winchester Chest Clinic Fellows State of the Art Conference, “Tiotropium in Asthma” 2012 Griffin Hospital ICU Teaching Rounds, “Management of Acute Liver Failure”, “Acid-Base Disorders”, Assessment and Treatment of Delirium”, “Mechanical Ventilation” 2012 PCCSM Fellowship Summer Lecture Series, “Delirium in the ICU” 2012 Student-Faculty Rounds Ambulatory Component of the Internal Medicine Clerkship, Pulmonary Moderator 2012 Winchester Chest Clinic Fellows State of the Art Conference, “Vitamin D and COPD” 2012 Yale-New Haven Hospital Surgical ICU Nursing In-service, “Delirium assessment in the ICU” 2012 Yale-New Haven Hospital Intern Reflection Rounds, Faculty Moderator 2012-2013 22 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 Yale Geriatrics-Brown Bag Lunch Series, “Career Paths-Struggles and Accomplishments” 2012-2013 Winchester Chest Clinic Fellows State of the Art Conference, “Steroids in COPD Exacerbations, what does the evidence show?” 2013 Greenwich Hospital, Resident Lecture, “Sleep and delirium in the ICU” 2013 Yale Physician’s Assistant Program Lecture, “Delirium, sedation and pain in the ICU” 2013 Yale Program on Aging Research Seminar, “Dementia, delirium and sleep: critically important to older ICU patients” 2014 PCCSM Fellows Research Retreat, “What to expect, what to request: The mentormentee relationship” 2014, 2015 Greenwich Hospital, Resident Lecture, “Sedation and pain control in the ICU” 2015 Waterbury Hospital Medical Grand Rounds 2015 Griffin Hospital ICU Teaching Rounds 2015 Yale Department of Geriatrics, Aging Brown Bag Lunch, “Research career pathways and clinical time” 2015 PCCSM Summer Lecture Series, “Altered mental status in the intensive care unit” 2015 Yale-New Haven Hospital Resident Reflection Rounds, Faculty Moderator 2015 Danbury Hospital, Resident Lecture, “Mechanical Ventilation” 2015 Greenwich Hospital, Resident Lecture, “Sleep and altered mental status in critically ill patients” 2015 Greenwich Hospital, “Sleep in the Critically Ill: Absent, Impact, Improvement”, Medical Grand Rounds May 2016 Bridgeport Hospital Internal Medicine Professor Rounds, October 2016 VOLUNTEER SERVICE Cub Scout Leader, Tashua Elementary School, Trumbull, CT 2004-2005 Junior Achievement Course Leader, Tashua School, Trumbull, CT 2005-2006, 2011present Angel Tree Coordinator, Long Hill United Methodist Church, Trumbull, CT 2006-2011 The Chest Foundation Community Outreach Program 2006-2013 Children’s Center Board Member, Long Hill United Methodist Church, Trumbull, CT 2007-2009 Tashua School Brownie Troop, Anti-Smoking Educational Program, Trumbull, CT 2013 Volunteer, Tape your Teacher to the Wall, Tashua School, Trumbull, CT 2013 Coordinator Visiting Author Day, Tashua School, Trumbull, CT 2014 23 MARGARET ANN PISANI, M.D., M.P.H. 86 Old Tree Farm Lane Trumbull, CT 06611 [email protected] [email protected] H (203) 268-9046 C (203) 572-4013 24